EP2837628A4 - Verfahren zur herstellung eines rivaroxabanzwischenprodukts - Google Patents

Verfahren zur herstellung eines rivaroxabanzwischenprodukts

Info

Publication number
EP2837628A4
EP2837628A4 EP13751142.4A EP13751142A EP2837628A4 EP 2837628 A4 EP2837628 A4 EP 2837628A4 EP 13751142 A EP13751142 A EP 13751142A EP 2837628 A4 EP2837628 A4 EP 2837628A4
Authority
EP
European Patent Office
Prior art keywords
rivaroxaban intermediate
preparing rivaroxaban
preparing
rivaroxaban
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13751142.4A
Other languages
English (en)
French (fr)
Other versions
EP2837628B1 (de
EP2837628A1 (de
Inventor
Fuli Zhang
Bin Liang
Chunbo Yang
Chonghao Liu
Yang Gao
Jian Wang
Min Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Pharmaceutical Industry
China National Medicines Guorui Pharmaceutical Co Ltd
Original Assignee
Shanghai Institute of Pharmaceutical Industry
China National Medicines Guorui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute of Pharmaceutical Industry, China National Medicines Guorui Pharmaceutical Co Ltd filed Critical Shanghai Institute of Pharmaceutical Industry
Publication of EP2837628A1 publication Critical patent/EP2837628A1/de
Publication of EP2837628A4 publication Critical patent/EP2837628A4/de
Application granted granted Critical
Publication of EP2837628B1 publication Critical patent/EP2837628B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
EP13751142.4A 2012-02-24 2013-02-22 Verfahren zur herstellung eines rivaroxabanzwischenprodukts Active EP2837628B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210044359.XA CN103288814B (zh) 2012-02-24 2012-02-24 一种利伐沙班中间体的制备方法
PCT/CN2013/071769 WO2013123893A1 (zh) 2012-02-24 2013-02-22 一种利伐沙班中间体的制备方法

Publications (3)

Publication Number Publication Date
EP2837628A1 EP2837628A1 (de) 2015-02-18
EP2837628A4 true EP2837628A4 (de) 2015-03-04
EP2837628B1 EP2837628B1 (de) 2016-11-30

Family

ID=49005013

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13751142.4A Active EP2837628B1 (de) 2012-02-24 2013-02-22 Verfahren zur herstellung eines rivaroxabanzwischenprodukts

Country Status (5)

Country Link
US (1) US9079892B2 (de)
EP (1) EP2837628B1 (de)
CN (1) CN103288814B (de)
ES (1) ES2614876T3 (de)
WO (1) WO2013123893A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012153155A1 (en) * 2011-05-06 2012-11-15 Egis Gyógyszergyár Nyilvãnosan Müködö Részvény-Társaság Process for the preparation of a rivaroxaban and intermediates formed in said process
CN103254148B (zh) * 2012-02-15 2016-04-13 浙江海正药业股份有限公司 利奈唑胺中间体的制备方法
CN103288814B (zh) 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法
ES2610020T3 (es) * 2012-12-26 2017-04-25 Wanbury Limited Producto intermedio de rivaroxabán y preparación del mismo
CN105085507B (zh) * 2014-04-22 2017-11-24 北大方正集团有限公司 一种合成利伐沙班的方法
CN105085371B (zh) * 2014-04-22 2017-06-16 北大方正集团有限公司 (s)‑{1‑(氯甲酸酯基)‑2‑[2‑(1,3‑二氧异吲哚)基]乙基}卤化盐及其制备方法
CN105085508B (zh) * 2014-04-22 2017-12-08 北大方正集团有限公司 一种合成利伐沙班关键中间体的方法
CN104311545B (zh) * 2014-09-29 2017-03-22 哈药集团制药总厂 一种利伐沙班关键中间体的制备方法
JP7205529B2 (ja) * 2018-02-26 2023-01-17 住友化学株式会社 オキサゾリジノン化合物の製造方法
CN112500403B (zh) * 2020-12-28 2022-04-05 南京法恩化学有限公司 一种利伐沙班的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011137222A1 (en) * 2010-04-30 2011-11-03 Indiana University Research And Technology Corporation Processes for preparing linezolid
EP2816039A1 (de) * 2012-02-15 2014-12-24 Zhejiang Hisun Pharmaceutical Co. Ltd. Verfahren zur herstellung eines linezolidzwischenprodukts

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
ATE315562T1 (de) 2002-09-25 2006-02-15 Daiso Co Ltd Verfahren zur herstellung von glycidylphthalimid
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10342570A1 (de) * 2003-09-15 2005-04-14 Bayer Healthcare Ag Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
US8309547B2 (en) 2009-04-28 2012-11-13 Apotex Pharmachem Inc. Processes for the preparation of rivaroxaban and intermediates thereof
CN101619061B (zh) * 2009-08-11 2014-12-17 沈阳药科大学 氰基吡啶基取代的噁唑烷酮类化合物
EP2521723A1 (de) 2010-01-04 2012-11-14 Enantia, S.L. Verfahren zur herstellung von rivaroxaban und zwischenprodukten davon
EP2354128A1 (de) * 2010-02-10 2011-08-10 Sandoz Ag Verfahren zur Herstellung von Rivaroxaban
CN102250076A (zh) * 2011-05-27 2011-11-23 横店集团家园化工有限公司 一种利伐沙班中间体及利伐沙班的制备方法
CN102320988B (zh) * 2011-06-03 2014-04-09 中国科学院上海有机化学研究所 4-(4-氨基苯基)-3-吗啉酮中间体酰胺、合成方法和用途
CN103288814B (zh) 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011137222A1 (en) * 2010-04-30 2011-11-03 Indiana University Research And Technology Corporation Processes for preparing linezolid
EP2816039A1 (de) * 2012-02-15 2014-12-24 Zhejiang Hisun Pharmaceutical Co. Ltd. Verfahren zur herstellung eines linezolidzwischenprodukts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GREGORY W A ET AL: "ANTIBACTERIALS. SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES. I. ÖTHE B GROUP", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 8, 1 August 1989 (1989-08-01), pages 1673 - 1681, XP000573960, ISSN: 0022-2623, DOI: 10.1021/JM00128A003 *
See also references of WO2013123893A1 *

Also Published As

Publication number Publication date
EP2837628B1 (de) 2016-11-30
WO2013123893A1 (zh) 2013-08-29
CN103288814B (zh) 2016-07-06
CN103288814A (zh) 2013-09-11
EP2837628A1 (de) 2015-02-18
ES2614876T3 (es) 2017-06-02
US9079892B2 (en) 2015-07-14
US20150038704A1 (en) 2015-02-05

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