EP2889313A4 - Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung - Google Patents

Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung

Info

Publication number
EP2889313A4
EP2889313A4 EP13822582.6A EP13822582A EP2889313A4 EP 2889313 A4 EP2889313 A4 EP 2889313A4 EP 13822582 A EP13822582 A EP 13822582A EP 2889313 A4 EP2889313 A4 EP 2889313A4
Authority
EP
European Patent Office
Prior art keywords
preparing
protein mixture
charge repulsion
repulsion effect
homodimer protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13822582.6A
Other languages
English (en)
French (fr)
Other versions
EP2889313B1 (de
EP2889313A1 (de
Inventor
Ting Xu
Tao Xu
Xiaoxiao Wang
Xinglu Sun
Ying Fan
Yan Zeng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Alphamab Co Ltd
Jiangsu Alphamab Biopharmaceuticals Co Ltd
Original Assignee
Suzhou Alphamab Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Alphamab Co Ltd filed Critical Suzhou Alphamab Co Ltd
Priority to EP18196046.9A priority Critical patent/EP3444280A1/de
Publication of EP2889313A1 publication Critical patent/EP2889313A1/de
Publication of EP2889313A4 publication Critical patent/EP2889313A4/de
Application granted granted Critical
Publication of EP2889313B1 publication Critical patent/EP2889313B1/de
Priority to HRP20190272TT priority patent/HRP20190272T1/hr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP13822582.6A 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung Active EP2889313B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP18196046.9A EP3444280A1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung
HRP20190272TT HRP20190272T1 (hr) 2012-07-25 2019-02-11 Postupak pripreme mješavine homodimera proteina koristeći učinak odbijanja naboja

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012102585928A CN102851338A (zh) 2012-07-25 2012-07-25 利用电荷排斥作用制备同二聚体蛋白混合物的方法
PCT/CN2013/080060 WO2014015804A1 (zh) 2012-07-25 2013-07-25 利用电荷排斥作用制备同二聚体蛋白混合物的方法

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP18196046.9A Division EP3444280A1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung
EP18196046.9A Division-Into EP3444280A1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung

Publications (3)

Publication Number Publication Date
EP2889313A1 EP2889313A1 (de) 2015-07-01
EP2889313A4 true EP2889313A4 (de) 2016-05-25
EP2889313B1 EP2889313B1 (de) 2018-12-05

Family

ID=47398314

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18196046.9A Withdrawn EP3444280A1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung
EP13822582.6A Active EP2889313B1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18196046.9A Withdrawn EP3444280A1 (de) 2012-07-25 2013-07-25 Verfahren zur herstellung einer homodimerproteinmischung durch anwendung einer ladungsabstossungswirkung

Country Status (9)

Country Link
US (1) US9708389B2 (de)
EP (2) EP3444280A1 (de)
JP (1) JP6185584B2 (de)
CN (2) CN102851338A (de)
DK (1) DK2889313T3 (de)
ES (1) ES2710936T3 (de)
HR (1) HRP20190272T1 (de)
HU (1) HUE041454T2 (de)
WO (1) WO2014015804A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851338A (zh) 2012-07-25 2013-01-02 苏州康宁杰瑞生物科技有限公司 利用电荷排斥作用制备同二聚体蛋白混合物的方法
CN105820251B (zh) * 2015-01-08 2019-10-15 江苏康宁杰瑞生物制药有限公司 具有共同轻链的双特异性抗体或抗体混合物
CN106883297B (zh) * 2015-12-16 2019-12-13 苏州康宁杰瑞生物科技有限公司 基于ch3结构域的异二聚体分子、其制备方法及用途
WO2017205014A1 (en) * 2016-05-26 2017-11-30 Qilu Puget Sound Biotherapeutics Corporation Mixtures of antibodies
CN110312523B (zh) 2016-11-08 2024-04-26 齐鲁皮吉特湾生物治疗有限公司 抗pd1和抗ctla4抗体
WO2020192648A1 (en) * 2019-03-25 2020-10-01 Dingfu Biotarget Co., Ltd. Proteinaceous heterodimer and use thereof
CN114466863A (zh) 2019-07-01 2022-05-10 苏州康宁杰瑞生物科技有限公司 百日咳毒素结合蛋白
GB202005879D0 (en) * 2020-04-22 2020-06-03 Petmedix Ltd Heterodimeric proteins
CA3188566A1 (en) 2020-07-03 2022-01-06 Suzhou Alphamab Co., Ltd. Coagulation factor xi (fxi) binding protein
EP4172194A1 (de) 2020-07-31 2023-05-03 CureVac SE Nukleinsäurecodierte antikörpermischungen
CN112977908B (zh) * 2021-03-02 2022-12-02 康宁杰瑞(吉林)生物科技有限公司 灌装加塞机及其灌装的方法
WO2023280092A1 (zh) 2021-07-05 2023-01-12 江苏康宁杰瑞生物制药有限公司 抗体药物偶联物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1870459A1 (de) * 2005-03-31 2007-12-26 Chugai Seiyaku Kabushiki Kaisha Verfahren zur polypeptidherstellung mit regulation des zusammenbaus

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1231268E (pt) 1994-01-31 2005-11-30 Univ Boston Bancos de anticorpos policlonais
ES2442615T5 (es) 2002-07-18 2023-03-16 Merus Nv Producción recombinante de mezclas de anticuerpos
GB0601513D0 (en) * 2006-01-25 2006-03-08 Univ Erasmus Medical Ct Binding molecules 3
JP2009541275A (ja) * 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス 二重特異性抗体の生産
WO2009089004A1 (en) * 2008-01-07 2009-07-16 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
CN104262483A (zh) 2009-01-26 2015-01-07 根马布股份公司 用于生成抗体混合物的方法
JP2013511281A (ja) * 2009-11-23 2013-04-04 アムジェン インコーポレイテッド 単量体抗体Ｆｃ
CN102558355B (zh) * 2011-12-31 2015-02-25 苏州康宁杰瑞生物科技有限公司 基于电荷网络的异二聚体fc改造方法及异二聚体蛋白的制备方法
CN102851338A (zh) * 2012-07-25 2013-01-02 苏州康宁杰瑞生物科技有限公司 利用电荷排斥作用制备同二聚体蛋白混合物的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1870459A1 (de) * 2005-03-31 2007-12-26 Chugai Seiyaku Kabushiki Kaisha Verfahren zur polypeptidherstellung mit regulation des zusammenbaus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K. SAKURAI ET AL: "Manipulating Monomer-Dimer Equilibrium of Bovine beta -Lactoglobulin by Amino Acid Substitution", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 28, 5 July 2002 (2002-07-05), US, pages 25735 - 25740, XP055264325, ISSN: 0021-9258, DOI: 10.1074/jbc.M203659200 *
NOHAILE M J ET AL: "Altering dimerization specificity by changes in surface electrostatics", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 98, no. 6, 13 March 2001 (2001-03-13), pages 3109 - 3114, XP002412033, ISSN: 0027-8424, DOI: 10.1073/PNAS.051624498 *
See also references of WO2014015804A1 *

Also Published As

Publication number Publication date
ES2710936T3 (es) 2019-04-29
JP2015522295A (ja) 2015-08-06
US9708389B2 (en) 2017-07-18
CN103388013B (zh) 2015-03-11
JP6185584B2 (ja) 2017-08-23
US20150274807A1 (en) 2015-10-01
EP3444280A1 (de) 2019-02-20
EP2889313B1 (de) 2018-12-05
HUE041454T2 (hu) 2019-05-28
CN103388013A (zh) 2013-11-13
HRP20190272T1 (hr) 2019-04-05
EP2889313A1 (de) 2015-07-01
CN102851338A (zh) 2013-01-02
DK2889313T3 (en) 2019-02-18
WO2014015804A1 (zh) 2014-01-30

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