HK1100945A1 - Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents - Google Patents

Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Info

Publication number
HK1100945A1
HK1100945A1 HK07108953.1A HK07108953A HK1100945A1 HK 1100945 A1 HK1100945 A1 HK 1100945A1 HK 07108953 A HK07108953 A HK 07108953A HK 1100945 A1 HK1100945 A1 HK 1100945A1
Authority
HK
Hong Kong
Prior art keywords
analogs
salts
tumor agents
isophosphoramide mustard
isophosphoramide
Prior art date
Application number
HK07108953.1A
Other languages
English (en)
Inventor
Lee Morgan
Original Assignee
Dekk Tec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dekk Tec Inc filed Critical Dekk Tec Inc
Publication of HK1100945A1 publication Critical patent/HK1100945A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK07108953.1A 2004-10-25 2007-08-16 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents HK1100945A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62208704P 2004-10-25 2004-10-25
US67270705P 2005-04-18 2005-04-18
PCT/US2005/038523 WO2006047575A2 (fr) 2004-10-25 2005-10-25 Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux

Publications (1)

Publication Number Publication Date
HK1100945A1 true HK1100945A1 (en) 2007-11-16

Family

ID=35788704

Family Applications (2)

Application Number Title Priority Date Filing Date
HK07108953.1A HK1100945A1 (en) 2004-10-25 2007-08-16 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
HK15110402.4A HK1209752A1 (en) 2004-10-25 2015-10-22 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15110402.4A HK1209752A1 (en) 2004-10-25 2015-10-22 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Country Status (17)

Country Link
US (4) US7678778B2 (fr)
EP (3) EP2336139A3 (fr)
JP (1) JP5336082B2 (fr)
KR (2) KR20130041384A (fr)
CN (3) CN101087800B (fr)
AU (1) AU2005299385B2 (fr)
CA (1) CA2585125C (fr)
DK (2) DK1805192T3 (fr)
ES (2) ES2397165T3 (fr)
HK (2) HK1100945A1 (fr)
IL (3) IL182752A (fr)
NO (1) NO20072478L (fr)
NZ (2) NZ589418A (fr)
PL (1) PL1805192T3 (fr)
PT (1) PT1805192E (fr)
SI (1) SI1805192T1 (fr)
WO (1) WO2006047575A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1805192E (pt) 2004-10-25 2013-01-23 Dekk Tec Inc Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
RU2527531C2 (ru) * 2007-04-06 2014-09-10 Зайофарм Онколоджи, Инк. Соли изофосфорамидного иприта и его аналогов
WO2010014841A1 (fr) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues
EP2401285B1 (fr) 2009-02-24 2012-10-10 Dekk-Tec, Inc. Complexes des 4-hydroperoxy ifosfamide comme inhibiteur du carcinoma
CN102659841B (zh) * 2012-04-24 2015-03-25 石家庄学院 多元酚磷酰胺衍生物及其制备方法与应用
EP2948134B1 (fr) 2013-01-24 2020-03-04 Palvella Therapeutics, Inc. Compositions pour une administration transdermique d'inhibiteurs de mtor
ES2969743T3 (es) * 2015-09-10 2024-05-22 Becton Dickinson Co Análogos de la ciclofosfamida para uso como inmunógenos y conjugados en un inmunoensayo para la ciclofosfamida y la ifosfamida
EP3565520A4 (fr) 2017-01-06 2020-08-19 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
US11199529B2 (en) 2017-09-21 2021-12-14 Becton, Dickinson And Company Hazardous contaminant collection kit and rapid testing
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
JP7520822B2 (ja) * 2018-09-25 2024-07-23 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用
AU2020215639A1 (en) 2019-01-28 2021-08-05 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
CN111943979B (zh) 2020-10-19 2020-12-22 南京卓康医药科技有限公司 一种异环磷酰胺中间体及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU427945A1 (ru) 1972-07-24 1974-05-15 Институт элементоорганических соединений СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ
JPS5159886A (fr) 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
ZA871260B (en) * 1986-02-22 1987-09-30 Asta Werke Ag Chem Fab Novel heterocyclic compounds having a 2-(2-(n,n-bis-(2-chloroethyl)-diamidophosphoryloxy)ethyl)radical
US4841085A (en) * 1986-06-30 1989-06-20 Board Of Regents, University Of Texas System Aldophosphamides
US5055459A (en) * 1986-06-30 1991-10-08 Board Of Regents, The University Of Texas Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates
JPH07505887A (ja) 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
AU773061B2 (en) 1999-05-24 2004-05-13 Southern Research Institute Isophosphoramide mustard analogs and use thereof
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
MXPA02010089A (es) 2000-04-13 2004-08-19 Hsc Res Dev Lp Compuestos para modular la proliferacion celular.
DE10064312C2 (de) * 2000-12-22 2003-05-22 Degussa Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung
EP1506203B1 (fr) 2002-08-23 2007-01-03 Sloan-Kettering Institute For Cancer Research Synthese d'epothilones, leurs intermediaires, leurs analogues et leurs utilisations
PT1805192E (pt) * 2004-10-25 2013-01-23 Dekk Tec Inc Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais
RU2527531C2 (ru) * 2007-04-06 2014-09-10 Зайофарм Онколоджи, Инк. Соли изофосфорамидного иприта и его аналогов
WO2010014841A1 (fr) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues

Also Published As

Publication number Publication date
CA2585125C (fr) 2014-04-22
US7678778B2 (en) 2010-03-16
IL211936A (en) 2012-12-31
CN103172662A (zh) 2013-06-26
ES2565929T3 (es) 2016-04-07
KR20070121632A (ko) 2007-12-27
US20150152125A1 (en) 2015-06-04
EP2336140A3 (fr) 2012-01-11
ES2397165T3 (es) 2013-03-05
US20130149296A1 (en) 2013-06-13
CA2585125A1 (fr) 2006-05-04
NO20072478L (no) 2007-06-25
PL1805192T3 (pl) 2013-03-29
EP2336140A2 (fr) 2011-06-22
EP2336139A3 (fr) 2012-01-04
NZ555323A (en) 2010-12-24
IL182752A (en) 2012-09-24
US8795659B2 (en) 2014-08-05
JP2008517949A (ja) 2008-05-29
SI1805192T1 (sl) 2013-02-28
CN101087800B (zh) 2015-01-07
WO2006047575A2 (fr) 2006-05-04
EP2336139A2 (fr) 2011-06-22
DK2336140T3 (en) 2016-03-21
AU2005299385A1 (en) 2006-05-04
EP1805192B1 (fr) 2012-10-17
EP2336140B1 (fr) 2016-01-27
US20060089333A1 (en) 2006-04-27
US20080267945A1 (en) 2008-10-30
DK1805192T3 (da) 2013-02-04
JP5336082B2 (ja) 2013-11-06
WO2006047575A3 (fr) 2006-08-10
US9346836B2 (en) 2016-05-24
CN101087800A (zh) 2007-12-12
KR20130041384A (ko) 2013-04-24
CN104558023A (zh) 2015-04-29
PT1805192E (pt) 2013-01-23
IL211935A0 (en) 2011-05-31
AU2005299385B2 (en) 2011-06-16
EP1805192A2 (fr) 2007-07-11
IL182752A0 (en) 2007-07-24
NZ589418A (en) 2012-03-30
KR101292026B1 (ko) 2013-08-01
US8232262B2 (en) 2012-07-31
IL211936A0 (en) 2011-05-31
HK1209752A1 (en) 2016-04-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20161025