BRPI0520433A2 - sais farmaceuticamente aceitáveis de 2,4,6-trimetil-3-hidroxipiridina, com ácidos dicarboxìlicos inferiores e método para preparação dos mesmos - Google Patents

sais farmaceuticamente aceitáveis de 2,4,6-trimetil-3-hidroxipiridina, com ácidos dicarboxìlicos inferiores e método para preparação dos mesmos

Info

Publication number
BRPI0520433A2
BRPI0520433A2 BRPI0520433-0A BRPI0520433A BRPI0520433A2 BR PI0520433 A2 BRPI0520433 A2 BR PI0520433A2 BR PI0520433 A BRPI0520433 A BR PI0520433A BR PI0520433 A2 BRPI0520433 A2 BR PI0520433A2
Authority
BR
Brazil
Prior art keywords
trimethyl
hydroxypyridine
pharmaceutically acceptable
acceptable salts
dicarboxylic acids
Prior art date
Application number
BRPI0520433-0A
Other languages
English (en)
Inventor
Leonid Dmitrievich Smipnov
Michail Arkadievich Ostrovsky
Aleksey Michailovich Sipyagin
Aleksandr Evgenievich Doncov
Original Assignee
Marvel Lifesciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marvel Lifesciences Ltd filed Critical Marvel Lifesciences Ltd
Publication of BRPI0520433A2 publication Critical patent/BRPI0520433A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

SAIS FARMACEUTICAMENTE ACEITáVEIS DE 2,4,6-TRIMETIL-3-HIDROXIPIRIDINA, COM áCIDOS DICARBOXìLICOS INFERIORES E MéTODO PARA PREPARAçãO DOS MESMOS. A presente invenção refere-se ao campo de medicamentos, notadamente, a novos compostos biologicamente ativos, especificamente, a derivados de 2,4,6-trimetil-3-hidroxipiridina e sais dos mesmos (composto 1), apresentando atividade antioxidante, geroprotetora e antiisquêmica. Os sais do composto (1) são preparados mediante reação de quantidades eqúimolares de 2,4,6-trimetil-3-hidroxipiridina e ácido dicarboxílico, em uma solução de um álcool inferior a uma temperatura de 6O-100°C, seguido de tratamento da massa reacional com um solvente orgânico por 2-5 horas, a uma temperaturade 1O-15°C.
BRPI0520433-0A 2004-05-12 2005-07-11 sais farmaceuticamente aceitáveis de 2,4,6-trimetil-3-hidroxipiridina, com ácidos dicarboxìlicos inferiores e método para preparação dos mesmos BRPI0520433A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2004114314/04A RU2276138C2 (ru) 2004-05-12 2004-05-12 Вещество, обладающее антиоксидантной, геропротекторной и противоишемической активностью, и способ его получения
PCT/IB2005/003636 WO2007017713A1 (en) 2004-05-12 2005-07-11 The substance having antioxidant, geroprotective and anti-ischemic activity and method for preparing thereof

Publications (1)

Publication Number Publication Date
BRPI0520433A2 true BRPI0520433A2 (pt) 2009-05-12

Family

ID=36021747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520433-0A BRPI0520433A2 (pt) 2004-05-12 2005-07-11 sais farmaceuticamente aceitáveis de 2,4,6-trimetil-3-hidroxipiridina, com ácidos dicarboxìlicos inferiores e método para preparação dos mesmos

Country Status (11)

Country Link
US (1) US8044210B2 (pt)
EP (1) EP1911746B1 (pt)
JP (1) JP2009501712A (pt)
CN (1) CN101233110B (pt)
AT (1) ATE440819T1 (pt)
BR (1) BRPI0520433A2 (pt)
CA (1) CA2614857A1 (pt)
DE (1) DE602005016317D1 (pt)
PL (1) PL1911746T3 (pt)
RU (1) RU2276138C2 (pt)
WO (1) WO2007017713A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2276138C2 (ru) 2004-05-12 2006-05-10 Марвел Лайф Сайнсез Лтд. Вещество, обладающее антиоксидантной, геропротекторной и противоишемической активностью, и способ его получения
EA011238B1 (ru) * 2007-04-03 2009-02-27 Марвел Лайфсайнсез Лтд. Средство, обладающее противогипоксическим, противоинсультным, улучшающим память действием
KR101214353B1 (ko) * 2007-12-18 2012-12-20 드미트리 발레리에비치 비류코프 치환된 3-히드록시피리딘 및 그것의 약학적 조성물
EA201001326A1 (ru) * 2008-02-19 2011-04-29 Марвел Лайфсайнсез Лтд. Стерильные офтальмологические композиции и способ их получения
EP2265253A2 (en) * 2008-02-19 2010-12-29 Marvel Lifesciences Limited Oral dosage form containing a pyridinol derivative
EA201001327A1 (ru) * 2008-02-19 2011-04-29 Марвел Лайфсайнсез Лтд. Инъецируемые составы и способ их получения
WO2014012593A1 (en) 2012-07-19 2014-01-23 HandelsOrt AG Alkyl substituted 3-hydroxypyridines for the treatment of depression
RU2671200C2 (ru) * 2015-12-07 2018-10-30 Закрытое Акционерное Общество "Фармфирма "Сотекс" Способ получения 6-метил-2-этилпиридин-3-ол соли (2S)-2-ацетаминопентандиовой кислоты

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2847926B2 (ja) * 1990-08-01 1999-01-20 トヨタ自動車株式会社 自動変速機の変速制御装置
JPH0496277A (ja) * 1990-08-06 1992-03-27 Fujitsu Ltd 不揮発性半導体記憶装置
RU2070010C1 (ru) * 1993-08-31 1996-12-10 Эдуард Сергеевич Аветисов Средство антиоксидантной защиты сред и тканей глаза
RU2112512C1 (ru) 1995-09-22 1998-06-10 Иванов Евгений Васильевич Биологичеcки активная пищевая добавка "глутапирон", обладающая антиканцерогенным и геропротекторным действием
RU2153872C2 (ru) * 1997-10-15 2000-08-10 Амбалов Юрий Михайлович Способ лечения дифтерии
RU2197199C2 (ru) * 2000-05-12 2003-01-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Способ лечения амблиопии
JP2002017295A (ja) * 2000-07-05 2002-01-22 Yamagami Suehito 眼疾患改善作用及び眼の機能維持作用を有する健康補助食品
RU2250210C1 (ru) * 2003-07-25 2005-04-20 Институт Проблем Химической Физики Российской Академии Наук (Ипхф Ран) Нитроксисукцинат 2,4,6-триметил-3-оксипиридина и способ его получения
RU2276138C2 (ru) 2004-05-12 2006-05-10 Марвел Лайф Сайнсез Лтд. Вещество, обладающее антиоксидантной, геропротекторной и противоишемической активностью, и способ его получения

Also Published As

Publication number Publication date
JP2009501712A (ja) 2009-01-22
EP1911746B1 (en) 2009-08-26
CN101233110A (zh) 2008-07-30
CA2614857A1 (en) 2007-02-15
ATE440819T1 (de) 2009-09-15
EP1911746A1 (en) 2008-04-16
WO2007017713A1 (en) 2007-02-15
DE602005016317D1 (de) 2009-10-08
US20090198068A1 (en) 2009-08-06
PL1911746T3 (pl) 2010-07-30
CN101233110B (zh) 2011-09-14
RU2276138C2 (ru) 2006-05-10
US8044210B2 (en) 2011-10-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2203 DE 26/03/2013.