EP2393028A3 - Medikamentenauswahlverfahren - Google Patents

Medikamentenauswahlverfahren Download PDF

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Publication number
EP2393028A3
EP2393028A3 EP20110001368 EP11001368A EP2393028A3 EP 2393028 A3 EP2393028 A3 EP 2393028A3 EP 20110001368 EP20110001368 EP 20110001368 EP 11001368 A EP11001368 A EP 11001368A EP 2393028 A3 EP2393028 A3 EP 2393028A3
Authority
EP
European Patent Office
Prior art keywords
methods
selecting
genotype
patient
genes encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20110001368
Other languages
English (en)
French (fr)
Other versions
EP2393028A2 (de
EP2393028B1 (de
Inventor
David A. Mrazek
Dennis J. O'kane
John L. Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Mayo Clinic in Florida
Original Assignee
Mayo Foundation for Medical Education and Research
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, Mayo Clinic in Florida filed Critical Mayo Foundation for Medical Education and Research
Publication of EP2393028A2 publication Critical patent/EP2393028A2/de
Publication of EP2393028A3 publication Critical patent/EP2393028A3/de
Application granted granted Critical
Publication of EP2393028B1 publication Critical patent/EP2393028B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/10Ontologies; Annotations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Bioethics (AREA)
  • Primary Health Care (AREA)
  • Medicinal Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Business, Economics & Management (AREA)
EP11001368.7A 2003-02-20 2004-02-20 Verfahren zur Auswahl von Antidepressiva-Medikationen Expired - Lifetime EP2393028B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44854703P 2003-02-20 2003-02-20
EP04713404.4A EP1599576B1 (de) 2003-02-20 2004-02-20 Verfahren zur auswahl von antidepressiva-medikationen

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP04713404.4 Division 2004-02-20
EP04713404.4A Division-Into EP1599576B1 (de) 2003-02-20 2004-02-20 Verfahren zur auswahl von antidepressiva-medikationen
EP04713404.4A Division EP1599576B1 (de) 2003-02-20 2004-02-20 Verfahren zur auswahl von antidepressiva-medikationen

Publications (3)

Publication Number Publication Date
EP2393028A2 EP2393028A2 (de) 2011-12-07
EP2393028A3 true EP2393028A3 (de) 2012-02-29
EP2393028B1 EP2393028B1 (de) 2015-09-30

Family

ID=32908604

Family Applications (2)

Application Number Title Priority Date Filing Date
EP04713404.4A Expired - Lifetime EP1599576B1 (de) 2003-02-20 2004-02-20 Verfahren zur auswahl von antidepressiva-medikationen
EP11001368.7A Expired - Lifetime EP2393028B1 (de) 2003-02-20 2004-02-20 Verfahren zur Auswahl von Antidepressiva-Medikationen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP04713404.4A Expired - Lifetime EP1599576B1 (de) 2003-02-20 2004-02-20 Verfahren zur auswahl von antidepressiva-medikationen

Country Status (6)

Country Link
US (6) US8401801B2 (de)
EP (2) EP1599576B1 (de)
JP (3) JP5348840B2 (de)
DK (2) DK1599576T3 (de)
ES (2) ES2557885T3 (de)
WO (1) WO2004074456A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8401801B2 (en) 2003-02-20 2013-03-19 Mayo Foundation For Medical Education And Research Methods for selecting medications
US8688385B2 (en) * 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
CA3113166A1 (en) 2004-09-30 2006-04-13 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
EP3223182A1 (de) * 2005-11-29 2017-09-27 Children's Hospital Medical Center Optimierung und individualisierung von medikamentenauswahl und -dosierung
EP1976426A4 (de) * 2006-01-19 2011-01-19 Samuel R Valenti Medizinisches diagnosesystem und verfahren
WO2007133506A2 (en) * 2006-05-09 2007-11-22 University Of Louisville Research Foundation , Inc. Personalized medicine management software
WO2008052167A2 (en) * 2006-10-27 2008-05-02 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication
WO2008076434A2 (en) * 2006-12-18 2008-06-26 Theragenetics Predicting a response to risperidone
US8099298B2 (en) 2007-02-14 2012-01-17 Genelex, Inc Genetic data analysis and database tools
US7795033B2 (en) * 2007-03-19 2010-09-14 The United States Of America As Represented By The Department Of Health And Human Services Methods to predict the outcome of treatment with antidepressant medication
JP2011501276A (ja) * 2007-10-12 2011-01-06 ペイシェンツライクミー, インコーポレイテッド 健康関連の転帰を予測するためのオンラインコミュニティを使用した自己改善方法
US8688416B2 (en) * 2008-10-20 2014-04-01 Michael Fearon Methods and systems for improved pharmaceutical intervention in coagulation control
US8315815B2 (en) 2008-12-30 2012-11-20 The Invention Science Fund I, Llc Computational methods and systems for suggesting modulators of CYP450 as treatment options
US8073633B2 (en) * 2008-12-30 2011-12-06 The Invention Science Fund I, Llc Computational methods and systems for suggesting modulators of CYP450 as treatment options
US8321151B2 (en) 2008-12-30 2012-11-27 The Invention Science Fund I, Llc Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity
WO2010090203A1 (ja) 2009-02-04 2010-08-12 株式会社トクヤマ 多結晶シリコンの製造法
CA2758481C (en) 2009-04-30 2018-03-20 Patientslikeme, Inc. Systems and methods for encouragement of data submission in online communities
US9558320B2 (en) * 2009-10-26 2017-01-31 Genomas, Inc. Physiogenomic method for predicting drug metabolism reserve for antidepressants and stimulants
JP5672705B2 (ja) * 2010-01-26 2015-02-18 住友化学株式会社 発光装置およびその製造方法
US10435746B2 (en) 2010-10-21 2019-10-08 Mayo Foundation For Medical Education And Research Methods for selecting medications for treating patients having attention-deficit hyperactivity disorder
CN110838348A (zh) * 2010-11-01 2020-02-25 皇家飞利浦电子股份有限公司 包括专有测试的特许使用费的自动化代理的体外诊断测试
US20120209081A1 (en) * 2011-02-11 2012-08-16 Abbas Sadeghian Method of preventing patient injury
US9235686B2 (en) 2012-01-06 2016-01-12 Molecular Health Gmbh Systems and methods for using adverse event data to predict potential side effects
WO2014055398A1 (en) 2012-10-05 2014-04-10 Siemens Healthcare Diagnostics Inc. Method for detecting an increased risk or incidence of colorectal cancer
US10210312B2 (en) 2013-02-03 2019-02-19 Youscript Inc. Systems and methods for quantification and presentation of medical risk arising from unknown factors
US20140243211A1 (en) 2013-02-28 2014-08-28 Indiana University Research & Technology Corporation Blood biomarkers for suicidality
US20170253928A1 (en) * 2013-03-15 2017-09-07 Pathway Genomics Corporation Method and system to predict response to treatments for mental disorders
US20140274764A1 (en) * 2013-03-15 2014-09-18 Pathway Genomics Corporation Method and system to predict response to treatments for mental disorders
US20190055603A1 (en) * 2015-04-28 2019-02-21 Proove Biosciences, Inc. System and method for processing genotype information relating to drug metabolism
WO2016176482A1 (en) * 2015-04-28 2016-11-03 Proove Biosciences, Inc. System and method for processing genotype information relating to non-opioid response
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
CN108291259A (zh) 2015-06-12 2018-07-17 印第安纳大学研究与技术公司 使用组合的基因组和临床风险评估预测自杀倾向
US12071669B2 (en) 2016-02-12 2024-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for detection of abnormal karyotypes
EP3635130A4 (de) 2017-05-12 2021-06-09 Indiana University Research and Technology Corporation Präzisionsmedikament zur behandlung und prävention von suizidalität
CN120636518A (zh) 2017-05-12 2025-09-12 密歇根大学董事会 个体和队列药理学表型预测平台
US12417825B2 (en) 2017-09-15 2025-09-16 Alden Scientific, Inc. Systems and methods for collecting and analyzing comprehensive medical information
WO2019083024A1 (ja) * 2017-10-27 2019-05-02 シスメックス株式会社 遺伝子解析方法、遺伝子解析装置、管理サーバ、遺伝子解析システム、プログラム、および記録媒体
JP7320345B2 (ja) * 2017-10-27 2023-08-03 シスメックス株式会社 遺伝子解析方法、遺伝子解析装置、遺伝子解析システム、プログラム、および記録媒体
US10950354B1 (en) * 2018-03-02 2021-03-16 Allscripts Software, Llc Computing system for pharmacogenomics
US11894139B1 (en) 2018-12-03 2024-02-06 Patientslikeme Llc Disease spectrum classification
US11965206B2 (en) 2018-12-21 2024-04-23 John Stoddard Method of dosing a patient with multiple drugs using adjusted phenotypes of CYP450 enzymes
AU2020326626A1 (en) * 2019-08-02 2022-03-10 Tempus Ai, Inc. Data-based mental disorder research and treatment systems and methods
CN110643689A (zh) * 2019-10-29 2020-01-03 陕西佰美基因股份有限公司 一种检测HTR2A基因rs6313位点的TaqMan探针实时荧光PCR方法及其引物探针组合
EP4329759A4 (de) 2021-04-30 2025-07-16 Mind Medicine Inc Lsd-salzkristallformen
EP4387624A4 (de) 2021-08-19 2025-07-30 Mind Medicine Inc Formulierungen von d-lysrgsäurediethylester mit sofortiger freisetzung für therapeutische anwendungen
AR132917A1 (es) 2023-03-22 2025-08-13 Neomente Corp Método para la selección de fármacos neuropsiquiátricos para el tratamiento de la depresión

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002012434A2 (en) * 2000-08-10 2002-02-14 Glaxo Group Limited A global electronic medicine response profile testing network

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5833599A (en) 1993-12-13 1998-11-10 Multum Information Services Providing patient-specific drug information
DE19782097T1 (de) 1996-11-06 1999-10-14 Sequenom Inc Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger
US20020010595A1 (en) 1998-02-27 2002-01-24 Kapp Thomas L. Web-based medication management system
CN1304512A (zh) * 1998-04-03 2001-07-18 三角药品公司 为疗法选择提供指导的系统、方法和计算机程序产品
US6183963B1 (en) 1998-10-23 2001-02-06 Signalgene Detection of CYP1A1, CYP3A4, CYP2D6 and NAT2 variants by PCR-allele-specific oligonucleotide (ASO) assay
WO2000050639A2 (en) * 1999-02-22 2000-08-31 Variagenics, Inc. Gene sequence variations with utility in determining the treatment of disease
US20010034023A1 (en) * 1999-04-26 2001-10-25 Stanton Vincent P. Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
US6297014B1 (en) * 1999-07-02 2001-10-02 Cedars-Sinai Medical Center Genetic test to determine non-responsiveness to statin drug treatment
AU2001231091A1 (en) * 2000-01-21 2001-07-31 Vincent P. Stanton Jr. Identification of genetic components of drug response
JP2001256305A (ja) * 2000-03-13 2001-09-21 Kazutoshi Mogi 遺伝子検査データ活用方法
WO2001079540A2 (en) * 2000-04-18 2001-10-25 Virco Bvba Methods for measuring drug resistance
US20020010552A1 (en) * 2000-05-26 2002-01-24 Hugh Rienhoff System for genetically characterizing an individual for evaluation using genetic and phenotypic variation over a wide area network
US20020076774A1 (en) 2000-06-21 2002-06-20 Chunhua Yan Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
JP2002024385A (ja) 2000-06-30 2002-01-25 Coreflow Technologies:Kk 遺伝子情報管理システム及びその管理方法
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
JPWO2002025519A1 (ja) * 2000-09-20 2004-01-29 株式会社東芝 遺伝子による診療情報提供方法、診療情報提供端末及び診療情報受給端末
WO2002025528A1 (en) 2000-09-21 2002-03-28 Theradoc.Com, Inc. Systems and methods for manipulating medical data via a decision support system
US6450956B1 (en) 2000-11-06 2002-09-17 Siemens Corporate Research, Inc. System and method for treatment and outcome measurement analysis
JP2002197189A (ja) 2000-12-26 2002-07-12 Sanyo Electric Co Ltd 薬品テーラーメイドシステム
JP2002245171A (ja) 2001-02-13 2002-08-30 Canon Sales Co Inc 医療情報管理装置、その方法、プログラム、記憶媒体
US20030170176A1 (en) 2001-03-14 2003-09-11 Mcgill University Individualization of therapy with antipsychotics
JP2002318858A (ja) * 2001-04-19 2002-10-31 Toshitada Kameda 医療計画作成支援システム及びコンピュータプログラム
US20020187483A1 (en) * 2001-04-20 2002-12-12 Cerner Corporation Computer system for providing information about the risk of an atypical clinical event based upon genetic information
WO2003008637A2 (en) 2001-07-17 2003-01-30 Xanthus Life Sciences, Inc. Use of genotyping in the individualization of therapy
US7529685B2 (en) * 2001-08-28 2009-05-05 Md Datacor, Inc. System, method, and apparatus for storing, retrieving, and integrating clinical, diagnostic, genomic, and therapeutic data
US7461006B2 (en) 2001-08-29 2008-12-02 Victor Gogolak Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data
US20030105596A1 (en) 2001-10-29 2003-06-05 Goldstein David Benjamin Methods for evaluating responses of a group of test subjects to a drug or other clinical treatment and for predicting responses in other subjects
US20030108938A1 (en) * 2001-11-06 2003-06-12 David Pickar Pharmacogenomics-based clinical trial design recommendation and management system and method
US20030157110A1 (en) 2002-01-07 2003-08-21 Millennium Pharmaceuticals, Inc. Methods for the treatment of metabolic disorders, including obesity and diabetes
US7274707B2 (en) 2002-03-07 2007-09-25 Koninklijke Philips Electronics N. V. Coexistence of stations capable of different modulation schemes in a wireless local area network
US20030204415A1 (en) * 2002-04-30 2003-10-30 Calvin Knowlton Medical data and medication selection and distribution system
US7809585B1 (en) 2002-06-12 2010-10-05 Anvita, Inc. System and method for patient-specific optimization of medical therapy by simultaneous symbolic reasoning in all clinical dimensions
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
US8401801B2 (en) 2003-02-20 2013-03-19 Mayo Foundation For Medical Education And Research Methods for selecting medications
US20040193446A1 (en) 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
WO2005038049A2 (en) 2003-10-06 2005-04-28 Heinrich Guenther System and method for optimizing drug therapy
US7813880B2 (en) 2004-03-25 2010-10-12 University Of Maryland, Baltimore Apparatus and method for providing optimal concentrations for medication infusions
AU2005241496A1 (en) 2004-05-03 2005-11-17 Cygene Laboratories, Inc. Method and system for a comprehensive knowledge-based anonymous testing and reporting, and providing selective access to test results and report
US20050260549A1 (en) 2004-05-19 2005-11-24 Feierstein Roslyn E Method of analyzing question responses to select among defined possibilities and means of accomplishing same
US7546285B1 (en) 2004-09-24 2009-06-09 Sprint Communications Company L.P. System and method for scoring development concepts
KR101178463B1 (ko) 2004-12-21 2012-09-07 아카데미아 시니카 와파린의 감도를 예측하는 유전적 변이체
WO2006075254A2 (en) 2005-01-13 2006-07-20 Progenika Biopharma, S.A. Methods and products for in vitro genotyping
US20060280786A1 (en) 2005-06-14 2006-12-14 Rabinow Barrett E Pharmaceutical formulations for minimizing drug-drug interactions
FR2887663A1 (fr) 2005-06-24 2006-12-29 Ippm Holding Sa Procede et systeme d'information pour generer des donnees d'optimisation d'un traitement medical, et equipement mis en oeuvre dans ce systeme
EP3223182A1 (de) 2005-11-29 2017-09-27 Children's Hospital Medical Center Optimierung und individualisierung von medikamentenauswahl und -dosierung
US20140046696A1 (en) * 2012-08-10 2014-02-13 Assurerx Health, Inc. Systems and Methods for Pharmacogenomic Decision Support in Psychiatry

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002012434A2 (en) * 2000-08-10 2002-02-14 Glaxo Group Limited A global electronic medicine response profile testing network

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EVANS WILLIAM E ET AL: "Pharmacogenomics: Translating functional genomics into rational therapeutics", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 487 - 491, XP002193947, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.286.5439.487 *

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ES2557885T3 (es) 2016-01-29
JP2010273681A (ja) 2010-12-09
US20130311202A1 (en) 2013-11-21
EP2393028A2 (de) 2011-12-07
US20070003931A1 (en) 2007-01-04
EP1599576B1 (de) 2016-04-27
DK1599576T3 (en) 2016-08-01
JP2007525154A (ja) 2007-09-06
US8401801B2 (en) 2013-03-19
HK1164503A1 (en) 2012-09-21
JP5348840B2 (ja) 2013-11-20
EP1599576A2 (de) 2005-11-30
US20230420139A1 (en) 2023-12-28
JP5438610B2 (ja) 2014-03-12
JP5438524B2 (ja) 2014-03-12
EP2393028B1 (de) 2015-09-30
JP2010176661A (ja) 2010-08-12
WO2004074456A3 (en) 2006-07-27
US20200048712A1 (en) 2020-02-13
DK2393028T3 (en) 2016-01-11
US20160237494A1 (en) 2016-08-18
ES2575903T3 (es) 2016-07-04

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