Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
  • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
  • A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
  • A61B5/0055—Detecting, measuring or recording by applying mechanical forces or stimuli by applying suction

Definitions

• the invention is directed to a method and a measuring device for collecting measurement signals from vital tissue, in particular for determining the substance composition of vessel-bound hemoglobin-leading tissue.
• the invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which provide more comprehensive information, in particular with regard to the presence or concentration of substances in a vessel-forming tissue system.
• This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
• Light is coupled into a vital tissue region to be examined
• measuring signals are generated by means of the spectrometer device, which as such represent the intensity of the remission light in association with the wavelength, the measurement being carried out in such a way that it extends over a period of time (T), and within that time the presence of hemoglobin in the examined tissue section is actively changed by changing the tissue pressure, wherein from the determined for different tissue pressures spectra hemoglobin concentration-related changes in the spectra are determined and calculated from these different spectra, the concentrations of selected substances in the tissue section.
• T period of time
• the active change in the pressure of the tissue region to be examined is effected by subjecting the tissue region to a gaseous pressure medium.
• This pressure medium in particular ambient air, is preferably applied by an elastomeric bell connected to an optical measuring head.
• the overpressure can be generated by elastic deformation and compression of the trapped air.
• the resulting pressures can be detected by a pressure sensor integrated in the measuring head.
• a pressure range of 1000 to about 1700 mbar can be passed through here.
• spectra are preferably recorded at pressure intervals of 50 mbar.
• the pressure change may also be otherwise applied, e.g. purely mechanically by pressing a window element, preferably under hereby associated pressure force measurement, or by active compressed gas supply, or suction, in particular a Schulichtán be brought about.
• the light source is preferably incorporated in the measuring head.
• the spectrum of the light generated by the light source is preferably adjusted so that fluorescence effects of the substances to be detected are ensured.
• light in the near infrared range is suitable for the detection of blood constituents.
• FIG. 1 shows a sketch to illustrate a measuring arrangement according to the invention for the subsequent generation of substance spectra, in each case incrementally increasing the pressure on the tissue section to be examined;
• Figure 2 is a diagram illustrating the increase in tissue pressure with increasing compression of an elastomeric bell element.
• FIG. 1 shows in a greatly simplified manner a measuring arrangement for generating spectrometric measuring signals.
• This measuring arrangement comprises a light source 1, preferably embodied as an LED light source, and a receiver system 2 symbolized here only for the purpose of illustration as a prism, by means of which the light Ll emerging from a vital tissue section G can be detected.
• the receiver system 2 comprises a spectrometer device, by means of which measurement signals are generated, which as such represent the intensity of the remission light L 1 associated with the wavelength.
• the measuring arrangement according to the invention is operated in such a way that the pressure p on the tissue section to be examined is increased over a relatively short period of time, wherein a plurality of spectra S1, S2..., S6 are recorded in the tissue as part of this increase in the pressure p.
• the concentration of certain substances can be determined on the basis of a correlation approach be calculated in terms of its composition less pressure-sensitive, vascularizing areas of the tissue.
• the calculation of the concentrations of these substances is carried out using a phenomenon that is that by changing the tissue pressure, the concentration of hemoglobin in this tissue area is changed.
• concentration of a substance known with regard to its spectral properties it becomes possible to determine the (largely unchanged) concentrations of the other substances which are quasi-stationary in the tissue region. If the concentration of hemoglobin contained in the overall system is changed, the absorption contribution of this substance changes depending on the concentration, in particular in the near and middle infrared range.
• This effect is used according to the invention for the quantification of quasi-stationary substances incorporated in the tissue section to be examined.
• the pressure of the tissue to be examined is changed while changing the concentration of substances with known spectral properties, and at the same time the absorption spectra are measured for a plurality of, preferably relatively closely spaced, pressure levels.
• ⁇ a ⁇ ci ⁇ i be the absorption coefficient of hemoglobin.

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• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• Physics & Mathematics (AREA)
• Heart & Thoracic Surgery (AREA)
• Molecular Biology (AREA)
• Pathology (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Veterinary Medicine (AREA)
• Medical Informatics (AREA)
• Biophysics (AREA)
• Surgery (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Optics & Photonics (AREA)
• Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
• Investigating Or Analysing Materials By Optical Means (AREA)

Applications Claiming Priority (2)

Publications (1)

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• 2009
  • 2009-02-25 JP JP2010547126A patent/JP2011528234A/ja active Pending
  • 2009-02-25 WO PCT/EP2009/001340 patent/WO2009106314A1/de not_active Ceased
  • 2009-02-25 DE DE112009000264T patent/DE112009000264A5/de not_active Withdrawn
  • 2009-02-25 US US12/866,042 patent/US20110046460A1/en not_active Abandoned
  • 2009-02-25 KR KR1020107021545A patent/KR20110036877A/ko not_active Ceased
  • 2009-02-25 EP EP09716005A patent/EP2252198A1/de not_active Withdrawn

Non-Patent Citations (1)

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