EP2258695A3 - Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien - Google Patents

Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien Download PDF

Info

Publication number
EP2258695A3
EP2258695A3 EP10008870A EP10008870A EP2258695A3 EP 2258695 A3 EP2258695 A3 EP 2258695A3 EP 10008870 A EP10008870 A EP 10008870A EP 10008870 A EP10008870 A EP 10008870A EP 2258695 A3 EP2258695 A3 EP 2258695A3
Authority
EP
European Patent Office
Prior art keywords
liquid crystal
crystal media
chroman derivatives
liquid
media
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10008870A
Other languages
English (en)
French (fr)
Other versions
EP2258695B1 (de
EP2258695A2 (de
Inventor
Markus Klein
Peer Kirsch
Eike Poetsch
Michael Heckmeier
Peter Best
Andreas Taugerbeck
Melanie Klasen-Memmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP2258695A2 publication Critical patent/EP2258695A2/de
Publication of EP2258695A3 publication Critical patent/EP2258695A3/de
Application granted granted Critical
Publication of EP2258695B1 publication Critical patent/EP2258695B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00Liquid crystal materials
    • C09K19/04Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06Non-steroidal liquid crystal compounds
    • C09K19/34Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • C09K19/3402Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00Liquid crystal materials
    • C09K19/04Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06Non-steroidal liquid crystal compounds
    • C09K19/34Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00Liquid crystal materials
    • C09K19/04Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06Non-steroidal liquid crystal compounds
    • C09K19/34Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • C09K19/3402Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom
    • C09K2019/3422Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom the heterocyclic ring being a six-membered ring
    • C09K2019/3425Six-membered ring with oxygen(s) in fused, bridged or spiro ring systems
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2323/00Functional layers of liquid crystal optical display excluding electroactive liquid crystal layer characterised by chemical composition

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Pyrane Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft Chroman-Derivate der allgemeinen Formeln (Ia) und (IIa)
Figure imga0001
worin R1, R2, A1, A2, Z, Z2, L1, L2, L3, L4, m und n die in Anspruch 1 angegebenen Bedeutungen aufweisen, Verfahren zu ihrer Herstellung, ihre Verwendung als Komponente(n) in flüssigkristallinen Medien sowie Flüssigkristall- und elektrooptische Anzeigeelemente, die die erfindungsgemäßen, flüssigkristallinen Medien enthalten.
EP10008870.7A 2004-10-07 2005-09-28 Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien Not-in-force EP2258695B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004048853 2004-10-07
EP05796927A EP1831190A2 (de) 2004-10-07 2005-09-28 Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP05796927.1 Division 2005-09-28

Publications (3)

Publication Number Publication Date
EP2258695A2 EP2258695A2 (de) 2010-12-08
EP2258695A3 true EP2258695A3 (de) 2011-04-13
EP2258695B1 EP2258695B1 (de) 2013-05-29

Family

ID=35466047

Family Applications (2)

Application Number Title Priority Date Filing Date
EP05796927A Ceased EP1831190A2 (de) 2004-10-07 2005-09-28 Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien
EP10008870.7A Not-in-force EP2258695B1 (de) 2004-10-07 2005-09-28 Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP05796927A Ceased EP1831190A2 (de) 2004-10-07 2005-09-28 Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien

Country Status (6)

Country Link
US (1) US20080020148A1 (de)
EP (2) EP1831190A2 (de)
JP (1) JP2008522958A (de)
KR (1) KR20070074595A (de)
TW (1) TW200630465A (de)
WO (1) WO2006040009A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4940626B2 (ja) * 2004-11-09 2012-05-30 Jnc株式会社 ベンゼン環にアルキル基を有する化合物、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
JP2006199941A (ja) * 2004-12-20 2006-08-03 Chisso Corp クロマン環を有する化合物を含有する液晶組成物
KR101703465B1 (ko) * 2006-06-23 2017-02-06 메르크 파텐트 게엠베하 메소제닉 화합물, 액정 매질 및 액정 디스플레이
JP5450095B2 (ja) * 2007-01-31 2014-03-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング クロマン化合物
JP5535930B2 (ja) * 2007-11-27 2014-07-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾ[f]クロメンおよびピラノ[3,2−f]クロメン誘導体
AU2009220163B2 (en) * 2008-03-06 2011-10-06 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
JP5343967B2 (ja) 2008-04-11 2013-11-13 Jnc株式会社 液晶組成物および液晶表示素子
CA2773142A1 (en) * 2009-09-02 2011-03-10 Neville Everton Drysdale Polyaramid comprising fluorovinylether functionalized aromatic moieties
US20110218319A1 (en) * 2009-09-02 2011-09-08 E. I. Du Pont De Nemours And Company Polyaramid films comprising fluorovinylether functionalized aromatic moieties
MX2012002643A (es) 2009-09-02 2012-03-14 Du Pont Diesteres aromaticos con grupos funcionales fluoroeter y derivados de estos.
AU2010289576B2 (en) * 2009-09-02 2015-07-16 E. I. Du Pont De Nemours And Company Polyester films with improved oil repellency
BR112012004774A2 (pt) * 2009-09-02 2017-05-30 Du Pont polímero e processo
US8293928B2 (en) * 2009-09-02 2012-10-23 E I Du Pont De Nemours And Company Fluorinated 4-oxo-chroman-7-carboxylates
JP5962949B2 (ja) * 2011-11-28 2016-08-03 Dic株式会社 重合性液晶化合物
DE102013103563A1 (de) 2013-04-10 2014-10-16 Basf Se Verfahren zur Herstellung von Citronellal
EP3730590A1 (de) * 2014-03-10 2020-10-28 Merck Patent GmbH Flüssigkristalline medien mit homöotroper ausrichtung
DE102018004733A1 (de) * 2018-06-14 2019-12-19 Merck Patent Gmbh Verfahren zur Herstellung eines elektronischen Bauteils enthaltend eine selbstorganisierte Monolage
CN111778040B (zh) * 2019-04-03 2022-03-22 北京八亿时空液晶科技股份有限公司 一种液晶化合物及其制备方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025598A1 (de) * 1979-09-13 1981-03-25 The Wellcome Foundation Limited Verwendung von 2-Phenyltetralin-Derivaten oder heterocyclischer Analoga in Arzneien und sie enthaltende pharmazeutische Zusammensetzungen
JPH0525158A (ja) * 1991-07-23 1993-02-02 Kanto Chem Co Inc クロマン誘導体並びにそれらを含む液晶組成物
JPH06256339A (ja) * 1993-03-10 1994-09-13 Dainippon Ink & Chem Inc クロマン誘導体
JPH06256337A (ja) * 1993-03-10 1994-09-13 Dainippon Ink & Chem Inc 光学活性な環状エーテル化合物及びそれを含有する液晶組成物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3509170C2 (de) * 1985-03-14 1995-01-05 Merck Patent Gmbh trans-Ethenylenverbindungen
KR920701195A (ko) * 1989-12-08 1992-08-11 위르겐 호이만·라인하르트 슈틀러 페닐디옥산
DE4326151A1 (de) * 1993-08-04 1995-02-09 Hoechst Ag Aromatische Verbindungen und ihre Verwendung in flüssigkristallinen Mischungen
JP3975562B2 (ja) 1998-06-25 2007-09-12 チッソ株式会社 誘電率異方性値が負の液晶性化合物、この液晶性化合物を含有する液晶組成物、及びこの液晶組成物を用いた液晶表示素子
JP4487343B2 (ja) * 1999-09-29 2010-06-23 チッソ株式会社 ジアミノ化合物およびこれを用いた樹脂組成物、液晶配向膜、液晶表示素子
KR100980561B1 (ko) 2001-05-16 2010-09-07 메르크 파텐트 게엠베하 전기광학 광 변조 소자, 표시장치 및 매질
DE10253325A1 (de) 2002-11-14 2004-05-27 Merck Patent Gmbh Elektrooptisches Lichtsteuerelement, elektrooptische Anzeige und Steuermedium
DE10253606A1 (de) 2002-11-15 2004-05-27 Merck Patent Gmbh Elektrooptisches Lichtsteuerelement, elektrooptische Anzeige und Steuermedium
DE10313979A1 (de) 2003-03-27 2004-10-07 Merck Patent Gmbh Elektrooptisches Lichsteuerelement, elektrooptische Anzeige und Steuermedium
ATE374232T1 (de) * 2002-11-27 2007-10-15 Merck Patent Gmbh Flüssigkristalline verbindungen
EP1618101B1 (de) * 2003-02-25 2017-12-20 Merck Patent GmbH Benzochromenderivate
JP4742215B2 (ja) * 2003-06-23 2011-08-10 Jnc株式会社 クロマン化合物、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
EP1491612B1 (de) * 2003-06-23 2006-10-18 Chisso Petrochemical Corporation Chromanverbindung, Flüssigkristallzusammensetzung enthaltend die Verbindung und Flüssigkristallanzeigeelement enthaltend die Flüssigkristallzusammensetzung
US7226644B2 (en) * 2003-06-30 2007-06-05 Dainippon Ink And Chemicals, Inc. Chroman derivative and liquid-crystal composition containing the compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025598A1 (de) * 1979-09-13 1981-03-25 The Wellcome Foundation Limited Verwendung von 2-Phenyltetralin-Derivaten oder heterocyclischer Analoga in Arzneien und sie enthaltende pharmazeutische Zusammensetzungen
JPH0525158A (ja) * 1991-07-23 1993-02-02 Kanto Chem Co Inc クロマン誘導体並びにそれらを含む液晶組成物
JPH06256339A (ja) * 1993-03-10 1994-09-13 Dainippon Ink & Chem Inc クロマン誘導体
JPH06256337A (ja) * 1993-03-10 1994-09-13 Dainippon Ink & Chem Inc 光学活性な環状エーテル化合物及びそれを含有する液晶組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 017, no. 309 (C - 1070) 14 June 1993 (1993-06-14) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 656 (C - 1286) 13 December 1994 (1994-12-13) *

Also Published As

Publication number Publication date
EP1831190A2 (de) 2007-09-12
EP2258695B1 (de) 2013-05-29
KR20070074595A (ko) 2007-07-12
EP2258695A2 (de) 2010-12-08
TW200630465A (en) 2006-09-01
WO2006040009A3 (de) 2006-07-27
US20080020148A1 (en) 2008-01-24
JP2008522958A (ja) 2008-07-03
WO2006040009A2 (de) 2006-04-20

Similar Documents

Publication Publication Date Title
EP2258695A3 (de) Chroman-derivate sowie ihre verwendung in flüssigkristallinen medien
WO2004076438A3 (de) Benzochromenderivate
EP2677018A3 (de) Flüssigkristallines Medium
EP2703472A3 (de) Flüssigkristallines Medium
EP2065361A3 (de) Polymerisierbare Verbindungen
CN102256910B (zh) 夹层玻璃用层叠体及夹层玻璃用中间膜
EP1146104A3 (de) Flüssigkristallines Medium
EP2514800A3 (de) Verbindungen und flüssigkristallines Medium
HK1099083A1 (en) Composition for liquid crystal film formation, optically anisotropic film and process for producing them
AU2002321844A1 (en) Liquid crystal display for performing time divisional color display, method of driving the same backlight unit for liquid crystal display
DE502005007840D1 (de) 7-phenylamino-4-chinolon-3-carbonsäure-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE602006017345D1 (de) Öle von capsaicinoiden und verfahren zu ihrer herstellung und verwendung
ATE381564T1 (de) Arylsubstituierte polycyclische amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE537826T1 (de) Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
EP2295422A3 (de) Glucopyranosylsubstituierte Benzolderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE102013011923A1 (de) Verbindung mit einer 2,2-Difluorvinyloxy-Gruppe oder 1,2,2-Trifluorvinyloxy-Gruppe, Flüssigkristall-Zusammensetzung und Flüssigkristall-Anzeigevorrichtung
EP2316830A3 (de) N-sulfonylierte aminosäurederivate und ihre verwendung als matriptase- inhibitoren
EP0748852A3 (de) Photovernetzbare flüssigkristalline Farbstoffe
EP1895197A3 (de) Differentialkorb für ein Fahrzeug
WO2007120621A3 (en) Nonel 1,2,3,4-tetrahydroquinoline derivatives
ATE517092T1 (de) Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
DE69416203T2 (de) Eine Silacyclohexanverbindung, deren Herstellung und diese enthaltende Flüssigkristallzusammensetzungen
DE502006002136D1 (de) Aminocarbonsäureester mit eo/po/buo-blockpolymerisaten und deren verwendung als emulsionsspalter
WO2015011147A1 (de) Transparenter klebstoff mit einem brechungsindex im bereich von 1,7 bis 1,73
EP2080756A3 (de) Verfahren zur Herstellung von Losartan

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100826

AC Divisional application: reference to earlier application

Ref document number: 1831190

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RTI1 Title (correction)

Free format text: CHROMAN DERIVATIVES AND USE THEREOF IN LIQUID CRYSTAL MEDIA

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 1831190

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 614329

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130615

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502005013747

Country of ref document: DE

Effective date: 20130725

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130929

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130909

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130830

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130930

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20130529

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130829

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

BERE Be: lapsed

Owner name: MERCK PATENT G.M.B.H.

Effective date: 20130930

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

26N No opposition filed

Effective date: 20140303

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20130928

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502005013747

Country of ref document: DE

Effective date: 20140303

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20140530

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130928

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130928

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 614329

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130928

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130928

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130529

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130928

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20050928

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20190917

Year of fee payment: 15

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502005013747

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210401