EP2451361B1 - Occluseur - Google Patents
Occluseur Download PDFInfo
- Publication number
- EP2451361B1 EP2451361B1 EP10724243.0A EP10724243A EP2451361B1 EP 2451361 B1 EP2451361 B1 EP 2451361B1 EP 10724243 A EP10724243 A EP 10724243A EP 2451361 B1 EP2451361 B1 EP 2451361B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- occluder
- coupling part
- region
- wires
- expanded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00619—Locking means for locking the implement in expanded state
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00862—Material properties elastic or resilient
Definitions
- the present invention relates to an occluder according to the preamble of patent claim 1.
- Occluders are implants used to occlude passageways or openings in circulatory systems, such as blood vessels or shunt connections, and are typically positioned and expanded via a sheath introduced into a vein. Occluders are used in particular for closing openings in the heart or in another body passage of the human or animal body. They serve, for example, to occlude a persistent ductus arteriosus (PDA), an atrial septal defect (ASD) or a ventricular septal defect (VSD). Other applications in the human and animal body are possible.
- PDA persistent ductus arteriosus
- ASD atrial septal defect
- VSD ventricular septal defect
- occluders In the prior art, the most varied embodiments of occluders are known. You can, for example, be designed as a spiral spring or can be stretched like an umbrella. You can also close the passage only from one side or from both sides. These occluders can usually be made into an elongated shape so that they can be brought by means of the catheter to the passage, which is to be closed. There, the occluder is released and he takes either automatically or led his expanded form of use.
- WO 2005/074813 discloses an occluder, according to the preamble of claim 1, with two expansion units and two closure bodies, which rest on one side of the passage.
- This occluder is in the Figures 1 and 2 shown.
- the expansion units are formed by wires 3, which are held with a first end in a first coupling part 1 and with a second end in a second coupling part 2.
- the closure bodies are circular membranes 4, 5, which are penetrated by the wires 3.
- these membranes 4, 5 are stretched by the wires 3. They close the body passage from both sides.
- the coupling parts 1, 2 can be in accordance with the expanded appearance FIG. 2 stuck together, so that the occluder is fixed in this form.
- WO 2007/115117 is an occluder with both sides of the body passage adjacent expansion units known, the distance between the expansion units is adaptable to the depth of the passage.
- the occluder according to the invention for closing an opening in a circulation system can be converted from a compact appearance extending along a longitudinal axis into an expanded appearance extending transversely to the longitudinal axis.
- the occluder has a first expansion unit and a second expansion unit, which lie in the expanded appearance on each side of the opening.
- the occluder further includes a first coupling part and a second coupling part engageable with each other so as to fix the occluder in its expanded appearance.
- the first coupling part has an area which in the expanded appearance at least partially extends between the first and second expansion unit. According to the invention, this region is designed to be stretchable along, ie in the direction of, the longitudinal axis. Preferably, it is stretchable against a restoring force, that is designed to be resilient or elastic.
- the distance between the two expansion units and, if present, between two closure bodies can be adjusted automatically. If the occluder is placed in the body opening to be closed and brought into its expanded appearance and the two coupling parts are connected to each other, the depth of the opening or the thickness of the surrounding body wall determines the distance between the two expansion units.
- the stretchable area is stretched accordingly, so that the expansion units and, if present, the closure body, adapt to the wall and can lie as flat as possible. The opening is thereby optimally closed and acting as a fixing expansion units are optimally against the wall.
- the expandable region may be provided on the distal and / or proximal coupling part.
- Proximal here means the doctor and thus the entry point in the body facing and distal to the doctor facing away, so patient side.
- the expansion unit can itself form a closure unit for closing the opening or it can span a separate closure body.
- the area is cylindrical. It may be a coil spring or be formed by a grid structure.
- the first coupling part having this area preferably has a cylindrical hollow shaft which can be connected in a plug-in manner to the second coupling part, wherein the hollow shaft comprises the expandable area.
- the hollow shaft comprises the expandable area.
- other types of connections between the first and second coupling parts are possible.
- a threaded connection may be present.
- the coupling parts are preferably made of metal or plastic or combinations thereof.
- the stretchable region is made of metal.
- the occluder has a structure as in the aforementioned WO 2005/074813 is described, wherein the hollow shaft of the one coupling part or a holder is designed to be stretchable.
- the hollow shaft of the one coupling part or a holder is designed to be stretchable.
- other embodiments of occluders can also be provided according to the invention with stretchable coupling parts.
- the first expansion unit is attached to the first coupling part and the second expansion unit is attached to the second coupling part.
- the expansion units comprise wires, the first ends of which are held in the coupling parts, the wires of each expansion unit in the expanded form forming a substantially flat structure resting on either side of the opening.
- the closure body is a membrane which is penetrated by the wires.
- the membrane may be circular or have a different shape. It can preferably be clamped by means of the wires in the expanded appearance, for example by these fold by external force in rosette-like expansion units
- the two expansion units and, if present, the membranes are mirror-symmetrical to one another.
- the second coupling part has a cylindrical neck, which can be inserted into the hollow shaft of the first coupling part, wherein the neck has a circumferential retaining bead at its free end and wherein the first coupling part has a groove running inside the hollow shaft for connection to the retention bead.
- This embodiment can be particularly in an occluder according to the initially described WO 2005/074813 or another occluder, wherein in an example not forming part of the invention the coupling member need not necessarily have a stretchable region.
- an occluder according to the prior art is shown.
- This occluder can, as described below, provided with a fiction coupling part.
- This occluder is a preferred embodiment.
- teaching according to the invention can also be applied to other occluders.
- the occluder has a distal coupling part 1 and a proximal coupling part 2.
- the coupling parts 1, 2 are preferably made of plastic or metal or combinations thereof.
- the middle region described below is preferably made of metal. For example, it consists of Phynox or Nitinol.
- wires 3 which are held with their first ends in the distal coupling part 1 and with their second ends in the proximal coupling part 2.
- the wires 3 and the sleeves 33 described below are preferably made of platinum iridium or nitinol or a resorbable material.
- the occluder further comprises two diaphragms 4, 5, each of which has a central passage opening 41, 51 and peripheral passage openings 40, 50 uniformly distributed over its circumference.
- the membranes 4, 5 are preferably made of PET or Dacron.
- the peripheral through holes 40, 50 are penetrated by the wires 3.
- the individual wires 3 are subdivided into a distal wire section 30, a middle wire section 31 lying between the two membranes 4, 5 and a proximal wire section 32.
- the wires 3 are provided with sleeves held immovably on the wires, which define the relative position of the membranes 4, 5 to these sections 30, 31, 32. On the sleeves can also be dispensed with or they can be replaced by similar acting means.
- the central passage openings 41, 51 have such a large diameter that they can be penetrated by the distal and / or proximal coupling part 1, 2.
- the two coupling parts 1, 2 each have a flange 11, 21, the outer diameter is preferably greater than the diameter of the through holes 41, 51st
- FIG. 1 it can be seen how the occluder can be inserted into a body opening.
- the occluder has a compressed appearance. This is in FIG. 1 not played.
- the occluder is elongated and the wires 3 are approximately fully stretched. As a result, the membranes 4, 5 are crumpled or folded together.
- the occluder can be brought by means of a catheter 6 in place of the opening to be closed.
- This catheter 6 is in FIG. 1 reproduced only with its distal end. It has a hollow catheter body 60, which is preferably formed by a flexible tube. On this catheter body 60, a rigid head with an internal thread is attached at its end. With this internal thread, the catheter 6 with an external thread 20 (see FIG. 8 ) of the proximal coupling part 2 of the occluder.
- a catheter tube 61 extends, which passes through the proximal coupling part 2 and which merges into a catheter tip.
- the catheter tube is preferably designed to be flexible, wherein it can exhibit different hardnesses along its length and in particular can also have a stiff region.
- This catheter tip is connected to the distal coupling part 1.
- a guidewire 62 penetrating the catheter tube 61 facilitates insertion of the compressed occluder.
- the occluder is compressed and brought to its expanded appearance by applying an axial tensile force transmitted via the catheter system to the wires 3.
- the wires 3 form a proximal and a distal expansion unit and the membranes 4, 5 a distal and a proximal closure body.
- the occluder can also be brought into its expanded form by pushing the proximal coupling part 2 towards the distal coupling part 1 by means of the catheter body 60 and thus compressing the occluder.
- These units and these closure bodies come to lie on one side of the passage to be closed.
- the wires 3 thereby form approximately flat structures. They have been folded into two rosette-like or flower-shaped formations when they have joined together. So they turn into these structures (to twist).
- FIG. 2 Such an expanded state is in FIG. 2 shown.
- the distal wire sections 31 of the wires 3 form a first expansion unit and the proximal wire sections 32 of the wires 3 form a second expansion unit.
- These two expansion units span the membranes 4, 5 and fix the occluder on either side of a passage through a body wall.
- the tube 61 is retracted even further, or the catheter body 60 is pushed further, so that the two coupling parts 1, 2 interlock and fix the occluder in the clamped position.
- the connections between catheter and occluder are released and the catheter is removed.
- At least one of the two coupling parts is now provided with an expandable region, wherein at least part of this region comes to rest between the two expansion units 30, 32 in the expanded state of the occluder.
- the distal coupling part 1 is provided with such a portion 12.
- FIGS. 3, 4 and 5 a first embodiment of such a distal coupling part 1 is shown, which has a hollow shaft.
- the basic shape of the coupling part 1 is cylindrical and it is hollow throughout with an inlet opening and an outlet opening. In the region of the proximal inlet opening, an internal thread for connection to the catheter tube 61 is preferably present.
- the coupling part 1 has a distal end piece 10 with an end flange 11.
- the end flange 11 has a larger outer diameter than the central through-opening 41 of the distal membrane 4.
- receiving openings are provided in the end piece 10 or in the end flange 11 in order to receive and hold the ends of the wires 3.
- At the end piece 10 of the stretchable region 12 connects. It preferably has a constant outer diameter. This outer diameter is equal to or smaller than the diameter of the central through-hole 41 of the distal membrane 4, and preferably also the proximal membrane 5.
- the stretchable region 12 is as in FIG. 5 is recognizable, provided with a grid structure. Webs 121 are detached from slots 120.
- This grid structure can stretch along the longitudinal axis of the occluder or along the longitudinal axis of the distal coupling part 1, so that the distal coupling part 1 is extended by the external application of force, ie by the wall of the opening to be closed.
- the longitudinal axis of the occluder and of the distal coupling part extend congruently to each other and they are provided with the reference numeral 7 in the figures.
- To the stretchable area 12 includes a plug 13, which with a encircling retaining lug 130 is provided.
- This insertion piece 13 can be inserted into a corresponding receiving socket of the associated proximal coupling part 2 and fixed by means of the retention nose 130 in a corresponding inner groove of the proximal coupling part 2.
- FIG. 6a and 6b a second embodiment is shown.
- the distal coupling part is formed substantially the same as in the example described above.
- the lattice structure of the stretchable portion 12 has a different shape.
- the webs and slots are narrower than in the first example.
- the stretchable region 12 formed as a spiral spring, or the stretchable region 12 is provided with a helically circumferential slot.
- the proximal coupling part 2 is inserted into the distal coupling part 1.
- the proximal coupling part 2 according to FIG. 8 has a threaded connector 20 with an external thread for connection to the catheter body 60.
- the receiving body 22 then follows with the receiving openings 220 in which the ends of the wires 3 are held.
- a plug-in connection 23 with an encircling end Retaining bead 230 forms the distal end of this coupling part 2.
- the distal coupling part 1 has a distal end piece 10 ', which is already designed as a flange, with receiving openings 100.
- the proximal end of this coupling part 1 is formed by a receiving socket 13 ', in which the insertion piece 23 can be inserted.
- receiving socket 13 ' is a groove 130' is provided, in which the retaining bead 230 engages, as shown in FIG. 10 is recognizable.
- the coupling can alternatively also be the same as the coupling according to the in the FIGS. 3, 4 and 6b illustrated embodiments.
- the embodiment according to the FIGS. 8 to 10 has a stretchable area 12 which can be the same as in the examples described above.
- distal coupling part 1 is formed in two parts.
- the main body which comprises the expandable region 12, is preferably made of metal or plastic.
- This base body 12 is surrounded at one end by a sleeve 10 'which forms the end piece of the distal coupling part 1.
- the sleeve 10 ' is preferably pushed over the distal end of the expandable portion 12 and held there in particular form-fitting manner.
- the expandable portion 12 may have at this distal end a radially outwardly projecting flange which may snap into a corresponding, inner circumferential groove or shoulder of the sleeve 10 '.
- the distal end piece 10 'and the proximal coupling part 2 are preferably made of plastic. This two-part design and the mentioned choice of material can also be applied to the other embodiments described here.
- the occluder is placed in a closed body opening.
- the rosette-like bent wires 3 and the membranes 4, 5 abut on both sides of the body wall W.
- the coupling parts 1, 2 are brought into engagement with each other, preferably inserted into one another. It can be seen how the stretchable region 12 lying between the expansion units 3 and between the membranes 4, 5 adapts to the external conditions and expands, so that the expansion units 3 and the membranes 4, 5 can lie against the wall W as flat as possible on both sides ,
- the occluder according to the invention thus allows an automatic adjustment of the distance between two expansion and / or closure units according to the structural conditions at the location of the opening to be closed.
- distal coupling part 30 distal wire section 10 distal end piece 31 middle wire section 10 ' distal end piece 32 proximal wire section 100 receiving opening 33 shell 11 end flange 12 stretchable area 4 distal membrane 120 slot 40 peripheral passage opening 121 web 41 central passage opening 13 push-in 13 ' receiving socket 5 proximal membrane 130 Retention tab 50 peripheral passage opening 130 ' groove 51 central passage opening 2 proximal coupling part 6 catheter 20 threaded connector 60 catheter body 21 flange 61 catheter tube 22 receiving body 62 guidewire 220 receiving opening 23 push-in 7 longitudinal axis 230 retaining bead W wall 3 wire
Claims (15)
- Occluseur destiné à fermer une ouverture dans un système de circuit, dans lequel l'occluseur peut être converti d'un état compact, s'étendant le long d'un axe longitudinal (7), à un état expansé, dans lequel l'occluseur présente une première unité d'expansion et une deuxième unité d'expansion, qui s'appliquent dans l'état expansé chacune sur un côté de l'ouverture, et dans lequel l'occluseur présente en outre une première pièce de couplage (1) et une deuxième pièce de couplage (2), qui peuvent être mises en prise l'une avec l'autre, de telle manière qu'elles fixent l'occluseur dans son état expansé, dans lequel la première pièce de couplage (1) présente une zone (12) qui, dans l'état expansé, s'étend au moins en partie entre la première et la deuxième unités d'expansion, caractérisé en ce que cette zone (12) est réalisée sous forme extensible le long de l'axe longitudinal (7).
- Occluseur selon la revendication 1, dans lequel cette zone (12) est réalisée sous forme élastique.
- Occluseur selon l'une des revendications 1 ou 2, dans lequel cette zone (12) est de forme cylindrique.
- Occluseur selon l'une quelconque des revendications 1 à 3, dans lequel cette zone (12) est formée par un ressort hélicoïdal.
- Occluseur selon l'une quelconque des revendications 1 à 3, dans lequel cette zone (12) est formée par une structure de grille.
- Occluseur selon l'une quelconque des revendications 1 à 5, dans lequel la première pièce de couplage (1) présentant cette zone (12) présente un arbre creux cylindrique, qui peut être assemblé par engagement avec la deuxième pièce de couplage (2), dans lequel l'arbre creux comprend la zone extensible (12).
- Occluseur selon l'une quelconque des revendications 1 à 6, dans lequel la zone extensible (12) est fabriquée en métal.
- Occluseur selon l'une quelconque des revendications 1 à 7, dans lequel la première unité d'expansion est fixée sur la première pièce de couplage (1) et la deuxième unité d'expansion est fixée sur la deuxième pièce de couplage (2).
- Occluseur selon la revendication 8, dans lequel les unités d'expansion comprennent des fils (3), dont les extrémités sont maintenues dans les pièces de couplage (1, 2), dans lequel les fils (3) de chaque unité d'expansion forment, dans l'état expansé, une structure essentiellement plate, qui s'applique respectivement sur un côté de l'ouverture.
- Occluseur selon l'une quelconque des revendications 1 à 9, dans lequel au moins une des deux unités d'expansion présente un corps de fermeture (4, 5) .
- Occluseur selon la revendication 10, dans lequel le corps de fermeture est une membrane (4, 5), qui est traversée par les fils (3).
- Occluseur selon l'une quelconque des revendications 1 à 11, dans lequel les deux unités d'expansion sont réalisées de façon miroir symétrique l'une par rapport à l'autre.
- Occluseur selon les revendications 9 et 10, dans lequel le corps de fermeture (4, 5) peut être serré au moyen des fils (3) de l'unité d'expansion correspondante dans l'état expansé.
- Occluseur selon l'une des revendications 9 ou 13, dans lequel les fils (3) sont maintenus par leur première extrémité dans la première pièce de couplage (1) et par leur deuxième extrémité dans la deuxième pièce de couplage (2).
- Occluseur selon la revendication 6, dans lequel la deuxième pièce de couplage (2) présente un embout cylindrique (23), qui peut être engagé dans l'arbre creux (13') de la première pièce de couplage (1), dans lequel l'embout (23) présente un bourrelet de retenue périphérique (230) à son extrémité libre et dans lequel la première pièce de couplage (1) présente une rainure (130') s'étendant à l'intérieur de l'arbre creux (13') en vue de l'assemblage avec le bourrelet de retenue (230).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01073/09A CH701417A1 (de) | 2009-07-10 | 2009-07-10 | Okkluder. |
CH00086/10A CH701394A2 (de) | 2009-07-10 | 2010-01-22 | Okkluder. |
PCT/CH2010/000155 WO2011003213A1 (fr) | 2009-07-10 | 2010-06-15 | Occluseur |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2451361A1 EP2451361A1 (fr) | 2012-05-16 |
EP2451361B1 true EP2451361B1 (fr) | 2013-11-06 |
Family
ID=42710817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10724243.0A Active EP2451361B1 (fr) | 2009-07-10 | 2010-06-15 | Occluseur |
Country Status (9)
Country | Link |
---|---|
US (1) | US9636095B2 (fr) |
EP (1) | EP2451361B1 (fr) |
JP (1) | JP5770176B2 (fr) |
CN (1) | CN102469996B (fr) |
BR (1) | BR112012000455B1 (fr) |
CH (1) | CH701394A2 (fr) |
ES (1) | ES2444969T3 (fr) |
RU (1) | RU2533972C2 (fr) |
WO (1) | WO2011003213A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2524653A1 (fr) | 2011-05-17 | 2012-11-21 | Carag AG | Elément d'occlusion |
EP3028648B1 (fr) * | 2011-05-19 | 2019-07-10 | Terumo Puerto Rico L.L.C. | Adaptateur de gaine procédurale pour dispositif de fermeture vasculaire |
BR112016007023B1 (pt) * | 2013-10-10 | 2022-01-25 | Carag Ag | Oclusor para obstrução de uma passagem em um sistema circulatório |
RU2655531C2 (ru) * | 2016-07-27 | 2018-05-28 | Общество с ограниченной ответственностью "НаноМед" | Окклюдер для врожденных пороков сердца с мембраной из биоинтегрируемого материала |
CN110215252B (zh) * | 2018-03-02 | 2021-12-03 | 上海微创医疗器械(集团)有限公司 | 封堵器及医疗器械 |
CN109199656A (zh) * | 2018-09-06 | 2019-01-15 | 葛明均 | 一种血管支架及血管扩张元件 |
CN110974315B (zh) * | 2019-11-19 | 2021-07-20 | 先健科技(深圳)有限公司 | 封堵器 |
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RU5914U1 (ru) * | 1997-02-20 | 1998-02-16 | Научный центр сердечно-сосудистой хирургии им.А.Н.Бакулева РАМН | Устройство для закрытия сообщений между полостями сердца и сосудов |
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US8870913B2 (en) * | 2006-03-31 | 2014-10-28 | W.L. Gore & Associates, Inc. | Catch system with locking cap for patent foramen ovale (PFO) occluder |
US8551135B2 (en) * | 2006-03-31 | 2013-10-08 | W.L. Gore & Associates, Inc. | Screw catch mechanism for PFO occluder and method of use |
US8109946B2 (en) * | 2006-03-31 | 2012-02-07 | W.L. Gore & Associates, Inc. | Adjustable length patent foramen ovale (PFO) occluder and catch system |
US7972361B2 (en) * | 2006-06-19 | 2011-07-05 | Cardia, Inc. | Occlusion device with flexible spring connector |
US7691115B2 (en) * | 2006-06-19 | 2010-04-06 | Cardia, Inc. | Occlusion device with flexible fabric connector |
EP1891902A1 (fr) * | 2006-08-22 | 2008-02-27 | Carag AG | Dispositif d'occlusion |
CN200960183Y (zh) * | 2006-09-29 | 2007-10-17 | 中国人民解放军第四军医大学 | 一种可塑性支气管封堵器 |
US9005242B2 (en) | 2007-04-05 | 2015-04-14 | W.L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US8715319B2 (en) * | 2007-09-28 | 2014-05-06 | W.L. Gore & Associates, Inc. | Catch member for septal occluder with adjustable-length center joint |
CN201082203Y (zh) * | 2007-10-26 | 2008-07-09 | 先健科技(深圳)有限公司 | 心脏缺损封堵器 |
-
2010
- 2010-01-22 CH CH00086/10A patent/CH701394A2/de not_active Application Discontinuation
- 2010-06-15 EP EP10724243.0A patent/EP2451361B1/fr active Active
- 2010-06-15 CN CN201080031088.3A patent/CN102469996B/zh active Active
- 2010-06-15 US US13/383,357 patent/US9636095B2/en active Active
- 2010-06-15 RU RU2012102505/14A patent/RU2533972C2/ru active
- 2010-06-15 BR BR112012000455A patent/BR112012000455B1/pt active IP Right Grant
- 2010-06-15 JP JP2012518717A patent/JP5770176B2/ja active Active
- 2010-06-15 WO PCT/CH2010/000155 patent/WO2011003213A1/fr active Application Filing
- 2010-06-15 ES ES10724243.0T patent/ES2444969T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
ES2444969T3 (es) | 2014-02-27 |
CN102469996B (zh) | 2014-11-12 |
CH701394A2 (de) | 2011-01-14 |
EP2451361A1 (fr) | 2012-05-16 |
US20120179190A1 (en) | 2012-07-12 |
BR112012000455A2 (pt) | 2016-02-16 |
RU2533972C2 (ru) | 2014-11-27 |
JP5770176B2 (ja) | 2015-08-26 |
US9636095B2 (en) | 2017-05-02 |
CN102469996A (zh) | 2012-05-23 |
RU2012102505A (ru) | 2013-08-20 |
WO2011003213A1 (fr) | 2011-01-13 |
BR112012000455B1 (pt) | 2020-04-07 |
JP2012531980A (ja) | 2012-12-13 |
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