EP2252198A1 - Procédé et dispositif de mesure pour relever des signaux de mesure dans un tissu vital - Google Patents

Procédé et dispositif de mesure pour relever des signaux de mesure dans un tissu vital

Info

Publication number
EP2252198A1
EP2252198A1 EP09716005A EP09716005A EP2252198A1 EP 2252198 A1 EP2252198 A1 EP 2252198A1 EP 09716005 A EP09716005 A EP 09716005A EP 09716005 A EP09716005 A EP 09716005A EP 2252198 A1 EP2252198 A1 EP 2252198A1
Authority
EP
European Patent Office
Prior art keywords
tissue
spectra
examined
light
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09716005A
Other languages
German (de)
English (en)
Inventor
Holger Jungmann
Michael Schietzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mbr Optical Systems Gmbh&co KG
Original Assignee
Mbr Optical Systems Gmbh&co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mbr Optical Systems Gmbh&co KG filed Critical Mbr Optical Systems Gmbh&co KG
Publication of EP2252198A1 publication Critical patent/EP2252198A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0055—Detecting, measuring or recording by applying mechanical forces or stimuli by applying suction

Definitions

  • the invention is directed to a method and a measuring device for collecting measurement signals from vital tissue, in particular for determining the substance composition of vessel-bound hemoglobin-leading tissue.
  • the invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which provide more comprehensive information, in particular with regard to the presence or concentration of substances in a vessel-forming tissue system.
  • This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
  • Light is coupled into a vital tissue region to be examined
  • measuring signals are generated by means of the spectrometer device, which as such represent the intensity of the remission light in association with the wavelength, the measurement being carried out in such a way that it extends over a period of time (T), and within that time the presence of hemoglobin in the examined tissue section is actively changed by changing the tissue pressure, wherein from the determined for different tissue pressures spectra hemoglobin concentration-related changes in the spectra are determined and calculated from these different spectra, the concentrations of selected substances in the tissue section.
  • T period of time
  • the active change in the pressure of the tissue region to be examined is effected by subjecting the tissue region to a gaseous pressure medium.
  • This pressure medium in particular ambient air, is preferably applied by an elastomeric bell connected to an optical measuring head.
  • the overpressure can be generated by elastic deformation and compression of the trapped air.
  • the resulting pressures can be detected by a pressure sensor integrated in the measuring head.
  • a pressure range of 1000 to about 1700 mbar can be passed through here.
  • spectra are preferably recorded at pressure intervals of 50 mbar.
  • the pressure change may also be otherwise applied, e.g. purely mechanically by pressing a window element, preferably under hereby associated pressure force measurement, or by active compressed gas supply, or suction, in particular a Schulichtán be brought about.
  • the light source is preferably incorporated in the measuring head.
  • the spectrum of the light generated by the light source is preferably adjusted so that fluorescence effects of the substances to be detected are ensured.
  • light in the near infrared range is suitable for the detection of blood constituents.
  • FIG. 1 shows a sketch to illustrate a measuring arrangement according to the invention for the subsequent generation of substance spectra, in each case incrementally increasing the pressure on the tissue section to be examined;
  • Figure 2 is a diagram illustrating the increase in tissue pressure with increasing compression of an elastomeric bell element.
  • FIG. 1 shows in a greatly simplified manner a measuring arrangement for generating spectrometric measuring signals.
  • This measuring arrangement comprises a light source 1, preferably embodied as an LED light source, and a receiver system 2 symbolized here only for the purpose of illustration as a prism, by means of which the light Ll emerging from a vital tissue section G can be detected.
  • the receiver system 2 comprises a spectrometer device, by means of which measurement signals are generated, which as such represent the intensity of the remission light L 1 associated with the wavelength.
  • the measuring arrangement according to the invention is operated in such a way that the pressure p on the tissue section to be examined is increased over a relatively short period of time, wherein a plurality of spectra S1, S2..., S6 are recorded in the tissue as part of this increase in the pressure p.
  • the concentration of certain substances can be determined on the basis of a correlation approach be calculated in terms of its composition less pressure-sensitive, vascularizing areas of the tissue.
  • the calculation of the concentrations of these substances is carried out using a phenomenon that is that by changing the tissue pressure, the concentration of hemoglobin in this tissue area is changed.
  • concentration of a substance known with regard to its spectral properties it becomes possible to determine the (largely unchanged) concentrations of the other substances which are quasi-stationary in the tissue region. If the concentration of hemoglobin contained in the overall system is changed, the absorption contribution of this substance changes depending on the concentration, in particular in the near and middle infrared range.
  • This effect is used according to the invention for the quantification of quasi-stationary substances incorporated in the tissue section to be examined.
  • the pressure of the tissue to be examined is changed while changing the concentration of substances with known spectral properties, and at the same time the absorption spectra are measured for a plurality of, preferably relatively closely spaced, pressure levels.
  • ⁇ a ⁇ ci ⁇ i be the absorption coefficient of hemoglobin.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un procédé et un dispositif de mesure pour relever des signaux de mesure spectrométriques dans un tissu vital. L'objectif de l'invention est de créer des solutions qui permettent de générer au moyen d'une mesure spectrométrique, des valeurs de mesure qui fournissent des informations plus détaillées par rapport aux méthodes d'enregistrement existant jusqu'à présent. A cette fin la présente invention propose un procédé de génération de signaux de mesure spectrométriques suivant lequel de la lumière est intégrée à une zone de tissu vital à analyser, la lumière de réflexion qui s'échappe en tant que telle de la zone de tissu à analyser est amenée à un dispositif de spectrométrie, et, par le biais du dispositif de spectrométrie, des signaux de mesure sont générés, lesquels représentent en tant que tels l'intensité de la lumière de réflexion associée à la longueur d'onde. La mesure se déroule de telle sorte qu'elle s'étende sur une période de temps et qu'à l'intérieur de cette période de temps, la présence d'hémoglobine dans la section de tissu à analyser est modifiée activement par modification de la pression de tissu, à l'occasion de quoi, à partir des spectres déterminés qui se succèdent pour des pressions de tissu  différentes, des variations dépendant de la concentration en hémoglobine des spectres sont déterminées et, à partir de ces différents spectres, les concentrations de substances choisies dans la section de tissu sont calculées. Il est par là possible d'une manière avantageuse de générer, dans une succession relativement étroite dans le temps plusieurs spectres pour la section de tissu qui est à la base de l'examen, ce spectre présentant des différences (« distorsions ») l'un par rapport à l'autre par des modifications provoquées de manière active de la pression de tissu, qui en tant que telles sont suffisantes pour la détermination de la concentration de substances à indiquer à l'intérieur des zones de vascularisation du système de tissu.
EP09716005A 2008-02-25 2009-02-25 Procédé et dispositif de mesure pour relever des signaux de mesure dans un tissu vital Withdrawn EP2252198A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008011245 2008-02-25
PCT/EP2009/001340 WO2009106314A1 (fr) 2008-02-25 2009-02-25 Procédé et dispositif de mesure pour relever des signaux de mesure dans un tissu vital

Publications (1)

Publication Number Publication Date
EP2252198A1 true EP2252198A1 (fr) 2010-11-24

Family

ID=40765472

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09716005A Withdrawn EP2252198A1 (fr) 2008-02-25 2009-02-25 Procédé et dispositif de mesure pour relever des signaux de mesure dans un tissu vital

Country Status (6)

Country Link
US (1) US20110046460A1 (fr)
EP (1) EP2252198A1 (fr)
JP (1) JP2011528234A (fr)
KR (1) KR20110036877A (fr)
DE (1) DE112009000264A5 (fr)
WO (1) WO2009106314A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102539142B1 (ko) * 2016-09-05 2023-06-01 삼성전자주식회사 스펙트럼 분석 장치와 방법, 및 혈당 측정 장치

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5295957A (en) * 1991-12-23 1994-03-22 Pigeon Co., Ltd. Breast pump having a pressure adjusting mechanism
JP3873359B2 (ja) * 1996-10-03 2007-01-24 セイコーエプソン株式会社 触覚検出装置、触覚再現装置、触覚伝送システム、脈診装置、脈診教育装置および脈診情報伝送システム
JP4152532B2 (ja) * 1999-07-23 2008-09-17 倉敷紡績株式会社 光学測定用プローブ
IL135077A0 (en) * 2000-03-15 2001-05-20 Orsense Ltd A probe for use in non-invasive measurements of blood related parameters
US7519406B2 (en) * 2004-04-28 2009-04-14 Sensys Medical, Inc. Noninvasive analyzer sample probe interface method and apparatus
JP2004148070A (ja) * 2002-10-29 2004-05-27 Tse:Kk 血中多成分検出装置
EP1628564B1 (fr) * 2003-06-03 2014-02-12 Orsense Ltd. Procédé et système destinés à être utilisés dans des mesures optiques non invasives de paramètres sanguins
DE10353703A1 (de) * 2003-11-18 2005-06-16 Mbr Gmbh Verfahren und Vorrichtung zur Erhebung spektrometrischer Messsignale
JP2006068491A (ja) * 2004-08-02 2006-03-16 Nippon Seimitsu Sokki Kk 血液の流動性評価方法及び装置
JP4880963B2 (ja) * 2005-09-27 2012-02-22 パナソニック電工株式会社 プローブ支持具、プローブ装置、生体内成分測定装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009106314A1 *

Also Published As

Publication number Publication date
US20110046460A1 (en) 2011-02-24
WO2009106314A1 (fr) 2009-09-03
KR20110036877A (ko) 2011-04-12
DE112009000264A5 (de) 2011-03-03
JP2011528234A (ja) 2011-11-17

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