EP2560484A4 - Composition pharmaceutique de nanoparticules - Google Patents

Composition pharmaceutique de nanoparticules

Info

Publication number
EP2560484A4
EP2560484A4 EP11772343.7A EP11772343A EP2560484A4 EP 2560484 A4 EP2560484 A4 EP 2560484A4 EP 11772343 A EP11772343 A EP 11772343A EP 2560484 A4 EP2560484 A4 EP 2560484A4
Authority
EP
European Patent Office
Prior art keywords
nanoparticles
pharmaceutical composition
pharmaceutical
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11772343.7A
Other languages
German (de)
English (en)
Other versions
EP2560484A1 (fr
Inventor
Hosheng Tu
Hsing-Wen Sung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NANOMEGA MEDICAL Corp
Original Assignee
NANOMEGA MEDICAL CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/799,283 external-priority patent/US7910086B1/en
Priority claimed from US12/800,848 external-priority patent/US7879313B1/en
Application filed by NANOMEGA MEDICAL CORP filed Critical NANOMEGA MEDICAL CORP
Publication of EP2560484A1 publication Critical patent/EP2560484A1/fr
Publication of EP2560484A4 publication Critical patent/EP2560484A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP11772343.7A 2010-04-21 2011-01-31 Composition pharmaceutique de nanoparticules Withdrawn EP2560484A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/799,283 US7910086B1 (en) 2005-01-04 2010-04-21 Nanoparticles for protein drug delivery
US12/800,848 US7879313B1 (en) 2005-01-04 2010-05-24 Nanoparticles for protein drug delivery
PCT/US2011/000183 WO2011133198A1 (fr) 2010-04-21 2011-01-31 Composition pharmaceutique de nanoparticules

Publications (2)

Publication Number Publication Date
EP2560484A1 EP2560484A1 (fr) 2013-02-27
EP2560484A4 true EP2560484A4 (fr) 2014-05-28

Family

ID=44834439

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11772343.7A Withdrawn EP2560484A4 (fr) 2010-04-21 2011-01-31 Composition pharmaceutique de nanoparticules

Country Status (8)

Country Link
EP (1) EP2560484A4 (fr)
JP (1) JP2013525351A (fr)
KR (1) KR20130100897A (fr)
CN (1) CN102970864A (fr)
AU (1) AU2011243226A1 (fr)
CA (1) CA2796853A1 (fr)
RU (1) RU2012144776A (fr)
WO (1) WO2011133198A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014011123A (es) * 2012-03-22 2014-12-05 Nanotherapeutics Inc Composiciones y metodos de administracion oral de particulas de dietilentriaminopentaacetato encapsuladas.
EP2978428A4 (fr) * 2013-03-28 2016-12-28 Bbs Nanotechnology Ltd Nanocomposition stable comprenant de l'épirubicine, procédé pour sa préparation, son utilisation et compositions pharmaceutiques la contenant
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
ES2630106T3 (es) 2014-10-07 2017-08-18 Cyprumed Gmbh Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos
CN104740647A (zh) * 2015-04-08 2015-07-01 东莞市麦亘生物科技有限公司 一种艾塞那肽口服制剂及其制备方法
WO2016179120A1 (fr) * 2015-05-01 2016-11-10 Mir Imran Compositions pharmaceutiques et procédés de fabrication de masses solides comprenant des polypeptides et/ou des protéines
GB201507760D0 (en) * 2015-05-06 2015-06-17 Anabio Technologies Ltd Gelated microparticle suitable for oral delivery of therapeutic peptides to the lower intestine
EP3359181A1 (fr) 2015-10-07 2018-08-15 Cyprumed GmbH Formulations pharmaceutiques pour l'administration par voie orale de médicaments peptidiques
JP6850546B2 (ja) * 2016-04-07 2021-03-31 アリメント工業株式会社 極小ソフトカプセルの製造方法
WO2018065634A1 (fr) 2016-10-07 2018-04-12 Cyprumed Gmbh Compositions pharmaceutiques pour l'administration par voie nasale de médicaments de type peptide ou protéine
KR102083481B1 (ko) * 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
JP7442823B2 (ja) 2018-04-06 2024-03-05 シプルメット・ゲーエムベーハー 治療用ペプチド及び治療用タンパク質の経粘膜送達のための薬学的組成物
KR102140185B1 (ko) * 2018-09-21 2020-08-03 (주)세포활성연구소 천연물 유래 발효추출물 발모제를 포함하는 하이드로젤 나노입자, 이의 제조방법
CN109675020B (zh) * 2019-01-11 2021-05-04 浙江大学 一种口服glp-1多肽类纳米制剂及其制备方法和应用
CN110327221A (zh) * 2019-04-16 2019-10-15 中国人民解放军第四军医大学 一种牙本质胶原纤维脱矿材料及其制备方法与应用
CN116419750A (zh) 2020-09-07 2023-07-11 西普鲁梅有限公司 改进的glp-1受体激动剂的药物制剂
WO2023166179A1 (fr) 2022-03-03 2023-09-07 Cyprumed Gmbh Formulations pharmaceutiques orales améliorées de peptides et de protéines thérapeutiques
KR20240103309A (ko) * 2022-12-27 2024-07-04 삼육대학교산학협력단 폴리에틸렌글라이콜 기반의 비이온성 계면활성제와 함께 안정화된 소수성약물을 담지한 초음파 감응 마이크로 버블 약물전달체 및 이의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090155374A1 (en) * 2005-01-04 2009-06-18 Hsing-Wen Sung Nanoparticles for protein drug delivery
US20090202628A1 (en) * 2005-01-04 2009-08-13 Hsing-Wen Sung Nanoparticles for protein drug delivery
WO2009137711A1 (fr) * 2008-05-07 2009-11-12 Medivas, Llc Polymères chélatants métallifères biodégradables et vaccins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009143720A1 (fr) * 2008-05-27 2009-12-03 The Chinese University Of Hong Kong Nanoparticules, procédés de fabrication de celles-ci et marquage de cellules utilisant celles-ci

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090155374A1 (en) * 2005-01-04 2009-06-18 Hsing-Wen Sung Nanoparticles for protein drug delivery
US20090202628A1 (en) * 2005-01-04 2009-08-13 Hsing-Wen Sung Nanoparticles for protein drug delivery
WO2009137711A1 (fr) * 2008-05-07 2009-11-12 Medivas, Llc Polymères chélatants métallifères biodégradables et vaccins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "complexone - definition of complexone by the Free Online Dictionary, Thesaurus and Encyclopedia.", 14 April 2014 (2014-04-14), XP055114484, Retrieved from the Internet <URL:http://www.thefreedictionary.com/complexone> [retrieved on 20140417] *
See also references of WO2011133198A1 *

Also Published As

Publication number Publication date
JP2013525351A (ja) 2013-06-20
CN102970864A (zh) 2013-03-13
CA2796853A1 (fr) 2011-10-27
RU2012144776A (ru) 2014-05-27
KR20130100897A (ko) 2013-09-12
EP2560484A1 (fr) 2013-02-27
AU2011243226A1 (en) 2012-10-11
WO2011133198A1 (fr) 2011-10-27

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