EP2197590A1 - Device for separately storing a substance, preferably a medical or pharmaceutical substance, and a liquid and mixing the same prior to the delivery thereof - Google Patents

Device for separately storing a substance, preferably a medical or pharmaceutical substance, and a liquid and mixing the same prior to the delivery thereof

Info

Publication number
EP2197590A1
EP2197590A1 EP08801309A EP08801309A EP2197590A1 EP 2197590 A1 EP2197590 A1 EP 2197590A1 EP 08801309 A EP08801309 A EP 08801309A EP 08801309 A EP08801309 A EP 08801309A EP 2197590 A1 EP2197590 A1 EP 2197590A1
Authority
EP
European Patent Office
Prior art keywords
substance
container
liquid
pump
tubular insert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08801309A
Other languages
German (de)
French (fr)
Other versions
EP2197590B1 (en
Inventor
Stephan Kneer
Roland Kneer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gaplast GmbH
Original Assignee
Gaplast GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gaplast GmbH filed Critical Gaplast GmbH
Publication of EP2197590A1 publication Critical patent/EP2197590A1/en
Application granted granted Critical
Publication of EP2197590B1 publication Critical patent/EP2197590B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0078—Arrangements for separately storing several components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1043—Sealing or attachment arrangements between pump and container
    • B05B11/1046—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
    • B05B11/1047—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/30—Dip tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means

Definitions

  • Device for the separate storage of a substance, preferably a medicinal or pharmaceutical active substance, and a liquid, and for mixing them before delivery
  • the invention relates to an apparatus for separately storing a substance such as a pharmaceutical agent and a liquid, and mixing them before dispensing, with a first container containing the liquid, a second container containing the substance having a bottom to be opened so that the Substance can enter the liquid, and with a device which is advanceable to exert a force on the bottom of the second container, so that it is opened, further comprising a tubular insert which is inserted into a neck of the first container, wherein the front part of a pump device slidably engages in the tubular insert and forms the force-applying device.
  • a substance such as a pharmaceutical agent and a liquid
  • the substance may be any substance in solid or liquid form which is initially intended to be kept separate from the liquid in the first container and mixed with this liquid before use.
  • the substance may be, for example, freeze-dried lactic acid bacteria, which is mixed with a suitable suspension liquid for probiotic applications before use.
  • the second container containing the substance is constituted by a tubular insert inserted in the neck of the first container having a bottle shape.
  • a predetermined breaking groove is formed, so that the soil can be broken or unfolded by the action of force, so that the substance falls into the liquid of the first container.
  • the opening of the floor is accomplished by the front part of an airless pump, which is slidably disposed in the insert. When the airless pump is advanced in the longitudinal direction of the first container, ie pushed into the container, it breaks open the bottom of the insert.
  • US 6,230,884 B1 discloses a container cap having a blister pack which is opened by depressing a neck portion of the cap, wherein a pen-like tab presses a tablet out of the blister pack which falls into the liquid in a bottle. This ambient air can enter the bottle unhindered.
  • US 4,770,323 is concerned with the problem of providing a sterile package for a fluid which is hermetically sealed by a rupturable sealing membrane until it is first dispensed, allowing unimpeded dispensing of the container contents over a long period of time after rupture of the sealing membrane.
  • a tubular perforating member is pushed through the sealing membrane and engages a riser in the container, the riser being connected to a dispensing channel extending through the cap of the package. Even with this packaging, air may enter the package after the sealing membrane breaks open.
  • the present invention has for its object to provide a device in which the above-mentioned malfunctions when pumping the liquid are largely avoided.
  • the invention provides that the front part of the pump device is held by a pump housing part, which limits an air space in the retracted initial position of the pump above the tubular insert, and in that in a wall, preferably the peripheral wall of the pump housing part, at least one through the wall Is formed opening through which the air escapes from the decreasing air space to the outside during the advancement of the airless pump, without this air enters the first container.
  • the front part of the pump device is sealed at its outer periphery by at least one annular seal against the tubular insert.
  • the peripheral wall of the tubular insert has at least one opening passing through the wall, preferably one or more elongated slots, preferably extending from the free end of the tubular insert to about half its height. Through these openings or slots enters the
  • the second container is formed by a blister pack which is attached to the tubular insert.
  • the substance is sealed in a housing which has a preferably flat bottom and a substantially cup-shaped or bubble-shaped upper chamber wall. To release the substance of the flat bottom or the flat rear wall is broken, wherein the chamber wall is preferably everted through the bottom.
  • the bottom wall consists of an aluminum foil or a multilayer foil containing aluminum, and this may also apply to the chamber wall.
  • an aluminum-containing multilayer film PE-AL-PVC is mentioned without the invention being limited thereto.
  • the chamber wall can be made of LDPE (possibly with an aluminum layer).
  • This blister pack is conveniently attached to the tubular insert, which may protrude into the first container.
  • the attachment can be made in any suitable manner, for example, by the fact that, for example, 3 to 4 mm wide edge of the blister pack is attached by ultrasonic welding to the lower edge of the insert element, with instead of attachment by hot stamping is possible. Other ways of attaching the blister pack are these for example, with an overcap to clamp firmly or to snag with the insert element. As mentioned, the attachment can be done in any suitable way.
  • the front part of the pump means preferably the suction part of an airless pump, is slidably disposed and constitutes the force applying means with which the bottom of the blister pack can be broken.
  • the front part of the pump device is advanced so that the bottom of the blister pack opens inevitably.
  • the curved chamber wall of the blister pack can be everted through the broken bottom without being injured or broken up.
  • the blister pack further closes the lower opening of the tubular insert.
  • a cutting device is attached, which may be formed for example by a sharp-edged metal ring.
  • the curved chamber wall of the blister pack is broken or cut.
  • the tubular insert forms the second container, as is the case with DE 197 42 559 C2.
  • the tubular insert when the bottom of the second container containing the substance is opened by advancing the suction end of the airless pump in the tubular insert, it is prevented that air is pressed into the interior of the liquid container.
  • a blister pack is used as a container for the substance or - as in the case of DE 197 42 559 C2 - the tubular insert itself forms the second container and has a ground réelleêtden.
  • Figure 1 is a side view of an embodiment of the invention
  • Figure 2 is a section A-A through the device of Figure 1;
  • Figure 3 is an enlarged view of the circled portion of Figure 2;
  • Figure 4 is a view similar to Figure 3, but in the position of use of
  • the device includes a bottom cap 1, above a tearing ring 2 for tamper-evident, which is attached to the lower edge of a housing part 3, and an upper cap 4.
  • the upper cap 4 covers a generally designated 5 airless pump 5 and should be removed before use.
  • the suction part 9 of the pump 5 is fixed to a pump housing part 1 1 having a cylindrical peripheral wall 12 which abuts against the outside of the wall portion 8 of the tubular insert 7, and one at the upper end portion of the Suction part 9 adjacent upper wall 12a includes, which define an annular chamber 13 together with the suction part 9 and the top of the tubular insert 7.
  • a pump housing part 1 1 having a cylindrical peripheral wall 12 which abuts against the outside of the wall portion 8 of the tubular insert 7, and one at the upper end portion of the Suction part 9 adjacent upper wall 12a includes, which define an annular chamber 13 together with the suction part 9 and the top of the tubular insert 7.
  • the peripheral wall 12 of the pump housing part 1 1 are passing through the wall holes or slots fourteenth
  • the insert 7 through the wall penetrating, elongated openings 15, which may extend to the lower edge of the insert 7 or short over it.
  • a blister pack 17 is secured in a suitable manner, for example by the edge of the blister pack 17 is welded to the edge 16 of the insert 7.
  • the blister pack 17 has a flat lower bottom 18 and an arched chamber wall 19 projecting upwardly into the interior of the insert 7.
  • the substance within the blister pack 17 is sealed, and by suitable choice of the material of the walls 18 and 19 vapor diffusion into the interior of the blister pack can be excluded.
  • the tear strip 2 is first removed, whereupon the pump 5 can be moved with its suction part 9 in the direction of the blister pack 17.
  • the housing part 3 whose outer wall is aligned with the outer walls of the lower cap 1 and the upper cap 4 in threaded engagement with an inwardly offset upper wall portion 21 of the lower cap. 1
  • the threaded engagement is indicated in Figure 3 by the reference numeral 22.
  • the housing part 3 can also be rotated with the help of the upper cap 4, which is deducted from the housing part 3 upwards but rotatably connected to this.
  • container liquid enters the suction region of the pump part 9, from which any air present therein can easily be displaced.
  • FIG. 4 shows that the head end 20 of the suction part 9 of the pump 5 is provided with a cutting ring 24 which has cut the curved chamber wall 19 of the blister pack 17.
  • FIG. 4 also shows details of the airless pump 5, which are known to the person skilled in the art, so that they will not be described here any more. These details can be seen in FIG.

Abstract

The device for separately storing a substance, such as a medical or pharmaceutical active substance, and a liquid, and for mixing the same prior to use, comprising a first receptacle containing the liquid, a second receptacle that contains the substance and has a bottom to be opened so that the substance passes into the liquid, and comprising a means that can be advanced in order to apply a force to the bottom of the second receptacle such that the bottom is opened, is characterized in that the second receptacle is a blister pack which is mounted inside or on the first receptacle. The substance is thereby sealed within a housing that has a preferably flat bottom and a substantially cup-shaped or blister-shaped upper chamber wall. The flat bottom is torn open in order to release the substance, with the chamber wall being preferably turned upside down through the bottom.

Description

Vorrichtung zum getrennten Aufbewahren einer Substanz, vorzugsweise eines medizinischen oder pharmazeutischen Wirkstoffs, und einer Flüssigkeit, und zum Mischen derselben vor der Abgabe Device for the separate storage of a substance, preferably a medicinal or pharmaceutical active substance, and a liquid, and for mixing them before delivery
Die Erfindung betrifft eine Vorrichtung zum getrennten Aufbewahren einer Substanz wie eines pharmazeutischen Wirkstoffs und einer Flüssigkeit, und zum Mischen derselben vor der Abgabe, mit einem die Flüssigkeit enthaltenden ersten Behälter, einem die Substanz enthaltenden zweiten Behälter, der einen zu öffnenden Boden hat, damit die Substanz in die Flüssigkeit gelangen kann, und mit einer Einrichtung, die vorschiebbar ist, um auf den Boden des zweiten Behälters eine Kraft auszuüben, damit dieser geöffnet wird, ferner mit einem rohrförmigen Einsatz, der in einen Hals des ersten Behälters eingesetzt ist, wobei der vordere Teil einer Pumpeneinrichtung verschieblich in den rohrförmigen Einsatz eingreift und die Kraft ausübende Einrichtung bildet.The invention relates to an apparatus for separately storing a substance such as a pharmaceutical agent and a liquid, and mixing them before dispensing, with a first container containing the liquid, a second container containing the substance having a bottom to be opened so that the Substance can enter the liquid, and with a device which is advanceable to exert a force on the bottom of the second container, so that it is opened, further comprising a tubular insert which is inserted into a neck of the first container, wherein the front part of a pump device slidably engages in the tubular insert and forms the force-applying device.
Bei der Substanz kann es sich um jede Substanz in fester oder auch flüssiger Form handeln, die zunächst von der Flüssigkeit in dem ersten Behälter getrennt aufbewahrt werden soll und vor dem Gebrauch mit dieser Flüssigkeit gemischt wird. Bei der Substanz kann es sich beispielsweise um gefriergetrocknete Milchsäurebakterien handeln, die für probiotische Anwendungen mit einer geeigneten Suspensionsflüssigkeit vermischt wird, bevor die Anwendung erfolgt.The substance may be any substance in solid or liquid form which is initially intended to be kept separate from the liquid in the first container and mixed with this liquid before use. The substance may be, for example, freeze-dried lactic acid bacteria, which is mixed with a suitable suspension liquid for probiotic applications before use.
Eine Vorrichtung der genannten Art ist in der DE 197 42 559 C2 des Anmelders der vorliegenden Patentanmeldung offenbart. Bei der bekannten Vorrichtung ist der die Substanz enthaltende zweite Behälter durch einen rohrförmigen Einsatz gebildet, der in den Hals des ersten Behälters, der eine Flaschenform hat, eingesetzt ist. Am Boden des Einsatzes ist eine Sollbruchnut ausgebildet, so dass der Boden durch Krafteinwirkung aufgebrochen bzw. aufgeklappt werden kann, damit die Substanz in die Flüssigkeit des ersten Behälters fällt. Das Öffnen des Bodens wird durch den vorderen Teil einer Airless-Pumpe bewerkstelligt, der verschieblich in dem Einsatz angeordnet ist. Wenn die Airless-Pumpe in Längsrichtung des ersten Behälters vorgeschoben, d.h. in den Behälter hineingeschoben wird, bricht sie den Boden des Einsatzes auf.A device of the type mentioned is disclosed in DE 197 42 559 C2 of the applicant of the present patent application. In the known apparatus, the second container containing the substance is constituted by a tubular insert inserted in the neck of the first container having a bottle shape. At the bottom of the insert, a predetermined breaking groove is formed, so that the soil can be broken or unfolded by the action of force, so that the substance falls into the liquid of the first container. The opening of the floor is accomplished by the front part of an airless pump, which is slidably disposed in the insert. When the airless pump is advanced in the longitudinal direction of the first container, ie pushed into the container, it breaks open the bottom of the insert.
Bei dieser bekannten Ausbildung tritt das Problem auf, dass beim Vorschieben bzw. Einschieben der Pumpeneinrichtung Luft in den Ansaugbereich der Pumpe gedrückt wird, was zu Funktionsstörungen beim Anpumpen der Flüssigkeit führen kann. Wenn zudem - wie dies bei einigen Anwendungen beispielsweise auf dem medizinischen oder pharmazeutischen Gebiet oder auf dem Gebiet der Hygiene der Fall ist - der Behälterinhalt steril bleiben soll, ist dies mit der vorbekannten Vorrichtung nicht zu gewährleisten, da die beim Vorschub der Pumpe ins Behälterinnere hineingepresste Luft kontaminiert sein kann.In this known training, the problem arises that when advancing or pushing the pump device air is pressed into the intake of the pump, which can lead to malfunction when pumping the liquid. Moreover, if - as is the case with some applications, for example in the medical or pharmaceutical field or in the field of hygiene - the container contents should remain sterile, this can not be guaranteed with the previously known device, since it was pressed into the container interior during the advancement of the pump Air may be contaminated.
US 6,230,884 B1 offenbart eine Behälterkappe mit einer Blisterpackung, die durch Niederdrücken eines Halsabschnitts der Kappe geöffnet wird, wobei ein Stift-ähnlicher Ansatz eine Tablette aus der Blisterpackung heraus drückt, die in die in einer Flasche befindliche Flüssigkeit fällt. Dabei kann Umgebungsluft ungehindert in die Flasche eintreten.US 6,230,884 B1 discloses a container cap having a blister pack which is opened by depressing a neck portion of the cap, wherein a pen-like tab presses a tablet out of the blister pack which falls into the liquid in a bottle. This ambient air can enter the bottle unhindered.
Die US 4,770,323 befasst sich mit dem Problem, eine sterile Packung für ein Fluid anzugeben, das bis zur ersten Abgabe durch eine aufbrechbare Dichtungsmembran hermetisch abgedichtet ist, wobei nach dem Aufbrechen der Dichtungsmembran eine ungehinderte Abgabe des Behälterinhalts über einen langen Zeitraum ermöglicht sein soll. Hierzu wird ein rohrförmiges Perforierungselement durch die Dichtungsmembran gedrückt und gerät in Eingriff mit einem Steigröhrchen in dem Behälter, wobei das Steigröhrchen mit einem Abgabekanal verbunden wird, der sich durch die Kappe der Verpackung erstreckt. Auch bei dieser Verpackung kann nach dem Aufbrechen der Dichtungsmembran Luft in die Verpackung eintreten.US 4,770,323 is concerned with the problem of providing a sterile package for a fluid which is hermetically sealed by a rupturable sealing membrane until it is first dispensed, allowing unimpeded dispensing of the container contents over a long period of time after rupture of the sealing membrane. For this purpose, a tubular perforating member is pushed through the sealing membrane and engages a riser in the container, the riser being connected to a dispensing channel extending through the cap of the package. Even with this packaging, air may enter the package after the sealing membrane breaks open.
D \anm08\07330deNeu doc Der vorliegenden Erfindung liegt die Aufgabe zugrunde, eine Vorrichtung anzugeben, bei der die oben erwähnten Funktionsstörungen beim Anpumpen der Flüssigkeit weitestgehend vermieden sind.D \ anm08 \ 07330deNew doc The present invention has for its object to provide a device in which the above-mentioned malfunctions when pumping the liquid are largely avoided.
Diese Aufgabe wird erfindungsgemäß durch die Merkmal des Patentanspruchs 1 gelöst.This object is achieved by the feature of claim 1.
Vorteilhafte Ausgestaltungen sind in den Unteransprüchen gekennzeichnet.Advantageous embodiments are characterized in the subclaims.
Die Erfindung sieht vor, dass der vordere Teil der Pumpeneinrichtung von einem Pumpengehäuseteil gehalten ist, das in der zurückgezogenen Ausgangsstellung der Pumpe über dem rohrförmigen Einsatz einen Luftraum begrenzt, und dass in einer Wand, vorzugsweise der Umfangswand des Pumpengehäuseteils, wenigstens eine durch die Wand durchgehende Öffnung ausgebildet ist, durch die beim Vorschub der Airless-Pumpe die Luft aus dem sich verkleinernden Luftraum nach außen entweicht, ohne dass diese Luft in den ersten Behälter eintritt. Hierzu ist außerdem erfindungsgemäß vorgesehen, dass der vordere Teil der Pumpeneinrichtung an seinem Außenumfang durch wenigstens eine Ringdichtung gegenüber dem rohrförmigen Einsatz abgedichtet ist.The invention provides that the front part of the pump device is held by a pump housing part, which limits an air space in the retracted initial position of the pump above the tubular insert, and in that in a wall, preferably the peripheral wall of the pump housing part, at least one through the wall Is formed opening through which the air escapes from the decreasing air space to the outside during the advancement of the airless pump, without this air enters the first container. For this purpose, it is also provided according to the invention that the front part of the pump device is sealed at its outer periphery by at least one annular seal against the tubular insert.
Durch diese Ausbildung ist erreicht, dass Funktionsstörungen beim Anpumpen der Airless-Pumpe vermieden sind, da beim Vorschub der Pumpe in die Gebrauchsstellung keine Luft in den Ansaugraum der Pumpe eintritt. Außerdem wird die Sterilität des Behälterinhalts nicht durch Eintritt von evtl. kontaminierter Luft in Frage gestellt.This design ensures that malfunctions when pumping the airless pump are avoided because when the pump is moved to the position of use no air enters the suction chamber of the pump. In addition, the sterility of the container contents is not questioned by the entry of possibly contaminated air.
Des weiteren wird mit Vorteil vorgeschlagen, dass die Umfangswand des rohrförmigen Einsatzes wenigstens eine durch die Wand hindurchgehende Öffnung, vorzugsweise einen oder mehrere lang gestreckte Schlitze aufweist, die sich vorzugsweise vom freien Ende des rohrförmigen Einsatzes bis etwa zu dessen halber Höhe erstrecken. Durch diese Öffnungen oder Schlitze tritt dieFurthermore, it is advantageously proposed that the peripheral wall of the tubular insert has at least one opening passing through the wall, preferably one or more elongated slots, preferably extending from the free end of the tubular insert to about half its height. Through these openings or slots enters the
D:\anm08\07330deNeu.doc Flüssigkeit in den Einsatz und damit in den Ansaugbereich der Pumpe ein, wobei gleichzeitig im Innenraum des rohrförmigen Einsatzes befindliche Luft durch diese Schlitze austreten kann.D: \ anm08 \ 07330deNeu.doc Liquid in the insert and thus in the suction of the pump, wherein at the same time in the interior of the tubular insert located air can escape through these slots.
Diese Ausbildung hat zur Folge, dass bei der erstmaligen Inbetriebnahme der Vorrichtung bereits ein oder zwei Pumpvorgänge der Airlesspumpe ausreichen, um Behälterinhalt abzugeben.As a result of this design, when the device is first put into operation, one or two pumping operations of the airless pump are sufficient to dispense container contents.
In weiterer Ausgestaltung der Erfindung kann vorgesehen sein, dass der zweite Behälter durch eine Blisterpackung gebildet ist, die an dem rohrförmigen Einsatz befestigt ist. Dabei ist die Substanz in ein Gehäuse eingesiegelt, das einen vorzugsweise ebenen Boden und eine im wesentlichen napfförmige oder blasenförmige obere Kammerwand hat. Zur Freigabe der Substanz wird der ebene Boden bzw. die ebene Rückwand aufgebrochen, wobei die Kammerwand vorzugsweise durch den Boden hindurch umgestülpt wird.In a further embodiment of the invention can be provided that the second container is formed by a blister pack which is attached to the tubular insert. In this case, the substance is sealed in a housing which has a preferably flat bottom and a substantially cup-shaped or bubble-shaped upper chamber wall. To release the substance of the flat bottom or the flat rear wall is broken, wherein the chamber wall is preferably everted through the bottom.
Wenn die Substanz - beispielsweise ein medizinischer oder pharmazeutischer Wirkstoff - sicher gegen eindringende Feuchtigkeit zu schützen ist, besteht zumindest die Bodenwand aus einer Aluminiumfolie oder einer Aluminium enthaltenden Mehrschichtfolie, wobei dies auch für die Kammerwand zutreffen kann. Als Beispiel für eine Aluminium enthaltende Mehrschichtfolie wird PE-AL- PVC genannt, ohne dass die Erfindung hierauf beschränkt ist. Die Kammerwand kann aus LDPE (evtl. mit einer Aluminiumschicht versehen) bestehen.If the substance - for example a medicinal or pharmaceutical active substance - is to be protected reliably against penetrating moisture, at least the bottom wall consists of an aluminum foil or a multilayer foil containing aluminum, and this may also apply to the chamber wall. As an example of an aluminum-containing multilayer film, PE-AL-PVC is mentioned without the invention being limited thereto. The chamber wall can be made of LDPE (possibly with an aluminum layer).
Diese Blisterpackung ist zweckmäßigerweise an dem rohrförmigen Einsatz befestigt, der in den ersten Behälter hineinragen kann.This blister pack is conveniently attached to the tubular insert, which may protrude into the first container.
Die Befestigung kann auf jede geeignete Weise erfolgen, beispielsweise dadurch, dass der z.B. 3 bis 4 mm breite Rand der Blisterpackung durch Ultraschallschweißen an dem unteren Rand des Einsatzelementes angebracht ist, wobei statt dessen auch eine Befestigung durch Heißprägen möglich ist. Weitere Möglichkeiten der Befestigung der Blisterpackung bestehen darin, diese beispielsweise mit einer Überkappe fest zu klemmen oder mit dem Einsatzelement zu verschnappen. Wie gesagt, kann die Befestigung auf jede geeignete Art erfolgen.The attachment can be made in any suitable manner, for example, by the fact that, for example, 3 to 4 mm wide edge of the blister pack is attached by ultrasonic welding to the lower edge of the insert element, with instead of attachment by hot stamping is possible. Other ways of attaching the blister pack are these for example, with an overcap to clamp firmly or to snag with the insert element. As mentioned, the attachment can be done in any suitable way.
Der vordere Teil der Pumpeneinrichtung, vorzugsweise der Saugteil einer Airless- Pumpe, ist verschieblich angeordnet und bildet die Kraft ausübende Einrichtung, mit der der Boden der Blisterpackung aufgebrochen werden kann. Hierzu wird der vordere Teil der Pumpeneinrichtung so vorgeschoben, dass sich der Boden der Blisterpackung zwangsläufig öffnet.The front part of the pump means, preferably the suction part of an airless pump, is slidably disposed and constitutes the force applying means with which the bottom of the blister pack can be broken. For this purpose, the front part of the pump device is advanced so that the bottom of the blister pack opens inevitably.
Hierbei kann die gewölbte Kammerwand der Blisterpackung durch den aufgebrochenen Boden hindurch umgestülpt werden, ohne dabei selbst verletzt bzw. aufgebrochen zu werden. In diesem Fall verschließt die Blisterpackung weiterhin die untere Öffnung des rohrförmigen Einsatzes.In this case, the curved chamber wall of the blister pack can be everted through the broken bottom without being injured or broken up. In this case, the blister pack further closes the lower opening of the tubular insert.
Es kann aber auch vorgesehen sein, dass an dem freien Ende des vorderen Teils der Pumpeneinrichtung eine Schneideinrichtung befestigt ist, die beispielsweise durch einen scharfkantigen Metallring gebildet sein kann. In diesem Fall wird auch die gewölbte Kammerwand der Blisterpackung aufgebrochen bzw. aufgeschnitten.But it can also be provided that at the free end of the front part of the pump device, a cutting device is attached, which may be formed for example by a sharp-edged metal ring. In this case, the curved chamber wall of the blister pack is broken or cut.
In einer alternativen Ausgestaltung der Erfindung bildet der rohrförmige Einsatz den zweiten Behälter, wie dies bei der DE 197 42 559 C2 der Fall ist.In an alternative embodiment of the invention, the tubular insert forms the second container, as is the case with DE 197 42 559 C2.
Gemäß der Erfindung ist verhindert, dass beim Öffnen des Bodens des die Substanz enthaltenden zweiten Behälters durch Vorschub des Saugendes der Airlesspumpe in dem rohrförmigen Einsatz Luft ins Innere des Flüssigkeitsbehälters gepresst wird. Dies ist unabhängig davon, ob als Behälter für die Substanz eine Blisterpackung verwendet wird oder - wie im Falle der DE 197 42 559 C2 - der rohrförmige Einsatz selbst den zweiten Behälter bildet und einen aufzubrechenden Boden hat. Dadurch, dass in der Wand des Pumpengehäuseteils oberhalb des rohrförmigen Einsatzes wenigstens eine vorzugsweise seitliche Wandöffnung ausgebildet ist, durch die beim Vorschub der Pumpeneinrichtung Luft nach außen - nicht in den ersten Behälter hinein - entweicht, und dass der - Q - vordere Teil der Pumpeneinrichtung an seinem Außenumfang durch eine Ringdichtung gegenüber dem rohrförmigen Einsatz abgedichtet ist, gelangt keine Luft in den Flüssigkeitsbehälter und damit auch nicht in den Ansaugraum der Pumpe.According to the invention, when the bottom of the second container containing the substance is opened by advancing the suction end of the airless pump in the tubular insert, it is prevented that air is pressed into the interior of the liquid container. This is independent of whether a blister pack is used as a container for the substance or - as in the case of DE 197 42 559 C2 - the tubular insert itself forms the second container and has a ground aufzubrechenden. Characterized in that in the wall of the pump housing part above the tubular insert at least one preferably lateral wall opening is formed through which the feed of the pump means air to the outside - not into the first container into - escapes, and that the - Q - front part of the pump device is sealed at its outer periphery by an annular seal against the tubular insert, no air enters the liquid container and thus not in the suction of the pump.
Weitere Einzelheiten der Erfindung ergeben sich aus der nachfolgenden Beschreibung von bevorzugten Ausführungsformen der Erfindung sowie anhand der Zeichnungen. Dabei zeigen;Further details of the invention will become apparent from the following description of preferred embodiments of the invention and from the drawings. Show;
Figur 1 eine Seitenansicht einer Ausführungsform der erfindungsgemäßenFigure 1 is a side view of an embodiment of the invention
Vorrichtung;Contraption;
Figur 2 einen Schnitt A-A durch die Vorrichtung gemäß Figur 1 ;Figure 2 is a section A-A through the device of Figure 1;
Figur 3 eine vergrößerte Darstellung des eingekreisten Bereichs der Figur 2; Figur 4 eine Darstellung ähnlich Figur 3, jedoch in der Gebrauchsstellung derFigure 3 is an enlarged view of the circled portion of Figure 2; Figure 4 is a view similar to Figure 3, but in the position of use of
Airless-Pumpe undAirless pump and
Wie Figur 1 zeigt, enthält die Vorrichtung eine Bodenkappe 1 , darüber einen Abreißring 2 zur Originalitätssicherung, der am unteren Rand eines Gehäuseteils 3 angebracht ist, sowie eine obere Kappe 4. Die obere Kappe 4 überdeckt eine allgemein mit 5 bezeichnete Airless-Pumpe 5 und ist vor deren Betätigung abzunehmen.As Figure 1 shows, the device includes a bottom cap 1, above a tearing ring 2 for tamper-evident, which is attached to the lower edge of a housing part 3, and an upper cap 4. The upper cap 4 covers a generally designated 5 airless pump 5 and should be removed before use.
In der Bodenkappe 1 sitzt - drehfest mit dieser verbunden - ein etwa flaschenförmiger Behälter 6, in dem sich eine Flüssigkeit befindet. In den Hals des Behälters 6 ist ein rohrförmiger Einsatz 7 eingesetzt, der den Behälterhals mit einem ringförmigen äußeren Wandabschnitt 8 übergreift. In dem Einsatz 7 sitzt verschieblich der vordere Teil oder Saugteil 9 der Airless-Pumpe 5. Am oberen Randbereich des Einsatzes 7 befindet sich eine Ringdichtung 10, die den Zwischenraum zwischen der Innenwand des Einsatzes 7 und der Außenwand des Saugteils 9 der Pumpe 5 abdichtet.In the bottom cap 1 sits - rotatably connected to this - an approximately bottle-shaped container 6, in which there is a liquid. In the neck of the container 6, a tubular insert 7 is inserted, which engages over the container neck with an annular outer wall portion 8. The front part or suction part 9 of the airless pump 5 is slidably seated in the insert 7. At the upper edge region of the insert 7 there is a ring seal 10 which seals the gap between the inner wall of the insert 7 and the outer wall of the suction part 9 of the pump 5.
Das Saugteil 9 der Pumpe 5 ist an einem Pumpengehäuseteil 1 1 befestigt, das eine zylindrische Umfangswand 12, die an der Außenseite des Wandabschnitts 8 des rohrförmigen Einsatzes 7 anliegt, und eine an dem oberen Endbereich des Saugteils 9 anliegende obere Wand 12a enthält, die zusammen mit dem Saugteil 9 und der Oberseite des rohrförmigen Einsatzes 7 eine ringförmige Kammer 13 begrenzen. In der Umfangswand 12 des Pumpengehäuseteils 1 1 befinden sich durch die Wand hindurchgehende Löcher oder Schlitze 14.The suction part 9 of the pump 5 is fixed to a pump housing part 1 1 having a cylindrical peripheral wall 12 which abuts against the outside of the wall portion 8 of the tubular insert 7, and one at the upper end portion of the Suction part 9 adjacent upper wall 12a includes, which define an annular chamber 13 together with the suction part 9 and the top of the tubular insert 7. In the peripheral wall 12 of the pump housing part 1 1 are passing through the wall holes or slots fourteenth
Im unteren Bereich enthält auch der Einsatz 7 durch die Wand hindurchgehende, langgestreckte Öffnungen 15, die sich bis zum unteren Rand des Einsatzes 7 erstrecken können oder kurz darüber enden.In the lower part also contains the insert 7 through the wall penetrating, elongated openings 15, which may extend to the lower edge of the insert 7 or short over it.
An dem unteren Rand 1 6 des Einsatzes 7 ist eine Blisterpackung 17 auf geeignete Weise befestigt, beispielsweise indem der Rand der Blisterpackung 17 an dem Rand 16 des Einsatzes 7 festgeschweißt ist. Die Blisterpackung 1 7 hat einen ebenen unteren Boden 18 und eine nach oben ins Innere des Einsatzes 7 hineinragende gewölbte Kammerwand 19. Die Substanz innerhalb der Blisterpackung 17 ist eingesiegelt, wobei durch geeignete Wahl des Materials der Wände 18 und 19 eine Dampfdiffusion ins Innere der Blisterpackung ausgeschlossen werden kann.At the lower edge 1 6 of the insert 7, a blister pack 17 is secured in a suitable manner, for example by the edge of the blister pack 17 is welded to the edge 16 of the insert 7. The blister pack 17 has a flat lower bottom 18 and an arched chamber wall 19 projecting upwardly into the interior of the insert 7. The substance within the blister pack 17 is sealed, and by suitable choice of the material of the walls 18 and 19 vapor diffusion into the interior of the blister pack can be excluded.
In der in den Figuren 2 und 3 dargestellten Ausgangslage ist das Kopfende 20 des Saugteils 9 der Pumpe 5 von der Blisterpackung 17 beabstandet.In the starting position shown in Figures 2 and 3, the head end 20 of the suction part 9 of the pump 5 is spaced from the blister pack 17.
Zum Vermischen der Substanz der Blisterpackung 17 mit der in dem Behälter 6 bzw. in einem Innenbeutel des Behälters 6 befindlichen Flüssigkeit wird zunächst der Abreißstreifen 2 entfernt, woraufhin die Pumpe 5 mit ihrem Saugteil 9 in Richtung der Blisterpackung 17 bewegt werden kann. Hierzu steht das Gehäuseteil 3, deren Außenwand mit den Außenwänden der unteren Kappe 1 und der oberen Kappe 4 fluchtet im Gewindeeingriff mit einem nach innen versetzten oberen Wandabschnitt 21 der unteren Kappe 1 . Der Gewindeeingriff ist in Figur 3 durch das Bezugszeichen 22 angedeutet. Das Gehäuseteil 3 kann dabei auch mit Hilfe der oberen Kappe 4 gedreht werden, die zwar von dem Gehäuseteil 3 nach oben abziehbar jedoch drehfest mit dieser verbunden ist.For mixing the substance of the blister pack 17 with the liquid contained in the container 6 or in an inner bag of the container 6, the tear strip 2 is first removed, whereupon the pump 5 can be moved with its suction part 9 in the direction of the blister pack 17. For this purpose, the housing part 3, whose outer wall is aligned with the outer walls of the lower cap 1 and the upper cap 4 in threaded engagement with an inwardly offset upper wall portion 21 of the lower cap. 1 The threaded engagement is indicated in Figure 3 by the reference numeral 22. The housing part 3 can also be rotated with the help of the upper cap 4, which is deducted from the housing part 3 upwards but rotatably connected to this.
Wenn das Gehäuseteil 3 auf dem Wandabschnitt 21 nach unten geschraubt wird, nimmt sein radial innerer Ringabschnitt 23 gleichzeitig das Pumpengehäuseteil 1 1 und damit den Saugteil 9 der Pumpe 5 nach unten mit, wobei das Kopfende 20 des Saugteils 9 auf die Blisterpackung 17 auftrifft, die Bodenwand 18 aufreißt und die obere Kammerwand 19 nach unten stülpt. Dieser Zustand ist in Figur 4 dargestellt.When the housing part 3 is screwed down on the wall portion 21, its radially inner ring portion 23 takes the same time Pump housing part 1 1 and thus the suction part 9 of the pump 5 down with, wherein the head end 20 of the suction member 9 impinges on the blister pack 17, the bottom wall 18 ruptures and inverts the upper chamber wall 19 down. This condition is shown in FIG.
Bei diesem Vorgang wird Luft aus dem Ringraum 13 durch die Wandöffnungen 14 verdrängt, ohne dass diese Luft wegen der Ringdichtung 10 ins Innere des rohrförmigen Einsatzes 7 gelangt.In this process, air is displaced from the annular space 13 through the wall openings 14, without this air passes into the interior of the tubular insert 7 because of the annular seal 10.
Durch die Schlitze 15 tritt Behälterflüssigkeit in den Saugbereich des Pumpenteils 9 ein, aus dem evtl. darin befindliche Luft leicht verdrängt werden kann.Through the slots 15, container liquid enters the suction region of the pump part 9, from which any air present therein can easily be displaced.
Figur 4 zeigt, dass das Kopfende 20 des Saugteils 9 der Pumpe 5 mit einem Schneidring 24 versehen ist, der die gewölbte Kammerwand 19 der Blisterpackung 17 aufgeschnitten hat.FIG. 4 shows that the head end 20 of the suction part 9 of the pump 5 is provided with a cutting ring 24 which has cut the curved chamber wall 19 of the blister pack 17.
Figur 4 zeigt im übrigen Einzelheiten der Airless-Pumpe 5, die dem Fachmann bekannt sind, so dass sie hier nicht mehr beschrieben werden. Diese Einzelheiten sind aus Figur 4 erkennbar.FIG. 4 also shows details of the airless pump 5, which are known to the person skilled in the art, so that they will not be described here any more. These details can be seen in FIG.
Es wird betont, dass die Erfindung nicht auf die beschriebenen und dargestellten Ausführungsformen beschränkt ist. Vielmehr sind alle offenbarten Merkmale auf jede sinnvolle Weise einzeln miteinander kombinierbar. It is emphasized that the invention is not limited to the described and illustrated embodiments. Rather, all disclosed features can be individually combined with each other in any meaningful way.

Claims

Patentansprüche claims
1 . Vorrichtung zum getrennten Aufbewahren einer Substanz wie eines pharmazeutischen Wirkstoffs und einer Flüssigkeit, und zum Mischen derselben vor der Abgabe mit einem die Flüssigkeit enthaltenden ersten Behälter, einem die Substanz enthaltenden zweiten Behälter, der einen zu öffnenden Boden hat, damit die Substanz in die Flüssigkeit gelangen kann, und mit einer Einrichtung, die vorschiebbar ist, um auf den Boden des zweiten Behälters eine Kraft auszuüben, damit dieser geöffnet wird, ferner mit einem rohrförmigen Einsatz, der in einen Hals des ersten Behälters eingesetzt ist, wobei der vordere Teil einer Pumpeneinrichtung verschieblich in den rohrförmigen Einsatz eingreift und die Kraft ausübende Einrichtung bildet, dadurch gekennzeichnet, dass der vordere Teil (9) der Pumpeneinrichtung (5) von einem1 . An apparatus for separately storing a substance such as a pharmaceutically active substance and a liquid, and mixing same prior to dispensing with a first container containing the liquid, a second container containing the substance having a bottom to be opened to allow the substance to enter the liquid can, and with means which can be advanced to exert a force on the bottom of the second container so that it is opened, further comprising a tubular insert which is inserted into a neck of the first container, wherein the front part of a pump device displaceable engages in the tubular insert and the force-applying device, characterized in that the front part (9) of the pump device (5) of a
Pumpengehäuseteil (1 1 ) gehalten ist, das in der zurückgezogenenPump housing part (1 1) is held in the retracted
Ausgangsstellung der Pumpeneinrichtung (5) über dem rohrförmigenStarting position of the pump device (5) above the tubular
Einsatz (7) einen Luftraum (13) begrenzt, dass in einer Wand (12) desInsert (7) an air space (13) limited that in a wall (12) of the
Pumpengehäuseteils (1 1 ) wenigstens eine Öffnung (14) ausgebildet ist, durch die beim Vorschub der Pumpeneinrichtung (5) Luft außerhalb des ersten Behälters (6) entweicht, und dass der vordere Teil (9) der Pumpeneinrichtung (5) an seinemPump housing part (1 1) at least one opening (14) is formed through which escapes during the advancement of the pump device (5) air outside the first container (6), and that the front part (9) of the pump device (5) at its
Außenumfang durch eine Ringdichtung (10) gegenüber dem rohrförmigenOuter circumference by an annular seal (10) relative to the tubular
Einsatz (7) abgedichtet ist.Insert (7) is sealed.
2. Vorrichtung nach Anspruch 1 , dadurch gekennzeichnet, dass die Umfangswand des rohrförmigen Einsatzes (7) wenigstens eine Öffnung, vorzugsweise wenigstens zwei Schlitze (15) aufweist. 2. Device according to claim 1, characterized in that the peripheral wall of the tubular insert (7) has at least one opening, preferably at least two slots (15).
3. Vorrichtung nach Anspruch 3, dadurch gekennzeichnet, dass an dem freien Ende (20) des vorderen Teils (9) der Pumpeneinrichtung (5) eine Schneideinrichtung (24) befestigt ist.3. A device according to claim 3, characterized in that at the free end (20) of the front part (9) of the pump device (5) has a cutting device (24) is attached.
4. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass der zweite Behälter eine Blisterpackung (17) ist, die an dem rohrförmigen Einsatz (7) befestigt ist, der in den ersten Behälter (6) hineinragt.4. Device according to one of claims 1 to 3, characterized in that the second container is a blister pack (17) which is fixed to the tubular insert (7) which projects into the first container (6).
5. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass der rohrförmige Einsatz (7) den zweiten Behälter bildet. 5. Device according to one of claims 1 to 3, characterized in that the tubular insert (7) forms the second container.
EP08801309A 2007-09-27 2008-09-08 Device for separately storing a substance, preferably a medical or pharmaceutical substance, and a liquid and mixing the same prior to the delivery thereof Not-in-force EP2197590B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007046625A DE102007046625B4 (en) 2007-09-27 2007-09-27 Device for the separate storage of a substance, preferably a medicinal or pharmaceutical active substance, and a liquid and for mixing the same before use
PCT/DE2008/001505 WO2009039821A1 (en) 2007-09-27 2008-09-08 Device for separately storing a substance, preferably a medical or pharmaceutical substance, and a liquid and mixing the same prior to the delivery thereof

Publications (2)

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EP2197590A1 true EP2197590A1 (en) 2010-06-23
EP2197590B1 EP2197590B1 (en) 2011-11-02

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CA (1) CA2701051C (en)
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010009102B4 (en) 2010-02-24 2014-08-28 Gaplast Gmbh Double-walled squeeze bottle with valve in the airless system
DE102010009101A1 (en) 2010-02-24 2011-08-25 GAPLAST GmbH, 82442 packaging
US8141700B2 (en) * 2010-05-28 2012-03-27 Tap the Cap, Inc. Bottle cap for dispersing powdered supplement in situ
KR101192603B1 (en) * 2010-11-22 2012-10-26 (주)연우 Cosmetic vessel having mixed two-type materials
US10226782B2 (en) * 2013-11-29 2019-03-12 Daizo Corporation Content-accommodating container, content-accommodating product using same, discharge product, and discharge device
FR3016617B1 (en) * 2014-01-17 2016-02-19 Aptar France Sas FLUID PRODUCT TANK AND DISPENSER INTEGRATING SUCH TANK.
EP2957347B1 (en) * 2014-06-18 2017-02-22 Albea Thomaston Inc. System for dispensing a mixture of a first product and a second product
KR101619957B1 (en) * 2015-04-10 2016-05-12 (주)연우 Cosmetic vessel having mixed two-type materials
WO2016174275A1 (en) * 2015-04-27 2016-11-03 Microgaia Biotech, S.L. Mixing stopper
FR3042181B1 (en) * 2015-10-08 2020-02-28 Qualipac DEVICE FOR PACKAGING AND DISPENSING BY DOSE OF A FLUID PRODUCT
CN106829184B (en) * 2017-01-20 2019-04-02 付佳琦 A kind of mixing vessel and production method of solute and liquid
FR3089431B1 (en) * 2018-12-05 2021-01-01 Qualipac Sa PACKAGING AND DISTRIBUTION DEVICE PER DOSE OF A FLUID PRODUCT, INCLUDING A REUSABLE BOTTLE
CN210556616U (en) * 2019-10-11 2020-05-19 浙江越甲药业有限公司 Bottle and bottle cap device thereof
CN110934794B (en) * 2019-12-18 2021-07-16 宁夏艾伊生物工程研发有限公司 Shampoo special for industrial enterprises

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080094A (en) * 1958-04-29 1963-03-05 Modern Lab Inc Compartmented pressurized container valve assembly and a cutter therefor
US3172568A (en) * 1959-03-27 1965-03-09 Modern Lab Inc Pressurized dispensing device
US3655096A (en) * 1969-10-22 1972-04-11 Pillsbury Co Container for diluting and dispensing material
FR2593147B1 (en) * 1986-01-17 1988-03-18 Aerosol Inventions Dev STERILE PACKAGING OF LIQUID AND SEMI-LIQUID FLUID SUBSTANCES.
IT1259853B (en) * 1992-12-09 1996-03-28 Bernardino Parise CONTAINER FOR CONCENTRATED SUBSTANCES IN POWDER OR LIQUID TO BE PUT IN SOLUTION WITHIN A WRAPPER AT THE TIME OF USE
US5642838A (en) * 1995-12-28 1997-07-01 Stoody; William Robert Frangible sealing lid for spile access
CN1092595C (en) * 1997-03-12 2002-10-16 弗雷德里克·迈克尔·库尔利 Discharge cap with releasable tablet basket
DE19742559C2 (en) 1997-09-26 1999-08-05 Gaplast Gmbh Container with a pump
US6098795A (en) * 1997-10-14 2000-08-08 Mollstam; Bo Device for adding a component to a package
FR2800360B1 (en) * 1999-10-29 2002-01-18 Valois Sa EXTEMPORANE MIXTURE DISPENSER
KR200266847Y1 (en) * 2001-12-05 2002-03-04 (주)연우 dispenser

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009039821A1 *

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RU2438797C1 (en) 2012-01-10
BRPI0815960A2 (en) 2018-02-14
DE102007046625B4 (en) 2012-06-06
AU2008302828A1 (en) 2009-04-02
CA2701051C (en) 2016-02-02
JP2011501721A (en) 2011-01-13
US20100219202A1 (en) 2010-09-02
ATE531460T1 (en) 2011-11-15
MX338713B (en) 2016-04-28
WO2009039821A1 (en) 2009-04-02
RU2010116416A (en) 2011-11-10
MX2010003344A (en) 2010-05-03
AU2008302828B2 (en) 2013-03-07
ES2375085T3 (en) 2012-02-24
BRPI0815960A8 (en) 2018-04-17
CA2701051A1 (en) 2009-04-02
CN101855023A (en) 2010-10-06
EP2197590B1 (en) 2011-11-02
US8267280B2 (en) 2012-09-18
JP5605781B2 (en) 2014-10-15
DE102007046625A1 (en) 2009-04-09
CN101855023B (en) 2013-03-13

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