EP2292740B1 - Acinetobacter baumannii-Phage - Google Patents

Acinetobacter baumannii-Phage Download PDF

Info

Publication number
EP2292740B1
EP2292740B1 EP10172708.9A EP10172708A EP2292740B1 EP 2292740 B1 EP2292740 B1 EP 2292740B1 EP 10172708 A EP10172708 A EP 10172708A EP 2292740 B1 EP2292740 B1 EP 2292740B1
Authority
EP
European Patent Office
Prior art keywords
phage
acinetobacter baumannii
phages
present
dsm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP10172708.9A
Other languages
English (en)
French (fr)
Other versions
EP2292740A1 (de
Inventor
Li-Kuang Chen
Nien-Tsung Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical
Original Assignee
Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Found
Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TW098127070A external-priority patent/TWI376418B/zh
Priority claimed from TW098127069A external-priority patent/TWI380777B/zh
Application filed by Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Found, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation filed Critical Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Found
Publication of EP2292740A1 publication Critical patent/EP2292740A1/de
Application granted granted Critical
Publication of EP2292740B1 publication Critical patent/EP2292740B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10211—Podoviridae
    • C12N2795/10231—Uses of virus other than therapeutic or vaccine, e.g. disinfectant

Definitions

  • nosocomial infections occur in an intensive care unit since patients in the intensive care unit have weak immunity and have invasive therapies such as being cannulated. According to statistics, the nosocomial infection rate in an intensive care unit is about from 2% to 3%.
  • the present invention provides an isolated Acinetobacter baumannii phage deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and having a deposition number DSM 23599.
  • the present invention also provides an isolated Acinetobacter baumannii phage deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and having a deposition number DSM 23600.
  • the present invention provides Acinetobacter baumannii phages for sterilizing Acinetobacter baumannii, and for preparing a pharmaceutical composition for treating diseases caused by Acinetobacter baumannii.
  • Acinetobacter baumannii phages are used as a sterilizing agent in health care centers (such as home care nursing), medical centers (such as hospitals, sanitaria, etc.) and medical research institutes, so as to reduce the amount of Acinetobacter baumannii in the environment.
  • Acinetobacter baumannii strains listed in Table 1 were used, in which 35 Acinetobacter baumannii strains were collected from Buddhist Tzu Chi General Hospital, Hualien, and 2 strains were obtained from ATCC (American Type Culture Collection).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (5)

  1. Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist,
    - bei welchem es sich um den Phagen DSM 23599 handelt, wobei der Phage DSM 23599 bei der DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen, Deutschland) hinterlegt ist und die Hinterlegungsnummer DSM 23599 besitzt, oder
    - welcher aus der Gruppe, bestehend aus dem Phagen DSM 23600 und Varianten des Phagen DSM 23600, ausgewählt ist, wobei der Phage DSM 23600 bei der DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen, Deutschland) hinterlegt ist und die Hinterlegungsnummer DSM 23600 besitzt, und wobei jede der Varianten des Phagen DSM 23600 eine oder mehrere Sequenzen aufweist, ausgewählt aus der Gruppe bestehend aus Sequenzen, die mehr als 80% Homologie zu
    SEQ ID NO: 1 und 2 aufweisen und eine RNA-Polymerase des Acinetobacter-baumannii-Phagen codieren, und zu
    SEQ ID NO: 3 und 4 aufweisen und einen Kopf-Schwanz-Konnektor des Acinetobacter-baumannii-Phagen codieren,
    und eine genomische Sequenz mit einer Homologie von mehr als 80% im Vergleich zur genomischen Sequenz des Phagen DSM 23600 aufweist.
  2. Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 1, der Bioaktivität bei pH 4 bis 12 aufweist.
  3. Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach einem der vorstehenden Ansprüche, der Bioaktivität in einem Tensid aufweist.
  4. Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 3, wobei das Tensid ausgewählt ist aus der Gruppe bestehend aus einem anionischen Tensid, einem kationischen Tensid, einem amphoteren Tensid und einem nicht-ionischen Tensid.
  5. Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 4, wobei das Tensid ein nicht-ionisches Tensid ist.
EP10172708.9A 2009-08-12 2010-08-12 Acinetobacter baumannii-Phage Not-in-force EP2292740B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW098127070A TWI376418B (en) 2009-08-12 2009-08-12 Phage of acinetobacter baumannii
TW098127069A TWI380777B (zh) 2009-08-12 2009-08-12 包含噬菌體之活體外殺菌組成物

Publications (2)

Publication Number Publication Date
EP2292740A1 EP2292740A1 (de) 2011-03-09
EP2292740B1 true EP2292740B1 (de) 2017-04-26

Family

ID=43530842

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10172706A Withdrawn EP2292245A1 (de) 2009-08-12 2010-08-12 Desinfektionszusammensetzung mit Phagen
EP10172708.9A Not-in-force EP2292740B1 (de) 2009-08-12 2010-08-12 Acinetobacter baumannii-Phage

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10172706A Withdrawn EP2292245A1 (de) 2009-08-12 2010-08-12 Desinfektionszusammensetzung mit Phagen

Country Status (4)

Country Link
US (2) US20120276612A1 (de)
EP (2) EP2292245A1 (de)
JP (2) JP5651407B2 (de)
AU (2) AU2010212280B2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120276612A1 (en) * 2009-08-12 2012-11-01 Tzu Chi Buddhist General Hospital Phage of acinetobacter baumannii
KR101391332B1 (ko) 2012-05-18 2014-05-07 연세대학교 산학협력단 카바페넴 제제에 내성을 보이는 아시네토박터 속의 균을 용균하는 박테리오파아지
US11058131B2 (en) 2015-04-16 2021-07-13 Kennesaw State University Research And Service Foundation, Inc. Escherichia coli O157:H7 bacteriophage Φ241
TW201710282A (zh) * 2015-09-04 2017-03-16 佛教慈濟醫療財團法人 衍生自鮑氏不動桿菌噬菌體之新穎抗菌胜肽及其用途
AU2017240069B2 (en) 2016-03-31 2024-03-07 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
WO2017173240A1 (en) 2016-03-31 2017-10-05 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
JP2020500860A (ja) 2016-11-23 2020-01-16 ゴジョ・インダストリーズ・インコーポレイテッド プロバイオティック／プレバイオティックな有効成分を含む消毒薬組成物
CN106701690A (zh) * 2016-12-13 2017-05-24 上海交通大学医学院 鲍曼不动杆菌噬菌体SH‑Ab15519及其应用
CN106947714B (zh) * 2017-03-17 2020-09-04 上海申启生物科技有限公司 鲍曼不动杆菌选择性增菌液及其制备方法
KR102275107B1 (ko) * 2018-12-18 2021-07-08 연세대학교 산학협력단 항생제 내성을 갖는 아시네토박터 속의 균을 용균하는 신규한 박테리오파지
KR102189126B1 (ko) * 2018-12-18 2020-12-09 연세대학교 산학협력단 항생제 내성을 갖는 아시네토박터 속의 균을 용균하는 신규한 박테리오파지
US20220333120A1 (en) * 2019-09-11 2022-10-20 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Bactericidal phage vectors
CN110747177A (zh) * 2019-12-01 2020-02-04 吉林大学第一医院 一株鲍曼不动杆菌噬菌体及医用用途
KR102604590B1 (ko) * 2020-09-28 2023-11-23 경북대학교 산학협력단 아시네토박터 바우마니에 대한 사멸능을 가지는 박테리오파지 및 이를 포함하는 조성물
GB202210435D0 (en) * 2022-07-15 2022-08-31 Carus Animal Health Ltd Agricultural compositions and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6290393A (ja) * 1985-10-17 1987-04-24 工業技術院長 製紙工程におけるスライム障害防止方法
GB8918983D0 (en) * 1989-08-21 1989-10-04 Unilever Plc Composition for hygiene purposes
JPH06100409A (ja) * 1992-09-17 1994-04-12 Japan Tobacco Inc 冷凍空調機器用冷却水域における細菌防除法
AU699322B2 (en) * 1994-04-05 1998-12-03 Exponential Biotherapies, Inc. Antibacterial therapy with genotypically modified bacteriophage
CA2251724A1 (en) * 1996-04-15 1997-10-23 Paul Averback Compositions containing bacteriophages and methods of using bacteriophages to treat infections
US6248324B1 (en) * 1997-10-31 2001-06-19 Vincent Fischetti Bacterial phage associated lysing enzymes for treating dermatological infections
US5997862A (en) * 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
CA2430501A1 (en) * 2000-01-11 2001-07-19 Intralytix, Inc. Method for produce sanitation using bacteriophages
US6485902B2 (en) * 2000-06-06 2002-11-26 Thomas E. Waddell Use of bacteriophages for control of escherichia coli O157
JP4471837B2 (ja) * 2002-07-08 2010-06-02 イービーアイ フードセイフティ ビー．ブイ． 食料品及び食品加工工場においてリステリアモノサイトゲネスを制御するための病原性ファージ
ES2363497T3 (es) * 2003-11-19 2011-08-05 Nestec S.A. Fagos aislados y su utilización como desinfectante en alimentos y para la higienización de un entorno de fabricación.
EP2197284B1 (de) * 2007-10-04 2017-04-12 AmpliPhi Biosciences Corporation Antibakterielle zusammensetzungen
KR20090059789A (ko) * 2007-12-07 2009-06-11 주식회사 인트론바이오테크놀로지 활성 생물소재를 포함한 살균조성물, 살균분무기 및 이를이용한 표면 살균방법
DE102008005193A1 (de) * 2008-01-18 2009-07-23 Dahlen, Neithard Bakteriophagenpräparation und Verwendung
RU2580248C9 (ru) * 2009-02-06 2018-01-17 Текнофахе, Инвестигасао Э Десенвольвименто Эм Биотекнолохия, Са Бактериофаг, обладащий активностью против pseudomonas aeruginosa, белки бактериофага и способы их применения
US20120276612A1 (en) * 2009-08-12 2012-11-01 Tzu Chi Buddhist General Hospital Phage of acinetobacter baumannii
PL2847323T3 (pl) * 2012-05-07 2018-10-31 Micreos B.V. Bakteriofag do biokontroli salmonelli i wytwarzania lub przetwarzania żywności

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
JP2011036246A (ja) 2011-02-24
AU2010212270A1 (en) 2011-03-03
AU2010212280A1 (en) 2011-03-03
EP2292245A1 (de) 2011-03-09
JP2011037856A (ja) 2011-02-24
US8273564B2 (en) 2012-09-25
JP5651407B2 (ja) 2015-01-14
JP5464664B2 (ja) 2014-04-09
US20120276612A1 (en) 2012-11-01
US20110038840A1 (en) 2011-02-17
AU2010212270B2 (en) 2015-02-19
AU2010212280B2 (en) 2015-09-24
EP2292740A1 (de) 2011-03-09

Similar Documents

Publication Publication Date Title
EP2292740B1 (de) Acinetobacter baumannii-Phage
CA2191213C (en) Lactobacillus strains of human origin, their compositions and uses thereof
JP6053727B2 (ja) 抗細菌組成物
EP3091992B1 (de) Phagentherapie von e.coli-infektionen
CN108697744A (zh) 假单胞菌感染的噬菌体疗法
WO2016003307A1 (en) Bacteriophage strains, compositions and related methods
JP7449967B2 (ja) 療法バクテリオファージ組成物
US20100291041A1 (en) Bacteriophage preparation and use
WO2009087356A1 (en) Host range change phage
US10435671B2 (en) Bacteriophage strains against proteus mirabilis and use thereof
CN102344911A (zh) 鲍氏不动杆菌的噬菌体
US20040146490A1 (en) Antibacterial therapy for multi-drug resistant bacteria
AboElmaaty et al. Studies on the application of bacteriophages and silver_nanparticles in the treatment of Pseudomonas spp
TW201105241A (en) Bactericide composition comprising a phage
AU2015264918A1 (en) Anti-bacteria compositions
TWI376418B (en) Phage of acinetobacter baumannii
AlHassany et al. Evaluate phage single and cocktail as therapy against bedsores infection causes by some MDR pathogenic bacteria
KR20190058896A (ko) 아시네토박터 바우마니의 박테리오파아지 pbab08
AU2013203570A1 (en) Anti-bacteria compositions

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME RS

17P Request for examination filed

Effective date: 20110909

17Q First examination report despatched

Effective date: 20150512

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20160624

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTC Intention to grant announced (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HUALIEN TZU CHI HOSPITAL, BUDDHIST TZU CHI MEDICAL

INTG Intention to grant announced

Effective date: 20161202

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 887912

Country of ref document: AT

Kind code of ref document: T

Effective date: 20170515

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: PATENTANWALTSKANZLEI NUECKEL, CH

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602010041811

Country of ref document: DE

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20170426

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 887912

Country of ref document: AT

Kind code of ref document: T

Effective date: 20170426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170727

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170726

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170826

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170726

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602010041811

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: OBERDORFSTRASSE 16, 8820 WAEDENSWIL (CH)

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20180129

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20170831

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170812

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20180822

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: MC

Payment date: 20180823

Year of fee payment: 9

Ref country code: FR

Payment date: 20180824

Year of fee payment: 9

Ref country code: DE

Payment date: 20180829

Year of fee payment: 9

Ref country code: IE

Payment date: 20180823

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20180827

Year of fee payment: 9

Ref country code: GB

Payment date: 20180828

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20100812

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602010041811

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20190812

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190902

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190831

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190812

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190812

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170426

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190831

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200303

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190812