JP6273304B2 - 慢性炎症および炎症性疾患を治療するための組成物および方法 - Google Patents
慢性炎症および炎症性疾患を治療するための組成物および方法 Download PDFInfo
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Description
1.a) 抗炎症活性を有する治療化合物;およびb) 薬学的に許容されるアジュバントを含む、薬学組成物。
2.薬学的に許容される溶媒をさらに含む、実施態様1に記載の薬学組成物。
3.a) 抗炎症活性を有する治療化合物;b) 薬学的に許容される溶媒;およびc) 薬学的に許容されるアジュバントを含む、薬学組成物。
4.a) 抗炎症活性を有する治療化合物;b) 薬学的に許容される溶媒;およびc) 薬学的に許容されるアジュバントを含み、前記薬学的に許容される溶媒と薬学的に許容されるアジュバントとの比が約0:1〜約1:25の範囲内である、薬学組成物。
5.前記薬学的に許容される溶媒と薬学的に許容されるアジュバントとの比が約0:1〜約1:25の範囲内である、実施態様2または3に記載の薬学組成物。
6.前記抗炎症活性が炎症誘発性分子のレベルを減少させる、実施態様1〜5のいずれかに記載の薬学組成物。
7.前記炎症誘発性分子が、P物質(SP)、カルシトニン遺伝子関連ペプチド(CGRP)、グルタミン酸、またはこれらの組合せを含む、実施態様6に記載の薬学組成物。
8.前記抗炎症活性が、SP、CGRP、グルタミン酸、またはこれらの組合せのレベルを少なくとも10%減少させる、実施態様7に記載の薬学組成物。
9.前記抗炎症活性が、炎症誘発性プロスタグランジンのレベルを減少させる、実施態様1〜8のいずれかに記載の薬学組成物。
10.前記炎症誘発性プロスタグランジンのレベルが少なくとも10%減少される、実施態様9に記載の薬学組成物。
11.前記抗炎症活性が、PPARシグナル伝達経路を刺激する、実施態様1〜10のいずれかに記載の薬学組成物。
12.前記PPARシグナル伝達経路が少なくとも10%刺激される、実施態様11に記載の薬学組成物。
13.前記抗炎症活性が、マクロファージM1細胞のアポトーシスを誘導し、マクロファージM2細胞の分化を促進させ、またはこれらの両方を行う、実施態様1〜12のいずれかに記載の薬学組成物。
14.前記抗炎症活性が、Th1細胞から放出されるインターフェロン・ガンマ(IFNγ)、腫瘍壊死因子アルファ(TNF-α)、インターロイキン12(IL-12)、もしくはこれらの組合せのレベルを減少させ、Th2細胞から放出されるIL-10のレベルを増加させ、またはこれらの両方を行う、実施態様1〜13のいずれかに記載の薬学組成物。
15.Th1細胞から放出されるIFNγ、TNF-α、IL-12、またはこれらの組合せのレベルが、少なくとも10%減少される、実施態様14に記載の薬学組成物。
16.Th2細胞から放出されるIL-10のレベルが、少なくとも10%増加される、実施態様14に記載の薬学組成物。
17.前記治療化合物が、有機溶媒中で可溶性であることを示すlogP値を有する、実施態様1〜16のいずれかに記載の薬学組成物。
18.前記治療化合物が、1.0より高いlogP値を有する、実施態様1〜17のいずれかに記載の薬学組成物。
19.前記治療化合物が、2.0より高いlogP値を有する、実施態様1〜17のいずれかに記載の薬学組成物。
20.前記治療化合物が、疎水性である極性表面積を有する、実施態様1〜19のいずれかに記載の薬学組成物。
21.前記治療化合物が、8.0 nm2未満の極性表面積を有する、実施態様1〜20のいずれかに記載の薬学組成物。
22.前記治療化合物が、6.0 nm2未満の極性表面積を有する、実施態様1〜20のいずれかに記載の薬学組成物。
23.前記治療化合物が、非ステロイド性抗炎症薬(NSAID)を含む、実施態様1〜22のいずれかに記載の薬学組成物。
24.前記NSAIDが、サリチル酸誘導体NSAID、p-アミノフェノール誘導体NSAID、プロピオン酸誘導体NSAID、酢酸誘導体NSAID、エノール酸誘導体NSAID、フェナム酸誘導体NSAID、非選択的シクロオキシゲナーゼ(COX)阻害剤、選択的シクロオキシゲナーゼ1(COX 1)阻害剤、選択的シクロオキシゲナーゼ2(COX 2)阻害剤、またはこれらの組合せを含む、実施態様23に記載の薬学組成物。
25.前記治療化合物が、PPARγアゴニストを含む、実施態様1〜24のいずれかに記載の薬学組成物。
26.前記PPARγアゴニストが、モナシン、イルベサルタン、テルミサルタン、ミコフェノール酸、レスベラトロール、デルタ(9)- テトラヒドロカンナビノール、カンナビジオール、クルクミン、シロスタゾール、ベンズブロマロン、6-ショウガオール、グリチルレチン酸、チアゾリジンジオン、NSAID、フィブラート、またはこれらの組合せを含む、実施態様25に記載の薬学組成物。
27.前記治療化合物が、核受容体結合剤を含む、実施態様1〜26のいずれかに記載の薬学組成物。
28.前記核受容体結合剤が、レチノイン酸受容体(RAR)結合剤、レチノイドX受容体(RXR)結合剤、肝臓X受容体(LXR)結合剤、ビタミンD結合剤、またはこれらの組合せを含む、実施態様27に記載の薬学組成物。
29.前記治療化合物が、抗高脂血症剤を含む、実施態様1〜28のいずれかに記載の薬学組成物。
30.前記抗高脂血症剤が、フィブラート、スタチン、トコトリエノール、ナイアシン、胆汁酸捕捉剤(レジン)、コレステロール吸収阻害剤、膵リパーゼ阻害剤、交感神経刺激アミン、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
31.前記フィブラートが、ベザフィブラート、シプロフィブラート、クロフィブラート、ゲムフィブロジル、フェノフィブラート、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
32.前記スタチンが、アトルバスタチン、フルバスタチン、ロバスタチン、ピタバスタチン、プラバスタチン、ロスバスタチン、シンバスタチン、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
33.前記ナイアシンが、アシピモックス、ナイアシン、ニコチンアミド、ビタミンB3、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
34.前記胆汁酸捕捉剤が、コレスチラミン、コレセベラム、コレスチポール、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
35.前記コレステロール吸収阻害剤が、エゼチミブ、フィトステロール、ステロール、スタノール、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
36.前記脂肪吸収阻害剤がオルリスタットを含む、実施態様29に記載の薬学組成物。
37.前記交感神経刺激アミンが、クレンブテロール、サルブタモール、エフェドリン、プソイドエフェドリン、メタンフェタミン、アンフェタミン、フェニレフリン、イソプロテレノール、ドブタミン、メチルフェニデート、リスデキサンフェタミン、カシン、カチノン、メトカチノン、コカイン、ベンジルピペラジン(BZP)、メチレンジオキシピロバレロン(MDPV)、4-メチルアミノレックス、ペモリン、フェンメトラジン、プロピルヘキセドリン、またはこれらの組合せを含む、実施態様29に記載の薬学組成物。
38.前記治療化合物が治療化合物のエステルを含む、実施態様1〜37のいずれかに記載の薬学組成物。
39.前記治療化合物が、実施態様23〜37のいずれかに記載の治療化合物のエステルを含む、実施態様1〜38のいずれかに記載の薬学組成物。
40.前記薬学的に許容される溶媒は、約20% (v/v)未満である、実施態様1〜39のいずれかに記載の薬学組成物。
41.前記薬学的に許容される溶媒が、薬学的に許容される極性非プロトン性溶媒、薬学的に許容される極性プロトン性溶媒、薬学的に許容される非極性溶媒、またはこれらの組合せを含む、実施態様1〜40のいずれかに記載の薬学組成物。
42.前記薬学的に許容される溶媒が、薬学的に許容されるアルコールを含む、実施態様1〜41のいずれかに記載の薬学組成物。
43.前記薬学的に許容されるアルコールが、非環式アルコール、一価アルコール、多価アルコール、不飽和脂肪族アルコール、脂環式アルコール、またはこれらの組合せを含む、実施態様42に記載の薬学組成物。
44.前記薬学的に許容されるアルコールが、C1-20アルコールを含む、実施態様42に記載の薬学組成物。
45.前記薬学的に許容されるアルコールが、メタノール、エタノール、プロパノール、ブタノール、ペンタノール、1-ヘキサデカノール、またはこれらの組合せを含む、実施態様42に記載の薬学組成物。
46.前記薬学的に許容される溶媒が、薬学的に許容されるアルコールと酸との薬学的に許容されるエステルを含む、実施態様1〜45のいずれかに記載の薬学組成物。
47.前記薬学的に許容されるエステルが、酢酸メチル、酪酸メチル、ギ酸メチル、酢酸エチル、酪酸エチル、ギ酸エチル、酢酸プロピル、酪酸プロピル、ギ酸プロピル、酢酸ブチル、酪酸ブチル、ギ酸ブチル、酢酸イソブチル、酪酸イソブチル、ギ酸イソブチル、酢酸ペンチル、酪酸ペンチル、ギ酸ペンチル、1-ヘキサデシルアセテート、1-ヘキサデシルブチレート、1-ヘキサデシルホルマート、またはこれらの組合せを含む、実施態様46に記載の薬学組成物。
48.前記薬学的に許容される溶媒が、薬学的に許容されるポリエチレングリコール(PEG)ポリマーを含む、実施態様1〜47のいずれかに記載の薬学組成物。
49.前記薬学的に許容されるポリエチレングリコール(PEG)ポリマーが、約2,000 g/mol未満である、実施態様48に記載の薬学組成物。
50.前記薬学的に許容されるポリエチレングリコール(PEG)ポリマーが、約2,000 g/mol超である、実施態様48に記載の薬学組成物。
51.前記薬学的に許容される溶媒が、薬学的に許容されるグリセリドを含む、実施態様1〜50のいずれかに記載の薬学組成物。
52.前記薬学的に許容されるグリセリドが、モノグリセリド、ジグリセリド、トリグリセリド、アセチル化モノグリセリド、アセチル化ジグリセリド、アセチル化トリグリセリド、またはこれらの組合せを含む、実施態様51に記載の薬学組成物。
53.前記薬学的に許容される溶媒は、20℃において液体状である、実施態様1〜52のいずれかに記載の薬学組成物。
54.前記薬学的に許容される溶媒は、20℃において固形状である、実施態様1〜52のいずれかに記載の薬学組成物。
55.前記薬学的に許容される固形状の溶媒はメントールを含む、実施態様54に記載の薬学組成物。
56.前記アジュバントは少なくとも80% (v/v)である、実施態様1〜55のいずれかに記載の薬学組成物。
57.前記薬学的に許容されるアジュバントは20℃において液体状である、実施態様1〜56のいずれかに記載の薬学組成物。
58.前記薬学的に許容されるアジュバントは20℃において固形状である、実施態様1〜56のいずれかに記載の薬学組成物。
59.前記薬学的に許容されるアジュバントは、薬学的に許容される脂質を含む、実施態様1〜58のいずれかに記載の薬学組成物。
60.前記薬学的に許容される脂質は、飽和脂肪酸、不飽和脂肪酸、またはこれらの組合せを含む、実施態様59に記載の薬学組成物。
61.前記薬学的に許容される脂質は、2つ以上の飽和または不飽和脂肪酸を含む、実施態様59または60に記載の薬学組成物。
62.前記2つ以上の飽和または不飽和脂肪酸が、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、またはこれらの組合せを含む、実施態様61に記載の薬学組成物。
63.前記不飽和脂肪酸が、20℃以下の融点を有する、実施態様60〜62のいずれかに記載の薬学組成物。
64.前記不飽和脂肪酸は20℃において固形状である、実施態様60〜62のいずれかに記載の薬学組成物。
65.前記不飽和脂肪酸はオメガ脂肪酸を含む、実施態様60〜62のいずれかに記載の薬学組成物。
66.前記薬学的に許容される脂質は、薬学的に許容される油を含む、実施態様59に記載の薬学組成物。
67.前記薬学的に許容される油は、アーモンド油、アラキス油、アボカド油、カノーラ油、ヒマシ油、ヤシ油、トウモロコシ油、綿実油、ブドウ種子油、へーゼルナッツ油、麻油、亜麻仁油、オリーブ油、パーム油、ピーナッツ油、ナタネ油、米糠油、ベニバナ油、ゴマ油、大豆油(soybean oil)、大豆油(soya oil)、ヒマワリ油、クルミ油、コムギ胚芽油、またはこれらの組合せを含む、実施態様66に記載の薬学組成物。
68.薬学的に許容される安定化剤をさらに含む、実施態様1〜67のいずれかに記載の薬学組成物。
69.前記薬学的に許容される安定化剤は、水、脂肪酸成分と酢酸とを含む犠牲酸、酢酸エチル、酢酸ナトリウム/酢酸、モノグリセリド、アセチル化モノグリセリド、ジグリセリド、アセチル化モノグリセリド、アセチル化ジグリセリド、脂肪酸、脂肪酸塩、またはこれらの組合せを含む、実施態様68に記載の薬学組成物。
70.前記薬学的に許容される安定化剤は、薬学的に許容される乳化剤を含む、実施態様68に記載の薬学組成物。
71.前記薬学的に許容される乳化剤は、界面活性剤、多糖類、レクチン、リン脂質、またはこれらの組合せを含む、実施態様70に記載の薬学組成物。
72.薬学的に許容される乳化剤を含まない、実施態様1〜69のいずれかに記載の薬学組成物。
73.薬学組成物の形成を可能とする条件下で、治療化合物を薬学的に許容されるアジュバントに接触させる工程を含む、薬学組成物を調製する方法。
74.a) 治療化合物が薬学的に許容される溶媒に溶解することを可能とする条件下で、前記薬学的に許容される溶媒を前記治療化合物に接触させることによって溶液を形成する工程であって、前記治療化合物は抗炎症活性を有する工程、および、b) 工程(a)で形成された溶液を、薬学組成物の形成を可能とする条件下で、薬学的に許容されるアジュバントに接触させる工程を含む、薬学組成物を調製する方法。
75.a) 治療化合物が薬学的に許容される溶媒に溶解することを可能とする条件下で、前記薬学的に許容される溶媒を前記治療化合物に接触させることによって溶液を形成する工程であって、前記治療化合物は抗炎症活性を有する工程、および、b) 工程(a)で形成された溶液を、薬学組成物の形成を可能とする条件下で、薬学的に許容されるアジュバントに接触させる工程を含み、前記薬学的に許容される溶媒と薬学的に許容されるアジュバントとの比が約0:1〜約1:25の範囲内である、薬学組成物を調製する方法。
76. 前記治療化合物が、有機溶媒中で可溶性であることを示すlogP値を有する、実施態様73〜75のいずれかに記載の方法。
77.前記治療化合物が、1.0より高いlogP値を有する、実施態様73〜76のいずれかに記載の方法。
78.前記治療化合物が、2.0より高いlogP値を有する、実施態様73〜76のいずれかに記載の方法。
79.前記治療化合物が、疎水性である極性表面積を有する、実施態様73〜78のいずれかに記載の方法。
80.前記治療化合物が、8.0 nm2未満の極性表面積を有する、実施態様73〜79のいずれかに記載の方法。
81.前記治療化合物が、6.0 nm2未満の極性表面積を有する、実施態様73〜79のいずれかに記載の方法。
82.前記治療化合物が、非ステロイド性抗炎症薬(NSAID)を含む、実施態様73〜81のいずれかに記載の方法。
83.前記NSAIDが、サリチル酸誘導体NSAID、p-アミノフェノール誘導体NSAID、プロピオン酸誘導体NSAID、酢酸誘導体NSAID、エノール酸誘導体NSAID、フェナム酸誘導体NSAID、非選択的シクロオキシゲナーゼ(COX)阻害剤、選択的シクロオキシゲナーゼ1(COX 1)阻害剤、選択的シクロオキシゲナーゼ2(COX 2)阻害剤、またはこれらの組合せを含む、実施態様82に記載の方法。
84.前記治療化合物が、PPARγアゴニストを含む、実施態様73〜83のいずれかに記載の方法。
85.前記PPARγアゴニストが、モナシン、イルベサルタン、テルミサルタン、ミコフェノール酸、レスベラトロール、デルタ(9)- テトラヒドロカンナビノール、カンナビジオール、クルクミン、シロスタゾール、ベンズブロマロン、6-ショウガオール、グリチルレチン酸、チアゾリジンジオン、NSAID、フィブラート、またはこれらの組合せを含む、実施態様84に記載の方法。
86.前記治療化合物が、核受容体結合剤を含む、実施態様73〜85のいずれかに記載の方法。
87.前記核受容体結合剤が、レチノイン酸受容体(RAR)結合剤、レチノイドX受容体(RXR)結合剤、肝臓X受容体(LXR)結合剤、ビタミンD結合剤、またはこれらの組合せを含む、実施態様86に記載の方法。
88.前記治療化合物が、抗高脂血症剤を含む、実施態様73〜87のいずれかに記載の方法。
89.前記抗高脂血症剤が、フィブラート、スタチン、トコトリエノール、ナイアシン、胆汁酸捕捉剤(レジン)、コレステロール吸収阻害剤、膵リパーゼ阻害剤、交感神経刺激アミン、またはこれらの組合せを含む、実施態様88に記載の方法。
90.前記フィブラートが、ベザフィブラート、シプロフィブラート、クロフィブラート、ゲムフィブロジル、フェノフィブラート、またはこれらの組合せを含む、実施態様89に記載の方法。
91.前記スタチンが、アトルバスタチン、フルバスタチン、ロバスタチン、ピタバスタチン、プラバスタチン、ロスバスタチン、シンバスタチン、またはこれらの組合せを含む、実施態様89に記載の方法。
92.前記ナイアシンが、アシピモックス、ナイアシン、ニコチンアミド、ビタミンB3、またはこれらの組合せを含む、実施態様89に記載の方法。
93.前記胆汁酸捕捉剤が、コレスチラミン、コレセベラム、コレスチポール、またはこれらの組合せを含む、実施態様89に記載の方法。
94.前記コレステロール吸収阻害剤が、エゼチミブ、フィトステロール、ステロール、スタノール、またはこれらの組合せを含む、実施態様89に記載の方法。
95.前記脂肪吸収阻害剤がオルリスタットを含む、実施態様89に記載の方法。
96.前記交感神経刺激アミンが、クレンブテロール、サルブタモール、エフェドリン、プソイドエフェドリン、メタンフェタミン、アンフェタミン、フェニレフリン、イソプロテレノール、ドブタミン、メチルフェニデート、リスデキサンフェタミン、カシン、カチノン、メトカチノン、コカイン、ベンジルピペラジン(BZP)、メチレンジオキシピロバレロン(MDPV)、4-メチルアミノレックス、ペモリン、フェンメトラジン、プロピルヘキセドリン、またはこれらの組合せを含む、実施態様89に記載の方法。
97.前記治療化合物が治療化合物のエステルを含む、実施態様73〜96のいずれかに記載の方法。
98.前記治療化合物が、実施態様76〜97のいずれかに記載の治療化合物のエステルを含む、実施態様73〜97のいずれかに記載の方法。
99.前記薬学的に許容される溶媒は、約20% (v/v)未満である、実施態様74〜98のいずれかに記載の方法。
100.前記薬学的に許容される溶媒が、薬学的に許容される極性非プロトン性溶媒、薬学的に許容される極性プロトン性溶媒、薬学的に許容される非極性溶媒、またはこれらの組合せを含む、実施態様74〜99のいずれかに記載の方法。
101.前記薬学的に許容される溶媒が、薬学的に許容されるアルコールを含む、実施態様74〜100のいずれかに記載の方法。
102.前記薬学的に許容されるアルコールが、非環式アルコール、一価アルコール、多価アルコール、不飽和脂肪族アルコール、脂環式アルコール、またはこれらの組合せを含む、実施態様101に記載の方法。
103.前記薬学的に許容されるアルコールが、C1-20アルコールを含む、実施態様101に記載の方法。
104.前記薬学的に許容されるアルコールが、メタノール、エタノール、プロパノール、ブタノール、ペンタノール、1-ヘキサデカノール、またはこれらの組合せを含む、実施態様101に記載の方法。
105.前記薬学的に許容される溶媒が、薬学的に許容されるアルコールと酸との薬学的に許容されるエステルを含む、実施態様101に記載の方法。
106.前記薬学的に許容されるエステルが、酢酸メチル、酪酸メチル、ギ酸メチル、酢酸エチル、酪酸エチル、ギ酸エチル、酢酸プロピル、酪酸プロピル、ギ酸プロピル、酢酸ブチル、酪酸ブチル、ギ酸ブチル、酢酸イソブチル、酪酸イソブチル、ギ酸イソブチル、酢酸ペンチル、酪酸ペンチル、ギ酸ペンチル、1-ヘキサデシルアセテート、1-ヘキサデシルブチレート、1-ヘキサデシルホルマート、またはこれらの組合せを含む、実施態様105に記載の方法。
107.前記薬学的に許容される溶媒が、薬学的に許容されるポリエチレングリコール(PEG)ポリマーである、実施態様74〜106のいずれかに記載の方法。
108.前記薬学的に許容されるポリエチレングリコール(PEG)ポリマーが、約2,000 g/mol未満である、実施態様107に記載の方法。
109.前記薬学的に許容されるポリエチレングリコール(PEG)ポリマーが、約2,000 g/mol超である、実施態様107に記載の方法。
110.前記薬学的に許容される溶媒が、薬学的に許容されるグリセリドを含む、実施態様74〜109のいずれかに記載の方法。
111.前記薬学的に許容されるグリセリドが、モノグリセリド、ジグリセリド、トリグリセリド、アセチル化モノグリセリド、アセチル化ジグリセリド、アセチル化トリグリセリド、またはこれらの組合せである、実施態様110に記載の方法。
112.前記薬学的に許容される溶媒は、20℃において液体状である、実施態様74〜111のいずれかに記載の方法。
113.前記薬学的に許容される溶媒は、20℃において固形状である、実施態様74〜111のいずれかに記載の方法。
114.前記薬学的に許容される固形状の溶媒はメントールである、実施態様113に記載の方法。
115.前記薬学的に許容されるアジュバントは少なくとも80% (v/v)である、実施態様73〜114のいずれかに記載の方法。
116.前記薬学的に許容されるアジュバントは20℃において液体状である、実施態様73〜115のいずれかに記載の方法。
117.前記薬学的に許容されるアジュバントは20℃において固形状である、実施態様73〜115のいずれかに記載の方法。
118.前記薬学的に許容されるアジュバントは、実施態様73〜117のいずれかに記載の方法。
119.前記薬学的に許容される脂質は、薬学的に許容される飽和脂肪酸、不飽和脂肪酸、またはこれらの組合せを含む、実施態様118に記載の方法。
120.前記薬学的に許容される脂質は、2つ以上の薬学的に許容される飽和または不飽和脂肪酸を含む、実施態様118または119に記載の方法。
121.前記2つ以上の薬学的に許容される飽和または不飽和脂肪酸が、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、またはこれらの組合せを含む、実施態様120に記載の方法。
122.前記薬学的に許容される不飽和脂肪酸が、20℃以下の融点を有する、実施態様119〜121のいずれかに記載の方法。
123.前記薬学的に許容される不飽和脂肪酸は20℃において固形状である、実施態様119〜121のいずれかに記載の方法。
124.前記薬学的に許容される不飽和脂肪酸はオメガ脂肪酸を含む、実施態様119〜123のいずれかに記載の方法。
125.前記薬学的に許容される脂質は、薬学的に許容される油を含む、実施態様118〜124のいずれかに記載の方法。
126.前記薬学的に許容される油は、アーモンド油、アラキス油、アボカド油、カノーラ油、ヒマシ油、ヤシ油、トウモロコシ油、綿実油、ブドウ種子油、へーゼルナッツ油、麻油、亜麻仁油、オリーブ油、パーム油、ピーナッツ油、ナタネ油、米糠油、ベニバナ油、ゴマ油、大豆油(soybean oil)、大豆油(soya oil)、ヒマワリ油、クルミ油、コムギ胚芽油、またはこれらの組合せを含む、実施態様125に記載の方法。
127.前記工程(b)において、前記薬学的に許容される溶媒と薬学的に許容されるアジュバントとの比が約0:1〜約1:25の範囲内である、実施態様74または76〜126のいずれかに記載の方法。
128.前記工程(a)は、薬学的に許容される安定化剤を前記薬学的に許容される溶媒と前記治療化合物とに接触させることをさらに含む、実施態様73〜127のいずれかに記載の方法。
129.前記薬学的に許容される安定化剤は、水、脂肪酸成分と酢酸とを含む犠牲酸、酢酸エチル、酢酸ナトリウム/酢酸、モノグリセリド、アセチル化モノグリセリド、ジグリセリド、アセチル化モノグリセリド、アセチル化ジグリセリド、脂肪酸、脂肪酸塩、またはこれらの組合せを含む、実施態様128に記載の方法。
130.前記薬学的に許容される安定化剤は、薬学的に許容される乳化剤を含む、実施態様128または129に記載の方法。
131.前記薬学的に許容される乳化剤は、界面活性剤、多糖類、レクチン、リン脂質、またはこれらの組合せを含む、実施態様130に記載の方法。
132.薬学的に許容される乳化剤を含まない、実施態様73〜129のいずれかに記載の方法。
133.前記薬学的に許容される溶媒を前記薬学組成物から除去することをさらに含む、実施態様74〜132のいずれかに記載の方法。
134.前記薬学的に許容される溶媒の少なくとも5%が前記薬学組成物から除去される、実施態様133に記載の方法。
135.本明細書に開示される薬学組成物からの溶媒の除去は、20℃より低い温度において行われる、実施態様133または134に記載の方法。
136.調製される前記薬学組成物が、実施態様1〜72のいずれかに記載のものである、実施態様73〜135のいずれかに記載の方法。
137.実施態様1〜72のいずれかに記載の薬学組成物を、それを必要とする個体に投与する工程であって、投与が慢性炎症に関連する症状の低減をもたらし、それによって前記個体を治療する工程を含む、慢性炎症を有する個体を治療する方法。
138.慢性炎症の治療用の医薬の製造における、実施態様1〜72のいずれかに記載の薬学組成物の使用。
139.慢性炎症の治療のための、実施態様1〜72のいずれかに記載の薬学組成物の使用。
140.前記慢性炎症は、挫瘡、呑酸/胸やけ、加齢黄斑変性症(AMD)、アレルギー、アレルギー性鼻炎、アルツハイマー病、筋萎縮性側索硬化症、貧血症、虫垂炎、動脈炎、関節炎、喘息、アテローム性動脈硬化症、自己免疫障害、亀頭炎、眼瞼炎、細気管支炎、気管支炎、水疱性類天疱瘡、火傷、滑液包炎、癌、心停止、心炎、セリアック病、蜂巣炎、子宮頸管炎、胆管炎、胆嚢炎、絨毛羊膜炎、慢性閉塞性肺疾患(COPD)、硬変症、大腸炎、うっ血性心不全、結膜炎、シクロホスファミド誘導性膀胱炎、嚢胞性線維症、膀胱炎、感冒、涙腺炎、認知症、皮膚炎、皮膚筋炎、糖尿病、糖尿病性神経障害、糖尿病性網膜症、糖尿病性腎症、糖尿病性潰瘍、消化器系疾患、湿疹、肺気腫、脳炎、心内膜炎、子宮内膜炎、腸炎、小腸結腸炎、上顆炎、精巣上体炎、筋膜炎、線維筋痛症、線維症、結合織炎、胃炎、胃腸炎、歯肉炎、糸球体腎炎、舌炎、心疾患、心臓弁機能障害、肝炎、化膿性汗腺炎、ハンチントン病、高脂血症性膵炎、高血圧症、回腸炎、感染症、炎症性腸疾患、炎症性心拡大、炎症性神経障害、インスリン抵抗性、間質性膀胱炎、間質性腎炎、虹彩炎、虚血、虚血性心疾患、角膜炎、角結膜炎、喉頭炎、ループス腎炎、乳腺炎、乳様突起炎、髄膜炎、メタボリック症候群(シンドロームX)、片頭痛、多発性硬化症、脊髄炎、心筋炎、筋炎、腎炎、非アルコール性脂肪性肝炎、肥満症、臍炎、卵巣炎、精巣炎、骨軟骨炎、骨減少症、骨髄炎、骨粗鬆症、骨炎、耳炎、膵炎、パーキンソン病、耳下腺炎、骨盤内炎症性疾患、尋常性天疱瘡、心膜炎、腹膜炎、咽頭炎、静脈炎、胸膜炎、間質性肺炎、多嚢胞性腎炎、直腸炎、前立腺炎、乾癬、歯髄炎、腎盂腎炎、門脈炎、腎不全、再灌流傷害、網膜炎、リウマチ熱、鼻炎、卵管炎、サルコイドーシス、唾液腺炎、副鼻腔炎、痙性結腸、狭窄症、口内炎、脳卒中、手術合併症、滑膜炎、腱炎、腱症、腱鞘炎、血栓性静脈炎、扁桃炎、外傷、外傷性脳損傷、移植片拒絶、三角部炎、結核、腫瘍、尿道炎、滑液包炎、ぶどう膜炎、腟炎、血管炎、または外陰炎と関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
141.前記慢性炎症が組織炎症である、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
142.前記慢性炎症が全身性炎症である、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
143.前記慢性炎症が関節炎である、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
144.前記関節炎が、単関節炎、少関節炎、または多発性関節炎である、実施態様140または143に記載の方法または使用。
145.前記関節炎が、自己免疫疾患または非自己免疫疾患である、実施態様140または143に記載の方法または使用。
146.前記関節炎が、変形性関節症、関節リウマチ、若年性特発性関節炎、敗血症性関節炎、脊椎関節症、痛風、偽痛風、またはスティル病である、実施態様140または143に記載の方法または使用。
147.前記脊椎関節症が、強直性脊椎炎、反応性関節炎(ライター症候群)、乾癬性関節炎、炎症性腸疾患に付随する腸炎性関節炎、ウィップル病、またはベーチェット病である、実施態様146に記載の方法。
148.前記慢性炎症が自己免疫障害である、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
149.前記自己免疫障害が、全身性自己免疫障害または器官特異的自己免疫障害である、実施態様140または148に記載の方法または使用。
150.前記自己免疫障害が、急性散在性脳脊髄炎(ADEM)、アジソン病、アレルギーもしくは過敏症、筋萎縮性側索硬化症、抗リン脂質抗体症候群(APS)、関節炎、自己免疫性溶血性貧血、自己免疫性肝炎、自己免疫性内耳疾患、自己免疫性膵炎、水疱性類天疱瘡、セリアック病、シャーガス病、慢性閉塞性肺疾患(COPD)、1型糖尿病(IDDM)、子宮内膜症、線維筋痛症、グッドパスチャー症候群、グレーブス病、ギラン・バレー症候群(GBS)、橋本甲状腺炎、化膿性汗腺炎、特発性血小板減少性紫斑病、炎症性腸疾患、間質性膀胱炎、ループス(円板状エリテマトーデス、薬剤誘発性ループスエリテマトーデス、ループス腎炎、新生児ループス、亜急性皮膚エリテマトーデス、および全身性エリテマトーデスを含む)、モルフェア、多発性硬化症(MS)、重症筋無力症、ミオパチー、ナルコレプシー、神経性筋強直症、尋常性天疱瘡、悪性貧血、原発性胆汁性肝硬変、再発性散在性脳脊髄炎(多相性散在性脳脊髄炎)、リウマチ熱、統合失調症、強皮症、シェーグレン症候群、腱鞘炎、血管炎、または白斑症である、実施態様140または148に記載の方法または使用。
151.前記慢性炎症がミオパチーである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
152.前記ミオパチーが、皮膚筋炎、封入体筋炎、または多発性筋炎である、実施態様137または148に記載の方法または使用。
153.前記慢性炎症が血管炎である、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
154.前記血管炎が、バージャー病、動脈炎、脳血管炎、チャーグ・ストラウス動脈炎、クリオグロブリン血症、本態性クリオグロブリン血管炎、巨細胞動脈炎、ゴルファーの血管炎、ヘノッホ・シェーンライン紫斑病、過敏性血管炎、川崎病、静脈炎、顕微鏡的多発動脈炎/多発性血管炎、結節性多発動脈炎、リウマチ性多発筋痛症(PMR)、リウマチ性血管炎、高安動脈炎、血栓性静脈炎、ウェゲナー肉芽腫症、または結合組織障害に伴って二次的に生じる血管炎、もしくはウイルス感染に伴って二次的に生じる血管炎である、実施態様140または153に記載の方法または使用。
155.前記慢性炎症が皮膚障害に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
156.前記皮膚障害が、皮膚炎、湿疹、うっ滞性皮膚炎、化膿性汗腺炎、乾癬、酒さ、または強皮症である、実施態様140または155に記載の方法または使用。
157.前記湿疹が、アトピー性湿疹、接触性湿疹、乾燥性湿疹、脂漏性湿疹、発汗障害、円盤状湿疹、静脈性湿疹、疱疹状皮膚炎、神経皮膚炎、または自家感作性皮膚炎である、実施態様156に記載の方法または使用。
158.前記乾癬が、尋常性乾癬、爪乾癬、滴状乾癬、頭皮乾癬、インバース乾癬、膿疱性乾癬、または紅皮症乾癬である、実施態様156に記載の方法または使用。
159.前記慢性炎症が胃腸障害に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
160.前記胃腸障害が、過敏性腸疾患または炎症性腸である、実施態様140または159に記載の方法または使用。
161.前記炎症性腸が、クローン病または潰瘍性大腸炎である、実施態様160に記載の方法または使用。
162.前記慢性炎症が心血管疾患に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
163.前記心血管疾患が、高血圧症、心臓弁機能障害、うっ血性心不全、心筋梗塞、糖尿病性心臓異常、血管炎症、動脈閉塞性疾患、末梢動脈疾患、動脈瘤、塞栓症、切開、偽動脈瘤、血管奇形、血管性母斑、血栓症、血栓性静脈炎、静脈瘤、または脳卒中である、実施態様140または162に記載の方法または使用。
164.前記慢性炎症が癌に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
165.前記慢性炎症が、薬理学的に誘発される炎症に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
166.前記慢性炎症が感染症に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
167.前記感染症が、細菌性膀胱炎、細菌性脳炎、世界的流行のインフルエンザ、ウイルス性脳炎、A型ウイルス性肝炎、B型ウイルス性肝炎、またはC型ウイルス性肝炎である、実施態様140または166に記載の方法または使用。
168.前記慢性炎症が、組織または器官の損傷に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
169.前記慢性炎症が、移植片拒絶または移植片対宿主病に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
170.前記慢性炎症が、Th1媒介性炎症疾患に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
171.前記慢性炎症が、慢性神経性炎症に関連するものである、実施態様137に記載の方法または実施態様138もしくは139に記載の使用。
172.前記実施態様1〜72に記載の治療化合物を含む薬学組成物は、個体に投与されると、前記薬学的に許容されるアジュバントを有しないこと以外はそれと同一である薬学組成物に含まれる治療化合物の体内分布とは異なる治療化合物体内分布をもたらす、実施態様137もしくは140〜171に記載の方法または実施態様138〜171に記載の使用。
173.前記実施態様1〜72に記載の薬学組成物の治療化合物のうち、個体に投与されるとマクロファージに送達されるものの量は、投与される薬学組成物中に含まれる治療化合物の総量の少なくとも5%である、実施態様137もしくは140〜172に記載の方法または実施態様138〜172に記載の使用。
174.前記実施態様1〜72に記載の薬学組成物は、個体に投与されると、前記薬学的に許容されるアジュバントを有しないこと以外はそれと同一である薬学組成物の場合と比較して、腸刺激を少なくとも5%低減させる、実施態様137もしくは140〜173に記載の方法または実施態様138〜173に記載の使用。
175.前記実施態様1〜72に記載の薬学組成物は、個体に投与されると、前記薬学的に許容されるアジュバントを有しないこと以外はそれと同一である薬学組成物の場合と比較して、胃刺激を少なくとも5%低減させる、実施態様137もしくは140〜171に記載の方法または実施態様138〜174に記載の使用。
この実施例は、本明細書で開示される薬学組成物を液体状製剤として作る作り方を示す。
この実施例は、本明細書で開示される薬学組成物を液体状製剤として作る作り方を示す。
この実施例は、本明細書で開示される薬学組成物を液体状製剤として作る作り方を示す。
この実施例は、本明細書で開示される薬学組成物を固形状製剤として作る作り方を示す。
本明細書で開示される薬学組成物が胃刺激症状を低減させるか否かを調べるために、腸びらんのマウスモデルを使用した実験を行った。
呼吸器炎症の治療における本明細書で開示される薬学組成物の有効性を調べるために、ウイルス誘発性インフルエンザのマウスモデルを使用して実験をおこなった。
炎症性腸疾患の治療における本明細書で開示される薬学組成物の有効性を調べるために、TBS誘発性大腸炎のマウスモデルを用いて実験を行った。
関節炎の治療における本明細書で開示される薬学組成物の有効性を調べるために、関節リウマチのような全身性関節炎を模倣するαコラーゲン抗体誘発性関節炎(ACAIA)のマウスモデルを用いて実験を行った。
片方の膝において反応性関節炎の診断を受けた47歳の女性が、20 mg/kgのイブプロフェン、10%エタノールおよび90%ナタネ油を含む本明細書で開示される薬学組成物(BC1054)によって3日間にわたって処置され(1200 mgを1日1回)、1日経過後には腫れおよび痛みが引き始め3日経過後には完全に改善したことが見出された。有効でない標準的なイブプロフェン治療はその後打ち切られた。3ヶ月の追跡調査において、反応性関節炎の徴候は観察されなかった。
62歳の女性が関節の硬直および腫れを訴え、関節リウマチと診断される。医師はその関節の硬直および腫れは慢性炎症によるものであると判断する。女性は、イブプロフェンを含む本明細書で開示される薬学組成物の1日2回の経口投与により治療される。あるいは、アスピリンを含む本明細書で開示される薬学組成物の1日3回の経口投与により治療される。あるいは、ナプロキセンを含む本明細書で開示される薬学組成物の1日2回の経口投与により治療される。女性の状態を監視し、約3日間の治療後、この女性は関節の硬直および腫れの低減を示す。1ヶ月および3ヶ月後の検診において、この女性は治療された部分における関節の硬直および腫れの低減が持続していることを示す。この慢性炎症症状の低減は、本明細書で開示される薬学組成物による治療が成功したことを示す。本明細書で開示される薬学組成物の同様な経口投与は、例えば変形性関節症、若年性特発性関節炎、敗血症性関節炎、脊椎関節症(強直性脊椎炎、反応性関節炎(ライター症候群)、乾癬性関節炎、炎症性腸疾患に付随する腸炎性関節炎、ウィップル病またはベーチェット病を含む)、滑膜炎、痛風、偽痛風、またはスティル病、さらには滑液包炎、リウマチ熱、もしくは腱鞘炎のような、あらゆる単関節炎、少関節炎、または多発性関節炎に関連する慢性炎症に罹患した患者を治療することに使用される。同様に、例えばサリチル酸誘導体NSAID、p-アミノフェノール誘導体NSAID、プロピオン酸誘導体NSAID、酢酸誘導体NSAID、エノール酸誘導体NSAID、フェナム酸誘導体NSAID、非選択的シクロオキシゲナーゼ(COX)阻害剤、選択的シクロオキシゲナーゼ1(COX 1)阻害剤、および選択的シクロオキシゲナーゼ2(COX 2)阻害剤、またはフィブラートのようなあらゆる治療化合物が薬学組成物に製剤され、上記のように患者に投与される。
Claims (7)
- a) イブプロフェン;
b) 少なくとも90% (v/v)の薬学的に許容される亜麻仁油;および
c) 10% (v/v)以下の薬学的に許容されるエタノール
を含む薬学組成物であって、前記薬学組成物は乳化剤を含まない、慢性炎症の治療のための薬学組成物。 - 前記イブプロフェンは塩または遊離塩基である、請求項1に記載の薬学組成物。
- 1〜10% (v/v)の薬学的に許容される前記エタノールを含む、請求項1または2に記載の薬学組成物。
- 抗炎症活性により、
炎症誘発性分子のレベルを減少させ;
炎症誘発性プロスタグランジンのレベルを減少させ;
PPARシグナル伝達経路を刺激し;
マクロファージM1細胞のアポトーシスを誘導し、マクロファージM2細胞の分化を促進させ、もしくはこれらの両方を行い;または
Th1細胞から放出されるインターフェロン・ガンマ(IFNγ)、腫瘍壊死因子アルファ(TNF-α)、インターロイキン12(IL-12)、もしくはこれらの組合せのレベルを減少させ、もしくはTh2細胞から放出されるIL-10のレベルを増加させ、もしくはこれらの両方を行うための、
請求項1〜3のいずれかに記載の薬学組成物。 - 慢性炎症の治療用の医薬の製造における、請求項1〜4のいずれかに記載の薬学組成物の使用。
- 前記慢性炎症が組織炎症または全身性炎症である、請求項5に記載の使用。
- 前記慢性炎症が自己免疫疾患または非自己免疫疾患である、請求項5に記載の使用。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021215409A1 (ja) | 2020-04-20 | 2021-10-28 | 株式会社 資生堂 | 光老化及び/又は真皮色素沈着を予防及び/又は改善する剤,それを用いた美容方法,及びその方法に適用するための美容装置 |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102784386A (zh) * | 2003-11-20 | 2012-11-21 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
GB201018289D0 (en) * | 2010-10-29 | 2010-12-15 | Biocopea Ltd | Treatment of respiratory disorders |
US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
KR20150028233A (ko) | 2012-05-07 | 2015-03-13 | 옴테라 파마슈티칼스, 인크. | 스타틴 및 오메가-3 지방산의 조성물 |
AU2013336683A1 (en) * | 2012-10-24 | 2015-05-14 | Biocopea Limited | Drug combinations containing statins for treating cardiovascular diseases |
WO2014108571A2 (en) | 2013-01-14 | 2014-07-17 | Biocopea Limited | Cancer drug and uses |
AU2014204739B2 (en) * | 2013-01-14 | 2016-08-11 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
ES2763352T3 (es) * | 2013-01-14 | 2020-05-28 | Infirst Healthcare Ltd | Composiciones de solución sólida y uso en inflamación crónica |
BR112015015870B1 (pt) * | 2013-02-04 | 2022-09-27 | Infirst Healthcare Limited | Uso de uma composição farmacêutica |
KR101344218B1 (ko) * | 2013-05-15 | 2013-12-20 | 충남대학교산학협력단 | 페노피브레이트를 함유하는 결핵 치료용 약학 조성물 |
RU2623876C2 (ru) * | 2014-11-10 | 2017-06-29 | Александр Владимирович Диковский | Фармацевтическая композиция для лечения гиперлипидемии |
KR101512606B1 (ko) | 2014-12-11 | 2015-04-15 | (주)이지코스 | 주름 및 아토피 개선과 피부 보습을 위한 화장료 조성물 |
CN105853405B (zh) * | 2015-01-23 | 2019-03-08 | 中国科学院上海药物研究所 | 苯溴马隆在制备电压门控钾离子通道kcnq激动剂中的应用 |
AU2016243681B2 (en) * | 2015-03-31 | 2020-10-08 | Mymd Pharmaceuticals, Inc. | Methods of treating cancers, autoimmune disorders, and other conditions associated with chronic inflammation |
EP3095465A1 (en) | 2015-05-19 | 2016-11-23 | U3 Pharma GmbH | Combination of fgfr4-inhibitor and bile acid sequestrant |
EP3307346A4 (en) * | 2015-06-15 | 2019-01-02 | Vital Therapies, Inc. | Composition and method for inducing anti-inflammatory response |
CN105294672A (zh) * | 2015-12-07 | 2016-02-03 | 范秀华 | 一种治疗子宫内膜炎的药物组合物 |
CN105753826A (zh) * | 2016-05-09 | 2016-07-13 | 宋晓梅 | 一种吉非罗齐的药物组合物及其医药用途 |
CN106074500A (zh) * | 2016-07-08 | 2016-11-09 | 重庆医药高等专科学校 | 脱氢洛伐他汀在制备抗炎症性肠病药物中的应用 |
CA3077624A1 (en) * | 2016-10-01 | 2018-04-05 | James Smeeding | Pharmaceutical compositions comprising a statin and a cannabinoid and uses thereof |
WO2018129095A1 (en) * | 2017-01-03 | 2018-07-12 | Thermolife International, Llc | Cinnamaldehyde compositions and methods |
JP6784973B2 (ja) * | 2017-03-30 | 2020-11-18 | 国立研究開発法人産業技術総合研究所 | 単層カーボンナノチューブ |
US20210137809A1 (en) * | 2017-06-14 | 2021-05-13 | Biosolution Co., Ltd | Cosmetic composition for wrinkle reduction or anti-inflammation, containing substance p |
JP6893012B2 (ja) * | 2017-07-18 | 2021-06-23 | 徳義制薬有限公司Deyi Pharmarmaceutical Ltd. | 肺高血圧症の治療におけるカンナビジオールの応用 |
US20230190662A1 (en) * | 2017-07-19 | 2023-06-22 | Ironwood Pharmaceuticals, Inc. | Efficacy of a Gastro-Retentive Bile Acid Sequestrant Dosage Form |
KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
CN109419786B (zh) * | 2017-08-31 | 2021-04-30 | 汉义生物科技(北京)有限公司 | 大麻二酚在制备抗流感的药物中的用途 |
EP3677258B1 (en) * | 2017-08-31 | 2022-02-09 | Hanyi Bio-Technology Company Ltd. | Uses of cannabidiol in preparation of drugs for resisting against influenza |
MX2020007462A (es) * | 2018-01-12 | 2020-09-14 | Metimedi Pharmaceuticals Co Ltd | Metodos de tratamiento de enfermedades inflamatorias cronicas. |
WO2019233285A1 (en) * | 2018-06-03 | 2019-12-12 | Chen Wen Pin | Method for treating non-compaction cardiomyopathy |
EP3856172A4 (en) * | 2018-09-28 | 2022-10-05 | Visceral Therapeutics Inc. | PHARMACEUTICALLY ACTIVE CANNABIS-BASED COMPOSITIONS AND METHODS FOR USE IN THE TREATMENT OF GASTROINTESTINAL CONDITIONS |
KR20210114409A (ko) | 2018-12-11 | 2021-09-23 | 디스럽션 랩스 인코퍼레이티드 | 치료제 전달용 조성물과 이의 이용 및 제조 방법 |
US20220168325A1 (en) * | 2019-03-25 | 2022-06-02 | The University Of Vermont | Methods to promote cerebral blood flow in the brain |
CN109846885A (zh) * | 2019-04-04 | 2019-06-07 | 南通大学附属医院 | 瑞舒伐他汀的新用途 |
WO2021113912A1 (en) * | 2019-12-11 | 2021-06-17 | Ambetex Pty Ltd | Therapeutic compositions and methods for prevention and treatment of diastolic dysfunction |
RU2749857C1 (ru) * | 2019-12-23 | 2021-06-17 | Псарева Нелли Александровна | Способ борьбы со средним и наружным отитом |
US20230082544A1 (en) | 2020-02-18 | 2023-03-16 | Novo Nordisk A/S | Pharmaceutical formulations |
RU2745687C1 (ru) * | 2020-05-19 | 2021-03-30 | Всеволод Иванович Киселев | Способ лечения эндометриоза с болевым синдромом и фармацевтическая композиция для его реализации |
CN112007165B (zh) * | 2020-08-27 | 2021-10-08 | 北京大学人民医院 | 巨噬细胞极化调节剂及其在促进血小板生成中的应用 |
CN112156089A (zh) * | 2020-09-27 | 2021-01-01 | 天津国际生物医药联合研究院 | 苯溴马隆在抗结核分枝杆菌感染中的应用 |
WO2023058975A1 (ko) * | 2021-10-07 | 2023-04-13 | (주)이노보테라퓨틱스 | 벤조퓨라닐 히드록시페닐 메타논 유도체를 포함하는 hsp47 억제용 약학 조성물 |
WO2023244738A1 (en) * | 2022-06-15 | 2023-12-21 | The Johns Hopkins University | Thiazolidinediones for the treatment of muscular dystrophies |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
US5059626A (en) * | 1988-07-25 | 1991-10-22 | Applied Analytical Industries, Inc. | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs |
IT1255007B (it) * | 1991-07-01 | 1995-10-11 | Altergon Sa | Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono. |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
WO2000057859A1 (en) * | 1999-03-31 | 2000-10-05 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US20030235595A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent |
CN1543358A (zh) * | 2000-12-19 | 2004-11-03 | �ÿ���˹ϵͳ��ѧ���»� | 利用含卵磷脂油和非甾体消炎药的制剂保护胃肠道和提高临床疗效的方法及组合物 |
US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
JP2005068060A (ja) * | 2003-08-22 | 2005-03-17 | Nrl Pharma Inc | ラクトフェリンを含有する医薬組成物ならびに加工食品の製造法 |
CN100486567C (zh) * | 2004-08-12 | 2009-05-13 | 山东绿叶天然药物研究开发有限公司 | 姜黄素乳剂及其制备方法 |
US20060138059A1 (en) | 2004-12-28 | 2006-06-29 | Vair Larry L Jr | Corona-treated polypropylene liquid filtration media |
US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
WO2008070950A1 (en) * | 2006-12-13 | 2008-06-19 | Laboratoires Mauves Inc. | Pharmaceutical solution formulations for encapsulation into gelatin capsules or other dosage forms |
WO2008144355A2 (en) * | 2007-05-17 | 2008-11-27 | Morton Grove Pharmaceuticals, Inc. | Stable, self-microemulsifying fenofibrate compositions |
CN101854912A (zh) * | 2007-09-07 | 2010-10-06 | 诺瓦瓦克斯股份有限公司 | 含贝特类药物和他汀类药物的组合的多相的纳米结构化的组合物 |
RU2363451C2 (ru) * | 2007-09-14 | 2009-08-10 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Композиция для приготовления обладающей пролонгированным действием лекарственной формы и способ получения этой формы |
US8461183B2 (en) | 2008-05-26 | 2013-06-11 | Genfit | PPAR agonist compounds, preparation and uses |
GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
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