EP2934750A1 - Tubule vissable et couvercle vissé pour matériau biologique - Google Patents

Tubule vissable et couvercle vissé pour matériau biologique

Info

Publication number
EP2934750A1
EP2934750A1 EP13821457.2A EP13821457A EP2934750A1 EP 2934750 A1 EP2934750 A1 EP 2934750A1 EP 13821457 A EP13821457 A EP 13821457A EP 2934750 A1 EP2934750 A1 EP 2934750A1
Authority
EP
European Patent Office
Prior art keywords
screw
tube
closing
screw cap
biomaterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13821457.2A
Other languages
German (de)
English (en)
Other versions
EP2934750B1 (fr
Inventor
Bernd Roman KRANZ
Sven MÜHLFRIEDEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Greiner Bio One GmbH Germany
Original Assignee
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Greiner Bio One GmbH Germany
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH, Greiner Bio One GmbH Germany filed Critical Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Publication of EP2934750A1 publication Critical patent/EP2934750A1/fr
Application granted granted Critical
Publication of EP2934750B1 publication Critical patent/EP2934750B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/04—Threaded or like caps or cap-like covers secured by rotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs

Definitions

  • the present invention relates to a biomaterial screw tube, a screw cap for capping such a biomaterial screw tube, and a screw tube and a screw cap system. Furthermore, the present invention relates to a storage device for receiving a plurality of such screw tubes. State of the art
  • biobanks In recent years, several larger biomaterials banks, hereafter referred to as biobanks, have been set up in what are known as cohort studies. In such biobanks, a plurality of individual biological samples are stored for a very long time (several decades) at very low temperatures (about -180 ° C). Typically, these are more than 100,000, sometimes more than 1,000,000 individual samples stored for several decades. Such storage In particular, it can also be done by means of automation in so-called "high-throughput" methods.
  • biobanks of large epidemiological cohort studies may, for example, be the follow-up of representative populations over decades.
  • biomaterial resources they can be used to analyze the causes of complex diseases and their early detection.
  • All such biobanks have in common that a large number of relatively small individual samples of different biomaterials are used for the single analysis use. In other words, repeated cycles of thawing and deep-freezing should be avoided.
  • these biobanks also have in common that the analytical methods are automated in the aforementioned "high-throughput" analysis methods, and therefore the corresponding tubes for the biomaterial should be easy to automate.
  • a biobank for the storage of 25 million samples at a storage temperature of -180 ° C on average in the gas phase of liquid nitrogen over a storage period of up to 30 years is currently being set up in Germany within the framework of the so-called 'National Cohort'.
  • FIGS. 1a-1d Examples of such prior art screwed-type screw-type tubing are shown in FIGS. 1a-1d.
  • FIGS. 1a-1d Examples of such prior art screwed-type screw-type tubing are shown in FIGS. 1a-1d.
  • the space distribution in these screw tubes and screw caps from the prior art is not optimal. In other words, more space and more material is used in the prior art than would be necessary. This results in more volume and mass that must be cooled down with the biological samples and kept at a low temperature than would be necessary.
  • the construction of the known tubes sometimes also leads to artificial losses of biological sample material, which is undesirable.
  • a first aspect of the present invention relates to a screw cap for closing a screw tube for biomaterial.
  • the screw cap can be understood as a screw and the tube as a nut.
  • the screw cap has a cylindrical screw portion having an external thread. Alternatively, this section may also be referred to as a threaded section which has a thread at least over part of its length.
  • This cylindrical screw portion defines a longitudinal axis.
  • the screw on a flange portion which can be understood as a screw head.
  • This flange section adjoins the screw section.
  • the screw cap has a recess which extends coaxially to the longitudinal axis of the screw cap. This recess extends longitudinally through the flange portion and at least partially along the screw portion.
  • this recess has a driving inner profile.
  • This driving inner profile is for opening and closing with a suitable key suitable. Furthermore, this driving inner profile extends axially at least partially along the screw portion.
  • the driving inner profile of the screw cap or of the rotary closure extends into a sealed cavity of the screw section, which has the external thread.
  • Such entrainment inner profile may have a relatively small diameter of less than 5 mm, preferably less than 4 mm and in particular of about 3.6 mm in comparison to the prior art, especially in the suitability for high torques for opening and Close a screw tube with the screw cap.
  • the ability to provide the driving inner profile with a relatively small diameter is advantageous, since in this way a suitable material thickness between driving profile and external thread can be realized.
  • This material thickness should in particular be large enough to ensure a suitable stability during power transmission to simultaneously driving profile and external thread.
  • the diameter of the driving profile is therefore kept as large as possible in order to keep the contact surface between wrench and screw cap as large as possible. It has been found that the above size ratios are advantageous in this respect.
  • the above-described screw cap allows a more compact and space-saving design than is possible with screw caps from the prior art. At the same time it is temperature resistant and resistant enough to be fully suitable for storage in the liquid nitrogen gas phase.
  • the screw cap according to the invention thus fulfills the objects of the invention.
  • the driving inner profile may extend axially over 30% to 99% of the screw portion, preferably over 50% to 90%, more preferably over 60% to 80% and in particular over about 70%. In this way, a sufficient and comparable with the prior art contact surface between driving profile and key can be created without the waste of space that have screw cap from the prior art, which do not use the screw section for the driving profile.
  • the coaxial length of the driving profile and the sealing of the tube contents are positively correlated with each other so far as maximum torque and thus the contact pressure between the screw as a screw and the tube as a mother are determined by the length of the driving profile.
  • the screw portion may have a substantially constant over the length outer diameter.
  • the flange portion corresponding to a screw head may be substantially cylindrical and have a larger outer diameter (for example, 8.7 mm) than the screw portion (5.95 mm).
  • the flange portion is flush with the outer diameter of a fferrschreibchens.
  • the projection of the flange of the screw cap over the screw portion forms an annular contact surface with the end portion of the screw tube, for example with the flange portion of the screw tube.
  • the width of the contact surface also determines the quality of the seal between the screw tube contents and the screw tube environment.
  • the external thread is designed to close the tube in about one revolution, for example, for 0.7 to 1.3 revolutions, particularly preferably for 0.9 to 1.1 revolutions.
  • the screw cap can also This makes it particularly small and compact, which further contributes to size / volume and material reduction of the screw cap.
  • the screw cap has a longitudinal length along the longitudinal axis of a total length between 5.2 mm and 8.0 mm, more preferably between 6.2 mm and 7.0 mm, most preferably between 6.5 mm and 6.7 mm, for example, 6.6 mm. It has been found that such a dimensioning ensures a suitable compromise between the shortest possible length on the one hand and a good sealing function on the other hand.
  • the total length of the screw cap may be the sum of the lengths of the screw portion and the flange portion.
  • the quotient between the length of the screw portion and the length of the flange portion is between 1.4 and 3.4, preferably between 2.1 and 2.7, more preferably between 2.3 and 2.5 and in particular about 2.4 .
  • the flange portion protrudes longitudinally, typically above the screw tube. It thus contributes directly to the overall length of a system with a screw tube and a screw cap. Therefore, it is particularly preferable if the length of the flange portion is selected as small as possible. At the same time, however, the flange portion also provides a part of the sealing effect of the screw cap.
  • the absolute length of the flange portion which is typically between 1.4 mm and 2.4 mm, preferably between 1.7 mm and 2.1 mm, more preferably between 1.8 mm and 2.0 mm and in particular about 1.9 mm.
  • the flange length or height is preferably sufficient, together with a Flanschrändelung to open the tube in the very rare exceptional case also manually (rule: automated opening by means of 'Capper Decapper' machine, possibly by means of a key).
  • the flange height can also ensure sufficient stability to transmit the necessary contact pressure on the sealing ring between the flange and the annular widened upper tube end.
  • the external thread may extend over 70% to 100%, preferably over 75% to 95%, more preferably over 80% to 90%, and for example over about 85% of the length of the screw portion. Again, this dimensioning has been found to be particularly advantageous in terms of sealing function on the one hand and a low material and space requirements on the other hand.
  • the screw cap comprises plastic and particularly preferably consists of plastic.
  • the screw cap in this case polypropylene and is particularly preferably made of this material. This material is particularly well suited to achieve a suitable sealing effect, even at low temperatures, even at very low temperatures. It is preferably a "medical grade" plastic or 'USP Class VF plastic.
  • the screw cap particularly preferably has an additional sealing ring, which is preferably formed of silicone and very particularly preferably of TPE or TPV.
  • a sealing ring can further improve the seal between the screw cap according to the invention and a corresponding screw tube.
  • Flat rings are preferred in which the tube has no bevel or chamfer at the top, but preferably a flange. This type of seal is preferred because thinner.
  • a screw tube for biomaterial is designed to be closed by a screw cap according to the invention.
  • the screw tube has a hollow cylinder section.
  • This hollow cylinder section has an internal thread.
  • This internal thread is designed to be in engagement with the external thread of the screw cap.
  • the hollow cylinder portion defines a tube axis and a tube longitudinal direction.
  • the screw tube is preferably suitable for storage at very low temperatures, for example from -180 ° or even lower temperatures.
  • the screw tube may be a nitrogen-adapted cryotube.
  • the internal thread of the hollow cylinder portion extends in the longitudinal direction of the screw tube in the vicinity of one end of the hollow cylinder portion.
  • Proximity in this context is understood to mean a distance of not more than 3 mm, preferably not more than 2 mm, more preferably not more than 1 mm and in particular not more than 0.5 mm.
  • the internal thread is thus displaced further into the vicinity of one end of the hollow cylinder section. In this way, a particularly suitable sealing can be achieved with the previously described screw cap with reduced length.
  • a flange section to adjoin an end of the hollow cylinder section.
  • Such a flange portion which may in particular have a larger area, further facilitates the sealing between the screw tube and the screw cap.
  • the screw tube preferably has a plastic and is particularly preferably made of a plastic. Particularly preferably, the screw tube to a polypropylene and very particularly preferably consists thereof.
  • the objects of the invention are also achieved by a system with a screw cap as described above and a screw tube as described above.
  • the screw cap comprises at least one of the materials comprising the screw tube.
  • the screw cap is made of the same material or of the same materials as the screw tube. This may in particular have the advantage that screw tubes and screw caps have the same or at least similar temperature expansion properties. This may be particularly important since screw caps and screw tubes may be designed for use at very low temperatures, for example -180 ° C. Also by the same choice of materials and by the same or similar temperature properties, for example Temperature coefficient of expansion, a suitable seal with low material costs and low space requirement is guaranteed.
  • a storage device for receiving a plurality of screw tubes according to the invention.
  • This device is designed such that the recorded sterrschreib chen flush in its longitudinal direction approximately flush with a flat end portion of the storage device.
  • this flush termination is configured such that there is a distance between a lower end of the accommodated screw tubes and the flat end portion of the storage device that is less than 3 mm, and preferably a distance smaller than 2 mm, and more preferably a distance which is smaller than 1 mm, for example, a distance of about 0.6 mm.
  • the height of the sidewalls of the storage device or of the "rack” is reduced compared with the prior art, so that the screw tubes or tubes end in the longitudinal direction at the level of a supporting surface of the storage device or the rack Reduction of the space requirement in the present invention.
  • the present invention thus avoids loss of space. This leads to a reduction in space requirements and a gain in storage efficiency. Furthermore, this is accompanied by a reduction in the cooling capacity to be maintained, ie, the entire system cooling can be dimensioned smaller and designed. This can be associated with considerable financial advantages in individual cases: for example, the reduction of the primary investment costs of nitrogen storage, be it manual or automated, the reduction of equipment maintenance and repair costs and the reduction of operating and especially energy costs.
  • the present invention is also ecologically advantageous because less volume and mass must be cooled, which consumes less energy and less C0 2 is ejected.
  • the invention comprises the following aspects: Screw cap for closing a screw tube for biomaterial, wherein the screw cap has
  • cylindrical screw portion defines a longitudinal axis
  • the recess has a driving inner profile, which is suitable for opening and
  • the driving inner profile extends axially at least partially along the screw portion.
  • Screw cap for closing a screw tube for biomaterial according to aspect 1 wherein the driving inner profile axially over 30% to 99%, preferably over 50% to 90%, more preferably over 60% to 80% and in particular about about 70% of the screw section extends.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects wherein the screw portion has a substantially constant outer diameter.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects wherein the external thread is designed approximately for one revolution, preferably for 0.7 to 1.3 revolutions and more preferably for 0.9 to 1.1 revolutions.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects wherein the screw cap in the longitudinal direction along the longitudinal axis has a total length between 5.2 mm and 8.0 mm, preferably between 6.2 mm and 7.0 mm, more preferably between 6.5 mm and 6.7 mm and in particular of 6.6 mm.
  • Screw cap for closing a screw tube for biomaterial wherein the total length of the screw cap is the sum of the lengths of the screw portion and the flange portion and wherein preferably the quotient between the length of the screw portion and the length of the flange portion between 1.4 and 3.4, preferably between 2.1 and 2.7, more preferably between 2.3 and 2.5 and in particular about 2.4.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects, wherein the length of the flange portion is between 1.4 mm and 2.4 mm, preferably between 1.7 and 2.1, more preferably between 1, 8 mm and 2.0 mm and in particular about 1, 9 mm.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects, wherein the external thread in the longitudinal direction over 70% to 95%, preferably over 75% to 92%, more preferably over 80% to 90%, for example about 85 % of the length of the screw section extends.
  • Screw cap for closing a screw tube for biomaterial according to one of the preceding aspects, wherein the screw cap plastic and preferably polypropylene and has particularly preferably made of plastic and preferably made of polypropylene.
  • Screw cap for closing a screw tube for biomaterial wherein the screw cap additionally comprises a sealing ring, preferably made of silicone and particularly preferably made of TPE or TPV.
  • a sealing ring preferably made of silicone and particularly preferably made of TPE or TPV.
  • a biomaterial screwing tube designed to be closed by a screw cap according to any one of the preceding aspects, wherein the screwing tube has a hollow cylindrical portion with an internal thread adapted to engage the external thread of the screwing cap and wherein the hollow cylinder portion defines a tube axis and a tube longitudinal direction.
  • Screw tube for biomaterial according to aspect 12 or 13, wherein at one end of the hollow cylinder portion, a flange adjoins section.
  • a screw tube for biomaterial according to any of aspects 12 to 14, wherein the screw tube plastic and preferably polypropylene, and more preferably made of plastic and preferably consists of polypropylene.
  • the screw cap has one of the materials of the screw tube and is preferably formed from the same material as the screw tube.
  • a storage device for holding a plurality of screw tubes according to one of the aspects 12 to 15, wherein the device is designed such that the recorded screw tubes in their longitudinal direction approximately flush with a flat end portion of the storage device and preferably such that between the recorded screw and the flat end portion of the storage device is a distance which is smaller than 3 mm, preferably a distance which is smaller than 2 mm, and particularly preferably a distance which is smaller than 1 mm, for example a distance of about 0.6 mm ,
  • Screw tube for biomaterial of the prior art a side view of a screw tube for biomaterial with a
  • Screw cap according to a first embodiment of the invention
  • Screwing tube according to an embodiment of the invention; a schematic sectional view of a screw cap for closing a
  • FIG. 5a-5c are schematic top plan views of screw on lid for closing a screw tube for biomaterial according to an embodiment of the invention.
  • Fig. 6 is a schematic sectional view of a screw tube for biomaterial according to an embodiment of the invention.
  • Figures la-ld show screw tubes 102 for biomaterial and corresponding screw caps 104 for closing the prior art screw tubes.
  • the screw cap 104 has a screw portion 106 and a projection portion 108. Further, the screw cap 104 has a sealing ring 116 made of silicone. The screw portion 106 has an external thread 110.
  • the overhang section which can be considered as a kind of screw head, has two formations, both of which serve for opening, namely a high knurling for manual opening on the outside and a recess for the opening on the inside by means of a wrench.
  • the prior art screw cap 104 has a recess 112 which extends coaxially with a longitudinal axis of the screw cap.
  • This recess 112 is disposed in the overhang portion 108 and has a driving inner profile, which is indicated by the lines 114.
  • This entrainment inner profile 114 extends along the recess 112 and thus only along the overhang section 108.
  • Screw tube 102 is designed to be closed by the screw cap 104.
  • Screw tube 102 in this case has a hollow cylinder section 122 with an internal thread 124.
  • the internal thread 124 is typically several millimeters from the open end of the hollow cylinder 122.
  • the screw cap 4 according to the invention can be distinguished from the prior art screw caps 104 according to FIGS. 2, 3, 4, 5 a, 5 b and 5 c.
  • the screw according to the invention according to Figures 2 and 6 is to be distinguished from the screw 102 of the prior art.
  • Screw cap 4 is suitable for closing a screw tube 2 for biomaterial.
  • the screw cap 4 has a screw portion 6. This screw portion 6 is preferably cylindrical and has an external thread 10 at one longitudinal end. Further, the screw portion 6 defines a longitudinal axis.
  • the screw cap 4 has a flange section 8, which adjoins the screw section 6.
  • the flange portion can be understood as a screw head with low knurling.
  • the flange portion 8 may be formed substantially cylindrical.
  • the screw portion 6 preferably has a constant outer diameter.
  • flange portion 8 typically has a constant outer diameter which is greater than the diameter of screw portion 6. This can be seen inter alia in FIGS. 3 and 4.
  • FIG. 4 shows a schematic sectional view of a screw cap 4 according to the invention.
  • the roughly hatched area here shows the sectional plane through the screw cap 4.
  • the surface 12 shows a surface of the screw cap 4, which is set back with respect to the cutting plane.
  • FIGS. 1c, 1d, and 6 some surfaces which are set back from the cut surface are finely hatched.
  • recess 112 in FIG. 1 d and recesses 12 in FIGS. 5 a to 5 c are also set back relative to the cut surface.
  • the screw cap 4 has a recess 12. As shown in FIG. 4, this recess 12 is coaxial with the longitudinal axis defined by the cylindrical screw portion 6. As further shown in particular by Fig. 4, the recess extends longitudinally both through the flange portion 8 and at least partially along the screw portion 6.
  • a driving inner profile which is indicated in Fig. 4 by lines 14.
  • This driving inner profile is designed for opening and closing with a corresponding key or suitable. Furthermore, this driving inner profile, as indicated by structures 14, extends axially at least partially along the screw section 6.
  • this driving inner profile also extends at least partially along the flange portion 8.
  • this Mitnalime inner profile may also extend along the entire longitudinal direction of the recess 12. That is to say, in particular along the entire section of the recess 12 which extends along the flange section 8 and along the entire section which extends along the screw section 6.
  • another embodiment also allows the driving inner profile to not extend along the entire flange portion 8, but to terminate at a distance from one end of the flange portion 8, in particular spaced from a surface or top 18 of the flange portion 8.
  • the recess 12 is "open” only to one side, namely to "outside”, but not to "inside”, that is not to an inner volume of the screw through the measures described above
  • artificial sample losses can also be avoided or reduced, in particular by reducing or avoiding that the screw section 6 does not have a recess which opens on the side which opens the side Flange portion in the longitudinal direction opposite, ie has no cavity which is arranged in use in the interior of the tube. If this is the case with the screw caps of the prior art, so liquid can accumulate therein, which can be lost when opened.
  • the screw cap 4 can also be understood as a screw cap, which corresponds in its essential structure of a screw.
  • the tube 2 then corresponds to a mother.
  • a sample can guarantee.
  • Figures 5a-5c show possible embodiments of the driving inner profile, in each case in a plan view from above on screw cap according to the invention 4.
  • the respective hatched area 18 respectively indicates the surface or top 18 of the flange portion 8.
  • the driving inner profile may be formed by corresponding webs 22. Although six such webs are shown in Figure 5a, those skilled in the art will appreciate that they can also use 3, 4, 5, 7, 8, etc. webs. It is also possible that instead of the webs 22 corresponding set back exceptions are formed (not shown).
  • the driving internal profile can also be effected by a corresponding configuration of the recess 12.
  • the recess 12 is designed as a polygon, here for example as an octagon 24. Again, it will be clear to the skilled person that he can arbitrarily choose from different, preferably uniform, polygons.
  • Fig. 5c shows another possible embodiment of the driving inner profile as eight-pointed star 26. Again, it will be apparent to those skilled in the art that the invention is not limited to an eight-pointed star, but that various multi-pointed stars can be used.
  • the integrated driving profile can also be designed as a so-called Torx inner profile (a star of David-like six-round) or as a so-called Torx Plus inner profile.
  • Torx inner profile a star of David-like six-round
  • Torx Plus inner profile a so-called Torx Plus inner profile.
  • These driving profiles, as well as the others described, are suitable for use in opening with a corresponding wrench outer profile.
  • the Torx profile and in particular the Torx Plus profile also allow easier placement of a wrench in an automated Capper Decapper system, in particular a good power transmission with high torque.
  • the driving inner profile can be made relatively short with a suitable power transmission, which further reduces the material and space requirements of the tube cover.
  • a high force or torque transmission and the rotary closure external thread can be made relatively short. This can lead to an increase of the inner volume of the tube at the same external height or a reduction of the outer height with the same inner volume of the tube.
  • a high torque, high torque transmission may also positively affect and thus permit the closing and sealing properties between the external thread 10 and an internal thread 36 of a tube are designed relatively short, for example, designed for only about one revolution. This can cause a further shortening of the total length with the same filling volume (or a higher filling volume with the same total length).
  • the driving inner profile can preferably be understood as an outwardly directed inner profile. This can be opened and closed with a Capper Decapper wrench.
  • the embodiment is also suitable for automated operation and can very particularly preferably replace a high configuration of the overhang section with inner profile, as in the prior art.
  • any non-circular design of the driving inner profile is suitable, which allows opening and closing with a corresponding key, but are preferably those that allow a good power transmission with high torque.
  • FIGS. 2, 3 and 4 show a sealing ring 16, which preferably surrounds the screw section 6.
  • this seal ring 16 is located at the portion of the screw portion 6 that does not have the external thread 10.
  • sealing ring 16 is made of silicone and particularly preferably of TPE or TPV.
  • This sealing ring 16 lies in use, as shown in Fig. 2, between the flange portion 8 of the screw cap 4 and the flange portion 38 of the screw tube 2 to seal the two elements against each other.
  • the sealing ring 16 closes (as best shown in FIG. 4) in the circumferential direction, which runs perpendicular to the longitudinal direction, preferably flush with the flange section 8.
  • the sealing ring in use with a tube 2 flush with an outer edge of the tube 2, for example, flush with a flange portion 38 terminates.
  • the recess 12 according to the invention and the corresponding driving inner profile extends axially at least partially along the screw portion 6.
  • This contributes to a compact and space-saving design of the screw cap 4 according to the invention or allows them.
  • the driving inner profile axially over 30% to 99%, preferably over 50% to 90%, more preferably over 60% to 80%, for example, about about 70% of the screw section extend.
  • a suitable selection of this parameter contributes to saving space, but on the other hand it also allows a sufficient stability of the screw cap and in particular of the screw portion. In particular, it is particularly preferred that it is ensured that the screw cap 4 can withstand very low temperatures for a very long period of time without being damaged.
  • the screw portion 6 of the screw cap 4 has an external thread 10. This is typically arranged at a longitudinal end of the screw section 6. It is preferred that this external thread 10 is designed approximately for one revolution, for example for 0.7 to 1.3 and particularly preferably for 0.9 to 1.1 revolutions. This configuration for only a small number of revolutions further contributes to the compactness and thus to the space savings. Furthermore, the steepness of the thread can also play a role.
  • screw cap 4 is molded from plastic and more preferably polypropylene. This ensures a lightweight construction of the screw 4. Further, such a material is so resistant that it allows the simple and compact design of the screw 4 and therefore further contributes to the compactness of the screw 4.
  • FIG. 1 Another aspect of the invention is directed to a screw tube 2 for biomaterial - see especially Figures 2 and 6.
  • This screw 2 is designed to be closed by a screw cap 4 as described above.
  • Screw 2 has a hollow cylinder section 32.
  • screw 2 may also have a tapered portion 34 adjoining the hollow cylinder portion 32, which tapers with increasing distance from the hollow cylinder portion 32.
  • hollow cylinder section 32 has an internal thread 36. This internal thread is designed to be in engagement with the external thread 10 of the above-described screw cap 4.
  • the hollow cylinder section 32 of screw tubes 2 defines a tube axis as well as a tube longitudinal direction.
  • the internal thread 36 of the screw tube 2 is designed for approximately one revolution, preferably for 0.7 to 1.3 revolutions and particularly preferably for 0.9 to 1.1 revolutions.
  • the screw cap 4 according to the invention is made relatively compact.
  • the thread 10 may extend only over 3 to 5 mm, for example about 3.9 mm.
  • the internal thread 36 of the hollow cylinder portion 32 of the screw tube 2 in the longitudinal direction of the screw 2 in the vicinity of one end of the hollow cylinder portion 32 extends.
  • Proximity should in this context mean a distance of not more than 3 mm, preferably not more than 2 mm, more preferably not more than 1 mm and in particular not more than 0.5 mm.
  • Fig. 6 in which internal thread 36 extends to the vicinity of the upper end of hollow cylinder section 32.
  • this end is an open end of the screw tube 2.
  • a flange 38 connects at one end of the hollow cylindrical portion 32 of the screw 2. This can, for example, lead to an increase in area, which further facilitates sealing between the screw tube 2 and the screw cap 4.
  • the screw tube on plastic and is particularly preferably formed from a plastic or consists thereof. A typical plastic that can be used for this is polypropylene.
  • the invention also comprises a system which has on the one hand a screw cap 4 and on the other hand a screw tube 2. It is preferred that in this system screw cap 4 and screw 2 have the same materials and more preferably consist of the same materials. This may therefore be advantageous, for example, that in this case tube 2 and cover 4 have the same or similar coefficients of thermal expansion. This can be particularly important when using such tubes and samples at very low temperatures. As a result, a suitable seal between tube 2 and cover 4 can be achieved even under extreme conditions. In particular, this also makes possible a particularly compact embodiment of the tube 2 and in particular of the lid 4. As can be seen in particular Figures 2 and 6, screw tube 2 has a tapered portion 34 at a lower end.
  • Such a storage device is typically designed to receive a plurality of screw tubes 2.
  • the device according to the invention is designed such that the recorded screw 2 close in its longitudinal direction approximately flush with a flat end portion of the storage device.
  • this flush conclusion is such that between the recorded screw 2 and the flat end portion of the Aufbewal tion device is a distance which is smaller than 3 mm, preferably a distance which is smaller than 2 mm, and more preferably a distance which is smaller is as 1 mm.
  • the distance can be about 0.6 mm.
  • Such a storage device for screw 2 further contributes to the compactness in the storage of the screw 2 and further reduces the space required for this. Numerical comparison of an embodiment with the prior art
  • an embodiment of the screw cap and the screw tube according to the invention is compared with a screw cap and a screw tube of the prior art.
  • the screw tube or the tube from the prior art is the so-called "0.5 ml screw cap tube” from Micronic.
  • Table 1 gives the dimensions of a prototype of the present invention in comparison with the Micronic 0.5 ml Screw Cap Tube.
  • Table 1 Comparison of the dimensions of a prototype of the present invention with an example of the prior art.
  • the height of the screw tube is indicated without the screw cap (1.1.).
  • the screw tubes can hold approximately equal volumes of fluid, even the screw tube of the prototype of the invention is 3.8 mm shorter than the screw tube from the prior art. This is partly due to the more compact design of the screw cap according to the invention and in particular the more compact design of the external thread of the screw cap. As a result, less volume of the screw is required for receiving the external thread of the screw. With approximately equal working volumes, this leads to a smaller height of the screw tube.
  • the flange portion of the present prototype has a height of approximately 1.9 mm in the longitudinal direction, as opposed to approximately 7.0 mm of the prior art overhang portion. This leads to a further reduction in the overall height of the screw cap with screw cap, when this screw cap is screwed tight, as in parameter 1.3. reproduced in the above table.
  • the maximum working volume in this case results from the pipetting determined maximum filling volume up to the lower edge of the screw portion of the screw cap divided by the factor 1.0903355. This takes into account the fact that aqueous liquids, which are typically filled into the screw tubes at room temperature, are subject to expansion when the water content freezes.
  • This material ring is wider than in the prior art, said sealing surface, together with the torque and material of the sealing ring, determines the degree of sealing of tube contents to tube environment
  • a better sealing effect can help to make the thread shorter without the overall sealing effect being reduced too much, which can help to save material and size
  • 2.2.1 and 2.2.3 Screw section between thread and driving profile, ie a thickness of the wall of the driving profile in the area of sortedenabsc height of (5.95 mm - 3.66 mm): 2 1.15 mm, which further contributes to a suitable screwing stability and allows or favors the overlap between the driving internal profile and the screw portion.
  • the section of the external thread of the screw cap directed in use to the internal volume of the tube or to the internal volume of the tube is hollow in the prior art by Micronic to the inner volume of the tube.
  • This cavity is on the one hand unusable and thus wasted in the sample storage space, on the other hand at the same time an artifact source insofar as liquid tube contents (before or after possibly deep freezing), for example, by shaking into this cavity and thus lost a use.
  • the height of the screw cap according to the embodiment of the invention is only 6.6 mm, thus reduced by 54% over the prior art of Micronic. The substantial reduction of this height is achieved inter alia by the overlap in the longitudinal direction between the screw portion with external thread on the one hand and the recess with driving inner profile on the other.
  • the space requirement of the tube according to the invention in the storage device is reduced by over 39% over the prior art of Micronic.
  • the considerable reduction in energy consumption (and thus also in energy costs) goes hand in hand with a considerable reduction in environmental pollution in the context of large, epidemiological cohort studies that have been going on for decades.
  • the invention also includes the exact or exact terms, features, numerical values, or ranges, etc., when, above or below, these terms, Features, numerical values, or ranges associated with terms such as “about, about, substantially, generally, at least, at least,” etc. (ie, “about 1” should also be “1” or “substantially constant “should also include” constant ")

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un couvercle à vis pour fermer un tubule vissable pour un matériau biologique. Le couvercle à vis comporte : un tronçon de filet cylindrique qui présente un filetage extérieur, le tronçon de filet cylindrique définissant un axe longitudinal; un tronçon à bride situé dans le prolongement du tronçon de filet cylindrique; un évidement coaxial à l'axe longitudinal, qui s'étend longitudinalement à travers le tronçon à bride et au moins en partie le long du tronçon fileté, l'évidement présentant un profil d'entraînement qui convient pour l'ouverture et la fermeture à l'aide d'une clé appropriée, le profil d'entraînement intérieur s'étendant axialement au moins en partie le long du tronçon fileté.
EP13821457.2A 2012-12-21 2013-12-17 Utilisation de tubes d'échantillons et de bouchons vissés pour stockage à froid de matériel biologique Active EP2934750B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012025254.4A DE102012025254A1 (de) 2012-12-21 2012-12-21 Schraubröhrchen und Schraubdeckel für Biomaterial
PCT/EP2013/076872 WO2014095840A1 (fr) 2012-12-21 2013-12-17 Tubule vissable et couvercle vissé pour matériau biologique

Publications (2)

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EP2934750A1 true EP2934750A1 (fr) 2015-10-28
EP2934750B1 EP2934750B1 (fr) 2019-08-07

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US (1) US10155608B2 (fr)
EP (1) EP2934750B1 (fr)
JP (1) JP6542126B2 (fr)
KR (1) KR102044878B1 (fr)
AU (1) AU2013361755B2 (fr)
DE (1) DE102012025254A1 (fr)
DK (1) DK2934750T3 (fr)
WO (1) WO2014095840A1 (fr)

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US20150048085A1 (en) 2013-08-16 2015-02-19 Corning Incorporated Vessels and methods for cryopreservation
CN108430217B (zh) * 2015-11-16 2021-10-22 康宁股份有限公司 低温用瓶组件
US10638748B2 (en) 2015-12-22 2020-05-05 Corning Incorporated Break away/tear away cryopreservation vial and methods for manufacturing and using same
CN106931270A (zh) * 2017-03-21 2017-07-07 广东联塑科技实业有限公司 一种管堵螺帽结构
CN107344129B (zh) * 2017-08-31 2022-07-22 中国科学院金属研究所 一种用于空间在轨材料科学实验的通用型样品安瓿
CN111077108B (zh) * 2019-12-31 2020-08-25 中国科学院地质与地球物理研究所 一种适用于深空探测的激光样品室

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DE4421220C1 (de) * 1994-06-17 1995-11-02 Werner & Mertz Gmbh Flaschen- oder Kanisterverschluß
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ITRN20110001U1 (it) 2011-01-24 2011-04-25 Polykap S R L Tappo filettato in materiale plastico per avvitamento forzato e facilitato
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Also Published As

Publication number Publication date
DK2934750T3 (da) 2019-10-21
WO2014095840A1 (fr) 2014-06-26
DE102012025254A1 (de) 2014-06-26
KR102044878B1 (ko) 2019-11-14
AU2013361755A1 (en) 2015-08-06
US10155608B2 (en) 2018-12-18
EP2934750B1 (fr) 2019-08-07
US20160031611A1 (en) 2016-02-04
JP6542126B2 (ja) 2019-07-10
AU2013361755B2 (en) 2018-03-08
JP2016502846A (ja) 2016-02-01
KR20150096799A (ko) 2015-08-25

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