US20170238597A1 - Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines - Google Patents

Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines Download PDF

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Publication number
US20170238597A1
US20170238597A1 US15/504,487 US201515504487A US2017238597A1 US 20170238597 A1 US20170238597 A1 US 20170238597A1 US 201515504487 A US201515504487 A US 201515504487A US 2017238597 A1 US2017238597 A1 US 2017238597A1
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United States
Prior art keywords
tobacco
aerosol
generating substrate
slurry
ultraviolet light
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Pending
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US15/504,487
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English (en)
Inventor
Gerhard Lang
Jan Carlos Hufnagel
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Philip Morris Products SA
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Philip Morris Products SA
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Assigned to PHILIP MORRIS PRODUCTS S.A. reassignment PHILIP MORRIS PRODUCTS S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LANG, GERHARD, HUFNAGEL, Jan Carlos
Publication of US20170238597A1 publication Critical patent/US20170238597A1/en
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/22—Treatment of tobacco products or tobacco substitutes by application of electric or wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/245—Nitrosamines
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors

Definitions

  • a known electrically operated smoking system comprises a resistively heated ceramic heater blade that is inserted into a tobacco rod to generate an aerosol comprising volatile compounds contained within the tobacco.
  • Cast leaf tobacco products are formed by casting and drying a tobacco slurry.
  • the present invention provides a method of forming an aerosol-generating substrate, the method comprising providing a liquid nicotine source containing at least one tobacco-specific nitrosamine, mixing the liquid nicotine source with a solvent and at least one aerosol former to form an aerosol-generating substrate, and irradiating the aerosol-generating substrate with ultraviolet light to reduce the amount of the at least one tobacco-specific nitrosamine.
  • aerosol-generating substrate refers to a substrate capable of releasing volatile compounds, which can form an aerosol.
  • the aerosols generated from aerosol-generating substrates according to the invention may be visible or invisible and may include vapours (for example, fine particles of substances, which are in a gaseous state, that are ordinarily liquid or solid at room temperature) as well as gases and liquid droplets of condensed vapours.
  • the UV irradiance step preferably comprises irradiating the aerosol-generating substrate with ultraviolet light for less than about 180 minutes, more preferably less than about 120 minutes, yet more preferably less than about 60 minutes, most preferably less than about 30 minutes. Irradiating the aerosol-generating substrate with ultraviolet light for a period within these ranges can provide significant reduction in the amount of the one or more TSNAs.
  • These time periods refer to the total duration of the UV irradiation and the total duration may be a single consecutive period of irradiance, or two or more discrete periods of irradiance.
  • the irradiance may be conducted in a single 30 minute step, or in two separate steps each of 15 minutes long.
  • the amount of the at least one tobacco-specific nitrosamine present in the aerosol-generating substrate after the irradiation step is preferably less than about 75 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the aerosol-generating substrate before the irradiation step, more preferably less than about 50 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the aerosol-generating substrate before the irradiation step, most preferably less than about 25 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the aerosol-generating substrate before the irradiation step.
  • the reduction in the amount of the at least one tobacco-specific nitrosamine can be increased by increasing at least one of the irradiance and the duration of the irradiating step.
  • the amount of the at least one tobacco-specific nitrosamine present in the aerosol-generating substrate decreases in a generally exponential manner during the period of irradiation.
  • the method according to the second aspect of present invention advantageously eliminates the need for chemical removal processes.
  • the method according to the second aspect of the present invention may therefore be cheaper, produce little or no waste, and minimise any health and environmental concerns when compared to existing processes.
  • the present invention utilises UV irradiation of a tobacco slurry it can be applied to tobacco plant material that has already been harvested and processed. This is in contrast to known methods, such as the chemical treatment method described above that requires treatment of the tobacco plant during cultivation and prior to harvest, and other known methods that attempt to reduce TSNA content by optimising the conditions under which the harvested tobacco is cured.
  • the tobacco slurry may be cast and dried to form a cast leaf tobacco.
  • the tobacco slurry may be irradiated before casting, after casting, or both.
  • Such a method may be advantageous in that it would allow for integration of an apparatus capable of irradiating the slurry directly into a casting line.
  • the term “cast leaf tobacco” refers to a homogenised tobacco material typically formed by casting a tobacco slurry comprising particulate tobacco and one or more binders onto a conveyor belt or other surface, drying the cast slurry to form a sheet of homogenised tobacco material and removing the sheet of homogenised tobacco material from the support surface.
  • the ultraviolet irradiance of the tobacco slurry is preferably at least about 4 milliwatts per square centimetre, more preferably at least about 40 milliwatts per square centimetre, most preferably at least about 400 milliwatts per square centimetre.
  • UV irradiance at or above these levels can provide significant reduction of the amount of the one or more TSNAs within a relatively short time period.
  • the irradiation level of a fluid can be determined using a UV radiometer.
  • the UV irradiance step preferably comprises irradiating the tobacco slurry with ultraviolet light for less than about 180 minutes, more preferably less than about 120 minutes, yet more preferably less than about 60 minutes, most preferably less than about 30 minutes. Irradiating the tobacco slurry with ultraviolet light for a period within these ranges can provide significant reduction in the amount of the one or more TSNAs.
  • These time periods refer to the total duration of the UV irradiation and the total duration may be a single consecutive period of irradiance, or two or more discrete periods of irradiance.
  • the irradiance may be conducted in a single 30 minute step, or in two separate steps each of 15 minutes long.
  • the total irradiation time may be varied according to the thickness of the tobacco slurry. That is, the total irradiation time may be increased as the thickness of the tobacco slurry is increased.
  • the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry after the irradiation step is preferably less than about 75 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step, more preferably less than about 50 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step, most preferably less than about 25 percent by weight of the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry before the irradiation step.
  • the reduction in the amount of the at least one tobacco-specific nitrosamine can be increased by increasing at least one of the irradiance and the duration of the irradiating step.
  • the amount of the at least one tobacco-specific nitrosamine present in the tobacco slurry decreases in a generally exponential manner during the period of irradiation.
  • the ultraviolet light used in the irradiating step preferably has a peak intensity at a wavelength of at least about 315 nanometres, more preferably at least about 335 nanometres, most preferably at least about 350 nanometres. Additionally, or alternatively, the ultraviolet light preferably has a peak intensity at a wavelength of less than about 400 nanometres, more preferably less than about 390 nanometres, most preferably less than about 380 nanometres.
  • the ultraviolet light has a peak intensity at a wavelength of between about 315 nanometres and about 400 nanometres, more preferably between about 335 nanometres and about 390 nanometres, most preferably between about 350 nanometres and about 380 nanometres.
  • the ultraviolet light may have a peak intensity at a wavelength of about 365 nanometres. UV light having a peak intensity at a wavelength within these ranges falls within the UV-A portion of the ultraviolet spectrum, which the present inventors have recognised provides effective reduction of TSNAs and is optimised for transmission through glass and common UV transparent polymeric packaging materials.
  • methods in accordance with these embodiments are particularly suited for the treatment of aerosol-generating substrates or tobacco slurries that are housed within a glass container, or housed within a container comprising a glass window through which the UV light is transmitted.
  • Use of radiation having a shorter wavelength is undesirable, as it may result in undesirable chemical decomposition of the nicotine.
  • the present invention provides an aerosol-generating substrate formed using the method according to either the first aspect of the invention or the second aspect of the invention, in accordance with any of the embodiments described above.
  • N-nitrosonornicotine N-nitrosonornicotine
  • NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • the UV irradiation caused a time-dependent decrease of NNK and NNN in all three nicotine/glycerin/propylene-glycol/water mixtures. Nicotine concentrations were not affected. The nitrosamine decay is approximately exponential with respect to irradiation time. Half-lives for NNN and NNK were in the ranges of 30-50 minutes and 60-70 minutes, respectively. The results are illustrated in FIGS. 1 to 3 .
  • a sample sheet of cast tobacco slurry having a thickness of 0.20 to 0.22 millimetres after drying to 195 to 200 grams per square metre was irradiated for 150 minutes, each, on both sides with UV light at a wavelength of 365 nanometres and an intensity of 4.5 milliwatts per square centimetre.
  • the irradiated cast leaf sample and a non-irradiated control were analysed for NNK, NNN, and nicotine content by mass spectroscopy. As compared to the control, the irradiated sample indicated no effect on nicotine content, a reduction of 12 percent in NNK content, and a reduction of 26 percent in NNN content.
US15/504,487 2014-08-20 2015-08-19 Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines Pending US20170238597A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14181679.3 2014-08-20
EP14181679 2014-08-20
PCT/EP2015/069091 WO2016026911A2 (en) 2014-08-20 2015-08-19 Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines

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US20170238597A1 true US20170238597A1 (en) 2017-08-24

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US15/504,487 Pending US20170238597A1 (en) 2014-08-20 2015-08-19 Methods for forming aerosol-generating substrates having a reduced amount of tobacco specific nitrosamines

Country Status (11)

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US (1) US20170238597A1 (hu)
EP (1) EP3182844B1 (hu)
JP (1) JP6602845B2 (hu)
KR (1) KR102486705B1 (hu)
CN (1) CN106714587B (hu)
BR (1) BR112017001255B1 (hu)
ES (1) ES2690876T3 (hu)
HU (1) HUE040016T2 (hu)
PL (1) PL3182844T3 (hu)
RU (1) RU2685845C2 (hu)
WO (1) WO2016026911A2 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180070627A1 (en) * 2015-03-18 2018-03-15 British American Tobacco (Investments) Limited Improvements in methods of treating tobacco

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024062588A1 (ja) * 2022-09-22 2024-03-28 日本たばこ産業株式会社 脱色たばこ材料およびその製造方法

Citations (5)

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US3472237A (en) * 1967-05-24 1969-10-14 Steber Corp Irradiated tobacco process and product
US5007440A (en) * 1989-11-14 1991-04-16 R. J. Reynolds Tobacco Company Process for providing smokable material
US5327917A (en) * 1990-08-15 1994-07-12 R. J. Reynolds Tobacco Company Method for providing a reconstituted tobacco material
US6564808B1 (en) * 2000-08-11 2003-05-20 Philip Morris Incorporated Method for reduction of tobacco specific nitrosamines
US20060016125A1 (en) * 2004-07-23 2006-01-26 Philip Morris Usa Inc. Light treatment for reduction of tobacco specific nitrosamines

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US1754117A (en) * 1929-05-03 1930-04-08 Charles M Richter Method of reducing the poisonous effects of nicotine and the product thereof
US6202649B1 (en) * 1996-12-02 2001-03-20 Regent Court Technologies Method of treating tobacco to reduce nitrosamine content, and products produced thereby
US6058940A (en) * 1997-04-21 2000-05-09 Lane; Kerry Scott Method and system for assay and removal of harmful toxins during processing of tobacco products
NZ507948A (en) * 1997-06-20 2002-02-01 Regent Court Technologies Method of treating tobacco to reduce nitrosamine content, and products produced thereby
CN100430001C (zh) * 2000-03-10 2008-11-05 英美烟草(投资)有限公司 烟草的处理
WO2002013636A1 (en) * 2000-08-11 2002-02-21 Philip Morris Products Inc. A method and apparatus for reducing tobacco specific nitrosamines
BR0114448A (pt) * 2000-10-05 2003-09-02 Nicolas Baskevitch Redução de nitrosaminas em tabaco e em produtos de tabaco
US20050039767A1 (en) * 2002-11-19 2005-02-24 John-Paul Mua Reconstituted tobacco sheet and smoking article therefrom
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Publication number Priority date Publication date Assignee Title
US3472237A (en) * 1967-05-24 1969-10-14 Steber Corp Irradiated tobacco process and product
US5007440A (en) * 1989-11-14 1991-04-16 R. J. Reynolds Tobacco Company Process for providing smokable material
US5327917A (en) * 1990-08-15 1994-07-12 R. J. Reynolds Tobacco Company Method for providing a reconstituted tobacco material
US6564808B1 (en) * 2000-08-11 2003-05-20 Philip Morris Incorporated Method for reduction of tobacco specific nitrosamines
US20060016125A1 (en) * 2004-07-23 2006-01-26 Philip Morris Usa Inc. Light treatment for reduction of tobacco specific nitrosamines

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180070627A1 (en) * 2015-03-18 2018-03-15 British American Tobacco (Investments) Limited Improvements in methods of treating tobacco

Also Published As

Publication number Publication date
KR20170044092A (ko) 2017-04-24
JP2017525363A (ja) 2017-09-07
EP3182844A2 (en) 2017-06-28
CN106714587A (zh) 2017-05-24
WO2016026911A3 (en) 2016-04-21
RU2017108898A (ru) 2018-09-20
BR112017001255A2 (pt) 2017-11-14
RU2017108898A3 (hu) 2018-10-30
ES2690876T3 (es) 2018-11-22
EP3182844B1 (en) 2018-08-15
JP6602845B2 (ja) 2019-11-06
BR112017001255B1 (pt) 2021-12-21
PL3182844T3 (pl) 2019-04-30
WO2016026911A2 (en) 2016-02-25
CN106714587B (zh) 2021-10-22
HUE040016T2 (hu) 2019-02-28
RU2685845C2 (ru) 2019-04-23
KR102486705B1 (ko) 2023-01-10

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