EP2292740B1 - Acinetobacter baumannii-Phage - Google Patents
Acinetobacter baumannii-Phage Download PDFInfo
- Publication number
- EP2292740B1 EP2292740B1 EP10172708.9A EP10172708A EP2292740B1 EP 2292740 B1 EP2292740 B1 EP 2292740B1 EP 10172708 A EP10172708 A EP 10172708A EP 2292740 B1 EP2292740 B1 EP 2292740B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- phage
- acinetobacter baumannii
- phages
- present
- dsm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10231—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
Definitions
- nosocomial infections occur in an intensive care unit since patients in the intensive care unit have weak immunity and have invasive therapies such as being cannulated. According to statistics, the nosocomial infection rate in an intensive care unit is about from 2% to 3%.
- the present invention provides an isolated Acinetobacter baumannii phage deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and having a deposition number DSM 23599.
- the present invention also provides an isolated Acinetobacter baumannii phage deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and having a deposition number DSM 23600.
- the present invention provides Acinetobacter baumannii phages for sterilizing Acinetobacter baumannii, and for preparing a pharmaceutical composition for treating diseases caused by Acinetobacter baumannii.
- Acinetobacter baumannii phages are used as a sterilizing agent in health care centers (such as home care nursing), medical centers (such as hospitals, sanitaria, etc.) and medical research institutes, so as to reduce the amount of Acinetobacter baumannii in the environment.
- Acinetobacter baumannii strains listed in Table 1 were used, in which 35 Acinetobacter baumannii strains were collected from Buddhist Tzu Chi General Hospital, Hualien, and 2 strains were obtained from ATCC (American Type Culture Collection).
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (5)
- Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist,- bei welchem es sich um den Phagen DSM 23599 handelt, wobei der Phage DSM 23599 bei der DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen, Deutschland) hinterlegt ist und die Hinterlegungsnummer DSM 23599 besitzt, oder- welcher aus der Gruppe, bestehend aus dem Phagen DSM 23600 und Varianten des Phagen DSM 23600, ausgewählt ist, wobei der Phage DSM 23600 bei der DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen, Deutschland) hinterlegt ist und die Hinterlegungsnummer DSM 23600 besitzt, und wobei jede der Varianten des Phagen DSM 23600 eine oder mehrere Sequenzen aufweist, ausgewählt aus der Gruppe bestehend aus Sequenzen, die mehr als 80% Homologie zuund eine genomische Sequenz mit einer Homologie von mehr als 80% im Vergleich zur genomischen Sequenz des Phagen DSM 23600 aufweist.SEQ ID NO: 1 und 2 aufweisen und eine RNA-Polymerase des Acinetobacter-baumannii-Phagen codieren, und zuSEQ ID NO: 3 und 4 aufweisen und einen Kopf-Schwanz-Konnektor des Acinetobacter-baumannii-Phagen codieren,
- Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 1, der Bioaktivität bei pH 4 bis 12 aufweist.
- Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach einem der vorstehenden Ansprüche, der Bioaktivität in einem Tensid aufweist.
- Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 3, wobei das Tensid ausgewählt ist aus der Gruppe bestehend aus einem anionischen Tensid, einem kationischen Tensid, einem amphoteren Tensid und einem nicht-ionischen Tensid.
- Isolierter lytischer Phage, der für Acinetobacter baumannii spezifisch ist, nach Anspruch 4, wobei das Tensid ein nicht-ionisches Tensid ist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW098127070A TWI376418B (en) | 2009-08-12 | 2009-08-12 | Phage of acinetobacter baumannii |
TW098127069A TWI380777B (zh) | 2009-08-12 | 2009-08-12 | 包含噬菌體之活體外殺菌組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2292740A1 EP2292740A1 (de) | 2011-03-09 |
EP2292740B1 true EP2292740B1 (de) | 2017-04-26 |
Family
ID=43530842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10172706A Withdrawn EP2292245A1 (de) | 2009-08-12 | 2010-08-12 | Desinfektionszusammensetzung mit Phagen |
EP10172708.9A Not-in-force EP2292740B1 (de) | 2009-08-12 | 2010-08-12 | Acinetobacter baumannii-Phage |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10172706A Withdrawn EP2292245A1 (de) | 2009-08-12 | 2010-08-12 | Desinfektionszusammensetzung mit Phagen |
Country Status (4)
Country | Link |
---|---|
US (2) | US20120276612A1 (de) |
EP (2) | EP2292245A1 (de) |
JP (2) | JP5464664B2 (de) |
AU (2) | AU2010212270B2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010212270B2 (en) * | 2009-08-12 | 2015-02-19 | Buddhist Tzu Chi Medical Foundation | Disinfectant composition comprising phage |
KR101391332B1 (ko) | 2012-05-18 | 2014-05-07 | 연세대학교 산학협력단 | 카바페넴 제제에 내성을 보이는 아시네토박터 속의 균을 용균하는 박테리오파아지 |
WO2016168560A1 (en) | 2015-04-16 | 2016-10-20 | Kennesaw State University Research And Service Foundation, Inc. | Escherichia coli o157:h7 bacteriophage φ241 |
TW201710282A (zh) * | 2015-09-04 | 2017-03-16 | 佛教慈濟醫療財團法人 | 衍生自鮑氏不動桿菌噬菌體之新穎抗菌胜肽及其用途 |
CA3018865A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
JP2019510036A (ja) | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティクス/プレバイオティクス有効成分を含む清浄剤組成物 |
AU2017365019A1 (en) | 2016-11-23 | 2019-07-11 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
CN106701690A (zh) * | 2016-12-13 | 2017-05-24 | 上海交通大学医学院 | 鲍曼不动杆菌噬菌体SH‑Ab15519及其应用 |
CN106947714B (zh) * | 2017-03-17 | 2020-09-04 | 上海申启生物科技有限公司 | 鲍曼不动杆菌选择性增菌液及其制备方法 |
KR102189126B1 (ko) * | 2018-12-18 | 2020-12-09 | 연세대학교 산학협력단 | 항생제 내성을 갖는 아시네토박터 속의 균을 용균하는 신규한 박테리오파지 |
KR102275107B1 (ko) * | 2018-12-18 | 2021-07-08 | 연세대학교 산학협력단 | 항생제 내성을 갖는 아시네토박터 속의 균을 용균하는 신규한 박테리오파지 |
US20220333120A1 (en) * | 2019-09-11 | 2022-10-20 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Bactericidal phage vectors |
CN110747177A (zh) * | 2019-12-01 | 2020-02-04 | 吉林大学第一医院 | 一株鲍曼不动杆菌噬菌体及医用用途 |
KR102604590B1 (ko) * | 2020-09-28 | 2023-11-23 | 경북대학교 산학협력단 | 아시네토박터 바우마니에 대한 사멸능을 가지는 박테리오파지 및 이를 포함하는 조성물 |
GB202210435D0 (en) * | 2022-07-15 | 2022-08-31 | Carus Animal Health Ltd | Agricultural compositions and methods |
WO2024115430A1 (en) * | 2022-11-28 | 2024-06-06 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Acinetobacter baumannii phages |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6290393A (ja) * | 1985-10-17 | 1987-04-24 | 工業技術院長 | 製紙工程におけるスライム障害防止方法 |
GB8918983D0 (en) * | 1989-08-21 | 1989-10-04 | Unilever Plc | Composition for hygiene purposes |
JPH06100409A (ja) * | 1992-09-17 | 1994-04-12 | Japan Tobacco Inc | 冷凍空調機器用冷却水域における細菌防除法 |
WO1995027043A1 (en) | 1994-04-05 | 1995-10-12 | Exponential Biotherapies, Inc. | Antibacterial therapy with genotypically modified bacteriophage |
US6121036A (en) | 1996-04-15 | 2000-09-19 | Ghanbari; Hossein A. | Compositions containing bacteriophages and methods of using bacteriophages to treat infections |
US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
US6248324B1 (en) | 1997-10-31 | 2001-06-19 | Vincent Fischetti | Bacterial phage associated lysing enzymes for treating dermatological infections |
AU2001230889A1 (en) | 2000-01-11 | 2001-07-24 | Intralytix, Inc. | Method and device for sanitation using bacteriophages |
US6485902B2 (en) | 2000-06-06 | 2002-11-26 | Thomas E. Waddell | Use of bacteriophages for control of escherichia coli O157 |
NZ538098A (en) * | 2002-07-08 | 2007-01-26 | Ebi Food Safety B V | Lytic phage P100 ATCC deposit designation PTA-4383 to control listeria monocytogenes in foodstuffs and in food processing plants and treat animals infected |
DE60336480D1 (de) * | 2003-11-19 | 2011-05-05 | Nestec Sa | Isolierte Bakteriophage und ihre Verwendung in Lebensmitteln oder zur Sanierung der Fabrik-Umgebung |
AU2008306626B2 (en) * | 2007-10-04 | 2013-05-09 | Novolytics Limited | Anti-bacteria compositions |
KR20090059789A (ko) * | 2007-12-07 | 2009-06-11 | 주식회사 인트론바이오테크놀로지 | 활성 생물소재를 포함한 살균조성물, 살균분무기 및 이를이용한 표면 살균방법 |
DE102008005193A1 (de) * | 2008-01-18 | 2009-07-23 | Dahlen, Neithard | Bakteriophagenpräparation und Verwendung |
ES2761835T3 (es) * | 2009-02-06 | 2020-05-21 | Technophage Investig E Desenvolvimento Em Biotecnologia Sa | Fagos antibacterianos, péptidos de fagos y métodos de uso de los mismos |
AU2010212270B2 (en) * | 2009-08-12 | 2015-02-19 | Buddhist Tzu Chi Medical Foundation | Disinfectant composition comprising phage |
BR112014027606B1 (pt) * | 2012-05-07 | 2022-11-29 | Micreos B.V | Um bacteriófago para o biocontrole de salmonella e para a fabricação ou processamento de alimentos |
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2010
- 2010-08-11 AU AU2010212270A patent/AU2010212270B2/en not_active Ceased
- 2010-08-11 AU AU2010212280A patent/AU2010212280B2/en not_active Ceased
- 2010-08-11 US US12/854,542 patent/US20120276612A1/en not_active Abandoned
- 2010-08-11 US US12/854,814 patent/US8273564B2/en active Active
- 2010-08-12 JP JP2010180903A patent/JP5464664B2/ja not_active Expired - Fee Related
- 2010-08-12 JP JP2010180902A patent/JP5651407B2/ja not_active Expired - Fee Related
- 2010-08-12 EP EP10172706A patent/EP2292245A1/de not_active Withdrawn
- 2010-08-12 EP EP10172708.9A patent/EP2292740B1/de not_active Not-in-force
Non-Patent Citations (1)
Title |
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None * |
Also Published As
Publication number | Publication date |
---|---|
EP2292740A1 (de) | 2011-03-09 |
AU2010212280B2 (en) | 2015-09-24 |
US8273564B2 (en) | 2012-09-25 |
JP5464664B2 (ja) | 2014-04-09 |
JP2011037856A (ja) | 2011-02-24 |
JP5651407B2 (ja) | 2015-01-14 |
AU2010212270A1 (en) | 2011-03-03 |
US20120276612A1 (en) | 2012-11-01 |
US20110038840A1 (en) | 2011-02-17 |
AU2010212270B2 (en) | 2015-02-19 |
AU2010212280A1 (en) | 2011-03-03 |
EP2292245A1 (de) | 2011-03-09 |
JP2011036246A (ja) | 2011-02-24 |
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