EP2308588B1 - Dispositif de mélange d'un échantillon de liquide - Google Patents

Dispositif de mélange d'un échantillon de liquide Download PDF

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Publication number
EP2308588B1
EP2308588B1 EP10009070.3A EP10009070A EP2308588B1 EP 2308588 B1 EP2308588 B1 EP 2308588B1 EP 10009070 A EP10009070 A EP 10009070A EP 2308588 B1 EP2308588 B1 EP 2308588B1
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EP
European Patent Office
Prior art keywords
holder
liquid container
cuvette
mixing
transfer arm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10009070.3A
Other languages
German (de)
English (en)
Other versions
EP2308588A3 (fr
EP2308588A2 (fr
Inventor
Achim Herz
Thorsten Michels
Holger Dr. Pufahl
Joerg Dr. Schmiedeskamp
Alexander Wiedekind-Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Siemens Healthcare Diagnostics Products GmbH
Siemens Healthcare Diagnostics GmbH Germany
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Products GmbH, Siemens Healthcare Diagnostics GmbH Germany filed Critical Siemens Healthcare Diagnostics Products GmbH
Publication of EP2308588A2 publication Critical patent/EP2308588A2/fr
Publication of EP2308588A3 publication Critical patent/EP2308588A3/fr
Application granted granted Critical
Publication of EP2308588B1 publication Critical patent/EP2308588B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/24—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a rectilinear movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Definitions

  • the present invention relates to a device for mixing and optionally transporting a fluid sample for use in automated analyzers for microbiology, analytics, forensics or clinical diagnostics.
  • Automated analyzers as routinely used today in microbiology, analytics, forensics, and clinical diagnostics, typically perform a series of repetitive steps. In many of these operations, different materials must be mixed together as evenly as possible in order to provide precise examination results. The need for uniform mixing concerns, in particular, liquid samples, e.g. Blood, serum or plasma samples. For example, they must be uniformly mixed with analysis reagents before being fed to an analysis unit.
  • liquid samples e.g. Blood, serum or plasma samples.
  • a gripper known which consists of two gripping arms, which are pulled together by a spring.
  • This gripper is attached to a holding element which is coupled to a transfer arm.
  • the combination of transfer arm and holding element can eg be part of a robot station for the treatment, manipulation and analysis of chemical, clinical and / or biological samples.
  • this device does not ensure that the vibration caused by the engine arrives in the cuvette in any case.
  • the inventors have observed that in certain cases the vibrations are transmitted at least in part to the transfer arm and thus, for example, the robot station in Vibrations is added, which affects the mixing result and may even endanger the robot station.
  • the transmission of vibration to the cuvette can be affected as soon as parts of the device become caught or jammed.
  • the oscillating vibration of the cuvette may be different due to variations or disturbances of components involved. This is undesirable because in all cuvettes should be mixed as identical as possible across different devices.
  • the motor is moved each time the transfer arm is moved, which may affect the functionality of the device.
  • the EP 742435 A1 discloses a device according to the preamble of claim 1.
  • this movement should preferably also be monitored.
  • This device 20 is not part of the invention.
  • an apparatus for mixing a liquid sample according to claim 1 is provided.
  • the device according to the invention can be e.g. integrate into a laboratory robot and has due to the provided flexible intermediate element has the advantage that it can be ensured that any movements of the shaker are overwhelmingly transferred to the liquid container without reducing the mobility of the holder for the liquid container to an up and down movement.
  • the flexible intermediate element ensures that a planar circular movement, which is generated by a shaker and transmitted via a coupling device to the holder for the liquid container, is not transmitted to the transfer arm. If the plane circular movement, into which the holder for the liquid container is displaced by means of the shaker, were also transferred to the transfer arm, stepping errors would occur in the activation of the transfer arm.
  • the shaker in the present invention is releasably connected to the transfer arm, it does not have to be moved with each movement of the transfer arm, as in the device according to EP 0742435 A1 the case is.
  • the device according to the invention has the advantage that it requires no contact of the contents with other tools for mixing the content of a liquid container to be mixed, since no magnetic particles or magnetic pins are added to the liquid container for mixing must, as is the case with magnetic mixing devices.
  • flexible intermediate element is intended below to designate a device which is mounted between the holder and the stand arm, which cushion the movement of the shaker, which prevents a movement transfer to the stand arm and which allows the holder enough mobility during the shaking to a To ensure optimal and efficient mixing of the liquid in the liquid container, but at the same time is rigid enough so that stand arm and holder cuvettes can accommodate, transport and deliver.
  • the flexible intermediate element consists of an elastic and / or damping material such as - but not limited to - elastomers, urethane rubber, rubber, rubber, foam or spring steel.
  • an elastic and / or damping material such as - but not limited to - elastomers, urethane rubber, rubber, rubber, foam or spring steel.
  • several separate intermediate elements can be used side by side or one above the other to ensure a security against rotation.
  • the flexible intermediate element ensures that the liquid container and not the transfer arm is shaken with any further system components arranged thereon, and that the holder for the liquid container is sufficiently movable (ie shakeable) in order to achieve optimal mixing of the liquid sample in the liquid container. At the same time, it also limits the deflection of the gripper during transport of the vessel due to its thickness.
  • stand arm is intended below to denote a device on which the holder for the liquid container is arranged over the flexible intermediate piece.
  • the stand arm is a transfer arm that can be used to move the holder for the liquid container.
  • the latter makes sense, in particular, when the transfer arm is part of a robotic station for the treatment, manipulation and analysis of chemical, clinical and / or biological samples.
  • the transfer arm serves, for example, for transporting liquid containers, such as e.g. Cuvettes, from a pipetting station to a photometer or a PCR cycler.
  • the transfer arm is robotic. It is furthermore preferably part of a laboratory automaton or laboratory system, for example for microbiology, analytics, forensics or clinical diagnostics.
  • shaker is intended to generally refer to a device that causes liquid in the fluid container to move to achieve thorough mixing.
  • the shaker has a motor-driven eccentric.
  • an eccentric e.g. rotatory are converted into translational movements and vice versa.
  • the motor may be, for example, an electric motor, a servomotor, or a stepping motor.
  • the eccentric can be coaxial, but also driven by a belt drive or a pinion drive.
  • liquid container is intended below to denote a device containing the liquid to be mixed and transported.
  • liquid sample or “sample” shall in the following mean a quantity of liquid such as are commonly used in microbiology, analytics, forensics or clinical diagnostics. Normally the sample will be a subset of the liquid to be analyzed, e.g. in a blood, plasma or serum sample. In exceptional cases, however, the sample may also represent all available liquid.
  • the device further comprises a sensor, with the aid of which the duration, the frequency, and qualitatively the amplitude of the gripper movement and thus the mixing process in the liquid container can be monitored.
  • a sensor is a Hall sensor.
  • a Hall sensor uses the Hall effect to measure magnetic fields and currents or for position detection.
  • a magnet is embedded in the holder for the liquid container whose magnetic field is measured by a fixed Hall sensor. Since the field of the magnet at the location of the Hall sensor decreases with the distance of the Hall sensor from the magnet, the position of the magnet relative to the Hall sensor and thus the distance of the holder can be determined from the value of the magnetic field at the location of the Hall sensor for the liquid container relative to the Hall sensor.
  • the motor and the holder for the liquid container are interconnected only during the mixing process.
  • holder is intended below to designate a device that can hold the liquid container.
  • the holder can grab, hold and release the liquid container. It is advantageous if the holder has an integrally manufactured gripper for the liquid container.
  • the gripping is a basic movement for detecting and holding and establishes the connection between robot or analyzer and workpiece, here liquid container.
  • Decisive for a secure connection are the type of active pairing and the number of contact levels.
  • the active combination can be achieved by force, shape or substance pairing.
  • the hold is generated by exerting a pressure on the workpiece surface.
  • the holding takes place via a shape-identical enclosure of the workpiece. Thereby are at safer Guide the transmitted clamping forces very small.
  • the contact with the workpiece takes place via the utilization of the adhesion.
  • the gripping systems can be subdivided according to their effect into mechanical, pneumatic, magnetic and adhesive systems. These effects can also be used in combination for greater flexibility of the gripping system.
  • mechanical grippers are preferably used, but in particular magnetic grippers can also be used.
  • Mechanical grippers are available as one-finger, two-finger or multi-finger grippers in a rigid, rigid-hinged or elastic design.
  • a gripper which consists of two pliers, which are pulled together by a spring.
  • the production of this gripper is associated with higher costs and a higher cost, since the different parts must be assembled.
  • the gripper preferred here is made of one piece. This allows a reproducible production of higher volumes, since no individual parts assembled and the proper operation of the compound gripper only randomly - but not for each individual piece - must be checked.
  • the one-piece gripper is configured elastically deformable and is in a clamping state. If he moves with sufficient force against an obstacle, it comes to a snap effect and the gripper opens. By moving further in the direction of the obstacle, the gripper encloses the obstacle and by the clamping state it snaps back to as soon as the obstacle is completely enclosed. In addition, the gripper is only on overcoming a release force, which is necessary to reopen the gripper, the enclosed obstacle free again.
  • a liquid container which is preferably a cuvette
  • This liquid container which is preferably a cuvette
  • the holder Upon reaching the cuvette, the holder is pressed on by a cuvette flange and encloses the cuvette by the spring action of the plastic material or the clamping state in a further process. After enclosing the cuvette, the cuvette can be lifted by an upward movement of the holder or the transfer arm. The cuvette is now held and can be moved by moving the transfer arm.
  • Coupled device is intended below to denote a means by which the shaker can be releasably connected to the holder for the liquid container, i. via an eccentric pin and a coupling hole.
  • This coupling device has a coupling hole, which is designed so that it can engage in a complementary device on the shaker.
  • the shaker has a coupling pin in the form of an eccentric pin, which can engage in that complementary coupling hole in the coupling device.
  • the shaker is a motor with eccentric.
  • the shaking device is preferably designed to be movable.
  • an automatic analyzer according to claim 10 for the treatment, manipulation and analysis of chemical and / or biological samples is further provided, which has a device according to the invention according to claim 1.
  • step c it is preferably provided that the mixing process is monitored, for example with the aid of a Hall sensor which registers the movements of a magnet in the holder for the liquid container.
  • step e the container is gripped in a pipetting station after reaction or sample liquid has been pipetted into the container.
  • step f) the container is moved to a different station in a robot / analyzer after completion of the mixing, for example to a photometer, a PCR cycler or the like.
  • step g e.g. be provided that the container is placed in a photometer, a PCR cycler or the like.
  • the shaking device and the holder are coupled to one another only during mixing.
  • Fig. 1 shows a preferred embodiment of the device according to the invention.
  • the device 10 which is part of an analyzer, comprises a transfer arm 11, a holder 12 for a cuvette, a flexible intermediate element (here a disc of rubber) 13, which is arranged between the transfer arm 11 and the cuvette holder 12 Shaking device in the form of a motor 14, a coupling device arranged on the cuvette holder (in this case a coupling hole) 15, which is complementary to an eccentric pin 17 arranged on the motor 14, and a cuvette 16.
  • the coupling hole 15 lowered to the Exzenterpin 17, so that a detachable connection is formed between the two.
  • the movement of the motor 14 can then be transmitted via the eccentric pin 17, which performs a circular movement (see arrow), to the cuvette holder 12 and thus to the cuvette 16.
  • the mixing of the cuvette contents takes place in a rotary motion.
  • the necessary for the mixing mobility of the cuvette holder 12 is ensured by the flexible rubber disc 13, which is repeatedly compressed by the movement of the cuvette holder.
  • the coupling hole 15 has a chamfer arranged at its opening, which contributes to the fact that the coupling hole 15 can always be moved directly onto the eccentric pin 17, without this having to be moved to a certain position beforehand.
  • the device further has a Hall sensor 18, symbolically represented on the transfer arm, which detects the magnetic field emanating from a magnet 19 arranged on the cuvette holder 12 and in particular can measure its movements and pass it on to a control device (not shown).
  • a Hall sensor 18 symbolically represented on the transfer arm, which detects the magnetic field emanating from a magnet 19 arranged on the cuvette holder 12 and in particular can measure its movements and pass it on to a control device (not shown).
  • Fig. 2 shows another embodiment, which is not part of the invention.
  • the device 20 which in turn is part of an analyzer, comprises a transfer arm 21, a holder 22 for a cuvette, a flexible intermediate element (here a disc of rubber) 23, which is arranged between the transfer arm 21 and the cuvette holder 22, a shaking device in the form of a loudspeaker 24, a coupling device 25 arranged on the cuvette holder with a contact element 27, and a cuvette 26.
  • a transfer arm 21 a holder 22 for a cuvette
  • a flexible intermediate element here a disc of rubber
  • the coupling device 25 can be brought into contact with the loudspeaker 24 via the contact element 27.
  • the coupling device 25 is moved by movement of the transfer arm 21 against the speaker 24.
  • the loudspeaker in turn, is connected to a frequency generator 28 which vibrates the former by means of an amplifier (not shown).
  • the vibrations of the loudspeaker 24 can then be transmitted via the contact element 27 to the cuvette holder 22 and thus to the cuvette 26.
  • the mixing of the cuvette contents takes place in a shaking motion, depending on the amplitude and phase of the sound waves of the loudspeaker.
  • the necessary for the mixing mobility of the cuvette holder 22 is ensured by the flexible rubber disc 23.
  • the shaking device is moved in order to produce the detachable connection.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Accessories For Mixers (AREA)

Claims (10)

  1. Dispositif (10) de mélange d'un échantillon de liquide comportant
    a) un bras (11) de transfert pouvant être déplacé robotiquement
    b) une fixation (12) pour un récipient à liquide
    c) au moins un élément (13) intermédiaire souple, qui est disposé entre le bras (11) de transfert pouvant être déplacé robotiquement et la fixation (12) pour le récipient à liquide
    d) un dispositif (14) de secouage et
    e) un dispositif (15) d'accouplement monté sur la fixation pour le récipient à liquide,
    dans lequel, à l'aide du dispositif (15) d'accouplement, une liaison desserable entre le dispositif (14) de secouage et la fixation (12) pour le récipient à liquide peut être ménagée, dans lequel
    le dispositif (14) de secouage a un excentrique entraîné par moteur,
    caractérisé en ce que
    le dispositif (15) d'accouplement comporte un trou d'accouplement, qui est conformé de manière à pouvoir pénétrer dans un dispositif complémentaire du dispositif (14) de secouage et
    le dispositif de secouage a un doigt d'accouplement sous la forme d'une broche d'excentrique, qui peut pénétrer dans le trou d'accouplement complémentaire du dispositif d'accouplement.
  2. Dispositif (10) suivant revendication 1,
    caractérisé en ce que
    l'élément (13) intermédiaire souple est en un matériau élastique et/ou amortissant.
  3. Dispositif (10) suivant revendication 2,
    caractérisé en ce que
    l'élément (13) intermédiaire élastique est constitué d'un disque en caoutchouc.
  4. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    la fixation (12) pour le récipient à liquide peut être mise en mouvement à l'aide du bras (11) de transfert pouvant être déplacé robotiquement.
  5. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    le récipient (10) à liquide est au moins un récipient choisi dans le groupe contenant
    • un récipient de microréaction,
    • une cuvette de photomètre et
    • un récipient de centrifugeuse
  6. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    le dispositif a en outre un capteur à l'aide duquel l'opération de mélange dans le récipient (16) à liquide peut être contrôlée.
  7. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    le dispositif (14) de secouage et la fixation (12) ne sont reliés l'un à l'autre que pendant l'opération de mélange.
  8. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    la fixation (12) pour le récipient à liquide a un élément de préhension d'une seule pièce du récipient (16) à liquide.
  9. Dispositif (10) suivant l'une des revendications précédentes,
    caractérisé en ce que
    le dispositif (14) de secouage est conformé de manière à pouvoir être mis en mouvement.
  10. Appareil d'analyse automatique pour le traitement, la manipulation et l'analyse d'échantillons chimiques et/ou biologiques comportant un dispositif (10) suivant l'une des revendications 1 à 9.
EP10009070.3A 2009-10-10 2010-09-01 Dispositif de mélange d'un échantillon de liquide Active EP2308588B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102009048918A DE102009048918A1 (de) 2009-10-10 2009-10-10 Vorrichtung zum Mischen einer Flüssigkeitsprobe

Publications (3)

Publication Number Publication Date
EP2308588A2 EP2308588A2 (fr) 2011-04-13
EP2308588A3 EP2308588A3 (fr) 2012-10-03
EP2308588B1 true EP2308588B1 (fr) 2015-10-28

Family

ID=43446684

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10009070.3A Active EP2308588B1 (fr) 2009-10-10 2010-09-01 Dispositif de mélange d'un échantillon de liquide

Country Status (5)

Country Link
US (1) US8899821B2 (fr)
EP (1) EP2308588B1 (fr)
JP (1) JP6016324B2 (fr)
DE (1) DE102009048918A1 (fr)
ES (1) ES2554173T3 (fr)

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EP3173794B1 (fr) 2015-11-25 2021-07-21 Siemens Healthcare Diagnostics Products GmbH Procede de transfert d'un volume de liquide dans un appareil d'analyse
EP3196649B1 (fr) * 2016-01-22 2021-08-18 Siemens Healthcare Diagnostics Products GmbH Systeme d'ajustement
EP3211423A1 (fr) 2016-02-23 2017-08-30 Siemens Healthcare Diagnostics Products GmbH Appareil d'analyse automatique ayant des positions de reception pour le recipient de liquide
EP3216517B1 (fr) * 2016-03-10 2018-09-12 Siemens Healthcare Diagnostics Products GmbH Procede de melange d'un liquide dans un appareil d'analyse automatique
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ES2900187T3 (es) 2016-03-17 2022-03-16 Siemens Healthcare Diagnostics Products Gmbh Sistema de aviso para resultados de medición potencialmente erróneos en un analizador automático
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CN109883800B (zh) * 2019-02-18 2021-12-24 深圳唯公生物科技有限公司 样本混匀与移动机构及其方法
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CN108535083A (zh) * 2018-03-29 2018-09-14 叶世雄 一种血液检测用血液震荡混合装置
CN108535083B (zh) * 2018-03-29 2020-09-11 滨州医学院附属医院 一种血液检测用血液震荡混合装置

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ES2554173T3 (es) 2015-12-16
EP2308588A3 (fr) 2012-10-03
EP2308588A2 (fr) 2011-04-13
JP6016324B2 (ja) 2016-10-26
JP2011078969A (ja) 2011-04-21
US8899821B2 (en) 2014-12-02
DE102009048918A1 (de) 2011-04-14
US20110086432A1 (en) 2011-04-14

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