EP2175024A3 - Fabrication microbiologique d'acides 3-hydroxypropion - Google Patents

Fabrication microbiologique d'acides 3-hydroxypropion Download PDF

Info

Publication number
EP2175024A3
EP2175024A3 EP09174021A EP09174021A EP2175024A3 EP 2175024 A3 EP2175024 A3 EP 2175024A3 EP 09174021 A EP09174021 A EP 09174021A EP 09174021 A EP09174021 A EP 09174021A EP 2175024 A3 EP2175024 A3 EP 2175024A3
Authority
EP
European Patent Office
Prior art keywords
genetically modified
hydroxypropionic acid
preparation
cell
catalyzes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09174021A
Other languages
German (de)
English (en)
Other versions
EP2175024B1 (fr
EP2175024A2 (fr
Inventor
Achim Dr. Marx
Volker F. Prof. Dr. Wendisch
Doris Rittmann
Stefan Dr. Buchholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Evonik Operations GmbH
Original Assignee
Evonik Degussa GmbH
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa GmbH, Forschungszentrum Juelich GmbH filed Critical Evonik Degussa GmbH
Publication of EP2175024A2 publication Critical patent/EP2175024A2/fr
Publication of EP2175024A3 publication Critical patent/EP2175024A3/fr
Application granted granted Critical
Publication of EP2175024B1 publication Critical patent/EP2175024B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP09174021.7A 2005-10-10 2006-10-09 Fabrication microbiologique d'acides 3-hydroxypropion Not-in-force EP2175024B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005048818A DE102005048818A1 (de) 2005-10-10 2005-10-10 Mikrobiologische Herstellung von 3-Hydroxypropionsäure
EP06807074A EP1934352A2 (fr) 2005-10-10 2006-10-09 Preparation micorbiologique d'acide 3-hydroxypropionique

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP06807074.7 Division 2006-10-09

Publications (3)

Publication Number Publication Date
EP2175024A2 EP2175024A2 (fr) 2010-04-14
EP2175024A3 true EP2175024A3 (fr) 2010-06-02
EP2175024B1 EP2175024B1 (fr) 2013-12-04

Family

ID=37806019

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06807074A Withdrawn EP1934352A2 (fr) 2005-10-10 2006-10-09 Preparation micorbiologique d'acide 3-hydroxypropionique
EP09174021.7A Not-in-force EP2175024B1 (fr) 2005-10-10 2006-10-09 Fabrication microbiologique d'acides 3-hydroxypropion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06807074A Withdrawn EP1934352A2 (fr) 2005-10-10 2006-10-09 Preparation micorbiologique d'acide 3-hydroxypropionique

Country Status (7)

Country Link
US (1) US20090325248A1 (fr)
EP (2) EP1934352A2 (fr)
CN (2) CN101974439A (fr)
BR (1) BRPI0617265A2 (fr)
DE (1) DE102005048818A1 (fr)
DK (1) DK2175024T3 (fr)
WO (1) WO2007042494A2 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008091627A2 (fr) 2007-01-22 2008-07-31 Genomatica, Inc. Procédés et organismes pour la production couplée à la croissance de l'acide 3-hydroxypropionique
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
WO2009089457A1 (fr) * 2008-01-11 2009-07-16 Novozymes A/S Procédés pour produire de l'acide 3-hydroxypropionique et composés correspondants
BRPI0918875A2 (pt) * 2008-09-15 2017-08-08 Opx Biotechnologies Inc Método para fazer um microorganismo geneticamente modificado, microorganismo e sistema de cultura
EP2350298A1 (fr) * 2008-10-27 2011-08-03 ButamaxTM Advanced Biofuels LLC Hôtes de production optimisée de la voie du carbone pour la production d'isobutanol
CN102300884B (zh) 2009-02-06 2014-05-14 株式会社日本触媒 聚丙烯酸(盐)系吸水性树脂及其制备方法
BRPI1014011A2 (pt) 2009-07-01 2015-10-27 Novozymes North America Inc processo para separar e recuperar ácido 3-hidróxi-propiônico.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CN102695799A (zh) 2009-09-27 2012-09-26 Opx生物工艺学公司 用于制备3-羟基丙酸和其它产物的方法
US10786064B2 (en) 2010-02-11 2020-09-29 Cj Cheiljedang Corporation Process for producing a monomer component from a genetically modified polyhydroxyalkanoate biomass
US20130043384A1 (en) 2010-04-26 2013-02-21 Nippon Shokubai Co., Ltd. Polyacrylic acid (salt), polyacrylic acid (salt)-based water-absorbing resin, and process for producing same
EP2643450A2 (fr) * 2010-11-22 2013-10-02 Novozymes, Inc. Compositions et procédés pour la production d'acide 3-hydroxypropionique
EP2660235A4 (fr) * 2010-12-28 2016-01-20 Nippon Catalytic Chem Ind Procédés pour la production d'acide acrylique et/ou d'un ester de celui-ci et polymère de l'acide acrylique et/ou de l'ester
AU2012316246B2 (en) 2011-09-30 2017-10-26 Novozymes A/S Dehydrogenase variants and polynucleotides encoding same
WO2013052717A2 (fr) * 2011-10-05 2013-04-11 The Procter & Gamble Company Microorganismes et procédés de production d'acrylate et autres produits à l'aide d'homosérine
US9850192B2 (en) 2012-06-08 2017-12-26 Cj Cheiljedang Corporation Renewable acrylic acid production and products made therefrom
CN104718282A (zh) 2012-08-10 2015-06-17 Opx生物工艺学公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
WO2014085330A1 (fr) * 2012-11-30 2014-06-05 Novozymes, Inc. Production d'acide 3-hydroxypropionique par des levures recombinantes
KR20150129007A (ko) * 2013-03-15 2015-11-18 카아길, 인코포레이팃드 단일 기능성 mcr + 3-hp 탈수소효소
WO2014145096A1 (fr) 2013-03-15 2014-09-18 Cindy Hoppe Evaporation éclair pour la purification de production et la récupération
US20150057465A1 (en) 2013-03-15 2015-02-26 Opx Biotechnologies, Inc. Control of growth-induction-production phases
WO2014144400A1 (fr) 2013-03-15 2014-09-18 Cargill, Incorporated Récupération d'acide 3-hydroxypropionique
US20150044746A1 (en) * 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
BR112016001778A2 (pt) * 2013-07-31 2017-09-05 Novozymes As Célula transgênica de levedura, composição, e, métodos de produção de 3-hp e de produção de ácido acrílico ou um sal do mesmo
KR102208963B1 (ko) 2014-05-14 2021-01-28 삼성전자주식회사 신규한 아크릴산 생성 경로를 갖는 미생물 및 이를 이용한 아크릴산 생산 방법
EP2993228B1 (fr) 2014-09-02 2019-10-09 Cargill, Incorporated Production d'esters d'acides gras
BR112017012718A2 (pt) * 2014-12-19 2018-05-15 Novozymes As célula de levedura recombinante, e, métodos para produzir 3-hp e para produzir ácido acrílico ou um sal do mesmo.
WO2016097289A1 (fr) * 2014-12-19 2016-06-23 Global Bioenergies Production enzymatique d'acrylyl-coa ou d'éthylène à partir de glycérol
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
BR112018011503A2 (pt) 2015-12-07 2018-12-04 Zymergen Inc promotores da corynebacterium glutamicum
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US20190153475A1 (en) * 2015-12-17 2019-05-23 Evonik Degussa (China) Co., Ltd. Gene cassette for homologous recombination knock-out in yeast cells
WO2018005655A2 (fr) 2016-06-30 2018-01-04 Zymergen Inc. Procédés de génération d'une bibliothèque d'hémoglobines bactériennes et utilisations associées
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
DE102016114555A1 (de) 2016-08-05 2018-02-08 Thyssenkrupp Ag Prozess zur Herstellung von Acrylsäure aus einer wässrigen 3-Hydroxypropanol-Lösung
JP2020506702A (ja) 2017-02-02 2020-03-05 カーギル インコーポレイテッド C6−c10脂肪酸誘導体を生成する遺伝子組み換え細胞
JP7066977B2 (ja) * 2017-04-03 2022-05-16 味の素株式会社 L-アミノ酸の製造法
WO2019011948A1 (fr) * 2017-07-11 2019-01-17 Adisseo France S.A.S. Levure productrice de métabolite améliorée
CN109852605A (zh) * 2019-01-16 2019-06-07 徐州工程学院 一种诱变筛选高产3-羟基丙酸菌株的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19831609A1 (de) * 1997-10-04 1999-04-15 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel
EP1083225A1 (fr) * 1999-09-09 2001-03-14 Degussa-Hüls Aktiengesellschaft Procédé pour la préparation d'acide pantothénique en utilisant les bactéries corynéformes
WO2003062173A2 (fr) * 2002-01-18 2003-07-31 Cargill, Incorporated Alanine 2,3- aminomutase

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301993A (fr) 1962-12-18
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドpcg2
JPH0783714B2 (ja) 1983-08-29 1995-09-13 味の素株式会社 発酵法によるl―アミノ酸の製造法
US4601893A (en) 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
GB2165546B (en) 1984-08-21 1989-05-17 Asahi Chemical Ind A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
JPH0746994B2 (ja) 1984-10-04 1995-05-24 味の素株式会社 発酵法によるl−アミノ酸の製造法
DE4027453A1 (de) 1990-08-30 1992-03-05 Degussa Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren
EP0878488B2 (fr) 1992-06-10 2010-10-27 Nippon Shokubai Co., Ltd. Procédé de préparation d'une résine hydrophile
JP3880636B2 (ja) 1994-01-10 2007-02-14 味の素株式会社 発酵法によるl−グルタミン酸の製造法
DE4440118C1 (de) 1994-11-11 1995-11-09 Forschungszentrum Juelich Gmbh Die Genexpression in coryneformen Bakterien regulierende DNA
ATE452979T1 (de) 1996-11-13 2010-01-15 Du Pont Herstellungsverfahren von 1,3-propandiol durch rekombinante organismen
JPH10229891A (ja) 1997-02-20 1998-09-02 Mitsubishi Rayon Co Ltd マロン酸誘導体の製造法
EP1073722B1 (fr) 1998-04-13 2010-02-17 The University Of Georgia Research Foundation, Inc. Organismes a metabolisme modifie, destines a la production de substances biochimiques derivees d'oxaloacetate
DE19855314A1 (de) 1998-12-01 2000-06-08 Degussa Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855313A1 (de) 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
US6171833B1 (en) 1998-12-23 2001-01-09 Massachusetts Institute Of Technology Pyruvate carboxylase from corynebacterium glutamicum
JP2000201692A (ja) 1999-01-13 2000-07-25 Ajinomoto Co Inc 発酵法によるl―グルタミン酸の製造法
DE19907347A1 (de) 1999-02-20 2000-08-24 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP3965821B2 (ja) 1999-03-09 2007-08-29 味の素株式会社 L−リジンの製造法
US6599732B1 (en) 1999-06-29 2003-07-29 Archer-Daniels-Midland Company Regulation of carbon assimilation
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
ATE340857T1 (de) 1999-07-23 2006-10-15 Archer Daniels Midland Co Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph
AU7093600A (en) 1999-08-30 2001-03-26 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
DE10031999A1 (de) 1999-09-09 2001-04-19 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
US6803218B1 (en) 1999-09-24 2004-10-12 Genencor Intl., Inc. Enzymes which dehydrate glycerol
DE19950409A1 (de) 1999-10-20 2001-04-26 Degussa Neue für das pck-Gen codierende Nukleotidsequenzen
DE19951975A1 (de) 1999-10-28 2001-05-03 Degussa Neue für das poxB-Gen codierende Nuleotidsequenzen
US6818432B2 (en) 2000-01-13 2004-11-16 Degussa Ag Nucleotide sequences encoding the ptsH gene
DE10045496A1 (de) 2000-09-14 2002-03-28 Degussa Neue für das ptsi-Gen kodierende Nukleotidsequenzen
US7186541B2 (en) 2000-11-20 2007-03-06 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
EP1392636B1 (fr) 2001-05-07 2008-04-23 Cargill, Incorporated Procede de preparation d'acides carboxyliques et de leurs derives
DE10138150A1 (de) 2001-08-03 2003-02-13 Basf Ag Verfahren zur Herstellung wasserabsorbierender Harze

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19831609A1 (de) * 1997-10-04 1999-04-15 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel
EP1083225A1 (fr) * 1999-09-09 2001-03-14 Degussa-Hüls Aktiengesellschaft Procédé pour la préparation d'acide pantothénique en utilisant les bactéries corynéformes
WO2003062173A2 (fr) * 2002-01-18 2003-07-31 Cargill, Incorporated Alanine 2,3- aminomutase
US20050221466A1 (en) * 2002-01-18 2005-10-06 Liao Hans H Alanine 2,3,aminomutase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ADRIE J J STRAATHOF ET AL: "Feasibility of acrylic acid production by fermentation", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 67, no. 6, 1 June 2005 (2005-06-01), pages 727 - 734, XP019331875, ISSN: 1432-0614 *
GEORGI ET AL: "Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: Roles of malic enzyme and fructose-1,6-bisphosphatase", METABOLIC ENGINEERING, ACADEMIC PRESS,, US, vol. 7, no. 4, July 2005 (2005-07-01), pages 291 - 301, XP005052640, ISSN: 1096-7176 *
XINGLIN JIANG ET AL: "Biosynthetic pathways for 3-hydroxypropionic acid production", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 82, no. 6, 17 February 2009 (2009-02-17), pages 995 - 1003, XP019705542, ISSN: 1432-0614 *

Also Published As

Publication number Publication date
DE102005048818A1 (de) 2007-04-12
WO2007042494A2 (fr) 2007-04-19
BRPI0617265A2 (pt) 2011-07-19
EP2175024B1 (fr) 2013-12-04
EP1934352A2 (fr) 2008-06-25
DK2175024T3 (en) 2014-03-10
WO2007042494A3 (fr) 2007-11-22
CN101283095A (zh) 2008-10-08
CN101974439A (zh) 2011-02-16
EP2175024A2 (fr) 2010-04-14
US20090325248A1 (en) 2009-12-31

Similar Documents

Publication Publication Date Title
EP2175024A3 (fr) Fabrication microbiologique d'acides 3-hydroxypropion
EP2602311B1 (fr) Cellules de Candida tropicalis et leur utilisation
WO2009112472A3 (fr) Sélection d’organismes capables de faire fermenter des substrats mélangés
EP1958933A1 (fr) Procédé destiné au nettoyage de L-cystéine
EP1001027A3 (fr) Procédé pour la préparation d'acide pantothénique par amplification des séquences nucléotides codantes pour la cétopantoate-réductase
Verdenal et al. Pre-flowering defoliation affects berry structure and enhances wine sensory parameters
Verdenal et al. Intensity and timing of defoliation on white cultivar Chasselas under the temperate climate of Switzerland
EP2069515B1 (fr) Procédé de production d'érythritol en utilisant des souches de moniliella tomentosa en présence de nitrates inorganiques comme source d'azote
WO2005121326A2 (fr) Alcool deshydrogenase pour la production stereoselective de composes hydroxy
AT506639A1 (de) Verfahren zur deracemisierung von enantiomerengemischen unter verwendung von enzymsystemen
WO2014146881A1 (fr) Souche de micro-organisme et procédé de production fermentative de composés c4 à partir de sucres c5
JP2020534806A5 (fr)
MX2011006794A (es) Metodo para aumentar el rendimiento de sacarosa en el cultivo agricola de remolacha azucarera y caña de azucar.
WO2013139936A1 (fr) Procédé d'amination asymétrique de cétones en mettant en œuvre des oméga-transaminases dans des solvants organiques
Campbell et al. The genetic basis of cis-regulatory divergence between the subspecies of cultivated rice (Oryza sativa)
Werner et al. Neue Biokatalysatoren zur Herstellung langkettiger Dicarbonsäuren
DD272476A5 (de) Verbessertes verfahren zur enzymatischen herstellung von l-2-amino-4-methylphosphinobuttersaeure
Schütz Opportunities and strategies of biorationalisation of forest tending within nature-based management
DE10058144C1 (de) Verminderung der Acetatbildung in Lebensmitteln, die eine alkoholische Fermentation erfahren, insbesondere in Most, Wein oder Fruchtsaft während des biologischen Säureabbaus durch Milchsäurebakterien
Leifels et al. Migrant start-ups–a stronger desire for self-employment
Tano et al. Effects of distillery vinasses on vineyard yield and quality in the DOC “Oltrepò Pavese Pinot Nero”–Lombardy, Italy
DE102016212497A1 (de) Mutanter Mikroorganismus, der ein Gen umfasst, das Methylmalonyl-CoA-Reductase codiert, und seine Verwendung
Gaspar et al. Bio-Technological Characterization of the Saccharomyces bayanus Yeast Strains in Order to Preserve the Local Specificity
End et al. Zellfreie Proteinexpression für Forschung und Produktion: Zellfreie Proteinsynthese
Žiarovská et al. Comparative analysis of allergenic chitinase expression in grape varieties.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20091026

AC Divisional application: reference to earlier application

Ref document number: 1934352

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20110325

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 502006013412

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: C12N0015520000

Ipc: C12P0007400000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: C12P 7/44 20060101ALI20130607BHEP

Ipc: C12P 7/42 20060101ALI20130607BHEP

Ipc: C12P 7/40 20060101AFI20130607BHEP

INTG Intention to grant announced

Effective date: 20130711

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 1934352

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

Ref country code: AT

Ref legal event code: REF

Ref document number: 643581

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140115

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502006013412

Country of ref document: DE

Effective date: 20140123

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20140306

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH

Owner name: EVONIK DEGUSSA GMBH

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

REG Reference to a national code

Ref country code: HU

Ref legal event code: HC9C

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH, DE

Free format text: FORMER OWNER(S): FORSCHUNGSZENTRUM JUELICH GMBH, DE

Ref country code: HU

Ref legal event code: HC9C

Owner name: EVONIK DEGUSSA GMBH, DE

Free format text: FORMER OWNER(S): FORSCHUNGSZENTRUM JUELICH GMBH, DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140404

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140404

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502006013412

Country of ref document: DE

REG Reference to a national code

Ref country code: HU

Ref legal event code: AG4A

Ref document number: E020365

Country of ref document: HU

REG Reference to a national code

Ref country code: SK

Ref legal event code: T3

Ref document number: E 16700

Country of ref document: SK

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20140905

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502006013412

Country of ref document: DE

Effective date: 20140905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502006013412

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20150501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141009

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20141009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141031

REG Reference to a national code

Ref country code: SK

Ref legal event code: MM4A

Ref document number: E 16700

Country of ref document: SK

Effective date: 20141009

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141009

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141031

Ref country code: SK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141009

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141009

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141031

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150501

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20150630

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20141031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150501

Ref country code: HU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141010

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141031

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141009

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141031

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 643581

Country of ref document: AT

Kind code of ref document: T

Effective date: 20141009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140305

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131204