NO20072478L - Salter av isofosforamidsennep og analoger av disse som antitumor midler - Google Patents
Salter av isofosforamidsennep og analoger av disse som antitumor midlerInfo
- Publication number
- NO20072478L NO20072478L NO20072478A NO20072478A NO20072478L NO 20072478 L NO20072478 L NO 20072478L NO 20072478 A NO20072478 A NO 20072478A NO 20072478 A NO20072478 A NO 20072478A NO 20072478 L NO20072478 L NO 20072478L
- Authority
- NO
- Norway
- Prior art keywords
- salts
- isophosphoramide mustard
- analogues
- methods
- antitumor agents
- Prior art date
Links
- BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical class ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000002246 antineoplastic agent Substances 0.000 title 1
- -1 aliphatic amines Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62208704P | 2004-10-25 | 2004-10-25 | |
| US67270705P | 2005-04-18 | 2005-04-18 | |
| PCT/US2005/038523 WO2006047575A2 (fr) | 2004-10-25 | 2005-10-25 | Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072478L true NO20072478L (no) | 2007-06-25 |
Family
ID=35788704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072478A NO20072478L (no) | 2004-10-25 | 2007-05-16 | Salter av isofosforamidsennep og analoger av disse som antitumor midler |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7678778B2 (fr) |
| EP (3) | EP2336139A3 (fr) |
| JP (1) | JP5336082B2 (fr) |
| KR (2) | KR20130041384A (fr) |
| CN (3) | CN101087800B (fr) |
| AU (1) | AU2005299385B2 (fr) |
| CA (1) | CA2585125C (fr) |
| DK (2) | DK1805192T3 (fr) |
| ES (2) | ES2397165T3 (fr) |
| HK (2) | HK1100945A1 (fr) |
| IL (3) | IL182752A (fr) |
| NO (1) | NO20072478L (fr) |
| NZ (2) | NZ589418A (fr) |
| PL (1) | PL1805192T3 (fr) |
| PT (1) | PT1805192E (fr) |
| SI (1) | SI1805192T1 (fr) |
| WO (1) | WO2006047575A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1805192E (pt) | 2004-10-25 | 2013-01-23 | Dekk Tec Inc | Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais |
| US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| RU2527531C2 (ru) * | 2007-04-06 | 2014-09-10 | Зайофарм Онколоджи, Инк. | Соли изофосфорамидного иприта и его аналогов |
| WO2010014841A1 (fr) * | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues |
| EP2401285B1 (fr) | 2009-02-24 | 2012-10-10 | Dekk-Tec, Inc. | Complexes des 4-hydroperoxy ifosfamide comme inhibiteur du carcinoma |
| CN102659841B (zh) * | 2012-04-24 | 2015-03-25 | 石家庄学院 | 多元酚磷酰胺衍生物及其制备方法与应用 |
| EP2948134B1 (fr) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Compositions pour une administration transdermique d'inhibiteurs de mtor |
| ES2969743T3 (es) * | 2015-09-10 | 2024-05-22 | Becton Dickinson Co | Análogos de la ciclofosfamida para uso como inmunógenos y conjugados en un inmunoensayo para la ciclofosfamida y la ifosfamida |
| EP3565520A4 (fr) | 2017-01-06 | 2020-08-19 | Palvella Therapeutics, Inc. | Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation |
| US11199529B2 (en) | 2017-09-21 | 2021-12-14 | Becton, Dickinson And Company | Hazardous contaminant collection kit and rapid testing |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| JP7520822B2 (ja) * | 2018-09-25 | 2024-07-23 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用 |
| AU2020215639A1 (en) | 2019-01-28 | 2021-08-05 | Becton, Dickinson And Company | Hazardous contaminant collection device with integrated swab and test device |
| CN111973583A (zh) * | 2020-07-29 | 2020-11-24 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用 |
| CN111943979B (zh) | 2020-10-19 | 2020-12-22 | 南京卓康医药科技有限公司 | 一种异环磷酰胺中间体及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU427945A1 (ru) | 1972-07-24 | 1974-05-15 | Институт элементоорганических соединений | СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ |
| JPS5159886A (fr) | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| ZA871260B (en) * | 1986-02-22 | 1987-09-30 | Asta Werke Ag Chem Fab | Novel heterocyclic compounds having a 2-(2-(n,n-bis-(2-chloroethyl)-diamidophosphoryloxy)ethyl)radical |
| US4841085A (en) * | 1986-06-30 | 1989-06-20 | Board Of Regents, University Of Texas System | Aldophosphamides |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| JPH07505887A (ja) | 1992-04-17 | 1995-06-29 | アボツト・ラボラトリーズ | タキソール誘導体 |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| AU773061B2 (en) | 1999-05-24 | 2004-05-13 | Southern Research Institute | Isophosphoramide mustard analogs and use thereof |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| MXPA02010089A (es) | 2000-04-13 | 2004-08-19 | Hsc Res Dev Lp | Compuestos para modular la proliferacion celular. |
| DE10064312C2 (de) * | 2000-12-22 | 2003-05-22 | Degussa | Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung |
| EP1506203B1 (fr) | 2002-08-23 | 2007-01-03 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, leurs intermediaires, leurs analogues et leurs utilisations |
| PT1805192E (pt) * | 2004-10-25 | 2013-01-23 | Dekk Tec Inc | Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais |
| RU2527531C2 (ru) * | 2007-04-06 | 2014-09-10 | Зайофарм Онколоджи, Инк. | Соли изофосфорамидного иприта и его аналогов |
| WO2010014841A1 (fr) * | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues |
-
2005
- 2005-10-25 PT PT58211251T patent/PT1805192E/pt unknown
- 2005-10-25 US US11/257,766 patent/US7678778B2/en not_active Expired - Fee Related
- 2005-10-25 NZ NZ589418A patent/NZ589418A/en not_active IP Right Cessation
- 2005-10-25 CA CA2585125A patent/CA2585125C/fr not_active Expired - Fee Related
- 2005-10-25 SI SI200531655T patent/SI1805192T1/sl unknown
- 2005-10-25 KR KR1020137008506A patent/KR20130041384A/ko not_active Application Discontinuation
- 2005-10-25 US US11/666,215 patent/US8232262B2/en not_active Expired - Fee Related
- 2005-10-25 JP JP2007538185A patent/JP5336082B2/ja not_active Expired - Fee Related
- 2005-10-25 WO PCT/US2005/038523 patent/WO2006047575A2/fr active Application Filing
- 2005-10-25 PL PL05821125T patent/PL1805192T3/pl unknown
- 2005-10-25 EP EP10178414A patent/EP2336139A3/fr not_active Withdrawn
- 2005-10-25 CN CN200580044803.6A patent/CN101087800B/zh not_active Expired - Fee Related
- 2005-10-25 EP EP05821125A patent/EP1805192B1/fr not_active Not-in-force
- 2005-10-25 DK DK05821125.1T patent/DK1805192T3/da active
- 2005-10-25 KR KR1020077011864A patent/KR101292026B1/ko not_active IP Right Cessation
- 2005-10-25 ES ES05821125T patent/ES2397165T3/es active Active
- 2005-10-25 ES ES10178422.1T patent/ES2565929T3/es active Active
- 2005-10-25 EP EP10178422.1A patent/EP2336140B1/fr not_active Not-in-force
- 2005-10-25 CN CN2013100286502A patent/CN103172662A/zh active Pending
- 2005-10-25 AU AU2005299385A patent/AU2005299385B2/en not_active Ceased
- 2005-10-25 NZ NZ555323A patent/NZ555323A/en not_active IP Right Cessation
- 2005-10-25 DK DK10178422.1T patent/DK2336140T3/en active
- 2005-10-25 CN CN201410730089.7A patent/CN104558023A/zh active Pending
-
2007
- 2007-04-23 IL IL182752A patent/IL182752A/en not_active IP Right Cessation
- 2007-05-16 NO NO20072478A patent/NO20072478L/no not_active Application Discontinuation
- 2007-08-16 HK HK07108953.1A patent/HK1100945A1/xx not_active IP Right Cessation
-
2011
- 2011-03-24 IL IL211936A patent/IL211936A/en not_active IP Right Cessation
- 2011-03-24 IL IL211935A patent/IL211935A0/en unknown
-
2012
- 2012-07-03 US US13/541,522 patent/US8795659B2/en not_active Expired - Fee Related
-
2014
- 2014-07-10 US US14/328,125 patent/US9346836B2/en not_active Expired - Fee Related
-
2015
- 2015-10-22 HK HK15110402.4A patent/HK1209752A1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20072478L (no) | Salter av isofosforamidsennep og analoger av disse som antitumor midler | |
| EA200970171A1 (ru) | Производные n-(аминогетероарил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии | |
| CY1112831T1 (el) | Παραγωγα αζαβιρηενυlαμινοβενζοιc acid σαν παραγοντες καταστολης dhodh | |
| NO20085060L (no) | Triazolpyrazinderivater anvendelige som anti-cancermidler | |
| EA200702375A1 (ru) | Производные мочевины, способы их получения и применения | |
| MX2010008101A (es) | Derivados de indol 2-carboxamidas y de azaindol 2-carboxamidas sustituidos con un silanilo, su preparacion y su aplicacion en terapeutica. | |
| MX2010001005A (es) | Derivados de (hetero)aril-metilen-n-cicloalquilcarboxamida condensados de 6 elementos con n como fungicidas. | |
| BR0313160A (pt) | Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto | |
| AP2001002358A0 (en) | Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4- pyrrolidin-1-yl-butyl)ureido]-isothiazole-4-carboxilic acid amide and method of production. | |
| WO2008093024A3 (fr) | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2-carboxamides, leur préparation et leur application en therapeutique | |
| CY1108529T1 (el) | Νεα αζαδικυκλικα παραγωγα, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τα περιεχουν | |
| DE602004019814D1 (de) | Imidazolderivate, verfahren zu deren herstellung und deren anwendungen | |
| NO20063865L (no) | Heterocyklisk substituerte 7-amino-4-kinolon-3-karboksylsyrederivater, fremgangsmate for fremstilling derav og deres anvendelse som medikamenter | |
| WO2007119001A3 (fr) | Derives d 'aminomethyl pyridine, leur preparation et leur application en therapeutique | |
| DK1476470T3 (da) | Stivelsesderivater, stivelse-aktivstof-konjugater, fremgangsmåde til fremstilling af disse og anvendelse af disse som lægemidler | |
| TNSN07395A1 (en) | Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives | |
| TW200745048A (en) | Novel benzimidazole and benzothiazole derivatives, preparation process therefor, application thereof as medicaments, pharmaceutical compositions and novel use especially as CMET inhibitors | |
| NO20073549L (no) | Fremgangsmate for fremstilling av organiske forbindelser | |
| CY1112012T1 (el) | Αμινουχα παραγωγα β-ομοανδροστανων και β-ετεροανδροστανων | |
| NO20054418L (no) | Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse | |
| DE602005019327D1 (de) | Neue 3-phenylpropionsäurederivate zur behandlung von diabetes | |
| NZ504298A (en) | 2,3-methano-amino acid compounds for treating serine protease disorders | |
| HUP0303174A2 (hu) | A terbinafin almasav addíciós sói, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CY1113675T1 (el) | Αλατα μουσταρδας ισοφωσφοραμιδιου και αναλογα αυτων ως αντικαρκινικοι παραγοντες | |
| DK1585728T3 (da) | Iminosyrederivater som inhibitorer af matrix-metalloproteinaser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |