EP2198270A1 - Procédé et dispositif de mesure pour prélever des signaux de mesure spectrométriques dans un tissu vivant - Google Patents

Procédé et dispositif de mesure pour prélever des signaux de mesure spectrométriques dans un tissu vivant

Info

Publication number
EP2198270A1
EP2198270A1 EP08802671A EP08802671A EP2198270A1 EP 2198270 A1 EP2198270 A1 EP 2198270A1 EP 08802671 A EP08802671 A EP 08802671A EP 08802671 A EP08802671 A EP 08802671A EP 2198270 A1 EP2198270 A1 EP 2198270A1
Authority
EP
European Patent Office
Prior art keywords
intensity
light
data
examined
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08802671A
Other languages
German (de)
English (en)
Inventor
Holger Jungmann
Michael Schietzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mbr Optical Systems Gmbh&co KG
Original Assignee
Mbr Optical Systems Gmbh&co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mbr Optical Systems Gmbh&co KG filed Critical Mbr Optical Systems Gmbh&co KG
Publication of EP2198270A1 publication Critical patent/EP2198270A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis

Definitions

  • the invention is directed to a method and a measuring device for collecting spectrometric measuring signals from vital tissue.
  • Measuring methods are known in which an analysis of vital tissue is accomplished by attaching a mobile spectrometer to a corresponding tissue region and recording the spectrum of remission light emerging from the tissue via this mobile spectrometer. On the basis of the spectrum thus recorded, a wide variety of substances present in the examined tissue region can be detected.
  • the invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which provide more comprehensive information compared to the aforementioned previous recording approaches.
  • This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
  • Light is coupled into a vital tissue region to be examined
  • Tissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
  • the inventive concept determines which of the substances appearing in the recorded spectra are subject to vasomotion or other action caused by vital processes. These substances can be assigned to a subsystem based on the kinematic profile recorded by the consequences of the spectra. In particular, it is possible by the inventive concept to determine which substances are incorporated into the bloodstream and which substances are substantially static in the tissue surrounding the bloodstream tissue systems. According to a particularly preferred embodiment of the invention, the indicative of the temporal course of the spectra data are recorded by the spectrometrically resolved wavelengths, the data are assigned to the time course of the intensity.
  • This storage can be done in particular by applying a data field for the recording of the spectrum, which contains data for each resolved wavelength value, which as such describe the time profile of the intensity, in particular the intensity dynamics.
  • intensity dynamics data can in particular be stored as members of a series, in particular FFT parameters.
  • the dynamic features generated according to the invention for the temporal change of the remission light spectrum can also be based on an evaluation method, whereby evaluation results are generated via this evaluation method, which as such describe or typify the physiological condition of a person.
  • Figure 1 is a schematic diagram illustrating the approach of the invention for generating a sequence of spectra and the inclusion of the hereby detected, caused by vital processes dynamic spectrum changes for the assignment of substances to certain tissue, or capillary.
  • FIG. 1 serves as an illustration of the method according to the invention for generating spectrometric measuring signals.
  • light L is coupled into a tissue region G to be examined by means of a light source 1 embodied here as a diode.
  • the light R emerging from this tissue region G is supplied to a spectrometer device 2, which is indicated here only by way of example as a prism.
  • a spectrometer device 2 which is indicated here only by way of example as a prism.
  • the light emerging from the tissue area to be examined light is decomposed into its spectral components.
  • the intensity I (alternatively optical density OD) of the remission light R represent assignment to the wavelength ⁇ .
  • the method according to the invention is characterized in that the measurement is processed in such a way that it extends over a time period T and that for this time period T data are generated which map the time profile of the intensity of the resolved wavelengths.
  • the remission light R supplied to the spectrometer device 2 contains light from different zones of the tissue region G.
  • this light contains fractions which are caused, for example, by substances flowing through capillary K of the tissue region G.
  • the remission light R also contains spectral components of substances which originate from zones H of the tissue region in which no special dynamic changes of substance presence occur.
  • the intensity of the spectra which are caused by substances that flow as such through the capillaries K, change in the example shown here in accordance with a Pulsomters made by Vasomotion.
  • this pulse pattern can be seen, in particular, for certain wave spectral components in the range from 650 to 900 nanometers in the characteristic diagram recognizable here.
  • the inventive concept consists in recognizing within a sum spectrum the spectral contributions of those substances whose presence alternates by vital mechanical effects. This makes it possible to isolate the spectrum of a pulsating liquid in a cloudy medium.
  • the temperature of the static tissue essentially corresponds to the temperature of the pulsating fluid.
  • the body is completely permeable and absorbs the fluid characteristically (such as blood), then the pulsating current can be measured by absorption changes by means of spectroscopic methods.
  • the recording of the temporal course of the intensity takes place with a resolution which supports evaluation-relevant vital kinematic effects per interval with at least five measuring points.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un procédé et un dispositif de mesure pour relever des signaux de mesure spectrométriques dans un tissu vital. L'objectif de l'invention est de créer des solutions qui permettent de générer, au moyen d'une mesure spectrométrique, des valeurs de mesure qui fournissent des informations plus détaillées par rapport aux méthodes d'enregistrement existant jusqu'à présent, précédemment mentionnées. A cette fin, l'invention propose un procédé de génération de signaux de mesure spectrométriques, qui consiste à intégrer de la lumière à une zone de tissu vital à analyser, à amener la lumière de réflexion qui s'échappe en tant que telle de la zone de tissu à analyser à un dispositif de spectrométrie, et à générer des signaux de mesure par le biais du dispositif de spectrométrie, ces signaux représentant en tant que tels l'intensité de la lumière de réflexion associée à la longueur d'onde. La mesure se déroule de telle sorte qu'elle s'étende sur une période de temps (T) et que des données, qui représentent le tracé temporel de l'intensité des longueurs d'ondes restituées, soient générées pour cette période de temps (T). Il est alors possible de générer de manière avantageuse, dans le cadre de la réalisation de la mesure spectrométrique, des signaux qui permettent en tant que tels l'attribution de certaines substances à certaines zones du tissu analysé.
EP08802671A 2007-09-26 2008-09-26 Procédé et dispositif de mesure pour prélever des signaux de mesure spectrométriques dans un tissu vivant Withdrawn EP2198270A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007046257 2007-09-26
PCT/EP2008/008226 WO2009043554A1 (fr) 2007-09-26 2008-09-26 Procédé et dispositif de mesure pour relever des signaux de mesure spectrométriques dans un tissu vital

Publications (1)

Publication Number Publication Date
EP2198270A1 true EP2198270A1 (fr) 2010-06-23

Family

ID=40328532

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08802671A Withdrawn EP2198270A1 (fr) 2007-09-26 2008-09-26 Procédé et dispositif de mesure pour prélever des signaux de mesure spectrométriques dans un tissu vivant

Country Status (6)

Country Link
US (1) US20100298715A1 (fr)
EP (1) EP2198270A1 (fr)
JP (1) JP2011506915A (fr)
KR (1) KR20100075553A (fr)
DE (1) DE102008049078A1 (fr)
WO (1) WO2009043554A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2399509A1 (fr) 2010-06-22 2011-12-28 Senspec GmbH Dispositif et procédé de reconnaissance et de surveillance de valeurs sanguines physiologiques
MX2012014873A (es) 2010-06-22 2013-01-24 Senspec Gmbh Dispositivo y metodo para identificar y monitorear contenido o propiedades de un medio de medicion, en particular valores sanguineos fisiologicos particulares.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58113736A (ja) * 1981-12-28 1983-07-06 Masaaki Motoi 測光方法及びその装置
EP0522674B1 (fr) * 1991-07-12 1998-11-11 Mark R. Robinson Oxymètre pour la détermination médicale de la saturation d'oxygène de sang pour un foetus
US6119031A (en) * 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
US6002952A (en) * 1997-04-14 1999-12-14 Masimo Corporation Signal processing apparatus and method
US6393310B1 (en) * 1998-09-09 2002-05-21 J. Todd Kuenstner Methods and systems for clinical analyte determination by visible and infrared spectroscopy
US6216021B1 (en) * 1999-06-04 2001-04-10 The Board Of Trustees Of The University Of Illinois Method for measuring absolute saturation of time-varying and other hemoglobin compartments
US7519406B2 (en) * 2004-04-28 2009-04-14 Sensys Medical, Inc. Noninvasive analyzer sample probe interface method and apparatus
JP2004248819A (ja) * 2003-02-19 2004-09-09 Citizen Watch Co Ltd 血液分析装置
US7460895B2 (en) * 2005-01-24 2008-12-02 University Of Iowa Research Foundation Method for generating a net analyte signal calibration model and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009043554A1 *

Also Published As

Publication number Publication date
US20100298715A1 (en) 2010-11-25
JP2011506915A (ja) 2011-03-03
KR20100075553A (ko) 2010-07-02
WO2009043554A1 (fr) 2009-04-09
DE102008049078A1 (de) 2009-04-09

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