EP2670389A1 - Compositions and methods for treating cardiovascular diseases - Google Patents
Compositions and methods for treating cardiovascular diseasesInfo
- Publication number
- EP2670389A1 EP2670389A1 EP12704295.0A EP12704295A EP2670389A1 EP 2670389 A1 EP2670389 A1 EP 2670389A1 EP 12704295 A EP12704295 A EP 12704295A EP 2670389 A1 EP2670389 A1 EP 2670389A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmaceutically
- pharmaceutical composition
- acceptable
- composition according
- therapeutic compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fertilizers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB1101937.9A GB201101937D0 (en) | 2011-02-04 | 2011-02-04 | Method of preparing a composition |
| GBGB1113729.6A GB201113729D0 (en) | 2011-08-10 | 2011-08-10 | Hyperlipidaemia |
| GB1113728.8A GB2487808A (en) | 2010-10-29 | 2011-08-10 | Oral adjuvant or formulation comprising a lipid and an alcohol |
| GBGB1113730.4A GB201113730D0 (en) | 2011-08-10 | 2011-08-10 | Solid dosage form |
| PCT/GB2011/052115 WO2012056251A1 (en) | 2010-10-29 | 2011-10-31 | Inflammatory disease |
| PCT/GB2012/050241 WO2012104654A1 (en) | 2011-02-04 | 2012-02-03 | Compositions and methods for treating cardiovascular diseases |
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| EP2670389A1 true EP2670389A1 (en) | 2013-12-11 |
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| EP12704295.0A Pending EP2670389A1 (en) | 2011-02-04 | 2012-02-03 | Compositions and methods for treating cardiovascular diseases |
| EP18213159.9A Active EP3494961B1 (en) | 2011-02-04 | 2012-02-03 | Compositions and methods for treating chronic inflammation and inflammatory diseases |
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| AU2004290862B2 (en) * | 2003-11-20 | 2010-06-03 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
| US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| GB201018289D0 (en) * | 2010-10-29 | 2010-12-15 | Biocopea Ltd | Treatment of respiratory disorders |
| US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| TW201347754A (zh) | 2012-05-07 | 2013-12-01 | Omthera Pharmaceuticals Inc | 史他汀及ω－３脂肪酸之組合物 |
| AU2013336683A1 (en) * | 2012-10-24 | 2015-05-14 | Biocopea Limited | Drug combinations containing statins for treating cardiovascular diseases |
| KR102235264B1 (ko) * | 2013-01-14 | 2021-04-02 | 인퍼스트 헬스케어 리미티드 | 고용체 조성물들 및 심각한 통증에서의 이들의 용도 |
| JP6513576B2 (ja) | 2013-01-14 | 2019-05-15 | ヘルス クリニックス リミテッド | 抗がん剤および使用 |
| BR112015015864B1 (pt) * | 2013-01-14 | 2022-08-23 | Infirst Healthcare Limited | Uso de uma composição farmacêutica no tratamento de uma condição de dor severa |
| CN105120900A (zh) * | 2013-02-04 | 2015-12-02 | 因佛斯特医疗有限公司 | 用于治疗慢性炎症和炎性疾病的组合物及方法 |
| KR101344218B1 (ko) * | 2013-05-15 | 2013-12-20 | 충남대학교산학협력단 | 페노피브레이트를 함유하는 결핵 치료용 약학 조성물 |
| RU2623876C2 (ru) * | 2014-11-10 | 2017-06-29 | Александр Владимирович Диковский | Фармацевтическая композиция для лечения гиперлипидемии |
| KR101512606B1 (ko) | 2014-12-11 | 2015-04-15 | (주)이지코스 | 주름 및 아토피 개선과 피부 보습을 위한 화장료 조성물 |
| CN105853405B (zh) * | 2015-01-23 | 2019-03-08 | 中国科学院上海药物研究所 | 苯溴马隆在制备电压门控钾离子通道kcnq激动剂中的应用 |
| EP3095465A1 (en) | 2015-05-19 | 2016-11-23 | U3 Pharma GmbH | Combination of fgfr4-inhibitor and bile acid sequestrant |
| CN107847657A (zh) * | 2015-06-15 | 2018-03-27 | 生命治疗有限公司 | 用于诱导抗炎反应的组合物和方法 |
| CN105294672A (zh) * | 2015-12-07 | 2016-02-03 | 范秀华 | 一种治疗子宫内膜炎的药物组合物 |
| CN105753826A (zh) * | 2016-05-09 | 2016-07-13 | 宋晓梅 | 一种吉非罗齐的药物组合物及其医药用途 |
| CN106074500A (zh) * | 2016-07-08 | 2016-11-09 | 重庆医药高等专科学校 | 脱氢洛伐他汀在制备抗炎症性肠病药物中的应用 |
| CA3077624A1 (en) * | 2016-10-01 | 2018-04-05 | James Smeeding | Pharmaceutical compositions comprising a statin and a cannabinoid and uses thereof |
| US20180125795A1 (en) * | 2017-01-03 | 2018-05-10 | Thermolife International, Llc | Cinnamaldehyde compositions and methods |
| JP6784973B2 (ja) * | 2017-03-30 | 2020-11-18 | 国立研究開発法人産業技術総合研究所 | 単層カーボンナノチューブ |
| SG11201907845SA (en) * | 2017-06-14 | 2019-09-27 | Biosolution Co Ltd | Anti-wrinkle or anti-inflammatory cosmetic composition including substance p |
| US11666542B2 (en) * | 2017-07-18 | 2023-06-06 | Deyi Pharmarmaceutical Ltd. | Use of cannabidiol in treatment of pulmonary hypertension |
| BR112020001071A2 (pt) * | 2017-07-19 | 2020-07-14 | Ironwood Pharmaceuticals, Inc. | métodos para reduzir um ou mais sintomas de doença do refluxo gastroesofágico, para tratar uma doença e para tratar/prevenir sinais e/ou sintomas associados com refluxo de ácido biliar, forma de dosagem oral gastrorretentiva, e, composição farmacêutica. |
| CN111050750A (zh) | 2017-08-24 | 2020-04-21 | 诺沃挪第克公司 | Glp-1组合物及其用途 |
| CN109419786B (zh) * | 2017-08-31 | 2021-04-30 | 汉义生物科技（北京）有限公司 | 大麻二酚在制备抗流感的药物中的用途 |
| US11452707B2 (en) * | 2017-08-31 | 2022-09-27 | Hanyi Bio-Technology (Beijing) Co., Ltd. | Use of cannabidiol in preparation of drugs for resisting against influenza |
| KR20200099172A (ko) * | 2018-01-12 | 2020-08-21 | (주) 메티메디제약 | 만성 염증성 질환의 치료 방법 |
| EP3801497B1 (en) * | 2018-06-03 | 2023-03-22 | Wen-Pin Chen | Method for treating non-compaction cardiomyopathy |
| WO2020061687A1 (en) * | 2018-09-28 | 2020-04-02 | Visceral Therapeutics Inc. | Pharmaceutically active cannabis-based compositions and methods of use for treating gastrointestinal conditions |
| US20210290562A1 (en) | 2018-12-11 | 2021-09-23 | Disruption Labs Inc. | Compositions for the delivery of therapeutic agents and methods of use and making thereof |
| US20220168325A1 (en) * | 2019-03-25 | 2022-06-02 | The University Of Vermont | Methods to promote cerebral blood flow in the brain |
| CN109846885A (zh) * | 2019-04-04 | 2019-06-07 | 南通大学附属医院 | 瑞舒伐他汀的新用途 |
| WO2021113912A1 (en) * | 2019-12-11 | 2021-06-17 | Ambetex Pty Ltd | Therapeutic compositions and methods for prevention and treatment of diastolic dysfunction |
| RU2749857C1 (ru) * | 2019-12-23 | 2021-06-17 | Псарева Нелли Александровна | Способ борьбы со средним и наружным отитом |
| CN115135305A (zh) | 2020-02-18 | 2022-09-30 | 诺和诺德股份有限公司 | 药物制剂 |
| EP4140544A1 (en) | 2020-04-20 | 2023-03-01 | Shiseido Company, Ltd. | Agent for preventing and/or improving photoaging and/or dermal pigmentation, cosmetic method using same, and cosmetic device to be applied in said method |
| RU2745687C1 (ru) * | 2020-05-19 | 2021-03-30 | Всеволод Иванович Киселев | Способ лечения эндометриоза с болевым синдромом и фармацевтическая композиция для его реализации |
| CN112007165B (zh) * | 2020-08-27 | 2021-10-08 | 北京大学人民医院 | 巨噬细胞极化调节剂及其在促进血小板生成中的应用 |
| CN112156089A (zh) * | 2020-09-27 | 2021-01-01 | 天津国际生物医药联合研究院 | 苯溴马隆在抗结核分枝杆菌感染中的应用 |
| WO2023058975A1 (ko) * | 2021-10-07 | 2023-04-13 | (주)이노보테라퓨틱스 | 벤조퓨라닐 히드록시페닐 메타논 유도체를 포함하는 hsp47 억제용 약학 조성물 |
| WO2023244738A1 (en) * | 2022-06-15 | 2023-12-21 | The Johns Hopkins University | Thiazolidinediones for the treatment of muscular dystrophies |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
| US5059626A (en) * | 1988-07-25 | 1991-10-22 | Applied Analytical Industries, Inc. | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs |
| IT1255007B (it) * | 1991-07-01 | 1995-10-11 | Altergon Sa | Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono. |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| WO2000057859A1 (en) * | 1999-03-31 | 2000-10-05 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
| US20030235595A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| IL156361A0 (en) * | 2000-12-19 | 2004-01-04 | Univ Texas | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providing enhanced therapeutic activity |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| JP2005068060A (ja) * | 2003-08-22 | 2005-03-17 | Nrl Pharma Inc | ラクトフェリンを含有する医薬組成物ならびに加工食品の製造法 |
| CN100486567C (zh) * | 2004-08-12 | 2009-05-13 | 山东绿叶天然药物研究开发有限公司 | 姜黄素乳剂及其制备方法 |
| US20060138059A1 (en) | 2004-12-28 | 2006-06-29 | Vair Larry L Jr | Corona-treated polypropylene liquid filtration media |
| US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
| WO2008070950A1 (en) * | 2006-12-13 | 2008-06-19 | Laboratoires Mauves Inc. | Pharmaceutical solution formulations for encapsulation into gelatin capsules or other dosage forms |
| WO2008144355A2 (en) * | 2007-05-17 | 2008-11-27 | Morton Grove Pharmaceuticals, Inc. | Stable, self-microemulsifying fenofibrate compositions |
| EP2224905A2 (en) * | 2007-09-07 | 2010-09-08 | Novavax, Inc. | Multi-phasic, nano-structured compositions containing a combination of a fibrate and a statin |
| RU2363451C2 (ru) * | 2007-09-14 | 2009-08-10 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Композиция для приготовления обладающей пролонгированным действием лекарственной формы и способ получения этой формы |
| WO2009153496A2 (fr) | 2008-05-26 | 2009-12-23 | Genfit | Composés agonistes ppar, préparation et utilisations |
| GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
| CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
-
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Non-Patent Citations (2)
| Title |
|---|
| None * |
| See also references of WO2012104654A1 * |
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