EP2336139A3 - Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux - Google Patents

Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux Download PDF

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Publication number
EP2336139A3
EP2336139A3 EP10178414A EP10178414A EP2336139A3 EP 2336139 A3 EP2336139 A3 EP 2336139A3 EP 10178414 A EP10178414 A EP 10178414A EP 10178414 A EP10178414 A EP 10178414A EP 2336139 A3 EP2336139 A3 EP 2336139A3
Authority
EP
European Patent Office
Prior art keywords
salts
isophosphoramide mustard
disclosed
analogs
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10178414A
Other languages
German (de)
English (en)
Other versions
EP2336139A2 (fr
Inventor
Lee Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dekk-Tec Inc
Dekk Tek Inc
Original Assignee
Dekk-Tec Inc
Dekk Tek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dekk-Tec Inc, Dekk Tek Inc filed Critical Dekk-Tec Inc
Publication of EP2336139A2 publication Critical patent/EP2336139A2/fr
Publication of EP2336139A3 publication Critical patent/EP2336139A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP10178414A 2004-10-25 2005-10-25 Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux Withdrawn EP2336139A3 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62208704P 2004-10-25 2004-10-25
US67270705P 2005-04-18 2005-04-18
EP05821125A EP1805192B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP05821125.1 Division 2005-10-25
EP05821125A Division-Into EP1805192B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux

Publications (2)

Publication Number Publication Date
EP2336139A2 EP2336139A2 (fr) 2011-06-22
EP2336139A3 true EP2336139A3 (fr) 2012-01-04

Family

ID=35788704

Family Applications (3)

Application Number Title Priority Date Filing Date
EP10178414A Withdrawn EP2336139A3 (fr) 2004-10-25 2005-10-25 Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux
EP10178422.1A Not-in-force EP2336140B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux
EP05821125A Not-in-force EP1805192B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP10178422.1A Not-in-force EP2336140B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux
EP05821125A Not-in-force EP1805192B1 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux

Country Status (17)

Country Link
US (4) US8232262B2 (fr)
EP (3) EP2336139A3 (fr)
JP (1) JP5336082B2 (fr)
KR (2) KR20130041384A (fr)
CN (3) CN101087800B (fr)
AU (1) AU2005299385B2 (fr)
CA (1) CA2585125C (fr)
DK (2) DK1805192T3 (fr)
ES (2) ES2397165T3 (fr)
HK (2) HK1100945A1 (fr)
IL (3) IL182752A (fr)
NO (1) NO20072478L (fr)
NZ (2) NZ589418A (fr)
PL (1) PL1805192T3 (fr)
PT (1) PT1805192E (fr)
SI (1) SI1805192T1 (fr)
WO (1) WO2006047575A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336139A3 (fr) 2004-10-25 2012-01-04 Dekk-Tec, Inc. Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
KR101505415B1 (ko) * 2007-04-06 2015-03-25 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
BRPI0916739A2 (pt) 2008-07-31 2015-11-03 Ziopharm Oncology Inc síntese e formulações de sais de mostarda de isofosforamida e análogos dos mesmos
EP2401285B1 (fr) * 2009-02-24 2012-10-10 Dekk-Tec, Inc. Complexes des 4-hydroperoxy ifosfamide comme inhibiteur du carcinoma
CN102659841B (zh) * 2012-04-24 2015-03-25 石家庄学院 多元酚磷酰胺衍生物及其制备方法与应用
ES2797376T3 (es) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Composiciones para la administración transdérmica de inhibidores de mTOR
ES2969743T3 (es) 2015-09-10 2024-05-22 Becton Dickinson Co Análogos de la ciclofosfamida para uso como inmunógenos y conjugados en un inmunoensayo para la ciclofosfamida y la ifosfamida
EP3565520A4 (fr) 2017-01-06 2020-08-19 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
JP7206258B2 (ja) 2017-09-21 2023-01-17 ベクトン・ディキンソン・アンド・カンパニー 危険汚染物質の収集キット及び迅速試験
EP3817743A4 (fr) 2018-07-02 2022-07-06 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
US20220033387A1 (en) * 2018-09-25 2022-02-03 The Usa, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
AU2020215639A1 (en) 2019-01-28 2021-08-05 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
CN111943979B (zh) 2020-10-19 2020-12-22 南京卓康医药科技有限公司 一种异环磷酰胺中间体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071134A1 (fr) * 1999-05-24 2000-11-30 Southern Research Institute Analogues d'yperite d'isophosphoramide et utilisation de ceux-ci

Family Cites Families (16)

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SU427945A1 (ru) 1972-07-24 1974-05-15 Институт элементоорганических соединений СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ
JPS5159886A (fr) 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
JPS62198691A (ja) * 1986-02-22 1987-09-02 アスタ・フアルマ・アクチエンゲゼルシヤフト 新規の複素環式化合物、その製法及びこれを含有する腫瘍疾病の治療剤
US4841085A (en) * 1986-06-30 1989-06-20 Board Of Regents, University Of Texas System Aldophosphamides
US5055459A (en) * 1986-06-30 1991-10-08 Board Of Regents, The University Of Texas Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates
WO1993021173A1 (fr) 1992-04-17 1993-10-28 Abbott Laboratories Derives de taxol
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
BR0110087A (pt) 2000-04-13 2004-02-17 Hsc Res Dev Lp Compostos para modular proliferação celular
DE10064312C2 (de) * 2000-12-22 2003-05-22 Degussa Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung
KR101173510B1 (ko) 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
EP2336139A3 (fr) 2004-10-25 2012-01-04 Dekk-Tec, Inc. Sels d'ypérite d'isophosphoramide et analogues de ceux-ci utilisés en tant qu'agents anti-tumoraux
KR101505415B1 (ko) * 2007-04-06 2015-03-25 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
BRPI0916739A2 (pt) * 2008-07-31 2015-11-03 Ziopharm Oncology Inc síntese e formulações de sais de mostarda de isofosforamida e análogos dos mesmos

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Publication number Priority date Publication date Assignee Title
WO2000071134A1 (fr) * 1999-05-24 2000-11-30 Southern Research Institute Analogues d'yperite d'isophosphoramide et utilisation de ceux-ci

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MILLIS K K ET AL: "COMPARISON OF THE PROTONATION OF ISOPHOSPHORAMIDE MUSTARD AND PHOSPHORAMIDE MUSTARD", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, 1 January 1995 (1995-01-01), pages 2166 - 2175, XP002453053, ISSN: 0022-2623, DOI: 10.1021/JM00012A017 *
SPEARS C PAUL: "Nucleophilic selectivity ratios of model and clinical alkylating agents by 4-(4'-nitrobenzyl)pyridine competition", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 19, no. 3, 1 January 1981 (1981-01-01), pages 496 - 504, XP008091839, ISSN: 0026-895X *
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Also Published As

Publication number Publication date
CN101087800B (zh) 2015-01-07
NO20072478L (no) 2007-06-25
EP2336140A2 (fr) 2011-06-22
KR20070121632A (ko) 2007-12-27
JP2008517949A (ja) 2008-05-29
IL182752A (en) 2012-09-24
IL211936A (en) 2012-12-31
US20080267945A1 (en) 2008-10-30
US20130149296A1 (en) 2013-06-13
US9346836B2 (en) 2016-05-24
PL1805192T3 (pl) 2013-03-29
WO2006047575A3 (fr) 2006-08-10
IL182752A0 (en) 2007-07-24
KR101292026B1 (ko) 2013-08-01
US20150152125A1 (en) 2015-06-04
EP1805192B1 (fr) 2012-10-17
EP2336140B1 (fr) 2016-01-27
KR20130041384A (ko) 2013-04-24
HK1209752A1 (en) 2016-04-08
DK1805192T3 (da) 2013-02-04
NZ555323A (en) 2010-12-24
CN101087800A (zh) 2007-12-12
NZ589418A (en) 2012-03-30
CA2585125C (fr) 2014-04-22
EP2336139A2 (fr) 2011-06-22
AU2005299385B2 (en) 2011-06-16
US8232262B2 (en) 2012-07-31
IL211936A0 (en) 2011-05-31
HK1100945A1 (en) 2007-11-16
US8795659B2 (en) 2014-08-05
JP5336082B2 (ja) 2013-11-06
EP2336140A3 (fr) 2012-01-11
ES2565929T3 (es) 2016-04-07
US7678778B2 (en) 2010-03-16
IL211935A0 (en) 2011-05-31
CA2585125A1 (fr) 2006-05-04
DK2336140T3 (en) 2016-03-21
EP1805192A2 (fr) 2007-07-11
AU2005299385A1 (en) 2006-05-04
ES2397165T3 (es) 2013-03-05
PT1805192E (pt) 2013-01-23
CN103172662A (zh) 2013-06-26
WO2006047575A2 (fr) 2006-05-04
CN104558023A (zh) 2015-04-29
SI1805192T1 (sl) 2013-02-28
US20060089333A1 (en) 2006-04-27

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