EP2166297A2 - Dispositif de transfert pour une installation de lyophilisation - Google Patents
Dispositif de transfert pour une installation de lyophilisation Download PDFInfo
- Publication number
- EP2166297A2 EP2166297A2 EP09170577A EP09170577A EP2166297A2 EP 2166297 A2 EP2166297 A2 EP 2166297A2 EP 09170577 A EP09170577 A EP 09170577A EP 09170577 A EP09170577 A EP 09170577A EP 2166297 A2 EP2166297 A2 EP 2166297A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- transfer device
- freeze
- station
- support frame
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004108 freeze drying Methods 0.000 title claims abstract description 58
- 230000008878 coupling Effects 0.000 claims abstract description 27
- 238000010168 coupling process Methods 0.000 claims abstract description 27
- 238000005859 coupling reaction Methods 0.000 claims abstract description 27
- 238000009434 installation Methods 0.000 claims abstract 3
- 238000007600 charging Methods 0.000 claims description 8
- 238000012423 maintenance Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 5
- 230000005540 biological transmission Effects 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 239000000356 contaminant Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/001—Handling, e.g. loading or unloading arrangements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
- F26B25/063—Movable containers or receptacles, e.g. carts, trolleys, pallet-boxes
Definitions
- the invention relates to a transfer device for a freeze-drying plant and a corresponding freeze-drying plant.
- Freeze drying systems are used for lyophilization, for example in the pharmaceutical industry, and typically contain several freeze drying stations and at least one loading and unloading station.
- a package with vials containing the substance to be freeze-dried is formed on a loading table.
- transfer carriages which can be moved on rails are usually used, the bottle pack formed on the loading table of the loading station first being pushed into the loading area of the transfer carriage.
- the transfer car then drives along a predetermined rail distance to the respective freeze-drying station, where the bottle pack is pushed with a slider from the loading area of the transfer carriage in the freeze-drying station.
- Each freeze-drying station picks up stacked bottles on several floors so that the transfer cart has to cycle several times between the loading station and the respective freeze-drying station in order to load them.
- the transfer carriage includes a laminar flow device arranged above the loading area for generating a laminar air flow in the loading area.
- the Laminarflow helped cleans the air and creates a running through the loading area and out of the transfer carriage guided laminar air flow to transport out any impurity particles from the loading area and keep away.
- class A clean room conditions must prevail in the loading area of the transfer cart.
- class B clean room conditions must prevail in the area where the transfer cart is moving.
- the class A clean room conditions must also prevail in the loading area of the transfer carriage if no product is being transported, because otherwise expensive proof would have to be provided that the product to be freeze-contaminated is not contaminated by existing contaminants in the loading area.
- the invention has for its object to provide a flexible transfer device for a freeze dryer with a simplified structure and to enable shorter loading times. Furthermore, a corresponding freeze-drying plant is to be provided.
- the transfer device according to the invention is defined by the features of claim 1.
- the freeze-drying device according to the invention is defined by the features of claim 8.
- the transfer device has a lift truck, which is mechanically connectable to the support frame for lifting and moving the support frame of the transfer device and which has a drive motor and a steering device.
- the lift truck can be moved by the drive motor and the steering device independently of the support frame of the transfer device.
- the distance to be traveled by the truck can be determined flexibly by the drive motor and by the steering device and is not fixed by a rail system.
- the pallet truck can be moved under the support frame for mechanical connection with the support frame and lift the support frame such that it is flexibly movable by the pallet truck.
- the lift truck can place the support frame in front of a loading station in such a way that the product to be freeze-dried is loaded from the loading station into the loading area of the transfer device.
- the truck can move the support frame along a freely definable route to the relevant freeze-drying station, where the product from the loading area in the freeze-drying station is transferred in a conventional manner.
- the laminar flow device allows continuous operation and thus clean room conditions both in the loaded, as well as in the discharged state of the support frame.
- the pallet truck can be decoupled from the support frame.
- the pallet truck can park the support frame, for example, in front of a loading station and during loading transfer another support frame from another loading station to a freeze-drying station.
- the truck can park a support frame in a separate area for maintenance, cleaning and / or sterilization and transport another support frame during the implementation of maintenance, cleaning or sterilization.
- the support frame, the lift truck or the entire transfer device for a sterilization with H 2 O 2 gas (VHP) is designed.
- the transfer device is more flexible due to the decoupled lift truck and can depart freely definable distances without being bound to a rail system. As a result, the loading times can be shortened.
- the lift truck may have a power supply device and be connectable to the support frame in such a way that the laminar flow device is supplied with the required energy by the power supply device.
- the lift truck can be moved into a separate area for maintenance, cleaning or sterilization of the lift truck, the drive motor and / or the steering device, without the support frame is transported.
- the corresponding support frame can be transported by another lift truck, so that the maintenance of the drive and / or steering of the transfer device does not hinder the loading of the freeze drying stations.
- coupling elements are provided at the freeze-drying station and / or the charging station, which are connected to a corresponding coupling device the transfer device to allow a precise positioning of the transfer device with respect to the respective freeze-drying station or charging station.
- the coupling elements are frusto-conical, upwardly projecting projections and the coupling device correspondingly complementary, so that engage by lowering the lift truck, the coupling elements in the coupling device and is automatically placed by lowering the support frame. Due to the mechanical engagement of coupling device and coupling elements of the support frame is fixed in the lowered state and slipping, z. B. during loading a freeze-drying station avoided.
- the coupling device and the coupling elements can have electrical contacts which, in the coupled state, produce an electrical connection which serves to switch on certain operating functions of the transfer device and / or the freeze-drying or charging station.
- electrical contacts can be supplied by the electrical contact, the Laminarflow achieved and / or the slider for moving the product to be freeze-dried or charged a battery in the truck.
- the lift truck may have a greater width than the support frame, wherein the width of the lift truck preferably corresponds to a multiple of the width of the support frame, so that the lift truck can accommodate several support frame side by side and transport at the same time. As a result, the flexibility of the transfer device is increased.
- the transfer device advantageously has a navigation device for determining the position.
- the navigation device may be formed on the support frame and determine the relative position to a freeze-drying station and / or to a charging station.
- the lift truck can use a navigation device for determining the relative position have the support frame.
- the transfer device preferably has a data transmission interface, e.g. B. in the form of a WLAN interface, adapted to receive control commands for the drive motor and the steering device.
- the control commands are sent as a function of the position previously determined by the navigation device.
- the navigation device can be used in a conventional manner z. B. be provided as a laser navigation system with mirrors.
- the position data can be transmitted via the data transmission interface to a control computer.
- the control computer can receive and process the position data of all transfer devices of a freeze-drying plant in the manner of a control center, in order subsequently to send to each transfer device individual control commands which enable a method of the relevant lift truck to avoid collisions.
- the loading station of the freeze-drying plant can be a conveyor, z.
- As a conveyor belt have to promote the product to be freeze-dried directly into the loading area of a correspondingly positioned transfer device.
- the bottle pack which is transferred from the transfer device to the freeze-drying station, can be formed directly in the loading area of the support frame.
- the loading area then serves as a loading or unloading table without the need for a separate loading or unloading table at the loading station.
- FIGS. 1 and 2 show the transfer device 10 in a schematically simplified representation in front of a freeze-drying station 12, wherein the transfer device 10 in the direction of arrow 13 of the freeze-drying station 12 approaches for loading.
- the transfer device 10 has a support frame 18 carried by a lift truck 16.
- the lift truck 16 has not shown mechanical receptacles for the support frame 18, wherein received by lifting the lift truck 16 of the support frame 18 in the recordings and held.
- the receptacles are free and the support frame 18 is on the ground, so that the lift truck 16 can be moved away from the support frame 18.
- the lift truck 16 has a power supply device 20 in the form of a battery, not shown, has servomotors for the drive motor, the steering device and the lifting device.
- the support frame 18 of the transfer device 10 has a central loading area 22 in which a bottle pack 24 of a certain number of vials with product to be freeze-dried is contained.
- the bottle pack 24 has been loaded with a sliding frame 26 from a loading station into the loading area of the transfer device.
- a laminar flow device 28 is fastened to the support frame 18.
- the Laminarflow recognized 28 is from the battery 20 in the truck 16 with Power supplied and generated in the loading area 22, a laminar flow of purified air, which is indicated schematically by the arrows 30.
- the laminar air flow 30 in the loading area 22 is always maintained to meet the purity requirements of the operation of the freeze-drying plant. Otherwise, in the event of an interruption of the laminar air flow 30 in the loading area 22, expensive proof would be required that a subsequently charged product will not be contaminated by existing contaminants in the loading area 22.
- a cabinet 32 is attached laterally.
- a WLAN interface 34 and a laser 36 are arranged at the top of the support frame 18.
- the laser 36 is together with mirrors 38 part of a laser navigation system for determining the position of the transfer device 10.
- the position data can be transmitted via the WLAN interface 34 to an external WLAN interface 40 of a central control computer.
- the central control computer can determine the required control commands for the drive motor, the steering device and the lifting device of the lift truck 16 on the basis of the position data. These control commands are sent to the data transmission interface 34 of the transfer device 10 and transmitted via the control cabinet 32 to the drive motor, the steering device and / or the lifting device.
- coupling elements 40 are arranged in the form of frustoconical elevations on the ground.
- the coupling elements 40 engage with corresponding coupling devices 42 on the underside of the support frame 18 in the lowered state.
- the conical shape of the coupling elements 40 is a fine positioning of the support frame 18 relative to the freeze-drying station 12.
- an accuracy of max ⁇ 1 ⁇ 2 mm is typically required to allow error-free loading of the freeze-drying station 12 by the transfer device 10.
- the coupling elements 40 also fix the support frame 18, so that a displacement relative to the freeze-drying station 12 during the Loading process is avoided.
- both the coupling elements 40 and the coupling means 42 via electrical contacts which in the contacted state z. B. start the loading process of the freeze-drying station 12 or charge the battery 20 of the lift truck 16.
- FIG. 3 shows a schematic representation of a plan view of a freeze-drying plant according to the invention.
- the freeze dryer includes a transfer cart 10, six freeze drying stations 12 and two loading and unloading stations 14, 16, the loading station 14 being an unloading station and the loading station 16 being a loading station.
- the freeze-drying plant includes a service area 18, in which a support frame 18 or a pallet truck 16 can be parked for maintenance, cleaning and / or sterilization.
- the arrows in FIG. 3 show possible directions of movement and paths of the transfer device 10.
- the transfer device 10 is in a position in front of one of the freeze-drying stations 12.
- the support frame 18 is moved by the lift truck 16 in front of the loading station 14.
- the lift truck 16 set down the support frame 18 and during loading by the loading station 14 another support frame, z. B. from another freeze-drying station 12, to the unloading station 14 or to the service area 18.
- the loading station 16 of the lift truck 16 After loading of the loading area 22 by the loading station 16 of the lift truck 16 lifts the loaded support frame 18 and moves the support frame 18 to the desired freeze-drying station 12.
- the truck 16, the support frame 18 also sell.
- the lift truck 16 can move another supporting frame 18, e.g. B. from a freeze-drying station 12 to the charging station 16 or in the service area 18, proceed.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Drying Of Solid Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202008012379U DE202008012379U1 (de) | 2008-09-18 | 2008-09-18 | Transfervorrichtung für eine Gefriertrocknungsanlage |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2166297A2 true EP2166297A2 (fr) | 2010-03-24 |
EP2166297A3 EP2166297A3 (fr) | 2010-10-13 |
EP2166297B1 EP2166297B1 (fr) | 2015-08-26 |
Family
ID=40157949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09170577.2A Active EP2166297B1 (fr) | 2008-09-18 | 2009-09-17 | Dispositif de transfert pour une installation de lyophilisation |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100070108A1 (fr) |
EP (1) | EP2166297B1 (fr) |
CN (1) | CN101676660A (fr) |
DE (1) | DE202008012379U1 (fr) |
ES (1) | ES2553137T3 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2003338C2 (en) * | 2009-08-07 | 2011-02-08 | Ima Life Srl | Method and assembly for handling containers in a freeze dryer. |
CN102305517A (zh) * | 2011-06-19 | 2012-01-04 | 上海东富龙科技股份有限公司 | 一种原料药冻干托盘自动转运至冻干机板层的方法 |
DE102011117628B4 (de) | 2011-11-04 | 2015-10-22 | Martin Christ Gefriertrocknungsanlagen Gmbh | Gefriertrockungsanlage mit einer Be- und Entladevorrichtung |
CN103625926B (zh) * | 2013-01-16 | 2015-12-02 | 世源科技工程有限公司 | 自洁净搬运方法 |
TW201447209A (zh) * | 2013-06-05 | 2014-12-16 | xiu-zhen Chen | 吊掛容置式之凍乾裝置 |
CN103335478B (zh) * | 2013-07-25 | 2015-04-08 | 钦龙金属工业(昆山)有限公司 | 升降式液态冷冻设备用升降框 |
ITUA20161823A1 (it) * | 2016-03-18 | 2017-09-18 | I M A Industria Macch Automatiche S P A In Sigla Ima S P A | Apparato per caricare e scaricare un liofilizzatore. |
US10272360B2 (en) | 2017-08-05 | 2019-04-30 | Priya Naturals, Inc. | Phytochemical extraction system and methods to extract phytochemicals from plants including plants of the family Cannabaceae sensu stricto |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618417A1 (fr) * | 1993-03-29 | 1994-10-05 | Hull Corporation | Système de chargement et de déchargement |
US7032763B1 (en) * | 2002-11-18 | 2006-04-25 | Mi-Jack Products, Inc. | System and method for automatically guiding a gantry crane |
EP1939114A1 (fr) * | 2006-12-29 | 2008-07-02 | Automha S.r.l. | Disposition pour le stockage automatique d'une unité de charge dans un rail de rangement |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US207638A (en) * | 1878-09-03 | Improvement in drying-cars for drain-tiles, bricks | ||
US4137984A (en) * | 1977-11-03 | 1979-02-06 | Jennings Frederick R | Self-guided automatic load transporter |
DE9001612U1 (de) * | 1989-04-07 | 1990-04-19 | Finn-Aqua Santasalo-Sohlberg GmbH, 50354 Hürth | Vorrichtung zum Beschicken und Entladen einer Gefriertrocknungseinrichtung |
US5261774A (en) * | 1989-11-20 | 1993-11-16 | Societe Anonyme Dite: Societe D'utilisation Scientifique Et Industrielle Du Froid: Usifroid | Device for loading and/or unloading the racks of a lyophilization tank |
DE4215781A1 (de) * | 1992-05-13 | 1993-11-18 | Santasalo Sohlberg Finn Aqua | Transfertisch |
US5304333A (en) * | 1992-10-23 | 1994-04-19 | Trevino Gonzales Francisco | Concrete product molding and curing plant methods and apparatus |
AU699042B2 (en) * | 1995-03-09 | 1998-11-19 | Boc Group, Inc., The | Transfer port system |
GB9505523D0 (en) * | 1995-03-18 | 1995-05-03 | Wellcome Found | Lyophilization process |
JP2000294615A (ja) * | 1999-04-09 | 2000-10-20 | Miyagi Oki Electric Co Ltd | 搬送システムおよび搬送方法 |
DE10307571A1 (de) * | 2003-02-22 | 2004-09-02 | Steris Gmbh | Einrichtung mit einer Stellfläche |
ITUD20070052A1 (it) * | 2007-03-07 | 2008-09-08 | Antonio Codatto | Impianto per la piegatura di elementi metallici piani, quali pannelli, lamiere, piastre o simili, macchina piegatrice per tali elementi metallici piani e relativo procedimento di piegatura |
-
2008
- 2008-09-18 DE DE202008012379U patent/DE202008012379U1/de not_active Expired - Lifetime
-
2009
- 2009-09-16 US US12/586,015 patent/US20100070108A1/en not_active Abandoned
- 2009-09-17 ES ES09170577.2T patent/ES2553137T3/es active Active
- 2009-09-17 EP EP09170577.2A patent/EP2166297B1/fr active Active
- 2009-09-18 CN CN200910173867A patent/CN101676660A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618417A1 (fr) * | 1993-03-29 | 1994-10-05 | Hull Corporation | Système de chargement et de déchargement |
US7032763B1 (en) * | 2002-11-18 | 2006-04-25 | Mi-Jack Products, Inc. | System and method for automatically guiding a gantry crane |
EP1939114A1 (fr) * | 2006-12-29 | 2008-07-02 | Automha S.r.l. | Disposition pour le stockage automatique d'une unité de charge dans un rail de rangement |
Also Published As
Publication number | Publication date |
---|---|
DE202008012379U1 (de) | 2008-12-24 |
CN101676660A (zh) | 2010-03-24 |
EP2166297B1 (fr) | 2015-08-26 |
ES2553137T3 (es) | 2015-12-04 |
US20100070108A1 (en) | 2010-03-18 |
EP2166297A3 (fr) | 2010-10-13 |
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