EP2198270A1 - Method and measuring instrument for collecting spectrometric test signals from living tissue - Google Patents

Method and measuring instrument for collecting spectrometric test signals from living tissue

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Publication number
EP2198270A1
EP2198270A1 EP08802671A EP08802671A EP2198270A1 EP 2198270 A1 EP2198270 A1 EP 2198270A1 EP 08802671 A EP08802671 A EP 08802671A EP 08802671 A EP08802671 A EP 08802671A EP 2198270 A1 EP2198270 A1 EP 2198270A1
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EP
European Patent Office
Prior art keywords
intensity
light
data
examined
measurement
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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EP08802671A
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German (de)
French (fr)
Inventor
Holger Jungmann
Michael Schietzel
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Mbr Optical Systems Gmbh&co KG
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Mbr Optical Systems Gmbh&co KG
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Publication of EP2198270A1 publication Critical patent/EP2198270A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis

Definitions

  • the invention is directed to a method and a measuring device for collecting spectrometric measuring signals from vital tissue.
  • Measuring methods are known in which an analysis of vital tissue is accomplished by attaching a mobile spectrometer to a corresponding tissue region and recording the spectrum of remission light emerging from the tissue via this mobile spectrometer. On the basis of the spectrum thus recorded, a wide variety of substances present in the examined tissue region can be detected.
  • the invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which provide more comprehensive information compared to the aforementioned previous recording approaches.
  • This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
  • Light is coupled into a vital tissue region to be examined
  • Tissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
  • the inventive concept determines which of the substances appearing in the recorded spectra are subject to vasomotion or other action caused by vital processes. These substances can be assigned to a subsystem based on the kinematic profile recorded by the consequences of the spectra. In particular, it is possible by the inventive concept to determine which substances are incorporated into the bloodstream and which substances are substantially static in the tissue surrounding the bloodstream tissue systems. According to a particularly preferred embodiment of the invention, the indicative of the temporal course of the spectra data are recorded by the spectrometrically resolved wavelengths, the data are assigned to the time course of the intensity.
  • This storage can be done in particular by applying a data field for the recording of the spectrum, which contains data for each resolved wavelength value, which as such describe the time profile of the intensity, in particular the intensity dynamics.
  • intensity dynamics data can in particular be stored as members of a series, in particular FFT parameters.
  • the dynamic features generated according to the invention for the temporal change of the remission light spectrum can also be based on an evaluation method, whereby evaluation results are generated via this evaluation method, which as such describe or typify the physiological condition of a person.
  • Figure 1 is a schematic diagram illustrating the approach of the invention for generating a sequence of spectra and the inclusion of the hereby detected, caused by vital processes dynamic spectrum changes for the assignment of substances to certain tissue, or capillary.
  • FIG. 1 serves as an illustration of the method according to the invention for generating spectrometric measuring signals.
  • light L is coupled into a tissue region G to be examined by means of a light source 1 embodied here as a diode.
  • the light R emerging from this tissue region G is supplied to a spectrometer device 2, which is indicated here only by way of example as a prism.
  • a spectrometer device 2 which is indicated here only by way of example as a prism.
  • the light emerging from the tissue area to be examined light is decomposed into its spectral components.
  • the intensity I (alternatively optical density OD) of the remission light R represent assignment to the wavelength ⁇ .
  • the method according to the invention is characterized in that the measurement is processed in such a way that it extends over a time period T and that for this time period T data are generated which map the time profile of the intensity of the resolved wavelengths.
  • the remission light R supplied to the spectrometer device 2 contains light from different zones of the tissue region G.
  • this light contains fractions which are caused, for example, by substances flowing through capillary K of the tissue region G.
  • the remission light R also contains spectral components of substances which originate from zones H of the tissue region in which no special dynamic changes of substance presence occur.
  • the intensity of the spectra which are caused by substances that flow as such through the capillaries K, change in the example shown here in accordance with a Pulsomters made by Vasomotion.
  • this pulse pattern can be seen, in particular, for certain wave spectral components in the range from 650 to 900 nanometers in the characteristic diagram recognizable here.
  • the inventive concept consists in recognizing within a sum spectrum the spectral contributions of those substances whose presence alternates by vital mechanical effects. This makes it possible to isolate the spectrum of a pulsating liquid in a cloudy medium.
  • the temperature of the static tissue essentially corresponds to the temperature of the pulsating fluid.
  • the body is completely permeable and absorbs the fluid characteristically (such as blood), then the pulsating current can be measured by absorption changes by means of spectroscopic methods.
  • the recording of the temporal course of the intensity takes place with a resolution which supports evaluation-relevant vital kinematic effects per interval with at least five measuring points.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The invention relates to a method and a measuring instrument for collecting spectrometric test signals from living tissue. The aim of the invention is to create solutions which make it possible to generate, in the course of a spectrometric measurement, test results that supply more comprehensive data than previously known recording attempts. Said aim is achieved by a method for generating spectrometric test signals, in which light (L) is injected into a living tissue area (G) to be examined, reflected light (R) emerging from the tissue area to be examined is fed to a spectrometer device, and test signals representing the intensity of the reflected light by associating the same with the wavelength are generated by means of the spectrometer device. The measurement is taken such that the measurement process lasts a certain period of time (T) during which data is generated that represents the time course of the intensity of the resolved wavelengths, thus advantageously making it possible to generate, during the spectrometric measurement, signals which allow specific substances, e.g. the blood components cholesterol and sugar, to be associated with specific zones of the examined tissue area.

Description

Verfahren und Messeinrichtung zur Erhebung spektrometrischer Method and measuring device for collecting spectrometric
Messsignale aus vitalem GewebeMeasuring signals from vital tissue
Die Erfindung richtet sich auf ein Verfahren und eine Messeinrichtung zur Erhebung spektrometrischer Messsignale aus vitalem Gewebe.The invention is directed to a method and a measuring device for collecting spectrometric measuring signals from vital tissue.
Es sind Messverfahren bekannt, bei welchen eine Analyse von vitalem Gewebe bewerkstelligt wird, indem an einen entsprechenden Gewebebereich ein mobiles Spektrometer angesetzt wird, und über dieses mobile Spektrometer das Spektrum von aus dem Gewebe austretendem Remissionslicht aufgezeichnet wird. Anhand des so aufgezeichneten Spektrums können verschiedenste in dem untersuchten Gewebebereich vorhandene Substanzen erkannt werden.Measuring methods are known in which an analysis of vital tissue is accomplished by attaching a mobile spectrometer to a corresponding tissue region and recording the spectrum of remission light emerging from the tissue via this mobile spectrometer. On the basis of the spectrum thus recorded, a wide variety of substances present in the examined tissue region can be detected.
Der Erfindung liegt die Aufgabe zugrunde, Lösungen zu schaffen, durch welche im Wege einer spektrometrischen Messung Messwerte generiert werden können, die gegenüber vorgenannten bisherigen Aufzeichnungsansätzen umfassendere Informationen liefern. Diese Aufgabe wird erfindungsgemäß gelöst durch ein Verfahren zur Generierung von spektrometrischen Messsignalen bei welchem:The invention has for its object to provide solutions by which measured values can be generated by means of a spectrometric measurement, which provide more comprehensive information compared to the aforementioned previous recording approaches. This object is achieved according to the invention by a method for generating spectrometric measurement signals in which:
Licht in einen zu untersuchenden vitalen Gewebebereich eingekoppelt wird,Light is coupled into a vital tissue region to be examined,
Remissionslicht das als solches aus dem zu untersuchendenRemission light that as such from the to be examined
Gewebebereich austritt einer Spektrometereinrichtung zugeführt wird, und über die Spektrometereinrichtung Messsignale generiert werden die als solche die Intensität desTissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
Remissionslichtes unter Zuordnung zur Wellenlänge darstellen, wobei die Messung derart abgewickelt wird, dass sich diese über einen Zeitraum (T) hinweg erstreckt, und dass für diesen Zeitraum (T) Daten generiert werden die den zeitlichen Verlauf der Intensität der aufgelöstenRepresenting remission light associated with the wavelength, wherein the measurement is carried out so that this extends over a period of time (T), and that for this period (T) data are generated which the time course of the intensity of the resolved
Wellenlängen abbilden.Reflect wavelengths.
Dadurch wird es auf vorteilhafte Weise möglich, im Rahmen der Durchführung der spektrometrischen Messung Signale zu generieren, die als solche eine Zuordnung bestimmter Stoffe zu bestimmten Zonen des untersuchten Gewebebereichs ermöglichen.This makes it possible in an advantageous manner, in the context of performing the spectrometric measurement to generate signals that allow as such an assignment of certain substances to certain zones of the examined tissue area.
Insbesondere wird es auf Grundlage des erfindungsgemäßen Konzeptes möglich, festzustellen, welche der in den aufgezeichneten Spektren auftauchenden Stoffe einer Vasomotion oder anderweitigen durch Vitalprozesse verursachten Einwirkung unterliegen. Diese Stoffen können anhand des durch die Folgen der Spektren aufgezeichneten kinematischen Profils einem Untersystem zugeordnet werden. Insbesondere wird es durch das erfindungsgemäße Konzept möglich, festzustellen, welche Stoffe in die Blutbahn und welche Stoffe im wesentlichen statisch in die, die Blutbahn umgebenden Gewebesysteme eingebunden sind. Gemäß einer besonders bevorzugten Ausführungsform der Erfindung werden die hinsichtlich des zeitlichen Verlaufs der Spektren indikativen Daten aufgezeichnet indem den spektrometrisch aufgelösten Wellenlängen die Daten zum zeitlichen Verlauf der Intensität zugeordnet werden. Diese Speicherung kann insbesondere erfolgen indem für die Aufzeichnung des Spektrums ein Datenfeld angelegt wird, das zu jedem aufgelösten Wellenlängenwert Daten enthält, die als solche die den zeitlichen Verlauf der Intensität, insbesondere die Intensitätsdynamik beschreiben. Diese Daten zur Intensitätsdynamik können insbesondere als Glieder einer Reihe, insbesondere FFT-Parameter abgelegt werden.In particular, it becomes possible on the basis of the inventive concept to determine which of the substances appearing in the recorded spectra are subject to vasomotion or other action caused by vital processes. These substances can be assigned to a subsystem based on the kinematic profile recorded by the consequences of the spectra. In particular, it is possible by the inventive concept to determine which substances are incorporated into the bloodstream and which substances are substantially static in the tissue surrounding the bloodstream tissue systems. According to a particularly preferred embodiment of the invention, the indicative of the temporal course of the spectra data are recorded by the spectrometrically resolved wavelengths, the data are assigned to the time course of the intensity. This storage can be done in particular by applying a data field for the recording of the spectrum, which contains data for each resolved wavelength value, which as such describe the time profile of the intensity, in particular the intensity dynamics. These intensity dynamics data can in particular be stored as members of a series, in particular FFT parameters.
Anhand der so aufgezeichneten Dynamikmerkmale kann eine Zuordnung der in dem Summenspektrum enthaltenen Einzelspektren sowie der dadurch charakterisierten Stoffe zu bestimmten Gewebe-, Kapillar- oder Fluidsystemen bewerkstelligt werden.On the basis of the dynamic characteristics recorded in this way, an assignment of the individual spectra contained in the sum spectrum as well as the substances characterized thereby to certain tissue, capillary or fluid systems can be achieved.
Wie bereits angegeben ist es möglich, anhand der erfindungsgemäß generierten Dynamikmerkmale festzustellen, ob sich ein Stoff in der Blutbahn befindet. Gemäß einem weiteren Aspekt der Erfindung ist es auch möglich, unter Verwertung der erfindungsgemäß erhobenen Dynamikmerkmale und anhand der zeitlichen Änderungen der Summenspektren eine Berechnung von Stoffkonzentrationen vorzunehmen. Diese Stoffkonzentrationen können dabei insbesondere auf Grundlage eines Ansatzes errechnet werden, der berücksichtigt, dass sich die Gesamtkonzentration eines über dasAs already stated, it is possible to determine, based on the dynamic characteristics generated according to the invention, whether a substance is present in the bloodstream. According to a further aspect of the invention, it is also possible to carry out a calculation of substance concentrations by utilizing the dynamic characteristics obtained according to the invention and by means of the temporal changes in the sum spectra. In particular, these substance concentrations can be calculated on the basis of an approach that takes into account that the total concentration of one over the
Gesamtremissionslichtspektrum erfassten Stoffes aus den Teilkonzentrationen dieses Stoffes in den einzelnen Gewebesystemen, insbesondere den Gewebe-, Kapillar- oder Fluidsystemen ergibt. Die erfindungsgemäß für die zeitliche Änderung des Remissionslichtspektrums generierten Dynamikmerkmale können gemäß einem weiteren Aspekt der vorliegenden Erfindung auch einem Auswertungsverfahren zugrunde gelegt werden, wobei über dieses Auswertungsverfahren Auswertungsergebnisse generiert werden, die als solche den physiologischen Zustand einer Person beschreiben oder typisieren.Total emission spectrum of detected substance from the partial concentrations of this substance in the individual tissue systems, in particular the tissue, capillary or fluid systems results. According to a further aspect of the present invention, the dynamic features generated according to the invention for the temporal change of the remission light spectrum can also be based on an evaluation method, whereby evaluation results are generated via this evaluation method, which as such describe or typify the physiological condition of a person.
Weitere Einzelheiten und Merkmale der Erfindung ergeben sich aus der nachfolgenden Beschreibung in Verbindung mit der Zeichnung. Es zeigt:Further details and features of the invention will become apparent from the following description taken in conjunction with the drawings. It shows:
Figur 1 eine Schemadarstellung zur Veranschaulichung des erfindungsgemäßen Ansatzes zur Generierung einer Seguenz von Spektren und der Heranziehung der hierbei erfassten, durch Vitalprozesse verursachten dynamischen Spektrumsänderungen zur Zuordnung von Stoffen zu bestimmten Gewebe-, oder Kapillarsystemen.Figure 1 is a schematic diagram illustrating the approach of the invention for generating a sequence of spectra and the inclusion of the hereby detected, caused by vital processes dynamic spectrum changes for the assignment of substances to certain tissue, or capillary.
Die Darstellung nach Figur 1 dient als solche der Veranschaulichung des erfindungsgemäßen Verfahrens zur Generierung von spektrometrischen Messsignalen.The illustration according to FIG. 1 serves as an illustration of the method according to the invention for generating spectrometric measuring signals.
Nach diesem Verfahren wird durch eine hier als Diode ausgeführte Lichtquelle 1 Licht L in einen zu untersuchenden Gewebebereich G eingekoppelt. Das aus diesem Gewebebereich G austretende Licht R wird einer, hier nur beispielhaft als Prisma angedeuteten, Spektrometereinrichtung 2 zugeführt. Über diese Spektrometereinrichtung 2 wird das aus dem zu untersuchenden Gewebebereich austretende Licht in seine Spektralanteile zerlegt. Im Wege dieser Spektralzerlegung werden Messsignale M generiert, die als solche die Intensität I (alternativ optische Dichte OD) des Remissionslichtes R unter Zuordnung zur Wellenlänge λ darstellen. Diese Messignale werden fortlaufend digital gespeichert.According to this method, light L is coupled into a tissue region G to be examined by means of a light source 1 embodied here as a diode. The light R emerging from this tissue region G is supplied to a spectrometer device 2, which is indicated here only by way of example as a prism. About this spectrometer 2, the light emerging from the tissue area to be examined light is decomposed into its spectral components. In the course of this spectral decomposition measurement signals M are generated, which as such, the intensity I (alternatively optical density OD) of the remission light R represent assignment to the wavelength λ. These measuring signals are stored continuously digitally.
Das erfindungsgemäße Verfahren zeichnet sich dadurch aus, dass die Messung derart abgewickelt wird, dass sich diese über einen Zeitraum T hinweg erstreckt und dass für diesen Zeitraum T Daten generiert werden, die den zeitlichen Verlauf der Intensität der aufgelösten Wellenlängen abbilden. Bei dem hier angedeuteten Messbeispiel beinhaltet das der Spektrometereinrichtung 2 zugeführte Remissionslicht R Licht aus verschiedenen Zonen des Gewebebereiches G. Insbesondere enthält dieses Licht Fraktionen, die beispielsweise durch Substanzen verursacht sind, die durch Kapillare K des Gewebebereiches G fließen. Weiterhin enthält das Remissionslicht R auch Spektralanteile von Substanzen, die aus Zonen H des Gewebebereiches stammen, in welchen keine besonderen dynamischen Änderungen von Stoffpräsenzen auftreten. Die Intensität der Spektren, die durch Substanzen verursacht sind, die als solche durch die Kapillaren K fließen, ändern sich bei dem hier gezeigten Beispiel nach Maßgabe eines durch Vasomotion verusachten Pulsmusters. Dieses Pulsmuster ist bei dem hier gezeigten Ausführungsbeispiel insbesondere für bestimmte Wellenspektralanteile im Bereich von 650 bis 900 Nanometern in dem hier erkennbaren Kennfeld ersichtlich.The method according to the invention is characterized in that the measurement is processed in such a way that it extends over a time period T and that for this time period T data are generated which map the time profile of the intensity of the resolved wavelengths. In the example of measurement indicated here, the remission light R supplied to the spectrometer device 2 contains light from different zones of the tissue region G. In particular, this light contains fractions which are caused, for example, by substances flowing through capillary K of the tissue region G. Furthermore, the remission light R also contains spectral components of substances which originate from zones H of the tissue region in which no special dynamic changes of substance presence occur. The intensity of the spectra, which are caused by substances that flow as such through the capillaries K, change in the example shown here in accordance with a Pulsomters made by Vasomotion. In the exemplary embodiment shown here, this pulse pattern can be seen, in particular, for certain wave spectral components in the range from 650 to 900 nanometers in the characteristic diagram recognizable here.
Das erfindungsgemäße Konzept besteht darin, innerhalb eines Summenspektrums die Spektralbeiträge jener Substanzen zu erkennen deren Präsenz durch vitalmechanische Effekte alterniert. Dadurch wird es möglich das Spektrum einer pulsierenden Flüssigkeit in einem trüben Medium zu isolieren.The inventive concept consists in recognizing within a sum spectrum the spectral contributions of those substances whose presence alternates by vital mechanical effects. This makes it possible to isolate the spectrum of a pulsating liquid in a cloudy medium.
Bei belebtem Gewebe, insbesondere blutdurchflossener Haut entspricht die Temperatur des statischen Gewebes im wesentlichen der Temperatur der pulsierenden Flüssigkeit. Ist der Körper völlig durchlässig und absorbiert die Flüssigkeit charakteristisch (wie z.B. Blut), dann kann der pulsende Strom mit Hilfe spektroskopischer Methoden durch Absorptionsänderungen gemessen werden. Vorzugsweise erfolgt die Aufzeichnung des zeitlichen Verlaufs der Intensität mit einer Auflösung die auswertungsrelevante vitalkinematische Effekte je Intervall mit wenigstens mit fünf Messpunkten stützt .In invigorated tissue, in particular blood-perfused skin, the temperature of the static tissue essentially corresponds to the temperature of the pulsating fluid. is the body is completely permeable and absorbs the fluid characteristically (such as blood), then the pulsating current can be measured by absorption changes by means of spectroscopic methods. Preferably, the recording of the temporal course of the intensity takes place with a resolution which supports evaluation-relevant vital kinematic effects per interval with at least five measuring points.
Misst man nun an verschiedenen Wellenlängen, erhält man in Abhängigkeit von der unterschiedlichen Absorption an unterschiedlichen Wellenlängen unterschiedliche Pulsamplituden. Ordnet man die Amplitudendifferenzen den Wellenlängen zu, erhält man ein Spektrum der pulsenden Flüssigkeit. Dieses Differenzspektrum ist nicht von der Umgebungssubstanz gestört. Ist das Spektrum der Flüssigkeit bekannt, so können beigemischte Substanzen anhand der Absorptionsänderung gegenüber dem bekannten Spektrum detektiert werden.If one then measures at different wavelengths, different pulse amplitudes are obtained depending on the different absorption at different wavelengths. Assigning the amplitude differences to the wavelengths gives a spectrum of the pulsating liquid. This difference spectrum is not disturbed by the surrounding substance. If the spectrum of the liquid is known, admixed substances can be detected on the basis of the change in absorption compared to the known spectrum.
Auf Grundlage des erfindungsgemäßen Konzeptes wird es insbesondere möglich, Blutinhaltsstoffe, wie Cholesterin und Zucker, auf optischem Wege zuverlässig zu erkennen. On the basis of the concept according to the invention, it becomes possible, in particular, to reliably detect blood constituents, such as cholesterol and sugar, by optical means.

Claims

Patentansprüche claims
1. Verfahren zur Generierung von spektrometrischen Messsignalen bei welchem:1. A method for generating spectrometric measurement signals in which:
Licht in einen zu untersuchenden vitalen Gewebebereich eingekoppelt wird,Light is coupled into a vital tissue region to be examined,
Remissionslicht das als solches aus dem zu untersuchendenRemission light that as such from the to be examined
Gewebebereich austritt einer Spektrometereinrichtung zugeführt wird, und über die Spektrometereinrichtung Messsignale generiert werden die als solche die Intensität desTissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
Remissionslichtes unter Zuordnung zur Wellenlänge darstellen, wobei die Messung derart abgewickelt wird, dass sich diese über einen Zeitraum (T) hinweg erstreckt, und dass für diesen Zeitraum (T) Daten generiert werden die den zeitlichen Verlauf der Intensität der aufgelöstenRepresenting remission light associated with the wavelength, wherein the measurement is carried out so that this extends over a period of time (T), and that for this period (T) data are generated which the time course of the intensity of the resolved
Wellenlängen beschreiben.Describe wavelengths.
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, dass innerhalb . des Zeitraums (T) eine Vielzahl von Spektren aufgezeichnet werden.2. The method according to claim 1, characterized in that within. of the period (T) a plurality of spectra are recorded.
3. Verfahren nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die hinsichtlich des zeitlichen Verlaufs der Intensität der aufgelösten Wellenlängen indikativen Daten unter Zuordnung zu den Wellenlängen gespeichert werden.3. The method according to claim 1 or 2, characterized in that the indicative of the time course of the intensity of the resolved wavelengths indicative data are stored in association with the wavelengths.
4. Verfahren nach Anspruch 3, dadurch gekennzeichnet, dass für die Aufzeichnung des Spektrums ein Datenfeld angelegt wird, das zu jedem aufgelösten Wellenlängenwert Daten enthält die als solche den Intensitätsverlauf oder die Intensitätsdynamik beschreiben. 4. The method according to claim 3, characterized in that for the recording of the spectrum, a data field is applied, which contains data for each resolved wavelength value data as such describe the intensity profile or the intensity dynamics.
5. Verfahren nach Anspruch 1, dadurch gekennzeichnet, dass die Daten zur Intensitätsdynamik als FFT-Parameter abgelegt werden .5. The method according to claim 1, characterized in that the data for the intensity dynamics are stored as FFT parameters.
6. Verfahren nach wenigstens einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass anhand von Dynamikmerkmalen eine Zuordnung von Spektren zu Gewebe-, Kapillar-, und/oder Fluidsystemen bewerkstelligt wird.6. The method according to at least one of claims 1 to 5, characterized in that on the basis of dynamic characteristics, an assignment of spectra to tissue, capillary, and / or fluid systems is accomplished.
7. Verfahren nach Anspruch 6, dadurch gekennzeichnet, dass anhand der Dynamikmerkmale festgestellt wird, ob ein Stoff sich in der Blutbahn befindet.7. The method according to claim 6, characterized in that it is determined on the basis of the dynamic characteristics, whether a substance is in the bloodstream.
8. Verfahren nach wenigstens einem der Ansprüche 1 bis , dadurch gekennzeichnet, dass unter Verwertung der Dynamikmerkmale eine Berechnung von Stoffkonzentrationen erfolgt .8. The method according to at least one of claims 1 to, characterized in that the utilization of the dynamic characteristics is carried out a calculation of substance concentrations.
9. Verfahren nach wenigstens einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass unter Verwertung der Dynamikmerkmale eine Berechnung der Stoffkonzentrationen der Stoffe im jeweiligen Gewebe-, Kapillar-, und/oder Fluidsystem erfolgt .9. The method according to at least one of claims 1 to 8, characterized in that taking advantage of the dynamic characteristics, a calculation of the substance concentrations of the substances in the respective tissue, capillary, and / or fluid system takes place.
10. Verfahren nach wenigstens einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass die Dynamikmerkmale einem Auswertungsverfahren zugrunde gelegt werden, wobei über dieses Auswertungsverfahren Auswertungsergebnisse generiert werden die als solche den physiologischen Zustand einer Person beschreiben.10. The method according to at least one of claims 1 to 9, characterized in that the dynamic characteristics are based on an evaluation, whereby evaluation results are generated via this evaluation method which describe as such the physiological state of a person.
11. Verfahren zur Generierung eines für den vasomotorischen Zustand einer Person indikativen Signales bei welchem Licht in einen Gewebebereich eingekoppelt wird, das aus dem Gewebebereich austretende Licht spektral zerlegt wird, und anhand des zeitlichen Verlaufs der Intensität bestimmter Wellenlängen ein den vasomotorischen Zustand der Person typisierendes Auswertungsergebnis generiert wird.11. A method for generating a signal indicative of the vasomotor state of a person in which light is coupled into a tissue region, the light emerging from the tissue region is spectrally decomposed, and On the basis of the time course of the intensity of specific wavelengths, an evaluation result typifying the vasomotor state of the person is generated.
12. Mobiles Spektrometer mit einer Speichereinrichtung und einer Auswertungsschaltung, wobei dieses Spektrometer derart konfiguriert ist, dass durch dieses eine Messung durchführbar ist bei welcher:12. A mobile spectrometer with a memory device and an evaluation circuit, wherein this spectrometer is configured such that through this a measurement is feasible in which:
Licht in einen zu untersuchenden vitalen Gewebebereich eingekoppelt wird,Light is coupled into a vital tissue region to be examined,
Remissionslicht das als solches aus dem zu untersuchendenRemission light that as such from the to be examined
Gewebebereich austritt einer Spektrometereinrichtung zugeführt wird, und über die Spektrometereinrichtung Messsignale generiert werden die als solche die Intensität desTissue region is fed to a spectrometer device, and the spectrometer device generates measurement signals which as such are the intensity of the
Remissionslichtes unter Zuordnung zur Wellenlänge darstellen, wobei die Messung derart abgewickelt wird, dass sich diese über einen Zeitraum (T) hinweg erstreckt, und dass für diesen Zeitraum (T) Daten generiert werden die den zeitlichen Verlauf der Intensität der aufgelöstenRepresenting remission light associated with the wavelength, wherein the measurement is carried out so that this extends over a period of time (T), and that for this period (T) data are generated which the time course of the intensity of the resolved
Wellenlängen beschreiben. Describe wavelengths.
EP08802671A 2007-09-26 2008-09-26 Method and measuring instrument for collecting spectrometric test signals from living tissue Withdrawn EP2198270A1 (en)

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EP2584956B1 (en) 2010-06-22 2021-08-04 Sentec GmbH Device and method for recognising and monitoring physiological blood values
EP2399509A1 (en) 2010-06-22 2011-12-28 Senspec GmbH Device and method for recognising and monitoring physiological blood values

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US6119031A (en) * 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
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