EP2475585B1 - Dispositif de distribution de liquide - Google Patents

Dispositif de distribution de liquide Download PDF

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Publication number
EP2475585B1
EP2475585B1 EP10768998.6A EP10768998A EP2475585B1 EP 2475585 B1 EP2475585 B1 EP 2475585B1 EP 10768998 A EP10768998 A EP 10768998A EP 2475585 B1 EP2475585 B1 EP 2475585B1
Authority
EP
European Patent Office
Prior art keywords
valve
wall
tubular wall
fastener
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10768998.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2475585A1 (fr
Inventor
Gaetan Painchaud
Guillaume Grevin
Xavier Julia
Thierry Decock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nemera la Verpilliere SAS
Original Assignee
Nemera la Verpilliere SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Nemera la Verpilliere SAS filed Critical Nemera la Verpilliere SAS
Priority to EP25184660.6A priority Critical patent/EP4596110A3/fr
Priority to EP16175332.2A priority patent/EP3090956A1/fr
Priority to EP16175337.1A priority patent/EP3090957B1/fr
Priority to EP22201129.8A priority patent/EP4147990B1/fr
Publication of EP2475585A1 publication Critical patent/EP2475585A1/fr
Application granted granted Critical
Publication of EP2475585B1 publication Critical patent/EP2475585B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2031—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the element being formed by a slit, narrow opening or constrictable spout, the size of the outlet passage being able to be varied by increasing or decreasing the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2081—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve port
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Definitions

  • the invention relates to the field of liquid distribution in the form of drops, in particular in the pharmaceutical field, for example ophthalmic or auricular fluid.
  • a liquid dispensing device comprising an elastomeric valve diaphragm disposed between a support and a hood mounted on the reservoir.
  • the diaphragm comprises a flat annular portion comprising or not an annular peripheral bead and is held on the device by clamping this annular portion and / or bead between the upper surface of the support and the lower surface of the cover. Maintaining the diaphragm in the device is therefore ensured by a pinch in the axial direction of the device.
  • a disadvantage of this type of assembly lies in the fact that, when a user presses on the reservoir to draw out liquid, the liquid exerts pressure on the diaphragm in the axial direction in order to open it, and that such pressure may generate liquid leakage at the periphery of the diaphragm. This risk of leakage is even more likely that the parts have dimensions or relative positions that can vary, because of manufacturing tolerances.
  • the presence of a leak in the device is troublesome, especially if the liquid has no preservative, because liquid is found in undesirable locations of the device, which promotes the development of bacteria and can subsequently contaminate the liquid.
  • the present invention is intended in particular to provide a dispensing device in which the sterility is improved.
  • the invention particularly relates to a liquid dispensing device according to claim 1.
  • the inner and outer tubular walls are arranged in such a way that they effect a radial compression of the wall for fixing the valve, that is to say that they support on both sides of the wall fastening, in the radial direction, corresponding to the direction perpendicular to the axis of the tubular walls, this radial compression ensuring a seal of the valve.
  • the dispensing device comprises, in the zone of attachment of the valve, three concentric tubes, possibly of short length, the inner tube corresponding to the inner tubular wall, the intermediate tube corresponding to the fixing wall of the valve and the outer tube corresponding to the outer tubular wall.
  • These tubes all have the same axis, corresponding to the axis of the dispensing device, this axis being generally an axis of revolution of the device, in particular the reservoir, corresponding to the direction in which the liquid leaves the valve. It is understood that, to ensure a satisfactory seal, the diameter of the inner tubular wall is slightly greater than the diameter of the fixing wall, itself slightly larger than the diameter of the outer tubular wall.
  • the seal is obtained by clamping in a direction other than the ejection direction of the liquid.
  • the pressure exerted by the liquid, in the axial direction is not exerted in the direction ensuring sealing of the fixing of the valve.
  • the liquid exerts an axial pressure on the valve, generating a relatively low stress in the radial direction of the valve.
  • the risk of displacement of the fasteners of the valve, such as the inner and outer tubular walls, is relatively low.
  • the proposed device requires less precision in the dimensions of the fasteners. Indeed, the pinching through the tubes ensures a good seal, even if the components have relative positions that may vary slightly in the axial direction due to manufacturing tolerances or positioning tolerances during assembly in the axial direction.
  • the outer or inner tubular wall can advantageously constitute a centering wall of the valve, which facilitates its assembly.
  • tubular walls is interesting in terms of compactness. Indeed, the axial position of the attachment zone can be moved further downstream of the dispensing device, for example on either side of the valve portion, which can reduce the diameter of the dispensing nozzle. . Moreover, because the sealing is exerted by tubular walls, the surface of the tubular is increased. compression exerted by the fasteners, which provides a better seal.
  • the outer tubular wall is carried by a support attached to a tank.
  • the proposed device is very useful in cases where it is desired to dispense a liquid without a preservative. Indeed, with this type of liquid, the respect of the seal must be particularly reliable.
  • the dispensed liquid is, in this example, a pharmaceutical liquid, such as ophthalmic or atrial fluid.
  • the device 10 comprises a dispensing nozzle 12 mounted by screwing on the neck of a reservoir 13.
  • the device 10 is configured to dispense liquid following a pressure exerted by the user on the reservoir 13.
  • the reservoir is elastically deformable, so as to resume its shape after a pressure exerted by the user.
  • the device 10, at least the reservoir 13 has an axis X of revolution, also corresponding to the direction of ejection of liquid.
  • the tip 12 comprises a support 14, a valve 16, a spring 17, a cover 18 and a hydrophobic filter 20.
  • the support 14 comprises, in this example, a portion 22, disposed at the proximal end of the tip, for fixing the support on the reservoir 13.
  • This portion 22 comprises an outer skirt 24, threaded so as to be screwed on the reservoir neck 13, and an inner skirt 26, of tubular shape, for sealing between the reservoir 12 and the dispensing nozzle 10.
  • the support 14 further includes an intermediate portion 28, forming a seat for the valve 16.
  • This intermediate portion 28 has substantially the shape of a disc, extending in a radial plane R perpendicular to the axis X.
  • the disc 28 is delimited, on its distal face, by an outer tubular wall 30. This wall forms a peripheral skirt of the disk 28, it extends perpendicularly to the disk 28, in the form of an X-axis tube, sufficiently high to receive the valve 16, as described below.
  • the disk 28 comprises, in the lower vicinity of the tubular wall 30, an annular rib 32 for delimiting a groove for centering and receiving the edge of the valve 16.
  • the disk 28 furthermore comprises a central cylindrical portion 34 for the closing the valve, projecting from its center, on the distal side of the disk 28 and carrying, at its distal end, a bearing surface 36 of the valve 16.
  • This part 34 forms a closure pin allowing the opening or the closing the valve 16.
  • the disc 28 is also traversed by a channel 38 for liquid passage from the reservoir.
  • This channel 38 emerges on a cavity 40 delimited in particular by a recess formed on the distal surface of the disk 28.
  • This cavity 40 also opens onto a second channel 42 for the passage of liquid, delimited by the pin 34 and the valve 16.
  • channels 38 and 42 have an axis substantially parallel to the axis X.
  • the disc 28, the outer tubular wall 30 and the shut-off pin 34 define a tubular cavity for receiving the valve 16.
  • the support 14 comprises a channel 44 for passage of air into the reservoir, this channel 44 opening onto a housing 46 for receiving the hydrophobic filter 20, this housing being cylindrical, open at its proximal end for the insertion of the filter 20.
  • the valve 16 comprises a central cylindrical portion 48, an annular peripheral skirt 50, the central portion 48 and the skirt 50 being interconnected by a web of material 52.
  • the web 52 carries, on its distal surface, a seat 53 of spring support 17.
  • the distal portion 54 of the central portion 48 is a valve portion, ensuring the blocking and the passage of liquid, by cooperation with the bearing surface 36.
  • the surface 36 forms a support for the part 54 forming valve when the latter is in the liquid blocking configuration.
  • the upper surface of the portion 48 comprises a channel 56 for ejecting the liquid, leading to a form 58 of drop dosing.
  • the skirt 50 forms a fixing edge of the valve 16 on the support, for the permanent fixing of the valve relative to the reservoir 13. It consists of a fixing wall 50, tubular X axis, diameter slightly greater than inside diameter of the outer tubular wall 30.
  • valve 16 is integrally made of an elastomeric material. Nevertheless, it can be provided that the valve comprises certain parts made of an elastomeric material and other parts made of a more rigid material, in particular the portion 53 forming a support for the spring 17.
  • the valve portion 54, the web 52 and the fixing wall 50 are made of elastomeric material.
  • the cover 18 is attached by snapping on the support 14, by means of latching means 59.
  • the latching means 59 make it possible to snap the cover 18 relative to the support 14 following an assembly in the axial direction X. It carries an inner tubular wall 60 of X axis and diameter slightly greater than the diameter of the fixing wall 50 of the valve.
  • the cover 18 also has an outer shell 62 forming an outer skirt, extending towards the direction proximal to the remainder of the cover 18, and a bottom 64, so that the wall 60, the bottom 64 and the 62 envelope delimit a groove intended to sandwich the fixing wall 50 and the outer tubular wall 30.
  • the cover 18 largely covers the valve 16, but is traversed at its center by the central portion 48 of the valve.
  • the cover 18 defines a cylindrical cavity by means of a tubular inner skirt 66, having a centering function of the valve 16.
  • the skirt 66 also defines a groove 68 forming a bearing seat of the spring 17.
  • the pressure of the fluid in the channel 42 deforms the valve portion 54 so as to change it from its liquid blocking configuration to a liquid passage configuration by detaching the portion 54 from the bearing surface 36. This deformation is facilitated by the compression of the spring 17 under the pressure of the liquid. The liquid is then dispensed as drops.
  • the assembly comprises a step of assembling the tip 12, followed by a step of screwing this tip 12 on the reservoir 13.
  • the assembly of the nozzle 12 begins with a step of installing the valve 16 on the support 14, by inserting the fixing wall 50 of the valve inside the tubular wall 30 of the support 14. This step is illustrated on the figure 2a , it is followed by a step of insertion of the spring 17 around the central portion 48 of the valve, illustrated on the figure 2b .
  • a step of installing the cover 18 above the valve 16, illustrated on the Figure 2c we proceed to a step of installing the cover 18 above the valve 16, illustrated on the Figure 2c , by insertion of the inner tubular wall 60 inside the fixing wall 50.
  • This installation of the cover 18 is terminated by a snap of the cover on the support 14, illustrated in FIG. figure 2d this snapping being simultaneous with the permanent fixing of the valve 16 on the nozzle 12, taken sandwiched between the inner tubular walls 60 and outer 30.
  • the web 2 is subjected to elastic stress so as to press the end 54 against the surface 36. This plating is facilitated in addition by the return force of the spring.
  • the static seal made around the fixing wall 50, by clamping the walls 60 and 30, is particularly effective. Indeed, when the liquid escapes from the tank 13, it exerts a pressure on the valve 16 in the X direction, and this pressure in the X direction does not affect the fixing part 50, the attachment of the valve being provided by a compression in the radial direction R.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Check Valves (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Devices For Dispensing Beverages (AREA)
  • Springs (AREA)
EP10768998.6A 2009-09-11 2010-09-09 Dispositif de distribution de liquide Active EP2475585B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP25184660.6A EP4596110A3 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet
EP16175337.1A EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0956278A FR2950036B1 (fr) 2009-09-11 2009-09-11 Dispositif de distribution de liquide
PCT/FR2010/051877 WO2011030062A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide

Related Child Applications (6)

Application Number Title Priority Date Filing Date
EP22201129.8A Division EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175337.1A Division-Into EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175337.1A Division EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A Division-Into EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet
EP16175332.2A Division EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet
EP25184660.6A Division EP4596110A3 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort

Publications (2)

Publication Number Publication Date
EP2475585A1 EP2475585A1 (fr) 2012-07-18
EP2475585B1 true EP2475585B1 (fr) 2018-01-17

Family

ID=42097280

Family Applications (5)

Application Number Title Priority Date Filing Date
EP10768998.6A Active EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide
EP25184660.6A Pending EP4596110A3 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A Active EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175337.1A Active EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A Withdrawn EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet

Family Applications After (4)

Application Number Title Priority Date Filing Date
EP25184660.6A Pending EP4596110A3 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A Active EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175337.1A Active EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A Withdrawn EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet

Country Status (10)

Country Link
US (1) US8863998B2 (enrdf_load_stackoverflow)
EP (5) EP2475585B1 (enrdf_load_stackoverflow)
JP (1) JP5739890B2 (enrdf_load_stackoverflow)
CN (1) CN102712395B (enrdf_load_stackoverflow)
BR (1) BR112012005428B1 (enrdf_load_stackoverflow)
ES (1) ES2961272T3 (enrdf_load_stackoverflow)
FR (1) FR2950036B1 (enrdf_load_stackoverflow)
IN (1) IN2012DN02150A (enrdf_load_stackoverflow)
PL (2) PL4147990T3 (enrdf_load_stackoverflow)
WO (1) WO2011030062A1 (enrdf_load_stackoverflow)

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FR2929249B1 (fr) 2008-03-27 2012-02-17 Rexam Pharma La Verpilliere Dispositif de distribution de liquide contenu dans un reservoir
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FR2980378B1 (fr) 2011-09-22 2016-02-26 Rexam Healthcare La Verpillier Dispositif de distribution de liquide sous forme de gouttes
FR2989290B1 (fr) * 2012-04-17 2014-05-16 Rexam Dispensing Sys Systeme de distribution d’un produit fluide contenu dans un recipient
EP2700588B1 (en) * 2012-08-21 2015-04-01 Aptar France SAS Dispensing closure having a vent valve
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FR3019067B1 (fr) * 2014-03-25 2016-04-22 Albea Le Treport Systeme de distribution d'un produit fluide conditionne dans un reservoir
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
EP3197792B1 (de) * 2014-09-24 2019-01-16 RPC Bramlage GmbH Zum ausdrücken von flüssiger bis pastöser masse ausgebildete kunststofftube
KR101984116B1 (ko) 2015-01-12 2019-05-31 켄달리온 테라퓨틱스 인코포레이티드 마이크로-액적 전달 장치 및 방법
JP2018521000A (ja) 2015-05-29 2018-08-02 シドネキシス，インク． Ｄ２ｏで安定化された医薬製剤
US10888454B2 (en) 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
WO2018141350A1 (de) * 2017-02-01 2018-08-09 Silgan Dispensing Systems Hemer Gmbh Austragvorrichtung für ein flüssiges medium
JP7219757B2 (ja) 2017-08-30 2023-02-08 ノボ・ノルデイスク・エー／エス 保存剤を有する流れ連通ユニット
WO2019042801A1 (en) 2017-08-30 2019-03-07 Novo Nordisk A/S MULTI-PURPOSE DRUG DELIVERY DEVICE FOR MEDICAMENTS WITH LESS PRESERVATIVES
JP7436363B2 (ja) 2017-12-08 2024-02-21 ノバルティス アーゲー 流体送達アライメントシステム
US12186234B2 (en) 2018-04-12 2025-01-07 Bausch + Lomb Ireland Limited Topical ocular delivery methods and devices for use in the same
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
JP7301874B2 (ja) 2018-04-13 2023-07-03 ノボ・ノルデイスク・エー／エス 非接続構成および接続構成を有する流れ連通ユニット
FR3080844B1 (fr) * 2018-05-07 2020-06-05 Horus Pharma Dispositif de conditionnement et distribution d'un produit avec flacon et embout doseur muni d'un filtre
WO2020010116A1 (en) 2018-07-03 2020-01-09 Kedalion Therapeutics, Inc. Topical ocular delivery devices and methods for using the same
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
WO2021028602A1 (en) * 2019-08-15 2021-02-18 Obrist Closures Switzerland Gmbh Closure
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
IL297215A (en) 2020-04-17 2022-12-01 Kedallon Therapeutics Inc Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
EP4212451B1 (de) 2020-10-02 2024-09-11 Aptar Radolfzell GmbH Tropfenspender
US11904330B2 (en) * 2022-02-28 2024-02-20 L'oreal Cosmetic dispenser with accordion bladder valve system

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Also Published As

Publication number Publication date
EP4596110A2 (fr) 2025-08-06
EP4147990A1 (fr) 2023-03-15
ES2961272T3 (es) 2024-03-11
EP3090957A1 (fr) 2016-11-09
BR112012005428B1 (pt) 2019-07-09
EP4147990B1 (fr) 2025-06-25
CN102712395B (zh) 2015-02-11
FR2950036B1 (fr) 2011-12-16
EP4596110A3 (fr) 2025-10-15
PL3090957T3 (pl) 2024-01-03
FR2950036A1 (fr) 2011-03-18
PL4147990T3 (pl) 2025-10-13
EP3090956A1 (fr) 2016-11-09
CN102712395A (zh) 2012-10-03
WO2011030062A1 (fr) 2011-03-17
EP3090957B1 (fr) 2023-08-09
EP2475585A1 (fr) 2012-07-18
JP5739890B2 (ja) 2015-06-24
US8863998B2 (en) 2014-10-21
IN2012DN02150A (enrdf_load_stackoverflow) 2015-08-07
US20120223106A1 (en) 2012-09-06
BR112012005428A2 (pt) 2016-04-12
JP2013504496A (ja) 2013-02-07

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