EP3182844B1 - Method for reducing the amount of tobacco specific nitrosamines in liquids containing nicotine - Google Patents

Method for reducing the amount of tobacco specific nitrosamines in liquids containing nicotine Download PDF

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Publication number
EP3182844B1
EP3182844B1 EP15753036.1A EP15753036A EP3182844B1 EP 3182844 B1 EP3182844 B1 EP 3182844B1 EP 15753036 A EP15753036 A EP 15753036A EP 3182844 B1 EP3182844 B1 EP 3182844B1
Authority
EP
European Patent Office
Prior art keywords
tobacco
nanometres
slurry
amount
tobacco slurry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15753036.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3182844A2 (en
Inventor
Gerhard Lang
Jan Carlos HUFNAGEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philip Morris Products SA
Original Assignee
Philip Morris Products SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip Morris Products SA filed Critical Philip Morris Products SA
Priority to PL15753036T priority Critical patent/PL3182844T3/pl
Publication of EP3182844A2 publication Critical patent/EP3182844A2/en
Application granted granted Critical
Publication of EP3182844B1 publication Critical patent/EP3182844B1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/22—Treatment of tobacco products or tobacco substitutes by application of electric or wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/245—Nitrosamines
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors

Definitions

  • the present invention relates to methods of forming aerosol-generating substrates having a reduced amount of tobacco-specific nitrosamines.
  • the aerosol-generating substrates formed according to the present invention find particular application as substrates for electrical smoking systems.
  • a known electrically operated smoking system comprises a shell and a replaceable mouthpiece wherein the shell comprises an electric power supply and electric circuitry.
  • the mouthpiece comprises a liquid storage portion, a capillary wick having a first end that extends into the liquid storage portion for contact with liquid therein, and a heating element for heating a second end of the capillary wick.
  • liquid is transferred from the liquid storage portion towards the heating element by capillary action in the wick. Liquid at the second end of the wick is vaporised by the heating element.
  • a known electrically operated smoking system comprises a resistively heated ceramic heater blade that is inserted into a tobacco rod to generate an aerosol comprising volatile compounds contained within the tobacco.
  • Cast leaf tobacco products are formed by casting and drying a tobacco slurry.
  • Liquid nicotine formulations and tobacco slurries are typically derived from cured tobacco materials.
  • liquid nicotine formulations and heated tobacco products formed from tobacco slurries may be undesirably contaminated with tobacco-specific nitrosamines (TSNAs), such as N -nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N- nitrosoanatabine (NAT) and N-Nitrosoanabasine (NAB).
  • TSNAs tobacco-specific nitrosamines
  • NNN N -nitrosonornicotine
  • NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • NAT N- nitrosoanatabine
  • NAB N-Nitrosoanabasine
  • WO 01/65954 A1 describes a process of treating tobacco to reduce or eliminate nitrosamines therefrom, the process comprising the use of a supercritical fluid extraction medium to remove nitrosamines from the tobacco.
  • the supercritical fluid extraction medium is irradiated with UV light before the supercritical fluid extraction medium is cycled back through the tobacco.
  • the use of a supercritical fluid extraction medium to remove nitrosamines from the tobacco is both costly and complex.
  • WO02/13636 discloses the UV treatment of tobacco leaves before or during curing in order to reduce the amount of TSNA-s, which is according to the teachings formed by exclusively bacterial activity.
  • US1754117 discloses that the UV treatment of cured tobacco will result in the reduction or neutralisation of the poisonous effects of nicotine.
  • CN101828763 discloses the UV treatment of cut and dried tobacco stems to improve the cut stem quality.
  • Another known method for reducing TSNA contamination of nicotine purified from cured tobacco materials includes chemical treatment of the tobacco plants prior to harvest to increase antioxidant production and prevent TSNA formation during curing.
  • the process of treating the tobacco plants is time consuming, costly, and care must be taken to prevent environmental contamination with the chemicals used.
  • a method for reducing the amount of at least one tobacco-specific nitrosamine in an aerosol-generating substrate comprising providing a tobacco slurry containing at least one tobacco-specific nitrosamine, irradiating the tobacco slurry with ultraviolet light, and drying the tobacco slurry to form an aerosol-generating substrate.
  • aerosol-generating substrate refers to a substrate capable of releasing volatile compounds, which can form an aerosol.
  • the aerosols generated from aerosol-generating substrates according to the invention may be visible or invisible and may include vapours (for example, fine particles of substances, which are in a gaseous state, that are ordinarily liquid or solid at room temperature) as well as gases and liquid droplets of condensed vapours.
  • the method according to the present invention advantageously eliminates the need for chemical removal processes.
  • the method according to the present invention may therefore be cheaper, produce little or no waste, and minimise any health and environmental concerns when compared to existing processes.
  • the present invention utilises UV irradiation of a tobacco slurry it can be applied to tobacco plant material that has already been harvested and processed. This is in contrast to known methods, such as the chemical treatment method described above that requires treatment of the tobacco plant during cultivation and prior to harvest, and other known methods that attempt to reduce TSNA content by optimising the conditions under which the harvested tobacco is cured.
  • the tobacco slurry may be cast and dried to form a cast leaf tobacco.
  • the tobacco slurry may be irradiated before casting, after casting, or both.
  • Such a method may be advantageous in that it would allow for integration of an apparatus capable of irradiating the slurry directly into a casting line.
  • the term "cast leaf tobacco” refers to a homogenised tobacco material typically formed by casting a tobacco slurry comprising particulate tobacco and one or more binders onto a conveyor belt or other surface, drying the cast slurry to form a sheet of homogenised tobacco material and removing the sheet of homogenised tobacco material from the support surface.
  • the ultraviolet irradiance of the tobacco slurry is preferably at least about 4 milliwatts per square centimetre, more preferably at least about 40 milliwatts per square centimetre, most preferably at least about 400 milliwatts per square centimetre.
  • UV irradiance at or above these levels can provide significant reduction of the amount of the one or more TSNAs within a relatively short time period.
  • the irradiation level of a fluid can be determined using a UV radiometer.
  • the UV irradiance step preferably comprises irradiating the tobacco slurry with ultraviolet light for less than about 180 minutes, more preferably less than about 120 minutes, yet more preferably less than about 60 minutes, most preferably less than about 30 minutes. Irradiating the tobacco slurry with ultraviolet light for a period within these ranges can provide significant reduction in the amount of the one or more TSNAs.
  • These time periods refer to the total duration of the UV irradiation and the total duration may be a single consecutive period of irradiance, or two or more discrete periods of irradiance.
  • the irradiance may be conducted in a single 30 minute step, or in two separate steps each of 15 minutes long.
  • the total irradiation time may be varied according to the thickness of the tobacco slurry. That is, the total irradiation time may be increased as the thickness of the tobacco slurry is increased.
  • a high UV irradiance is preferably used to minimise the total time required to reduce the TSNA content to a desired level.
  • the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry after the irradiation step is preferably less than about 75 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step, more preferably less than about 50 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step, most preferably less than about 25 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step.
  • the reduction in the amount of the at least one tobacco-specific nitrosamine can be increased by increasing at least one of the irradiance and the duration of the irradiating step.
  • the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry decreases in a generally exponential manner during the period of irradiation.
  • the ultraviolet light used in the irradiating step preferably has a peak intensity at a wavelength of at least about 315 nanometres, more preferably at least about 335 nanometres, most preferably at least about 350 nanometres. Additionally, or alternatively, the ultraviolet light preferably has a peak intensity at a wavelength of less than about 400 nanometres, more preferably less than about 390 nanometres, most preferably less than about 380 nanometres. In particularly preferred embodiments, the ultraviolet light has a peak intensity at a wavelength of between about 315 nanometres and about 400 nanometres, more preferably between about 335 nanometres and about 390 nanometres, most preferably between about 350 nanometres and about 380 nanometres.
  • the ultraviolet light may have a peak intensity at a wavelength of about 365 nanometres. UV light having a peak intensity at a wavelength within these ranges falls within the UV-A portion of the ultraviolet spectrum, which the present inventors have recognised provides effective reduction of TSNAs and is optimised for transmission through glass and common UV transparent polymeric packaging materials. Therefore, methods in accordance with these embodiments are particularly suited for the treatment of aerosol-generating substrates or tobacco slurries that are housed within a glass container, or housed within a container comprising a glass window through which the UV light is transmitted. Use of radiation having a shorter wavelength is undesirable, as it may result in undesirable chemical decomposition of the nicotine.
  • N-nitrosonornicotine N-nitrosonornicotine
  • NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • the UV irradiation caused a time-dependent decrease of NNK and NNN in all three nicotine/glycerin/propylene-glycol/water mixtures. Nicotine concentrations were not affected. The nitrosamine decay is approximately exponential with respect to irradiation time. Half-lives for NNN and NNK were in the ranges of 30-50 minutes and 60-70 minutes, respectively. The results are illustrated in Figures 1 to 3 .
  • a sample sheet of cast tobacco slurry having a thickness of 0.20 to 0.22 millimetres after drying to 195 to 200 grams per square metre was irradiated for 150 minutes, each, on both sides with UV light at a wavelength of 365 nanometres and an intensity of 4.5 milliwatts per square centimetre.
  • the irradiated cast leaf sample and a non-irradiated control were analysed for NNK, NNN, and nicotine content by mass spectroscopy. As compared to the control, the irradiated sample indicated no effect on nicotine content, a reduction of 12 percent in NNK content, and a reduction of 26 percent in NNN content.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
EP15753036.1A 2014-08-20 2015-08-19 Method for reducing the amount of tobacco specific nitrosamines in liquids containing nicotine Active EP3182844B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL15753036T PL3182844T3 (pl) 2014-08-20 2015-08-19 Sposoby wytwarzania substratów do wytwarzania aerozolu mających zmniejszoną ilość nitrozoamin specyficznych dla tytoniu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14181679 2014-08-20
PCT/EP2015/069091 WO2016026911A2 (en) 2014-08-20 2015-08-19 Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines

Publications (2)

Publication Number Publication Date
EP3182844A2 EP3182844A2 (en) 2017-06-28
EP3182844B1 true EP3182844B1 (en) 2018-08-15

Family

ID=51357871

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15753036.1A Active EP3182844B1 (en) 2014-08-20 2015-08-19 Method for reducing the amount of tobacco specific nitrosamines in liquids containing nicotine

Country Status (11)

Country Link
US (1) US20170238597A1 (hu)
EP (1) EP3182844B1 (hu)
JP (1) JP6602845B2 (hu)
KR (1) KR102486705B1 (hu)
CN (1) CN106714587B (hu)
BR (1) BR112017001255B1 (hu)
ES (1) ES2690876T3 (hu)
HU (1) HUE040016T2 (hu)
PL (1) PL3182844T3 (hu)
RU (1) RU2685845C2 (hu)
WO (1) WO2016026911A2 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201504587D0 (en) * 2015-03-18 2015-05-06 British American Tobacco Co Improvements in methods of treating tobacco.
WO2024062588A1 (ja) * 2022-09-22 2024-03-28 日本たばこ産業株式会社 脱色たばこ材料およびその製造方法

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Also Published As

Publication number Publication date
BR112017001255A2 (pt) 2017-11-14
KR20170044092A (ko) 2017-04-24
JP2017525363A (ja) 2017-09-07
RU2685845C2 (ru) 2019-04-23
WO2016026911A2 (en) 2016-02-25
ES2690876T3 (es) 2018-11-22
BR112017001255B1 (pt) 2021-12-21
PL3182844T3 (pl) 2019-04-30
WO2016026911A3 (en) 2016-04-21
EP3182844A2 (en) 2017-06-28
HUE040016T2 (hu) 2019-02-28
RU2017108898A3 (hu) 2018-10-30
US20170238597A1 (en) 2017-08-24
JP6602845B2 (ja) 2019-11-06
CN106714587A (zh) 2017-05-24
RU2017108898A (ru) 2018-09-20
CN106714587B (zh) 2021-10-22
KR102486705B1 (ko) 2023-01-10

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