EP3049390A1 - Substituierte phenylalanin-derivate - Google Patents

Substituierte phenylalanin-derivate

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Publication number
EP3049390A1
EP3049390A1 EP14771910.8A EP14771910A EP3049390A1 EP 3049390 A1 EP3049390 A1 EP 3049390A1 EP 14771910 A EP14771910 A EP 14771910A EP 3049390 A1 EP3049390 A1 EP 3049390A1
Authority
EP
European Patent Office
Prior art keywords
amino
substituted
methyl
group
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14771910.8A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ulrike RÖHN
Manuel ELLERMANN
Julia Strassburger
Astrid WENDT
Susanne Röhrig
Robert Alan WEBSTER
Martina Victoria SCHMIDT
Adrian Tersteegen
Kristin BEYER
Martina SCHÄFER
Anja BUCHMÜLLER
Christoph Gerdes
Michael Sperzel
Steffen SANDMANN
Stefan Heitmeier
Alexander Hillisch
Jens Ackerstaff
Carsten TERJUNG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Pharma AG
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Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Priority to EP14771910.8A priority Critical patent/EP3049390A1/de
Publication of EP3049390A1 publication Critical patent/EP3049390A1/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Definitions

  • the invention relates to substituted phenylalanine derivatives and processes for their preparation and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular diseases and / or perioperative severe blood loss.
  • Blood clotting is a protective mechanism of the organism that can rapidly and reliably "seal" defects in the blood vessel wall, thus preventing or minimizing blood loss, and hemostasis following vascular injury is essentially through the coagulation system, where an enzymatic cascade becomes more complex It involves numerous clotting factors, each of which, once activated, converts the next inactive precursor to its active form, transforming the soluble fibrinogen into the insoluble fibrin at the end of the cascade Traditionally, one differentiates between the intrinsic and the extrinsic system in blood coagulation, which culminate in a final common pathway, where factors Xa and IIa (thrombin) play key roles: Factor Xa bundles the signals of the two ger because it is produced both by Factor VIIa / Tissue Factor (extrinsic pathway) and the Tenase complex (intrinsic pathway) by reaction of Factor X. The activated serine protease Xa cleaves prothrombin to thrombin, which
  • coagulation is initiated by binding of activated factor VIIa to tissue factor (TF).
  • TF tissue factor
  • the resulting complex activates factor X, which in turn leads to thrombin generation with subsequent production of fibrin and platelet activation (via PAR-1) as hemorrhagic end-products of hemostasis.
  • PAR-1 tissue factor
  • the rate of thrombin production is small and limited by the appearance of TFPI as an inhibitor of the TF-FVIIa-FX complex.
  • a key component of the transition from initiation to amplification and propagation of coagulation is factor XIa.
  • Thrombin activated in positive feedback loops in addition to Factor V and Factor VIII and Factor XI to Factor XIa, which converts Factor IX to Factor IXa and on the thus generated Factor IXa / Factor VIIIa complex quickly larger amounts of Factor Xa produced. This triggers the production of large amounts of thrombin, which leads to strong thrombus growth and stabilizes the thrombus.
  • fibrinolysis Upon activation of plasminogen by tissue plasminogen activator (tPA), the active serine protease, plasmin, cleaves polymerized fibrin and thus degrades the thrombus. This process is called fibrinolysis - with plasmin as the key enzyme.
  • tissue plasminogen activator tPA
  • Uncontrolled activation of the coagulation system or defective inhibition of the activation processes can cause the formation of local thromboses or emboli in vessels (arteries, veins, lymphatics) or cardiac cavities. This can lead to serious thrombotic or thromboembolic disorders.
  • systemic hypercoagulability can lead to consumption coagulopathy in the context of disseminated intravascular coagulation.
  • Thromboembolic disorders are the most common cause of morbidity and mortality in most industrialized countries [Heart Disease: A Textbook of Cardiovascular Medicine, Eugene Braunwald, 5th Ed., 1997, W.B. Saunders Company, Philadelphia].
  • heparin In the therapy and prophylaxis of thromboembolic diseases, on the one hand heparin is used, which is administered parenterally or subcutaneously. Due to more favorable pharmacokinetic properties, although increasingly low molecular weight heparin is nowadays increasingly preferred; However, the known disadvantages described below can not thereby also be avoided be avoided, which consist in the therapy with heparin. Thus, heparin is orally ineffective and has only a comparatively low half-life.
  • a second class of anticoagulants are the vitamin K antagonists. These include, for example, 1,3-indandiones, but especially compounds such as warfarin, phenprocoumon, dicumarol and other coumarin derivatives, which are unsuitable for the synthesis of various products of certain vitamin K-dependent coagulation factors in the liver. Due to the mechanism of action, the effect is only very slow (latency until the onset of action 36 to 48 hours). Although the compounds can be administered orally, due to the high risk of bleeding and the narrow therapeutic index, a complex individual adjustment and observation of the patient is necessary [J. Hirsh, J. Dalen, D.R.
  • the therapeutic range is of central importance: The distance between the therapeutically effective dose for anticoagulation and the dose at which bleeding can occur should be as large as possible so that maximum therapeutic efficacy is achieved with a minimal risk profile.
  • W089 / 11852 describes inter alia substituted phenylalanine derivatives for the treatment of pancreatitis and WO 2007/070816 describes substituted thiophene derivatives as factor XIa inhibitors.
  • the invention relates to compounds of the formula
  • R is 5-membered heteroaryl, wherein heteroaryl may be substituted with one substituent selected from the group consisting of oxo, chloro, cyano, hydroxy and C 1 -C 3 -alkyl, wherein alkyl may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 fluorine substituents, or wherein alkyl is substituted with one substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl, methoxy, C t -alkoxycarbonyl, aminocarbonyl and C 1 -C 3 -alkylaminocarbonyl and in which alkyl is additionally substituted by 1 to 6 substituents fluoro,
  • R 7 is hydrogen, fluorine or chlorine, and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, which heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo , Chloro, cyano, hydroxy, hydroxycarbonyl, Ci-C 3 alkyl, pyrazolyl and pyridyl, wherein alkyl may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 fluorine substituents, or wherein alkyl is substituted with one substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl, methoxy, Ci-C / t-alkoxycarbonyl, aminocarbonyl and Ci-C3-alkylaminocarbonyl and wherein alkyl is additionally substituted with 1 to 6 substituents fluorine,
  • R 10 is hydrogen, fluorine, chlorine or hydroxycarbonyl, is hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl or a 4 to 8-membered heterocyclyl bonded via a carbon atom, where alkyl may be substituted by 1 to 2 substituents independently selected from the group consisting of fluoro, hydroxy, amino, hydroxycarbonyl, Ci-Cs-alkylamino, difluoromethyl, trifluoromethyl, - (OCH 2 CH 2 ) n -OCH 3 , - (OCH 2 CH 2 ) m -OH, trimethylaminium , Pyrrolidinyl, C3-C6-cycloalkyl, 4- to 8-membered heterocyclyl bonded via a carbon atom and 4- to 6-membered heterocyclylcarbonyl, wherein n is a number from 1 to 6, wherein m is a number from 1 to 6, wherein Hetero
  • R 3 is hydrogen or C 1 -C 3 -alkyl
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 4- to 8-membered heterocycle, wherein the heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, amino , Hydroxycarbonyl, C 1 -C 4 -alkyl, C 1 -C 3 -alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C 1 -C 4 -alkoxycarbonyl, aminocarbonyl and C 1 -C 3 -alkylaminocarbonyl,
  • R 4 is hydrogen, fluorine, chlorine, methyl or methoxy
  • R 5 is hydrogen, fluorine, chlorine, Ci-C t-alkyl, methoxy, ethoxy or trifluoromethyl
  • Compounds of the invention are the compounds of the formula (I) and their salts, solvates and solvates of the salts, as well as those of formula (I), hereinafter referred to as embodiment (e) and their salts, solvates and solvates of the salts, as far as the compounds of formula (I) mentioned below are not already salts, solvates and solvates of the salts.
  • the compounds of the invention may exist in different stereoisomeric forms depending on their structure, i. in the form of configurational isomers or optionally also as conformational isomers (enantiomers and / or diastereomers, including those in atropisomers).
  • the present invention therefore encompasses the enantiomers and diastereoisomers and their respective mixtures. From such mixtures of enantiomers and / or diastereomers, the stereoisomerically uniform components can be isolated in a known manner; Preferably, chromatographic methods are used for this, in particular HPLC chromatography on achiral or chiral phase.
  • the present invention encompasses all tautomeric forms.
  • the present invention also includes all suitable isotopic variants of the compounds of the invention.
  • An isotopic variant of a compound according to the invention is understood to mean a compound in which at least one atom within the compound according to the invention is exchanged for another atom of the same atomic number but with a different atomic mass than the atomic mass that usually or predominantly occurs in nature.
  • isotopes which can be incorporated into a compound of the invention are those of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, chlorine, bromine and iodine, such as 2 H (deuterium), 3 H (tritium), 13 C, 14 C, 15 N, 17 0, 18 0, 32 P, 33 P, 33 S, 34 S, 35 S, 36 S, 18 F, 36 C1, 82 Br, 123 I, 124 I, 129 I and 131 I.
  • isotopic variants of a compound of the invention such as, in particular, those in which one or more radioactive isotopes are incorporated, may be useful, for example, for the study of the mechanism of action or drug distribution in the body; Due to the comparatively easy production and detectability, compounds labeled with 3 H or 14 C isotopes are particularly suitable for this purpose.
  • isotopes such as deuterium may result in certain therapeutic benefits as a result of greater metabolic stability of the compound, such as prolonging the body's half-life or reducing the required effective dose;
  • Such modifications of the compounds of the invention may therefore optionally also constitute a preferred embodiment of the present invention.
  • Isotopic variants of the invention Compounds can be prepared by the methods known to the person skilled in the art, for example by the methods described below and the rules given in the exemplary embodiments, by using appropriate isotopic modifications of the respective reagents and / or starting compounds.
  • Salts used in the context of the present invention are physiologically acceptable salts of the compounds according to the invention. However, also included are salts which are not suitable for pharmaceutical applications themselves but can be used, for example, for the isolation or purification of the compounds according to the invention.
  • Physiologically acceptable salts of the compounds of the invention include acid addition salts of mineral acids, carboxylic acids and sulfonic acids, e.g. Salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, toluenesulfonic acid, benzenesulfonic acid, naphthalenedisulfonic acid, acetic acid, trifluoroacetic acid, propionic acid, lactic acid, tartaric acid, malic acid, citric acid, fumaric acid, maleic acid and benzoic acid.
  • salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, toluenesulfonic acid, benzenesulfonic acid, naphthalenedisulfonic acid acetic acid, trifluoroacetic acid, propionic acid
  • Physiologically acceptable salts of the compounds according to the invention also include salts of customary bases, such as, by way of example and by way of preference, alkali metal salts (for example sodium and potassium salts), alkaline earth salts (for example calcium and magnesium salts) and ammonium salts derived from ammonia or organic amines having 1 to 16 carbon atoms, for example and preferably, ethylamine, diethylamine, triethylamine, ethyldiisopropylamine, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, dimethylaminoethanol, procaine, dibenzylamine, N-methylmorpholine, arginine, lysine, ethylenediamine, N-methylpiperidine and choline.
  • customary bases such as, by way of example and by way of preference, alkali metal salts (for example sodium and potassium salts), alkaline earth salts (for example calcium and magnesium salts) and am
  • Solvates in the context of the invention are those forms of the compounds according to the invention which form a complex in the solid or liquid state by coordination with solvent molecules. Hydrates are a special form of solvates that coordinate with water.
  • the present invention also includes prodrugs of the compounds of the invention.
  • prodrugs includes compounds which may themselves be biologically active or inactive but which are converted during their residence time in the body into compounds of the invention (for example metabolically or hydrolytically) .
  • the following two representations (A) and (B) of a 1,4- disubstituted cyclohexyl derivative are equivalent to each other and are synonymous and in both cases descriptive of a trans-1,4-disubstituted cyclohexyl derivative.
  • the structural element of the tranexamic acid amide for example ⁇ N - [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl and iraws-4- (aminomethyl) cyclohexyl] carbonyl ⁇ .
  • this also applies to the structural element of trans- - hydroxycyclohexylamine, for example in (iraws-4-hydroxycyclohexyl) carbamoyl.
  • the representation (A) is preferably used for the tranexamic acid amide.
  • the enantiomers can be separated either directly after the coupling of the L-phenylalanine intermediates with the amine H2N-R 1 or at a later intermediate of the synthesis or else the compounds according to the invention can be separated.
  • the separation of the enantiomers is directly after the coupling of the L-phenylalanine intermediates with the amine H 2 NR 1 .
  • treatment includes inhibiting, delaying, arresting, alleviating, attenuating, restraining, reducing, suppressing, restraining or curing a disease, a disease, a disease, an injury or a medical condition , the unfolding, the course or progression of such conditions and / or the symptoms of such conditions.
  • therapy is understood to be synonymous with the term “treatment”.
  • prevention means the avoidance or reduction of the risk, a disease, a disease, a disease, an injury or a health disorder, a development or a Progression of such conditions and / or to get, experience, suffer or have the symptoms of such conditions.
  • the treatment or the prevention of a disease, a disease, a disease, an injury or a health disorder can be partial or complete.
  • Alkyl is a linear or branched alkyl radical having 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, particularly preferably 1 to 3 carbon atoms, by way of example and preferably methyl , Ethyl, n -propyl, iso -propyl, 2-methylprop-1-yl, n-butyl, feri-butyl, n-pentyl and n-hexyl.
  • Alkoxy represents a linear or branched alkoxy radical having 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, more preferably 1 to 3 carbon atoms, by way of example and preferably methoxy, ethoxy, n-propoxy, iso-propoxy, 2-methyl-prop-l -oxy, n-butoxy, ieri-butoxy, n-pentoxy and n-hexoxy.
  • Alkylamino represents an amino group having one or two independently selected identical or different linear or branched alkyl radicals, each having 1 to 3 carbon atoms, by way of example and preferably methylamino, ethylamino, n-propylamino, iso-propylamino, A ⁇ N-dimethylamino, A ⁇ N-dimethylamino, N-ethyl-N-memylamino, N-methyl-N-propylamino, N-iso-propyl-Nn-propylamino and .NN-diisopropylamino.
  • C 1 -C 3 -alkylamino is, for example, a monoalkylamino radical having 1 to 3 carbon atoms or a dialkylamino radical having in each case 1 to 3 carbon atoms per alkyl radical.
  • Alkoxycarbonyl is a linear or branched alkoxy radical which is bonded via a carbonyl group having 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, by way of example and preferably methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl and tert-butylcarbonyl. butoxycarbonyl.
  • Alkylaminocarbonyl is an amino group having one or two independently selected identical or different straight-chain or branched alkyl substituents, each having 1 to 3 carbon atoms, and which is bonded via a carbonyl group, by way of example and preferably methylaminocarbonyl, ethylaminocarbonyl, n-propylaminocarbonyl , iso-propylaminocarbonyl, A ⁇ N-dimemylaminocarbonyl, JV, JV-diethylaminocarbonyl, N-ethyl-N-methylaminocarbonyl, N-methyl-Nn-propylaminocarbonyl, N-iso-propyl-Nn-propylaminocarbonyl and A ⁇ N-diisopropylaminocarbonyl.
  • C 1 -C 3 -alkylaminocarbonyl is, for example, a monoalkylaminocarbonyl radical having 1 to 3 carbon atoms or a dialkylaminocarbonyl radical having in each case 1 to 3 carbon atoms per alkyl substituent.
  • Cycloalkyl represents a monocyclic cycloalkyl group having 3 to 6 carbon atoms, by way of example and preferably cycloalkyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
  • 4- to 8-membered heterocyclyl bonded via a carbon atom in the definition of the radical R 2 . is a saturated or partially unsaturated monocyclic or bicyclic radical which is bonded via a carbon atom having 4 to 8 ring atoms, preferably 5 or 6 ring atoms, and up to 3 heteroatoms and / or hetero groups, preferably 1 or 2 heteroatoms and / or hetero groups , from the series S, O, N, SO and SO 2 , where a nitrogen atom can also form an N-oxide, by way of example and preferably for azetidinyl, pyrrolidinyl, piperidinyl, tetrahydropyranyl, 3-azabicyclo [3.1.0] hex-6 yl, 8-azabicyclo [3.2.1] oct.
  • 3-yl and azepanyl most preferably pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-6-yl, 8-azabicyclo [3.2.1] oct-3-yl and octahydrocyclopenta [b] pyrrol-4-yl.
  • 4- to 6-membered heterocyclylcarbonyl in the definition of the radical R 2 is a saturated or partially unsaturated monocyclic radical which is bonded via a carbonyl group having 4 to 6 ring atoms, preferably 5 or 6 ring atoms, and up to 3 heteroatoms and / or hetero groups, preferably 1 or 2 heteroatoms and / or hetero groups, from the series S, O, N, SO and SO 2, where a nitrogen atom can also form an N-oxide, by way of example and preferably azetidinyl, pyrrolidinyl, piperidinyl and piperazinyl, especially preferably pyrrolidinyl and piperidinyl.
  • 4- to 8-membered heterocycle in the definition of the radicals R 2 and R 3 is a saturated or partially unsaturated monocyclic or bicyclic radical having 4 to 8 ring atoms, preferably 4 or 7 ring atoms, more preferably 5 or 6 ring atoms, and up to 3 heteroatoms and / or hetero groups, preferably 1 or 2 heteroatoms and / or hetero groups, from the series S, O, N, SO and SO2, where a nitrogen atom can also form an N-oxide, by way of example and preferably azetidinyl, pyrrolidinyl, morpholinyl , Thiomorpholinyl, piperidinyl, piperazinyl, 3-azabicyclo [3.1.0] hex-6-yl, 8-azabicyclo [3.2.1] oct-3-yl, azepanyl and hexahydro-pyrrolo [3,4-b] pyrrole-1 (2H) -yl, most preferably
  • 5-membered heteroaryl in the definition of the radical R 6 is an aromatic monocyclic radical having 5 ring atoms and up to 4 heteroatoms and / or hetero groups from the series S, O, N, SO and SO 2 , where a nitrogen atom is also an N- Oxide, for example and preferably for thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, triazolyl and tetrazolyl, particularly preferably imidazolyl, triazolyl and tetrazolyl.
  • 5-membered heterocycle in the definition of the radicals R 8 and R 9 is a saturated, partially unsaturated or aromatic monocyclic radical having 5 ring atoms and up to 2 heteroatoms and / or hetero groups from the series S, O, N, SO and SO 2, wherein a nitrogen atom may also form an N-oxide.
  • This 5-membered heterocycle together with the phenyl ring to which it is attached is by way of example and preferably 2,3-dihydro-1-benzothiophene-5-yl, 1,3-dihydro-2-benzothiophene-5-yl, 2 , 3-dihydro-1-benzofuran-5-yl, 1,3-dihydro-2-benzofuran-5-yl, indolin-5-yl, isoindolin-5-yl, 2,3-dihydro-1 / i-indazole -5-yl, 2,3-dihydro-l / i-benzimidazol-5-yl, l, 3-dihydro-2, l-benzoxazol-5-yl, 2,3-dihydro-l, 3-benzoxazole-5 - yl, l, 3-dihydro-2, l-benzothiazol-5-yl, 2,3-dihydro-l, 3-benzothi
  • R 6 is 5-membered heteroaryl, wherein heteroaryl may be substituted with a substituent selected from the group consisting of chloro and Ci-C3-alkyl, wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 substituents fluorine, or wherein alkyl is substituted with a substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl, methoxy, Ci-C t -alkoxycarbonyl, aminocarbonyl and Ci-C 3 alkylaminocarbonyl and wherein alkyl is additionally substituted with 1 to 6 substituents fluorine, is hydrogen or fluorine, and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, wherein the heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, chloro, hydroxy,
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 4- to 8-membered heterocycle, wherein the heterocycle may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, C 1 -C 4 -alkyl and C 1 -C 3 -alkylamino,
  • R 4 is hydrogen, fluorine, chlorine, methyl or methoxy
  • R 5 is hydrogen, fluorine, chlorine, C 1 -C 4 -alkyl, methoxy, ethoxy or trifluoromethyl
  • R 5b is hydrogen, fluorine, methyl or methoxy, and their salts, their solvates and the solvates of their salts.
  • R 1 is a group of the formula
  • # is the point of attachment to the nitrogen atom, is 5-membered heteroaryl, wherein heteroaryl may be substituted by a substituent selected from the group consisting of Ci-C3-alkyl, wherein alkyl may be substituted with a substituent
  • Hydroxy carbonyl or in which alkyl is substituted by a substituent hydroxycarbonyl and in which alkyl is additionally substituted by 1 to 6 substituents fluorine, is hydrogen
  • R 8 and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, wherein the heterocycle may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, hydroxy, methyl, ethyl and n-propyl, wherein methyl, ethyl and n-propyl may be substituted with a substituent hydroxycarbonyl, or wherein ethyl and n-propyl may be substituted with 4 to 7 substituents fluorine, or wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluoro,
  • R 10 is hydrogen, fluorine or chlorine, is hydrogen, Ci-Cö-alkyl, C 3 -C 6 -cycloalkyl or bonded via a carbon atom 4- to 8-membered heterocyclyl, wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of amino, Ci-C3-alkylamino and trifluoromethyl, and wherein cycloalkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of hydroxy, amino, methyl and C 1 -C 3 alkylamino, and wherein heterocyclyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxycarbonyl, Ci-C 4 alkyl, Ci-Cs-alkylamino, 2,2,2-trifluoroeth-l-yl and Ci -C 4 alkoxycarbonyl, wherein alkyl may be substituted with a hydroxy substituent, and where
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 4- to 6-membered heterocycle, R 4 is hydrogen or fluorine,
  • R 5 represents hydrogen, fluorine, chlorine, methyl, methoxy or trifluoromethyl
  • R 5b is hydrogen, fluorine, methyl or methoxy, and their salts, their solvates and the solvates of their salts.
  • R 1 is a group of the formula
  • R 6 is 5-membered heteroaryl, wherein heteroaryl may be substituted with one substituent selected from the group consisting of oxo, chloro, cyano, hydroxy and C 1 -C 3 -alkyl, wherein alkyl may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, or in which alkyl may be substituted by 1 to 7 substituents fluoro, or wherein alkyl is substituted with a substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy and wherein alkyl is additionally substituted with 1 to 6 substituents fluoro,
  • R 7 is hydrogen, fluorine or chlorine
  • R 8 and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, it being possible for the heterocycle to be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, chloro, cyano, hydroxy, and Ci C3-alkyl, pyrazolyl and pyridyl, wherein alkyl may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 fluorine substituents, or wherein Alkyl is substituted by a substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy and wherein alkyl is additionally substituted by 1 to 6 substituents fluorine,
  • R 10 is hydrogen, fluorine or chlorine, is hydrogen, Ci-Cö-alkyl, C 3 -C 6 -cycloalkyl or 4 to 8-membered heterocyclyl bonded via a carbon atom, wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of fluorine, hydroxyl, amino, hydroxycarbonyl, Ci-Cs-alkylamino, difluoromethyl, trifluoromethyl, - (OCH 2 CH 2 ) n -OCH 3 , - (OCH 2 CH 2 ) m -OH, trimethylamine and Pyrrolidinyl, wherein n is a number from 1 to 6, wherein m is a number from 1 to 6, and wherein cycloalkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, amino, Ci-C t-alkyl and C l -C3 - alky
  • heterocyclyl may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, amino, hydroxycarbonyl, Ci-C 4 alkyl, Ci-C 3 alkylamino, difluoromethyl, trifluoromethyl, 2 , 2,2-
  • R 3 is hydrogen or C 1 -C 3 -alkyl
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle, which heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, amino , Hydroxycarbonyl, C 1 -C 4 -alkyl, C 1 -C 3 -alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C 1 -C 4 -alkoxycarbonyl, aminocarbonyl and C 1 -C 3 -alkylaminocarbonyl, R 4 for Is hydrogen, fluorine, chlorine, methyl or methoxy,
  • R 5 is hydrogen, fluorine, chlorine, Ci-C t-alkyl, methoxy or trifluoromethyl, is hydrogen, and their salts, their solvates and the solvates of their salts. Preference is also given to compounds of the formula (I) in which, for a group of the formula
  • # is the point of attachment to the nitrogen atom, is 5-membered heteroaryl, where heteroaryl may be substituted by a substituent selected from the group consisting of chlorine and C 1 -C 3 -alkyl, in which alkyl may be substituted by 1 to 2 Substituents independently selected from the group consisting of hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 substituents fluorine, or wherein alkyl is substituted with a substituent hydroxycarbonyl and wherein alkyl is additionally substituted with 1 to 6 substituents fluoro,
  • R 7 is hydrogen or fluorine
  • R 8 and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, it being possible for the heterocycle to be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, chloro, hydroxy, Ci-C 3- alkyl, pyrazolyl and pyridyl, wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of hydroxycarbonyl and methoxy, or wherein alkyl may be substituted with 1 to 7 fluorine substituents, or wherein alkyl is substituted with one substituent hydroxycarbonyl and wherein alkyl is additionally substituted with 1 to 6 substituents fluorine,
  • R 10 is hydrogen or fluorine, is hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl or a 4 to 8-membered heterocyclyl bonded via a carbon atom, where alkyl may be substituted by 1 to 2 substituents independently of one another the group consisting of fluoro, hydroxy, amino, Ci-C3-alkylamino, difluoromethyl, trifluoromethyl, - (OCH2CH2) n -OCH 3 , trimethylaminium and pyrrolidinyl, wherein n is a number from 1 to 6, and wherein cycloalkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, amino, Ci-C t-alkyl and C l -C3 - Alky lamino, wherein alkyl and alkylamino may be substituted with 1 to 5 substituents fluorine, and where
  • R 3 is hydrogen or GC 3 alkyl
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle, wherein the heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, hydroxy, Ci -C t -alkyl and C 1 -C 3 -alkylamino,
  • R 4 is hydrogen, fluorine, chlorine, methyl or methoxy
  • R 5 is hydrogen, fluorine, chlorine, methyl, ethyl, methoxy or trifluoromethyl
  • R 5b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred.
  • R 6 is 5-membered heteroaryl, wherein heteroaryl may be substituted with a substituent selected from the group consisting of Ci-C3-alkyl, wherein alkyl may be substituted with a substituent hydroxy carbonyl, or wherein alkyl is substituted with a substituent hydroxycarbonyl and wherein alkyl is additionally substituted with 1 to 6 Substituents fluorine,
  • R 7 is hydrogen
  • R 8 and R 9 together with the carbon atoms to which they are attached form a 5-membered heterocycle, where the heterocycle may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, hydroxy, methyl, ethyl and n -Propyl, wherein methyl, ethyl and n-propyl may be substituted with a substituent hydroxycarbonyl, or wherein ethyl and n-propyl may be substituted with 4 to 7 substituents fluorine, or wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted by 4 to 6 substituents fluorine,
  • R 10 is hydrogen or fluorine, is hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl or a 4 to 8-membered heterocyclyl bonded via a carbon atom, where alkyl may be substituted by 1 to 2 substituents independently selected from the group consisting of amino and C 1 -C 3 -alkylamino, and wherein cycloalkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of amino, methyl and Ci-C3-alkylamino, and wherein heterocyclyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, Fluoro, hydroxycarbonyl, Ci-C 4 alkyl, Ci-Cs-alkylamino, 2,2,2-trifluoroeth-l-yl and Ci-C 4 alkoxycarbonyl, wherein alkyl substituted with a substituent hydroxy, and wherein heterocyclyl additionally substituted
  • R 3 is hydrogen, or
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycle, R 4 is hydrogen or fluorine,
  • R 5 is hydrogen, chlorine, methyl, methoxy or trifluoromethyl
  • R 5b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred.
  • R 6 is triazolyl or tetrazolyl, wherein triazolyl may be substituted with a substituent selected from the group consisting of methyl, ethyl and n-propyl, wherein methyl, ethyl and n-propyl may be substituted with a substituent hydroxycarbonyl, or wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine, R 7 is hydrogen, or
  • R 1 is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-1,3-benzoxazol-5-yl, IH-benzimidazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, 2,3-dihydro-1,3-benzoxazol-6-yl, IH-benzimidazol-6-yl, l / i-indazol-6-yl, 7-fluoro-2,3 dihydro-l / i-benzimidazol-5-yl, 7-fluoro-2,3-dihydro-l, 3-benzoxazol-5-yl or 4-fluoro-2,3-dihydro-l / i-indazole-6 -yl, wherein 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-l,
  • R 2 is hydrogen, C 1 -C 4 -alkyl, cyclopropyl, cyclohexyl or heterocyclyl bonded via a carbon atom selected from the group consisting of pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-6-yl and 8-azabicyclo [3.2.1 ] oct-3-yl wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of amino and Ci-C3-alkylamino, and wherein cyclohexyl may be substituted with a substituent selected from the group consisting of amino and Ci-C3-alkylamino, and wherein pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-6-yl and 8-azabicyclo [3.2.1] oct-3-yl may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo, Flu
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a pyrrolidinyl or piperazinyl,
  • R 4 is hydrogen or fluorine
  • R 5 is hydrogen, chlorine, methyl, methoxy or trifluoromethyl
  • R 5b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred.
  • # is the point of attachment to the nitrogen atom, is triazolyl or tetrazolyl, wherein triazolyl may be substituted with a substituent selected from the group consisting of methyl, ethyl and n-propyl, wherein methyl, ethyl and n-propyl may be substituted with a substituent hydroxycarbonyl, or wherein ethyl and n-propyl are substituted with a substituent Hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted by 4 to 6 substituents fluorine,
  • R 7 is hydrogen
  • R 3 is hydrogen, or
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a pyrrolidinyl or piperazinyl,
  • R 4 is hydrogen or fluorine
  • R 5 is hydrogen, chlorine, methyl, methoxy or trifluoromethyl
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • R 5b is hydrogen
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred
  • R 6 is triazolyl, wherein triazolyl is substituted with a substituent selected from the group consisting of ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine,
  • R 7 is hydrogen
  • R 2 is ethyl, iso-propyl, cyclopropyl, cyclobutyl, cyclohexyl or heterocyclyl bonded via a carbon atom selected from the group of pyrrolidinyl and piperidinyl, where ethyl is substituted by a substituent trifluoromethyl, and wherein cyclohexyl is substituted with a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino, and wherein pyrrolidinyl and piperidinyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo, fluoro, C 1 -C 4 alkyl and 2,2,2-trifluoroeth-1-yl, R 3 is hydrogen, or
  • R 2 and R 3 together with the nitrogen atom to which they are attached form a pyrrolidinyl or piperazinyl,
  • R 4 is hydrogen or fluorine
  • R 5 is hydrogen, fluorine, chlorine, methyl, methoxy or trifluoromethyl
  • R 5b is hydrogen, and their salts, their solvates, and the solvates of their salts.
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred
  • R 6 is triazolyl, wherein triazolyl is substituted with a substituent selected from the group consisting of ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine,
  • R 7 is hydrogen, ethyl, iso-propyl, cyclopropyl, cyclobutyl, cyclohexyl or heterocyclyl bonded via a carbon atom selected from the group consisting of pyrrolidinyl and piperidinyl, wherein ethyl is substituted by a substituent trifluoromethyl, and wherein cyclohexyl is substituted by a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino, and where pyrrolidinyl and piperidinyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo and methyl,
  • R 3 is hydrogen, R 4 is hydrogen or fluorine, R 5a is fluorine or methyl, R 5b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • Compounds of the formula (I) in which R 1 is a group of the formula are preferred.
  • R 6 is triazolyl, wherein triazolyl is substituted with a substituent selected from the group consisting of ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein Ethyl and n-propyl are additionally substituted by 4 to 6 substituents fluorine,
  • R 7 is hydrogen, heterocyclyl bonded to cyclohexyl or via a carbon atom selected from the group consisting of pyrrolidinyl and piperidinyl, where cyclohexyl is substituted by a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino, and where pyrrolidinyl and Piperidinyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl, R 3 is hydrogen, R 4 is hydrogen or fluorine, R 5a is fluorine or methyl, R 5b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • R 6 is triazolyl, wherein triazolyl is substituted with a substituent selected from the group consisting of ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine,
  • R 7 is hydrogen, is cyclohexyl, where cyclohexyl is substituted by a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino, is hydrogen, is hydrogen or fluorine, R is fluorine or methyl,
  • R 3b is hydrogen, and their salts, their solvates and the solvates of their salts.
  • R is triazolyl, wherein triazolyl is substituted with a substituent selected from the group consisting of ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6
  • substituents fluorine stands for hydrogen
  • R is heterocyclyl bonded via a carbon atom selected from the group of pyrrolidinyl and piperidinyl, where pyrrolidinyl and piperidinyl may be substituted by 1 to 2 substituents independently selected from the group consisting of oxo and methyl, R 3 is hydrogen, R 4 is hydrogen or fluorine, is fluorine or methyl, is hydrogen, and their salts, their solvates, and the solvates of their salts.
  • R 3 is hydrogen
  • R 4 is hydrogen or fluorine, is fluorine or methyl
  • R 1 is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-difrodrod-l, 3-benzoxazol-5-yl, benzimidazol-5-yl, 2,3-dihydro-1 i-indazol-6-yl, 2,3-difrodrod-l, 3-benzoxazol-6-yl, benzimidazol-6-yl or l / hndazol-6-yl, wherein the 5-membered heterocycle in 2 , 3-dihydro-1 / i-benzimidazol-5-yl, 2,3-dihydro-1,3-benzoxazol-5-yl, 1 / i-benzimidazol-5-yl, 2,3-dihydro-1 / i -indazol-6-yl, 2,3-dihydro-l, 3-benzoxazol-6-yl, l / i-benzimidazol-6-
  • R 2 is ethyl, iso-propyl, cyclopropyl, cyclobutyl, cyclohexyl or heterocyclyl bonded via a carbon atom selected from the group consisting of pyrrolidinyl and piperidinyl, wherein ethyl is substituted by a substituent trifluoromethyl, and wherein cyclohexyl is substituted by a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino, and wherein pyrrolidinyl and piperidinyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl,
  • R 3 is hydrogen
  • R 4 is hydrogen or fluorine
  • R 5a is fluorine, chlorine or methyl
  • R 5b is hydrogen, and their salts, their solvates and the solvates of their salts. Preference is also given to compounds of the formula (I) in which
  • R 1 is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-1,3-benzoxazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl , l / i-benzimidazol-6-yl or l / i-indazol-6-yl, where the 5-membered heterocycle is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro -l, 3-benzoxazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, l / i-benzimidazol-6-yl and l / i-indazol-6-yl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl, and wherein the benzyl ring in 2,
  • R 3 is hydrogen
  • R 4 is hydrogen
  • R 5a is chlorine or methyl
  • R 5b is hydrogen
  • their salts, their solvates and the solvates of their salts Preference is also given to compounds of the formula (I) in which, for a group of the formula
  • R 6 is triazolyl or tetrazolyl, wherein triazolyl may be substituted with a substituent selected from the group consisting of methyl, ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally are substituted with 4 to 6 substituents fluorine, and
  • R 7 is hydrogen
  • R 6 is triazolyl, wherein triazolyl may be substituted with a substituent selected from the group consisting of methyl, ethyl and n-propyl, wherein ethyl and n-propyl are substituted with a substituent hydroxycarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine , and
  • R 7 is hydrogen
  • R is tetrazolyl
  • R 7 is hydrogen.
  • R 6 is triazolyl, wherein triazolyl may be substituted with a substituent selected from the group consisting of methyl, ethyl and n-propyl, wherein ethyl and n-propyl are substituted with one substituent selected from the group consisting of hydroxycarbonyl, C 1 -C 4 alkoxycarbonyl, aminocarbonyl and Ci-C3-alkylaminocarbonyl and wherein ethyl and n-propyl are additionally substituted with 4 to 6 substituents fluorine, and
  • R 7 is hydrogen.
  • R 1 is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-1,3-benzoxazol-5-yl, IH-benzimidazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, 2,3-dihydro-l, 3-benzoxazol-6-yl, IH-benzimidazol-6-yl or l / hndazol-6-yl, wherein the 5-membered heterocycle in 2 , 3-dihydro-1 / i-benzimidazol-5-yl, 2,3-dihydro-1,3-benzoxazol-5-yl, 1 / i-benzimidazol-5-yl, 2,3-dihydro-1 / i -indazol-6-yl, 2,3-dihydro-l, 3-benzoxazol-6-yl, l / i-
  • R 1 represents 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-difrodrod-l, 3-benzoxazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl , l / i-benzimidazol-6-yl or l / i-indazol-6-yl, where the 5-membered heterocycle is 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro -l, 3-benzoxazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, l / i-benzimidazol-6-yl and l / i-indazol-6-yl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl, and wherein the benzyl ring in 2,
  • R 1 represents 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, l / i-benzimidazol-6-yl or 7-fluoro-2 , 3-dihydro-1,3-benzoxazol-5-yl, wherein 2,3-dihydro-l / i-benzimidazol-5-yl, 2,3-dihydro-l / i-indazol-6-yl, IH - Benzimidazol-6-yl and 7-fluoro-2,3-dihydro-l, 3-benzoxazol-5-yl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl.
  • R 2 is hydrogen, C 1 -C 4 -alkyl, cyclopropyl, cyclohexyl or heterocyclyl bonded via a carbon atom selected from the group consisting of pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-6-yl and 8-azabicyclo [3.2.1 ] oct-3-yl, wherein alkyl may be substituted with 1 to 2 substituents independently selected from the group consisting of amino and C 1 -C 3 -alkylamino, and wherein cyclohexyl may be substituted with a substituent selected from the group consisting of amino and C 1 -C 3 -alkylamino, and wherein pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-6-yl and 8-azabicyclo [3.2.1] oct-3-yl may be substituted by 1 to 2 substituents independently selected from the group consisting
  • R 2 is heterocyclyl which is bonded to ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl or a carbon atom selected from the group consisting of pyrrolidinyl and piperidinyl, where ethyl is substituted by a substituent trifluoromethyl, and wherein cyclohexyl is substituted with a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 alkylamino, and wherein pyrrolidinyl and piperidinyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl.
  • R 2 is heterocyclyl bonded to cyclohexyl or via a carbon atom and selected from the group pyrrolidinyl and piperidinyl, where cyclohexyl is substituted by a substituent selected from the group consisting of hydroxyl, amino and ci C 3 alkylamino, and wherein pyrrolidinyl and piperidinyl may be substituted with 1 to 2 substituents independently selected from the group consisting of oxo and methyl.
  • R 2 is cyclohexyl, wherein cyclohexyl is substituted with a substituent selected from the group consisting of hydroxy, amino and C 1 -C 3 -alkylamino.
  • R 2 is heterocyclyl bonded via a carbon atom selected from the group consisting of pyrrolidinyl and piperidinyl, where pyrrolidinyl and piperidinyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo and methyl.
  • R 3 is hydrogen.
  • 2,2,3,3-tetrafluoropropanoic acid hydrochloride or one of the salts, the solvates or the solvates of the salts of these compounds.
  • the invention further 2,2,3,3-tetrafluoro-3- [5- (4-nitrophenyl) -1 /, 2,4-triazol-3-yl] propanoic acid having the following formula
  • the invention further provides a process for the preparation of the compounds of the formula (I), or their salts, their solvates or the solvates of their salts, where the compounds of the formula
  • R 1 , R 2 , R 3 , R 4 , R 5 and R 5b have the meaning given above, are reacted with an acid.
  • the reaction is generally carried out in inert solvents, preferably in a temperature range from room temperature to 60 ° C at atmospheric pressure.
  • Inert solvents are, for example, halogenated hydrocarbons such as dichloromethane, trichloromethane, carbon tetrachloride or 1,2-dichloroethane, or ethers such as tetrahydrofuran or dioxane, dioxane is preferred.
  • Acids are for example trifluoroacetic acid or hydrogen chloride in dioxane, preferred is hydrogen chloride in dioxane.
  • R, R, R and R have the abovementioned meaning, with compounds of the formula
  • R 2 and R 3 have the abovementioned meaning, are reacted in the presence of a dehydrating reagent, or
  • R 1 and R 4 have the abovementioned meaning
  • Q 1 is -B (OH) 2 , a boronic acid ester, preferably boronic acid pinacol ester, or, with compounds of the formula
  • R 2 , R 3 , R 5a and R 5b have the abovementioned meaning, and X 1 is bromine or iodine, are reacted under Suzuki coupling conditions, or
  • R 2 , R 3 , R 4 , R 5 and R 5b have the abovementioned meaning, with compounds of the formula H 2 NR 1 ( vni), in which
  • R 1 has the meaning given above, be reacted in the presence of a dehydrating reagent.
  • reaction according to process [A] is generally carried out in inert solvents, if appropriate in the presence of a base, preferably in a temperature range from 0 ° C to reflux of the solvent at atmospheric pressure.
  • dehydrating reagents examples include carbodiimides such as ⁇ , ⁇ '-diethyl, A ⁇ A ⁇ '- dipropyl, A ⁇ A ⁇ ' - diisopropyl-, A ⁇ W-dicyclohexylcarbodiimide, ⁇ - (S-dimethylamino-isopropyl) -N'-ethylcarbodiimide hydrochloride (EDC) (optionally in the presence of pentafluorophenol (PFP)), N-cyclohexylcarbodiimide-N'-propyloxymethyl-polystyrene (PS-carbodiimide) or carbonyl compounds such as carbonyldiimidazole, or 1,2-oxazolium compounds such as 2-ethyl-5-phenyl-l, 2-oxazolium-3-sulfate or 2-tert-butyl-5-methyl-isoxazolium perchlorate,
  • HBTU tetra-methyluronium hexafluorophosphate
  • TPTU 2, 2,oxo-l- (2H) -pyridyl) - 1, 1, 3,3-tetramethyluronium tetrafluoroborate
  • TBTU bis-dimethylamino-methylium-fluoroborate
  • HATU 1-hydroxybenzotriazole
  • benzotriazol-1-yloxy-tris dimethylamino) phosphonium hexafluorophosphate (BOP), or Efhyl-cyano (hydroxy-imino) acetate (Oxyma), or (1-cyano-2 -ethoxy-2-oxoethylideneaminooxy) dimethylamin
  • Bases are, for example, alkali carbonates, e.g. Sodium or potassium carbonate, or hydrogen carbonate, or organic bases such as trialkylamines, e.g. Triethylamine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine or diisopropylethylamine, preferred is diisopropylethylamine.
  • alkali carbonates e.g. Sodium or potassium carbonate
  • hydrogen carbonate e.g. Sodium or potassium carbonate
  • organic bases such as trialkylamines, e.g. Triethylamine, N-methylmorpholine, N-methylpiperidine, 4-dimethylaminopyridine or diisopropylethylamine, preferred is diisopropylethylamine.
  • Inert solvents are, for example, halogenated hydrocarbons such as dichloromethane or trichloromethane, hydrocarbons such as benzene, or other solvents such as nitromethane, tetrahydrofuran, dioxane, dimethylformamide, dimethylsulfoxide, acetonitrile or pyridine, or mixtures of the solvents, preferably tetrahydrofuran or dimethylformamide or a mixture of dimethylformamide and pyridine.
  • halogenated hydrocarbons such as dichloromethane or trichloromethane
  • hydrocarbons such as benzene
  • other solvents such as nitromethane, tetrahydrofuran, dioxane, dimethylformamide, dimethylsulfoxide, acetonitrile or pyridine, or mixtures of the solvents, preferably tetrahydrofuran or dimethylformamide or a mixture of dimethylformamide and pyridine.
  • the compounds of the formula (IV) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • reaction according to process [B] is generally carried out in inert solvents, in the presence of a catalyst, if appropriate in the presence of an additional reagent, optionally in a microwave, preferably in a temperature range from room temperature to 150 ° C at atmospheric pressure to 3 bar.
  • Catalysts are for example customary for Suzuki reaction conditions palladium catalysts, preferred are catalysts such as dichlorobis (triphenylphosphine) palladium, tetrakistriphenylphosphinepalladium (O), palladium (II) acetate / triscyclohexylphosphine, tris (dibenzylideneacetone) dipalladium, bis (diphenylphosphanferrocenyl) palladium - (II) chloride, l, 3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene (1,4-naphthoquinone) palladium dimer, allyl (chloro) - (1,3-dimesityl-l, 3-dihydro -2H-imidazol-2-ylidene) palladium, palladium (II) acetate / dicyclohexyl (2 ',
  • Additional reagents are for example potassium acetate, cesium, potassium or sodium carbonate, potassium tert-butoxide, cesium fluoride or potassium phosphate, which may be present in aqueous solution, preference is given to additional reagents such as potassium acetate or a mixture of potassium acetate and sodium carbonate.
  • Inert solvents are, for example, ethers, such as dioxane, tetrahydrofuran or 1,2-dimethoxyethane, hydrocarbons, such as benzene, xylene or toluene, or carboxamides, such as dimethylformamide or dimethylacetamide, alkylsulfoxides, such as dimethylsulfoxide, or N-methylpyrrolidone or acetonitrile, or mixtures of the solvents with alcohols, such as methanol or ethanol and / or water, preferred is toluene, dimethylformamide or dimethyl sulfoxide.
  • ethers such as dioxane, tetrahydrofuran or 1,2-dimethoxyethane
  • hydrocarbons such as benzene, xylene or toluene
  • carboxamides such as dimethylformamide or dimethylacetamide
  • alkylsulfoxides such as dimethylsulfoxide, or N-
  • the compounds of the formula (VI) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • reaction according to method [C] is carried out as described for method [A].
  • the compounds of the formula (VIII) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • R 1 , R 4 , R 3a and R 5b have the abovementioned meaning, and R 11 is methyl or ethyl,
  • R 1 and R 4 have the abovementioned meaning, and X 2 is bromine or iodine,
  • R and R have the abovementioned meaning
  • Q 2 is -B (OH) 2 , a boronic acid ester, preferably boronic acid pinacol ester, or -BF 3 ⁇ K + , can be reacted under Suzuki coupling conditions.
  • the reaction according to process [D] is generally carried out in inert solvents, preferably in a temperature range from room temperature to reflux of the solvent at atmospheric pressure.
  • Inert solvents are, for example, halogenated hydrocarbons such as dichloromethane, trichloromethane, carbon tetrachloride or 1,2-dichloroethane, alcohols such as methanol or ethanol, ethers such as diethyl ether, methyl tert-butyl ether, 1,2-dimethoxyethane, dioxane or tetrahydrofuran, or other solvents such as dimethylformamide , Dimethylacetamide, acetonitrile or pyridine, or mixtures of solvents, or mixtures of solvent with water, preferred is a mixture of tetrahydrofuran and water.
  • Bases are, for example, alkali metal hydroxides such as sodium, lithium or potassium hydroxide, or alkali metal carbonates such as cesium carbonate, sodium or potassium carbonate, or alcoholates such as potassium or sodium tert-butoxide, preferably sodium hydroxide or lithium hydroxide.
  • reaction according to method [E] is carried out as described for method [B].
  • the compounds of the formula (XI) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • the compounds of formula (IX) are known or may be prepared by reacting [F] compounds of formula (X) with compounds of formula in which
  • R 5 and R 5b have the abovementioned meaning, R 11 is methyl or ethyl, and
  • Q 3 is -B (OH) 2 , a boronic acid ester, preferably boronic acid pinacol ester, or
  • R 4 , R 3a and R 5b have the abovementioned meaning, and R 11 is methyl or ethyl, are reacted with compounds of formula (VIII) in the presence of a dehydrating reagent.
  • the reaction according to method [F] is carried out as described for method [B].
  • the compounds of the formula (XII) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • the reaction according to method [G] is carried out as described for method [A].
  • the compounds of the formula (X) are known or can be prepared by reacting compounds of the formula
  • the reaction is carried out as described for method [A].
  • the compounds of the formula (XIV) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • the compounds of the formula ( ⁇ ) are known or can be prepared by reacting compounds of the formula (XIV) with compounds of the formula (XII) under Suzuki coupling conditions.
  • the reaction is carried out as described for method [B].
  • the compounds of formula (V) are known or can be prepared by reacting compounds of formula (X) with 4,4,4 ', 4', 5,5,5 ', 5'-octamethyl-2,2'-bi -l, 3,2-dioxaborolane.
  • the reaction is generally carried out in inert solvents, in the presence of a catalyst, optionally in the presence of an additional reagent, optionally in a microwave, preferably in a temperature range from room temperature to 150 ° C at atmospheric pressure to 3 bar.
  • Hydroylation in an acidic medium gives the corresponding boronic acids.
  • Working up with potassium hydrogen difluoride solution (KHF 2 solution) gives the corresponding trifluoroborates.
  • Catalysts are, for example, conventional palladium catalysts for the borylation of aryl halides, preferably catalysts such as e.g.
  • Additional reagents are for example potassium acetate, cesium, potassium or sodium carbonate, potassium or sodium tert-butoxide, cesium fluoride, potassium phosphate or potassium phenoxide, preferably potassium acetate.
  • Inert solvents are, for example, ethers, such as dioxane, tetrahydrofuran or 1,2-dimethoxyethane, hydrocarbons, such as benzene, xylene or toluene, or carboxamides, such as dimethylformamide or dimethylacetamide, alkylsulfoxides, such as dimethylsulfoxide, or N-methylpyrrolidone or acetonitrile; preference is given to dioxane, dimethylformamide or dimethylsulfoxide.
  • ethers such as dioxane, tetrahydrofuran or 1,2-dimethoxyethane
  • hydrocarbons such as benzene, xylene or toluene
  • carboxamides such as dimethylformamide or dimethylacetamide
  • alkylsulfoxides such as dimethylsulfoxide, or N-methylpyrrolidone or acetonitrile
  • R 2 , R 3 , R 5 and R 5b have the abovementioned meaning
  • Q 4 is -B (OH) 2 , a boronic acid ester, preferably boronic acid pinacol ester, or -BF 3 ⁇ K + , can be reacted under Suzuki coupling conditions.
  • the reaction is carried out as described for method [B].
  • the compounds of the formula (XV) are known, can be synthesized by known processes from the corresponding starting compounds or can be prepared analogously to the processes described in the Examples section.
  • the compounds of the invention show an unpredictable, valuable pharmacological spectrum of activity and a good pharmacokinetic behavior. These are compounds which influence the proteolytic activity of the serine proteases FXIa and kallikrein and optionally plasmin.
  • the compounds of the present invention inhibit the enzymatic cleavage of substrates which play an essential role in the activation of the blood coagulation cascade and the aggregation of platelets. If the compounds according to the invention inhibit plasmin activity, inhibition of fibrinolysis occurs.
  • Another object of the present invention is the use of the compounds of the invention for the treatment and / or prophylaxis of diseases, in particular cardiovascular diseases, preferably thrombotic or thromboembolic diseases and / or thrombotic or thromboembolic complications.
  • thromboembolic disorders include in particular diseases such as acute coronary syndrome (ACS), heart attack with ST segment elevation (STEMI) and without ST segment elevation (non-STEMI), stable angina pectoris, unstable Angina pectoris, reocclusions and restenoses after coronary interventions such as angioplasty, stent implantation or aortocoronary bypass, peripheral arterial occlusive diseases, pulmonary embolism, venous thrombosis, especially in deep leg veins and renal veins, transient ischemic attacks and thrombotic and thromboembolic stroke.
  • ACS acute coronary syndrome
  • STEMI heart attack with ST segment elevation
  • non-STEMI non-STEMI
  • stable angina pectoris unstable Angina pectoris
  • reocclusions reocclusions and restenoses after coronary interventions
  • coronary interventions such as angioplasty, stent implantation or aortocoronary bypass, peripheral arterial occlusive diseases, pulmonary embolism, ve
  • the compounds of the invention are therefore also useful in the prevention and treatment of cardiogenic thromboembolism, such as brain ischemia, stroke and systemic thromboembolism and ischaemia, in patients with acute, intermittent or persistent cardiac arrhythmias, such as atrial fibrillation, and those undergoing cardioversion , in patients with valvular heart disease or with artificial heart valves.
  • cardiogenic thromboembolism such as brain ischemia, stroke and systemic thromboembolism and ischaemia
  • cardiac arrhythmias such as atrial fibrillation
  • the compounds according to the invention are suitable for the treatment and prevention of disseminated intravascular coagulation (DIC), which occur, inter alia, in the context of sepsis, but also as a result of operations, tumor diseases, burns or other injuries and can lead to severe organ damage through microthromboses.
  • DIC disseminated intravascular coagulation
  • Thromboembolic complications also occur in microangiopathic hemolytic anemias, extracorpo
  • the compounds according to the invention also have an influence on wound healing, for the prophylaxis and / or treatment of atherosclerotic vascular diseases and inflammatory diseases such as rheumatic diseases of the locomotor system, coronary heart diseases, cardiac insufficiency, hypertension, inflammatory diseases such as asthma, inflammatory lung diseases, Glomerulonephritis and inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis, or acute renal failure into consideration, moreover, also for the prophylaxis and / or treatment of dementia diseases such.
  • atherosclerotic vascular diseases and inflammatory diseases such as rheumatic diseases of the locomotor system, coronary heart diseases, cardiac insufficiency, hypertension, inflammatory diseases such as asthma, inflammatory lung diseases, Glomerulonephritis and inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis, or acute renal failure into consideration, moreover, also for the prophylaxis and / or treatment of dementia diseases such.
  • the compounds of the present invention can inhibit tumor growth and metastasis, microangiopathies, age-related macular degeneration, diabetic retinopathy, diabetic nephropathy and other microvascular diseases, and for the prevention and treatment of thromboembolic complications such as venous thromboembolism. in tumor patients, especially those undergoing major surgery or chemo- or radiotherapy.
  • pulmonary hypertension covers certain forms of pulmonary hypertension as defined, for example, by the World Health Organization (WHO), such as pulmonary arterial hypertension, pulmonary hypertension in diseases of the left heart, pulmonary hypertension in pulmonary disease and / or hypoxia and pulmonary hypertension due to chronic thromboembolism (CTEPH).
  • WHO World Health Organization
  • CTEPH chronic thromboembolism
  • Pulmonary arterial hypertension includes idiopathic pulmonary arterial hypertension (IPAH, formerly referred to as primary pulmonary hypertension), familial pulmonary arterial hypertension (FPAH), and Associated pulmonary arterial hypertension (AP AH) associated with collagenosis, congenital systemic pulmonary shunt veins, portal hypertension, HIV infections, use of certain drugs and medications, other diseases (thyroid disease, glycogen storage disorders, Gaucher disease, here medical telangiectasia, hemoglobinopathies, myeloproliferative disorders, splenectomy), with diseases with significant venous / capillary involvement such as pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis, as well as persistent pulmonary hypertension of newborns.
  • Pulmonary hypertension in left heart disease includes left atrial or ventricular disease and mitral or aortic valve failure.
  • Pulmonary hypertension in lung disease and / or hypoxia includes chronic obstructive pulmonary disease, interstitial lung disease, sleep apnea syndrome, alveolar hypoventilation, chronic altitude sickness, and plant-related malformations.
  • Pulmonary hypertension due to chronic thromboembolism includes thromboembolic occlusion of proximal pulmonary arteries, thromboembolic occlusion of distal pulmonary arteries, and non-thrombotic pulmonary embolisms (tumor, parasites, foreign bodies).
  • Another object of the present invention is the use of the compounds of the invention for the preparation of medicaments for the treatment and / or prophylaxis of pulmonary hypertension in sarcoidosis, histiocytosis X and Lymphangiomatosis.
  • the substances according to the invention are also suitable for the treatment of pulmonary and hepatic fibroses.
  • the compounds according to the invention also come for the treatment and / or prophylaxis of disseminated intravascular coagulation in the context of infectious disease and / or systemic inflammatory syndrome (SIRS), septic organ dysfunction, septic organ failure and multi-organ failure, acute respiratory distress syndrome (ARDS), acute lung Injury (ALI), septic shock and / or septic organ failure.
  • SIRS systemic inflammatory syndrome
  • septic organ dysfunction septic organ dysfunction
  • septic organ failure and multi-organ failure multi-organ failure
  • ARDS acute respiratory distress syndrome
  • ALI acute lung Injury
  • septic shock and / or septic organ failure septic shock and / or septic organ failure.
  • DIC Dispersed Intravascular Coagulation
  • Consumption Coagulopathy hereinafter referred to as "DIC”
  • endothelial damage can result in increased vascular permeability and leakage of fluid and proteins into the extravasal space.
  • organ failure e.g., renal failure, liver failure, respiratory failure, CNS deficits and cardiovascular failure
  • multiple organ failure may occur.
  • DIC DIC
  • the surface of damaged endothelial cells, foreign body surfaces or extravasated extravascular tissue causes massive activation of the coagulation system.
  • coagulation occurs in small vessels of various organs with hypoxia and subsequent organ dysfunction. This can be prevented by the compounds of the invention.
  • coagulation factors e.g., Factor X, prothrombin, and fibrinogen
  • platelets are consumed, which lowers the blood's ability to coagulate and cause severe bleeding.
  • the compounds according to the invention are also suitable for the prophylaxis and / or treatment of hyperfibrinolysis.
  • Prophylaxis and / or treatment can reduce or eliminate severe perioperative blood loss. Strong bleeding occurs in severe surgery, such as. Coronary artery bypass graft surgery, transplantation or hysterectomy, as well as trauma, haemorrhagic shock, or postpartum hemorrhage.
  • perioperative use of extracorporeal circulation systems or filter systems such as, for example, heart lung machine, hemofiltration, hemodialysis, extracorporeal membrane oxygenation or ventricular support system, such as artificial heart, may occur.
  • This also requires anticoagulation, to which the compounds of the invention can also be used.
  • the compounds according to the invention are also suitable for anticoagulation during the renal replacement procedure, for example in continuous veno-venous hemofiltration or intermittent hemodialysis.
  • the compounds according to the invention can also be used for the prevention of coagulation ex vivo, e.g. for the preservation of blood and plasma products, for the cleaning / pretreatment of catheters and other medical devices and equipment, for the coating of artificial surfaces of in vivo or ex vivo used medical devices and devices or for biological samples which might contain Factor XIa.
  • Another object of the present invention is the use of the compounds of the invention for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases.
  • Another object of the present invention is the use of the compounds of the invention for the manufacture of a medicament for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases.
  • Another object of the present invention is a method for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases, using a therapeutically effective amount of a compound of the invention.
  • Another object of the present invention are the compounds of the invention for use in a method for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases, using a therapeutically effective amount of a compound of the invention.
  • Another object of the present invention are pharmaceutical compositions containing a compound of the invention and one or more other active ingredients.
  • Another object of the present invention is a method for preventing blood coagulation in vitro, especially in blood or biological samples that might contain factor XIa, which is characterized in that an anticoagulatory effective amount of the compound of the invention is added.
  • compositions containing a compound of the invention and one or more other active ingredients are pharmaceutical compositions containing a compound of the invention and one or more other active ingredients, in particular for the treatment and / or prophylaxis of the aforementioned diseases.
  • suitable combination active ingredients may be mentioned by way of example and preferably: Lipid-lowering agents, in particular HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (pravachol), fluvastatin (Lescol) and atorvastatin (Lipitor);
  • Coronary / vasodilators particularly ACE (angiotensin converting enzyme) inhibitors such as captopril, lisinopril, enalapril, ramipril, cilazapril, benazepril, fosinopril, quinapril and perindopril, or AII (angiotensin II) receptor antagonists such as embusartan , Losartan, valsartan, irbesartan, candesartan, eprosartan and temisarta, or beta-adrenoceptor antagonists such as carvedilol, alprenolol, bisoprolol, acebutolol, atenolol, betaxolol, carteolol, metoprolol, nadolol, penbutolol, pindolol, propranolol and timolol, or alpha- 1-adren
  • Plasminogen activators thrombolytics / fibrinolytics
  • thrombolysis / fibrinolysis-enhancing compounds such as inhibitors of the plasminogen activator inhibitor (PAI inhibitors) or inhibitors of the thrombin-activated fibrinolysis inhibitor (TAFI inhibitors) such as, for example, tissue plasminogen activator (t-PA), streptokinase, reteplase and urokinase
  • anticoagulant substances anticoagulants
  • UH tissue plasminogen activator
  • LMWH low molecular weight heparin
  • tinzaparin certoparin, parnaparin, nadroparin, ardeparin, enoxaparin, reviparin, dalteparin, danaparoid, semuloparin (AVE 5026), adomiparin (Ml 18) and EP-42675 / ORG42675
  • DTI direct thrombin inhibitors
  • Antiplatelet agents such as, for example, aspirin, ticlopidine (ticlid), clopidogrel (plavix), prasugrel, ticagrelor, cangrelor, elinogrel,
  • Fibrinogen receptor antagonists such as abciximab, eptifibatide, tirofiban, lamifiban, lefradafiban and fradafiban;
  • Vasopressors such as norepinephrine, dopamine and vasopressin;
  • Inotropic therapy such as dobutamine
  • Corticosteroids such as hydrocortisone and fludrocortisone
  • Recombinant human activated protein C such as Xigris
  • blood products such as red blood cell concentrates, platelet concentrates,
  • Combinations within the meaning of the invention not only pharmaceutical forms containing all components (so-called. Fixed combinations) and combination packs containing the components separated from each other, understood, but also simultaneously or temporally staggered applied components, if they are for prophylaxis and It is also possible to combine two or more active substances, ie two or more combinations.
  • the compounds according to the invention can act systemically and / or locally.
  • they can be applied in a suitable manner, such as, for example, orally, parenterally, pulmonarily, nasally, sublingually, lingually, buccally, rectally, dermally, transdermally, conjunctivally, otically or as an implant or stent.
  • the compounds according to the invention can be administered in suitable administration forms.
  • Parenteral administration can be accomplished by bypassing a resorption step (e.g., intravenously, intraarterially, intracardially, intraspinal, or intralumbar) or by resorting to absorption (e.g., intramuscularly, subcutaneously, intracutaneously, percutaneously, or intraperitoneally).
  • a resorption step e.g., intravenously, intraarterially, intracardially, intraspinal, or intralumbar
  • absorption e.g., intramuscularly, subcutaneously, intracutaneously, percutaneously, or intraperitoneally.
  • parenteral administration are suitable as application forms u.a. Injection and infusion preparations in the form of solutions, suspensions, emulsions, lyophilisates or sterile powders.
  • inhalation medicines including powder inhalers, nebulizers
  • nasal drops solutions, sprays
  • lingual, sublingual or buccal tablets films / wafers or capsules
  • suppositories ear or ophthalmic preparations
  • vaginal capsules aqueous suspensions (lotions, shake mixtures)
  • lipophilic suspensions ointments
  • creams transdermal therapeutic systems (such as patches)
  • milk Pastes, foams, scattering powders, implants or stents.
  • the compounds according to the invention can be converted into the stated administration forms. This can be done in a conventional manner by mixing with inert, non-toxic, pharmaceutically suitable excipients.
  • excipients include excipients (for example microcrystalline cellulose, lactose, mannitol), solvents (for example liquid polyethylene glycols), emulsifiers and dispersants or wetting agents (for example sodium dodecyl sulfate, polyoxysorbitol oleate), binders (for example polyvinylpyrrolidone), synthetic and natural polymers (For example, albumin), stabilizers (eg, antioxidants such as ascorbic acid), dyes (eg, inorganic pigments such as iron oxides) and flavor and / or odoriferous.
  • excipients for example microcrystalline cellulose, lactose, mannitol
  • solvents for example liquid polyethylene glycols
  • emulsifiers and dispersants or wetting agents for example sodium dodecyl sulfate, polyoxysorbitol oleate
  • binders for example polyvinylpyrrolidone
  • synthetic and natural polymers for example,
  • compositions containing at least one compound of the invention preferably together with one or more inert non-toxic, pharmaceutically suitable excipient, as well as their use for the purposes mentioned above.
  • Method 1 Instrument: Waters ACQUITY SQD UPLC System; Column: Waters Acquity UPLC HSS T3 1.8 ⁇ 50mm x 1mm; Eluent A: 1 l of water + 0.25 ml of 99% formic acid, eluent B: 1 l of acetonitrile + 0.25 ml of 99% formic acid; Gradient: 0.0 min 90% A -> 1.2 min 5% A -> 2.0 min 5% A; Oven: 50 ° C; Flow: 0.40 ml / min; UV detection: 210 - 400 nm.
  • Method 2 Instrument: Micromass Quattro Premier with Waters UPLC Acquity; Column: Thermo Hypersil GOLD 1.9 ⁇ 50 mm x 1 mm; Eluent A: 1 l of water + 0.5 ml of 50% formic acid, eluent B: 1 l of acetonitrile + 0.5 ml of 50% formic acid; Gradient: 0.0 min 97% A -> 0.5 min 97% A -> 3.2 min 5% A -> 4.0 min 5% A Oven: 50 ° C; Flow: 0.3 ml / min; UV detection: 210 nm.
  • Method 3 Instrument: Waters ACQUITY SQD UPLC System; Column: Waters Acquity UPLC HSS T3 1.8 ⁇ 30 mm x 2 mm; Eluent A: 1 l of water + 0.25 ml of 99% formic acid, eluent B: 1 l of acetonitrile + 0.25 ml of 99% formic acid; Gradient: 0.0 min 90% A-> 1.2 min 5% A -> 2.0 min 5% A Furnace: 50 ° C; Flow: 0.60 ml / min; UV detection: 208-400 nm.
  • Method 4 Instrument: Waters Acquity UPLC-MS SQD 3001; Column: Acquity UPLC BEH C18 1.7 ⁇ 50 mm x 2.1 mm; Eluent A: water + 0.1% formic acid, eluent B: acetonitrile; Gradient: 0-1.6 min 1-99% B, 1.6-2.0 min 99% B; Flow: 0.8 ml / min; Temperature: 60 ° C; Injection: 2 ⁇ ; DAD scan: 210-400 nm; ELSD.
  • Method 5 Instrument: Waters Acquity UPLC-MS SQD 3001; Column: Acquity UPLC BEH Cl 8 1.7 ⁇ 50 mm x 2.1 mm; Eluent A: water + 0.2% ammonia, eluent B: acetonitrile; Gradient: 0-1.6 min 1-99% B, 1.6-2.0 min 99% B; Flow: 0.8 ml / min; Temperature: 60 ° C; Injection: 2 ⁇ ; DAD scan: 210-400 nm; ELSD.
  • Method 6 System: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; Column: Chromatorex C-18 125 mm ⁇ 30 mm, eluent A: 0.1% formic acid in water, eluent B: acetonitrile, gradient: A 95% / B 5% -> A 55% / B 45%; Flow: 150 ml / min; UV detection: 254 nm.
  • Method 7 System: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; Column: Chromatorex C-18 125 mm ⁇ 30 mm, eluent A: 0.1% formic acid in water, eluent B: acetonitrile; Gradient: A 90% / B 10% -> A 50% / B 50%; Flow: 150 ml / min; UV detection: 254 nm.
  • Method 8 System: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; Column: Chromatorex C-18 125 mm ⁇ 30 mm, eluent A: 0.1% formic acid in water, eluent B: acetonitrile; Gradient: A 85% / B 15% -> A 45% / B 55%; Flow: 150 ml / min; UV detection: 254 nm.
  • Method 9 System: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; Column: Chromatorex C-18 125 mm ⁇ 30 mm, eluent A: 0.1% formic acid in water, eluent B: acetonitrile; Gradient: A 80% / B 20% -> A 40% / B 60%; Flow: 150 ml / min; UV detection: 254 nm.
  • Method 10 Instrument: Waters autopurification system SQD; Column: Waters XBrigde C18 5 ⁇ 100 mm x 30 mm; Eluent A: water + 0.1% formic acid (99%), eluent B: acetonitrile; Gradient: 0-8.0 min 1-100% B, 8.0-10.0 min 100% B; Flow 50.0 ml / min; Temperature: RT; Injection: 2500 ⁇ ; DAD scan: 210-400 nm.
  • Method 11 Instrument: Waters autopurification system SQD; Column: Waters XBrigde C18 5 ⁇ 100 mm x 30 mm; Eluent A: water + 0.2% ammonia (32%), eluent B: acetonitrile; Gradient: 0-8.0 min 1-100% B, 8.0-10.0 min 100% B; Flow 50.0 ml / min; Temperature: RT; Injection: 2500 ⁇ ; DAD scan: 210-400 nm.
  • Method 12 Instrument MS: Waters (Micromass) QM; Instrument HPLC: Agilent 1100 series; Column: Agient ZORBAX Extend-C18 3.0mm x 50mm 3.5-micron; Eluent A: 1 l of water + 0.01 mol of ammonium carbonate, eluent B: 1 l of acetonitrile; Gradient: 0.0 min 98% A-> 0.2 min 98% A -> 3.0 min 5% A ⁇ 4.5 min 5% A; Oven: 40 ° C; Flow: 1.75 ml / min; UV detection: 210 nm.
  • Method 13 Instrument: Waters ACQUITY SQD UPLC System; Column: Waters Acquity UPLC HSS T3 1.8 ⁇ 50 mm x 1 mm; Eluent A: 1 l of water + 0.25 ml of 99% formic acid, eluent B: 1 l of acetonitrile + 0.25 ml of 99% formic acid; Gradient: 0.0 min 95% A -> 6.0 min 5% A -> 7.5 min 5% A; Oven: 50 ° C; Flow: 0.35 ml / min; UV detection: 210 - 400 nm.
  • Method 14 Instrument MS: Waters (Micromass) Quattro Micro; Instrument HPLC: Agilent 1100 series; Column: YMC-Triart C18 3 ⁇ 50 mm x 3 mm; Eluent A: 1 l of water + 0.01 mol of ammonium carbonate, eluent B: 1 l of acetonitrile; Gradient: 0.0 min 10 0% A-> 2.75 min 5% A-> 4.5 min 5% A; Oven: 40 ° C; Flow: 1.25 ml / min; UV detection: 210 nm.
  • Method 15 System: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; Column: Chromatorex C-18 125 mm x 30 mm; Eluent A: 0.1% ammonia in water, eluent B: acetonitrile, gradient: A 90% / B 10% -> A 50% / B 50%; Flow: 150 ml / min; UV detection: 254 nm.
  • Method 16 Device Type MS: ThermoFisherScientific LTQ-Orbitrap-XL; Device type HPLC: Agilent 1200SL; Column: Agilent, POROSHELL 120, 3 mm x 150 mm, SB - C18 2.7 ⁇ ; Eluent A: 1 1 water + 0.1% trifluoroacetic acid; Eluent B: 1 liter acetonitrile + 0.1% trifluoroacetic acid; Gradient: 0.0 min 2% B -> 1.5 min 2% B -> 15.5 min 95% B -> 18.0 min 95% B; Oven: 40 ° C; Flow: 0.75 ml / min; UV detection: 210 nm.
  • Method 17 Device Type MS: Waters Synapt G2S; Device type UPLC: Waters Acquity I-CLASS; Column: Waters, HSST3, 2.1 mm x 50 mm, C18 1.8 ⁇ ; Eluent A: 1 liter of water + 0.01% of formic acid; Eluent B: 1 liter acetonitrile + 0.01% formic acid; Gradient: 0.0 min 10% B-> 0.3 min 10% B -> 1.7 min 95% B -> 2.5 min 95% B; Oven: 50 ° C; Flow: 1.20 ml / min; UV detection: 210 nm.
  • Method 18 Device Type MS: Waters Synapt G2S; Device type UPLC: Waters Acquity I-CLASS; Column: Waters, HSST3, 2.1 mm x 50 mm, C18 1.8 ⁇ ; Eluent A: 1 liter of water + 0.01% of formic acid; Eluent B: 1 liter acetonitrile + 0.01% formic acid; Gradient: 0.0 min 10% B-> 0.3 min 10% B -> 1.7 min 95% B -> 2.5 min 95% B; Oven: 50 ° C; Flow: 1.20 ml / min; UV detection: 210 nm.
  • Method 19 Device Type MS: ThermoFisherScientific LTQ-Orbitrap-XL; Device type HPLC: Agilent 1200SL; Column: Agilent, POROSHELL 120, 3 mm x 150 mm, SB - C18 2.7 ⁇ ; Eluent A: 1 1 water + 0.1% trifluoroacetic acid; Eluent B: 1 liter acetonitrile + 0.1% trifluoroacetic acid; Gradient: 0.0 min 2% B -> 1.5 min 2% B -> 15.5 min 95% B -> 18.0 min 95% B; Oven: 40 ° C; Flow: 0.75 ml / min; UV detection: 210 nm.
  • Microwave The microwave reactor used was a Biotage initiator.
  • the compounds of the invention may be in salt form, for example as trifluoroacetate, formate or ammonium salt, if the Compounds according to the invention contain a sufficiently basic or acidic functionality.
  • a salt can be converted into the corresponding free base or acid by various methods known to those skilled in the art.
  • Weaker salts can be converted to the corresponding chlorides by addition of some hydrochloride.
  • the starting compounds and examples contain an L-phenylalanine derivative as the central building block, the corresponding stereocenter is described as (S) -configuration. Unless otherwise stated, it was not examined whether in individual cases in the coupling of the L-phenylalanine intermediate with the amine H2N-R 1 partial epimerization of the stereocenter took place. Thus, a mixture of the compounds of (S) -enantiomer and (R) -enantiomer according to the invention may be present. The main component is the respectively depicted (S) -enantiomer.
  • the suspension was added dropwise with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in dimethylformamide, 766 ml, 1312 mmol) and then stirred for 3 h at RT.
  • the reaction mixture was stirred into water and extracted three times with ethyl acetate.
  • the organic phase was washed with aqueous saturated sodium bicarbonate solution, aqueous saturated ammonium chloride solution, and aqueous saturated sodium chloride solution. It was dried over sodium sulfate and the solvent removed. 420 g (97% of theory) of the title compound were obtained.
  • the reaction mixture was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2, 4,6-trioxide solution (50% in dimethylformamide, 1.0 ml, 2.19 mmol) and bis added to the precipitate with dimethylformamide and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate, washed four times with water and once with aqueous saturated sodium chloride solution.
  • the organic phase was dried over sodium sulfate and the solvent removed. The residue was stirred hot with acetonitrile, filtered off with suction and dried under high vacuum.
  • the suspension was added dropwise at 0 ° C with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinan- 2,4,6-trioxide solution (50% in dimethylformamide, 16.9 g, 27 mmol) and then stirred at RT for 16 h.
  • the reaction mixture was stirred into ethyl acetate (13,000 ml) and extracted three times with water (1570 ml each). The organic phase was dried with sodium sulfate and the solvent removed.
  • the crude product was stirred with acetonitrile and filtered with suction. 11.4 g (78% of theory) of the title compound were obtained.
  • the reaction mixture was treated with a 2,4,6-tripropyl-1,3,5,4,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in dimethylformamide, 1.5 ml, 2.51 mmol) and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate, washed three times with water and once with aqueous saturated sodium chloride solution.
  • the organic phase was dried over sodium sulfate and the solvent removed. 1.12 g (72% of theory, 87% purity) of the title compound were obtained.
  • the suspension was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2, 4,6-trioxide solution (50% in dimethylformamide, 2.2 ml, 3.7 mmol) and until added to the solution with dimethylformamide and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate, washed twice with water and once with sodium chloride solution.
  • the organic phase was dried with sodium sulfate and the solvent removed.
  • the crude product was stirred with acetonitrile and filtered with suction. The residue was separated twice by preparative HPLC (mobile phase: acetonitrile / water gradient, 0.1% TFA).
  • the suspension was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in dimethylformamide, 3.2 mg, 5 mmol) and until added to the solution with dimethylformamide and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate (2500 ml), washed three times with water (300 ml) and once with sodium chloride solution.
  • the organic phase was dried with sodium sulfate and the solvent removed.
  • the crude product was stirred with acetonitrile and filtered with suction. 1400 mg (54% of theory) of the title compound were obtained.
  • the suspension was treated with a 2,4,6-tripropyl-1,3,2,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in dimethylformamide, 7898 mg, 12 mmol) and until to the solution with dimethylformamide (20 ml) and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate (600 ml), washed three times with water (300 ml) and once with saturated aqueous sodium chloride solution (250 ml).
  • the precipitate in the organic phase was filtered off and washed with ethyl acetate.
  • the solvent of the filtrate was removed and the residue was dried under high vacuum. 4021 mg (62% of theory) of the title compound were obtained.
  • Methyl 4-iodo-L-phenylalaninate hydrochloride (5.7g, 16.7mmol), 5 ⁇ - ⁇ [(4-i-butoxycarbonyl) -amino] -methyl ⁇ -cyclohexanecarboxylic acid (4.4g, 16.7mmol) and N, N- Diisopropylethylamine (11.7 mL, 67 mmol) was suspended in 90 mL of ethyl acetate. The solution was cooled to 0 ° C.
  • Example 12A 4-Bromo-Na / j / ia - [(1 ⁇ '-4- ⁇ [(feri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -N- (3-chloro-1 / i-indazole-6 -yl) -L-phenylalanine amide
  • Example 16A 4-Bromo-N-alpha - [(trans-4- ⁇ [(ferric-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -N- ⁇ 4- [3- (heptafluoropropyl) -HH-1, 2, 4-triazol-5-yl] phenyl ⁇ -L-phenylalanine amide
  • Example 17A ieri-butyl-5- [4 - ( ⁇ 4-bromo-N - [(ira-A-4- ⁇ [(feri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -L-phenylalanyl ⁇ amino) phenyl ] -3-oxo-2,3-dihydro-1 / pyrazole-1-carboxylate
  • the suspension was treated with a 0.19 ml (0.33 mmol) 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in dimethylformamide) and until added to the solution with dimethylformamide and then stirred for 16 h at RT.
  • the reaction mixture was stirred into ethyl acetate, washed three times with water and once with sodium chloride solution.
  • the organic phase was dried over sodium sulfate and the solvent removed.
  • the crude product was dissolved in a little methanol and separated by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). 134 mg (64% of theory) of the title compound were obtained.
  • the reaction mixture was acidified with 1N hydrochloric acid. After the addition of ethyl acetate, the phases were separated. The organic phase was washed with water and aqueous saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated to dryness. 437 mg (61% of theory) of the title compound were obtained.
  • 2-Methyl-4-methoxycarbonylphenylboronic acid pinacol ester (1102 mg, 4.0 mmol) and tetrakis (triphenylphosphine) palladium (0) (461 mg, 0.40 mmol) were added and heated at 100 ° C for 4 h.
  • the reaction mixture was filtered through kieselguhr, the filtrate was adjusted to pH 1 with 1N hydrochloric acid solution and drawn onto silica gel.
  • the mixture was purified by chromatography (silica gel, cyclohexane / ethyl acetate 1: 1, then ethyl acetate / ethanol 1: 1, then ethanol) and the solvent removed. 5560 mg (90% of theory, 90% purity) of the title compound were obtained.
  • a solvent mixture tetrahydrofuran / water 3: 1, 120 ml
  • Methyl 4 '- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] amino ⁇ - 3-oxo-3- ⁇ [4- (2 / i-tetrazol-5-yl) phenyl] amino ⁇ propyl] -2-chlorobiphenyl-4-carboxylate (1150 mg, 1.4 mmol) was charged in a solvent mixture (tetrahydrofuran / water 3: 1, 14 ml) and washed with Lithium hydroxide monohydrate (573 mg, 14 mmol) and stirred for 16 h at RT.
  • reaction mixture was added with water (150 ml) and the solution was adjusted to pH 4 with 1N hydrochloric acid solution.
  • the resulting solid was filtered off and washed with water and dried in vacuo. 1051 mg (100% of theory) of the title compound were obtained.
  • N-alpha - [(trans-4- ⁇ [(feri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -N- [4- (2-i-tetrazol-5-yl) phenyl] was added.
  • L-phenylalanine amide (3000 mg, 4.8 mmol)
  • aqueous sodium carbonate solution (1 g sodium carbonate in 4.8 mL water, 9.6 mmol
  • [l, l-bis (diphenylphosphino) -ferrocene] dichloropalladium-dichloromethane complex 121 mg , 0.15 mmol
  • ethanol 15 ml
  • reaction mixture was treated with ethyl acetate and with 1N hydrochloric acid until pH 4.
  • the phases were separated and the organic phase washed with water and with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated to dryness. 103 mg (24% of theory) of the title compound were obtained over two stages.
  • the reaction mixture was stirred in the microwave at 110 ° C for 6 hours. Subsequently, it was mixed with plenty of acetonitrile and the precipitate was filtered off with suction through a frit and dried. 4.7 g (quant.) Of the title compound were obtained.
  • reaction mixture was treated with 50 ml of water and with 1N hydrochloric acid to pH 4.
  • the resulting precipitate was filtered off, washed with a little water and then dried under high vacuum. 798 mg (89% of theory, 86% purity) of the title compound were obtained.
  • reaction mixture was stirred at RT for 16 h, the tetrahydrofuran was removed to about 60%, then acidified with 1N hydrochloric acid solution. The resulting solid was washed with water and dried under high vacuum. 2402 mg (100% of theory) of the title compound were obtained.
  • Methyl 4-iodo-N- [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -L-phenylalaninate (3.8 g, 7.0 mmol) was dissolved in 55 ml of tetrahydrofuran, to 0 ° C cooled and treated with 5.3 ml of 2N sodium hydroxide solution. It was allowed to come to RT and stirred overnight at RT. The tetrahydrofuran was then stripped off and the aqueous phase was washed twice with tert-butylmethyl ether.
  • the aqueous phase was then adjusted to pH 3 with 1N hydrochloric acid and the precipitated solid was filtered off with suction.
  • the aqueous phase was extracted three times with dichloromethane and the organic phase was concentrated. The residue from the organic phase was combined with the solid and dried under high vacuum. 3.8 g (100% of theory) of the title compound were obtained.
  • Example 35A 4 '- ⁇ (2S) -2- ⁇ [( ⁇ - ⁇ -4- ⁇ [( ⁇ -butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] amino ⁇ -3 - [(3-chloro-1 / i -indazol-6-yl) amino] -3-oxopropyl ⁇ -2-methylbiphenyl-4-carboxylic acid
  • the reaction mixture was stirred at RT for 16 h and at 50 ° C. for a further 6 h.
  • the mixture was then taken up in ethyl acetate, washed with 0.5N hydrochloric acid solution, water and aqueous saturated sodium chloride solution and the organic phase dried over sodium sulfate, filtered and concentrated to 60%.
  • the precipitated solid was filtered off, washed with ethyl acetate and dried in vacuo. 454 mg (91% of theory) of the title compound were obtained.
  • the reaction mixture was stirred at RT for 16 h and at 50 ° C. for a further 6 h.
  • the mixture was then taken up in ethyl acetate, washed with 0.5N hydrochloric acid solution, water and aqueous saturated sodium chloride solution and the organic phase dried over sodium sulfate, filtered and concentrated to 60%.
  • the precipitated solid was filtered off, washed with ethyl acetate and dried in vacuo. 505 mg (96% of theory) of the title compound were obtained.
  • reaction mixture was partitioned between water and ethyl acetate, treated with 1N sodium hydroxide solution and extracted repeatedly with ethyl acetate.
  • organic phases were washed with aqueous saturated sodium chloride solution, dried over sodium sulfate, and the solvent was removed. 603 mg (41% of theory) of the title compound were obtained.
  • reaction mixture was stirred at RT for 16 h, neutralized with 1N acetic acid solution and separated between ethyl acetate and 10% strength citric acid solution. It was extracted with ethyl acetate / dioxane, dried over sodium sulfate and dried in vacuo. The resulting solid was suspended with acetonitrile, washed and dried under high vacuum. 507 mg (69% of theory, 93% purity) of the title compound were obtained.
  • reaction mixture was stirred for 16 h at RT, neutralized with 1N acetic acid solution and separated between ethyl acetate and 10% citric acid solution. It was extracted with ethyl acetate / dioxane, dried over sodium sulfate and dried in vacuo. The resulting solid was suspended with acetonitrile, washed and dried under high vacuum. 829 mg (63% of theory) of the title compound were obtained.
  • reaction mixture was stirred for 4 h at RT and separated between ethyl acetate and 10% citric acid solution. It was extracted with ethyl acetate / dioxane, dried over sodium sulfate and dried in vacuo. The residue was purified by chromatography (silica gel, dichloromethane / methanol 10: 1) and the solvent was removed. 699 mg (61% of theory) of the title compound were obtained.
  • the reaction mixture was filtered through kieselguhr and washed with ethyl acetate.
  • the filtrate was concentrated and separated between ethyl acetate and 10% citric acid solution. It was extracted with ethyl acetate, dried over sodium sulfate and dried in vacuo.
  • the resulting solid was suspended with acetonitrile, washed and dried under high vacuum. 8.77 g (80% of theory) of the title compound were obtained.
  • Example 52A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-methoxy 3-oxopropyl] -2-methylbiphenyl-4-yl ⁇ carbonyl) amino] piperidine-1-carbo
  • Methyl - [(ieri-butoxycarbonyl) amino] (dimethoxyphosphoryl) acetate (1.46 g, 4.93 mmol) was placed under an argon atmosphere in dichloromethane (30 ml) with l, 8-diazabicyclo (5.4.0) undec-7-ene ( 0.82 g, 5.42 mmol) and stirred for 10 min at RT.
  • a solution of 4-bromo-3-fluorobenzaldehyde (1.00 g, 23 mmol) in dichloromethane (6.5 ml) was added and stirred at RT for 90 min.
  • the reaction mixture was treated with ethyl acetate and the solution was treated with IN Hydrochloric acid solution adjusted to about pH 4.
  • Example 58A ieri-butyl-4 - [( ⁇ 4 '- [(2S) -2- ⁇ [(trans-A- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] amino ⁇ -3-oxo -3- ⁇ [4- (2 / i-tetrazol-5-yl) -phenyl] -amino ⁇ -propyl] -2-methyl-biphenyl-4-yl ⁇ carbonyl ⁇ amino] -piperidine-1-carboxy-lat
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 82 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 73 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 61 A tert-Butyl 4- [( ⁇ 4 '- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3- (1-i-indazol-6-ylamino) -3-oxo-propyl] -2-methyl-biphenyl-4-yl ⁇ carbonyl) -amino] -piperidine-1-carboxylate-trifluoroacetate
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 87 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 62A ieri-butyl-4- ( ⁇ 4'- [(2S) -2- [[(trans - ⁇ - [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3- (l / i-indazol-6-ylamino) -3-oxo-propyl] -2-methyl-biphenyl-4-yl ⁇ carbonyl) -piperazine-1-carboxylate trifluoroacetate
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 101 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 63A [2- (diethylamino) ethyl] carbamoyl ⁇ -2'-methylbiphenyl-4-yl) -1- (1-indazol-6-ylamino) -1 -oxopropan-2-yl] carbamoyl ⁇ cyclohexyl) methyl] carbamate trifluoroacetate 100 mg (0.15 mmol) of 4 '- [(2 l r S) -2- ⁇ [(ira " ⁇ -4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ -cyclohexyl) - carbonyl] amino ⁇ -3- (l / i-indazol-6-ylamino) -3-oxopropyl] -2-methylbiphenyl-4-carboxylic acid and 21 mg (0.18 mmol) of diethylaminoethylamine were dissolved in 5 ml of tetrahydrofuran
  • Example 64A ieri-butyl - [(ira ".y-4- ⁇ [(2 l S , ) -3- [4 '- (isopropylcarbamoyl) -2'-methylbiphenyl-4-yl] -l-oxo-l- ⁇ [4- (2-i-tetrazol-5-yl) phenyl] amino ⁇ propan-2-yl] carbamoyl ⁇ cyclohexyl) methyl] carbamate
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 49 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 61 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 59 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 68A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans - ⁇ - [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl 1] amino ⁇ -3-oxo -3 - ⁇ [4- (2 / i-tetrazol-5-yl) -phenyl] -amino ⁇ -propy 1] -2-chlorobiphenyl-4-yl ⁇ -carbonyl ⁇ amino] -piperidine-1-carboxy-lat
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 68 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 90 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 88 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 73A ieri-butyl-4- ( ⁇ 4'- [(2S) -2- ⁇ [(trans- ⁇ (ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl 1] amino ⁇ -3-oxo 3 - ⁇ [4- (2-i-tetrazol-5-yl) phenyl] amino ⁇ propyl 1] -2-methylbiphenyl-4-yl ⁇ carbonyl l) piperazine-1-carboxy-lat
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 95 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 110 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 60 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 44 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 51 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 64 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 87A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans- ⁇ (irei-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl 1] amino ⁇ -3-oxo 3 - ⁇ [4- (2-i-tetrazol-5-yl) phenyl] amino ⁇ propyl 1] -2-chlorobiphenyl-4-yl ⁇ carbonyl) amino] -2-methylpiperidine-1-carboxylate
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 71 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 52 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated twice by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 57 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 81 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water gradient, 0.1% trifluoroacetic acid). This gave 65 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 53 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 40 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 47 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.
  • Example 104A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans - ⁇ - ⁇ (- irei-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-oxo 3 - ( ⁇ 4- [3- (trifluoromethyl) -1 / il, 2,4-triazol-5-yl] phenyl ⁇ amino) propyl] -2-mbiphenyl-4-yl ⁇ carbonyl) amino] piperidine-1 carboxylate
  • reaction solution was separated by preparative HPLC (eluent: methanol-aqueous gradient, 0.01% trifluoroacetic acid).
  • product-containing fractions were combined and concentrated on a rotary evaporator.
  • the residue was dried under high vacuum. 57 mg (33% of theory, 93% purity) of the title compound were obtained.
  • Example 106A ieri-butyl-4- ⁇ [(4'- ⁇ (2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3- [ (2-methyl-1 / i-benzimidazol-6-yl) -amino] -3-oxo-propyl ⁇ -2-methyl-biphenyl-4-yl) -carbonyl 1] -amino ⁇ -piperidine-1-carboxylate
  • reaction solution was separated by preparative HPLC (mobile phase: acetonitrile / water gradient, 0.01% trifluoroacetic acid).
  • product-containing fractions were combined and concentrated on a rotary evaporator. There was obtained 23 mg (26% of theory) of the title compound.
  • Example 107A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans - ⁇ - [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-oxo 3- ⁇ [2- (pyridin-2-yl) -l / i-benzimidazol-5-yl] -amino-propyl] -2-methyl-biphenyl-4-yl ⁇ -carbonyl) amino) -piperidine-1-carboxy-lat
  • reaction solution was separated by preparative HPLC (mobile phase: acetonitrile / water gradient, 0.01%). Trifluoroacetic acid). The product-containing fractions were combined and concentrated on a rotary evaporator. 49 mg (33% of theory, 63% purity) of the title compound were obtained.
  • Example 108A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-oxo -3- ⁇ [2- (trifluoromethyl) -1 / benzimidazol-6-yl] amino ⁇ propyl] -2-methylbiphenyl-4-yl ⁇ carbonyl ⁇ amino] piperidine-1-carboxy late
  • reaction solution was separated by preparative HPLC (mobile phase: acetonitrile / water gradient, 0.01% trifluoroacetic acid).
  • product-containing fractions were combined and am Concentrated rotary evaporator. There were obtained 66 mg (71% of theory, 88% purity) of the title compound.
  • reaction solution was mixed with water, the resulting precipitate was filtered off. It was washed with acetonitrile, dilute sodium hydroxide solution, and diethyl ether and dried under high vacuum. 83 mg (92% of theory) of the title compound were obtained.
  • Example 110A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- [[(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3- ( ⁇ 4- [3- (methoxymethyl) -4 / il, 2,4-triazol-5-yl] phenyl ⁇ amino) -3-oxopropyl] -2-methylbiphenyl-4-yl ⁇ carbonyl) amino] piperidine 1-carboxylate
  • reaction solution was mixed with water, the resulting precipitate was filtered off. It was washed with acetonitrile, dilute sodium hydroxide solution, and diethyl ether and dried under high vacuum. The residue was dissolved in methanol and separated by preparative HPLC (mobile phase: methanol / water gradient, 0.01% trifluoroacetic acid). The product-containing fractions were combined and concentrated on a rotary evaporator. 43 mg (24% of theory, 89% purity) of the title compound were obtained.
  • Example IIIA ieri-butyl-4- ⁇ [(4'- ⁇ (2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-oxo -3 - [(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl) -amino] -propyl ⁇ -2-methylbiphenyl-4-yl) carbonyl 1] amino ⁇ piperidine-1-carboxy lat
  • Example 112A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3- ⁇ [4- (3-methyl-4-yl, 2,4-triazol-5-yl) -phenyl] -amino ⁇ -3-oxo-propyl] -2-methyl-biphenyl-4-yl ⁇ -carbonyl) amino) -piperidine-1-carboxy lat
  • Example 115A ieri-butyl-4- [( ⁇ 4'- [(2S) -2- ⁇ [(trans-4- ⁇ [(ieri-butoxycarbonyl) amino] methyl ⁇ cyclohexyl) carbonyl] -amino ⁇ -3-oxo -3- ⁇ [2- (pyridin-3-yl) -1H-benzimidazol-5-yl] amino ⁇ propyl] -2-methylbiphenyl-4-yl ⁇ carbonyl ⁇ amino] piperidine-1-carboxy-lat
  • reaction mixture was separated directly by preparative HPLC (mobile phase: acetonitrile / water with 0.1% TFA (gradient)). This gave 85 mg of a mixture of the title compound and the corresponding deprotected amine, which was used directly in the next step.

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