EP1965925B1 - Entsorgbare vorrichtung zum zentrifugieren von blut - Google Patents

Entsorgbare vorrichtung zum zentrifugieren von blut Download PDF

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Publication number
EP1965925B1
EP1965925B1 EP06817753A EP06817753A EP1965925B1 EP 1965925 B1 EP1965925 B1 EP 1965925B1 EP 06817753 A EP06817753 A EP 06817753A EP 06817753 A EP06817753 A EP 06817753A EP 1965925 B1 EP1965925 B1 EP 1965925B1
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Prior art keywords
chamber
blood
centrifugation
opening
centrifugation chamber
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EP06817753A
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English (en)
French (fr)
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EP1965925A1 (de
Inventor
Jean-Denis Rochat
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Publication of EP1965925A1 publication Critical patent/EP1965925A1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082—Skimmers for discharging liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges

Definitions

  • the present invention relates to a disposable blood centrifugation device for separating or also washing constituents of the blood.
  • blood may be for example whole blood, blood already leucocyte filtered or blood bled from an operative field.
  • centrifugation The most commonly used principle for separating blood components, such as red blood cells, plasma, white blood cells and platelets, from blood directly from the donor, a collection bag, an operating field or a sample blood, is the centrifugation.
  • separators consisting of a centrifugation chamber rotated about a vertical axis by a motor that can rotate at high speed, generally between 1'000 and 50'000 rpm.
  • the blood is introduced continuously or discontinuously into the centrifugation chamber through a feed channel forming part of a fixed axial member of the centrifuge device.
  • each blood component is conducted separately to a outlet channel located in the fixed axial member of the device. Once extracted from the centrifuge chamber by these outlet channels, they can be collected in separate pockets or re-injected to the patient.
  • the separation sets are packaged in a sterile package and are designed to define an enclosed space, sealed to any gas or fluid inlet other than the blood.
  • the different collection pockets of the blood products are generally pre-connected to the separation set.
  • the sterility of this assembly would not be complete if no means were provided to ensure the possible non-contamination of the centrifuge chamber at the junction of the fixed and movable parts, namely between the axial member of admission / evacuation and the centrifuge chamber.
  • This means must meet two main criteria which are, on the one hand to guarantee the sterility of the centrifugation device, and on the other hand to allow high rotation speeds of the centrifugation chamber by minimizing the heating between the fixed parts. and mobile device. This last criterion aims to prevent any heating of the blood by conduction within this device. Indeed, it is imperative to keep the blood at a temperature below 40 ° C to prevent its constituents from degrading.
  • the main disadvantages of this device lie in the fact that it is of complex construction, that it involves the bulky rotation of a tube around the centrifuge chamber and that this tube is subjected to a significant tensile stress generated by the centrifugal force to which it is subjected.
  • the document US 5,045,048 describes another device, much simpler manufacturing than the previous, wherein the junction between the fixed inlet / outlet ducts and the rotatable chamber is formed by a pair of parts having between them a very low coefficient of friction.
  • the first piece is part of the fixed set and, in order to ensure the sealing of the connection, is in abutment against the second piece which is secured to the centrifuge chamber.
  • This pair of parts can be achieved by means of a polymer V-ring, rotating on a metal washer, or consist of a ceramic ring based on a graphite ring.
  • sealing between the fixed and movable parts of the centrifuge device is achieved by means of a tubular seal.
  • One of the ends of this seal is fixed on a cylindrical portion of the fixed axial member, while the other end is introduced into an annular space of the neck of the centrifuge chamber while bearing against a convex surface of this collar.
  • the tubular seal undergoes a radial deformation which seals the centrifuge chamber.
  • the diameter of the neck of the centrifuge chamber against which rubs this seal is of small diameter, the fact remains that it results in a heating directly depending on the speed of rotation of the chamber. With this system, the maximum speed of rotation is limited because of this heating.
  • the use of chambers provided with a larger diameter neck would again remove any satisfaction in the use of this tubular joint to solve the problem of heating referred.
  • the document US 5,851,169 discloses a device for holding the centrifugation bowl of an autotransfusion machine.
  • This bowl comprises means for driving in rotation, guide means around its axis of revolution, a static admission / evacuation member engaged in the centrifugation bowl by its opening and at least one blood supply channel and an outlet channel of a constituent of this blood.
  • the document US 3,073,517 discloses another continuous flow centrifugation device comprising a centrifugation chamber located in a rotating rotor around a supply duct secured to a head.
  • the latter also incorporates a centrifugal liquid outlet channel which is pumped between two disks to the outlet port.
  • an opening has been provided in the head which communicates with the interior of the rotor. Through this opening is introduced the inert atmosphere which is maintained at a pressure slightly above atmospheric pressure. Thus, the introduced gas continually leaks and prevents air from entering the interior.
  • the document US 4,417,885 discloses a centrifuge with a vertical axis of rotation comprising a centrifugation bowl on which is mounted a lid held by a fixing ring.
  • the centrifugal liquid is introduced into the bowl via a central inlet duct on the outer walls of which two suction discs are fitted to extract the centrifuged liquid and a sealing disk.
  • a pressurized gas inlet channel opens under the sealing disc in an area between the latter and the upper suction disc. The introduction of the pressurized gas is intended to roll back the free surface of the liquid relative to the axis of rotation of the bowl.
  • the device also incorporates a stop fluid channel mounted at the periphery of the central arrival conduit. This channel opens above the sealing disc so that the excess fluid introduced into the stop chamber can leak through a space between the static member and the lid mounted integrally on the centrifugation bowl.
  • the purpose of the present invention aims to remedy at least in part the aforementioned drawbacks by suggesting a disposable blood centrifugation device which can allow, on the one hand to ensure the sterility of all the internal volumes of this device which are in contact with the blood, and secondly to eliminate any heating resulting from the rotation of this chamber around the static inlet / outlet member disposed on the axis of revolution of the chamber.
  • Another object of the present invention is to provide a centrifuge device which is also economical. Indeed, in the field of handling or blood processing, it is not uncommon that the material used is thrown after its first use. Although still functional from a functional point of view, such a centrifugation device will be intended for a single use for the reasons that are known and which aim to avoid any risk of blood contamination. It is therefore advantageous to provide a single-use device design that is as simple as possible while meeting the requirements of sterility and efficiency requirements.
  • the first advantage of this device lies in the fact that it suppresses any possible rise in temperature of the blood or its constituents. As a result, the quality of the latter is ensured since it is not altered.
  • the speed of rotation of the centrifugation chamber is no longer dependent on the means ensuring the sterility of the device relative to a non-sterile external medium.
  • the higher this speed the shorter the residence time of the blood in the chamber in order to obtain the separation of its constituents.
  • the treated blood flow can usefully be increased and the effectiveness of the device will also be improved.
  • the disposable device of the present invention comprises a centrifugation chamber 10 having an axis of revolution 2, preferably vertical. This axis of revolution passes through an opening 11 formed in the upper part 3 of the centrifugation chamber. The latter is rotated about its axis of revolution by drive means 20, such as an electric motor whose rotation shaft 21 is secured to the lower portion 4 of the centrifuge chamber.
  • drive means 20 such as an electric motor whose rotation shaft 21 is secured to the lower portion 4 of the centrifuge chamber.
  • guide means 22 preferably arranged in its upper part 3 so as to engage with the latter.
  • These means may for example consist of three centering rollers, engaged with a tread 13 and arranged at 120 ° around the axis of revolution 2 of the chamber.
  • they can be mounted retractable, for example at the end of a pivoting arm or a telescopic arm.
  • the tread 13 will preferably be part of the neck 12 of the centrifugation chamber and will be formed of a perfectly circular outer surface and concentric with the axis of revolution 2.
  • at least one centering roller could advantageously be mounted on an elastic suspension. Such an arrangement could for example be achieved by arranging a roller at the end of an arm pivotally mounted under the action of a return spring so as to ensure the permanent contact of the roller against the tread 13.
  • the opening 11 of the centrifugation chamber 10 is traversed by at least one static member 30 for admission / evacuation of the blood and at least one of its constituents.
  • the static connotation given to this member 30 is simply to clarify that it is not rotated, unlike the centrifuge chamber.
  • the device of the present invention comprises a part movable in rotation, through the opening of which is engaged at least one non-movable part in rotation. These parts may be fixed or preferably movable, relative to each other, in translation along the axis of revolution 2 as will be seen later.
  • the static inlet / outlet member 30 is engaged in the centrifuge chamber 10 through its opening 11, so that a portion of this member is located inside the centrifugation chamber 10 while another portion is outside of it.
  • This organ comprises at least one supply channel 31 of the blood, for example from a pocket, not shown, for collecting a determined volume of blood.
  • the flow of blood is continuously or intermittently from the outside to the inside of the centrifuge chamber.
  • the static member also comprises at least one outlet channel 32 of a blood component.
  • the flow of this component is from the inside to the outside of the chamber, according to the arrow 32a.
  • a constituent will for example consist of a concentrate of red blood cells.
  • the outlet channel 33 is a third channel which is preferably arranged within the static organ 30 and which is used to extract a second component of the blood, such as, for example, the platelet-rich plasma.
  • the direction of flow of this second blood constituent is in accordance with the illustration given by the arrow 33a.
  • an additional channel may be added to introduce into the centrifugation chamber 10 a blood wash solution, such as saline, for example.
  • a blood wash solution such as saline, for example.
  • This solution will be mixed with the blood in the chamber 10, then, thanks to the centrifugal forces, separated from the red blood cells by taking with it the impurities contained in the collected blood before being extracted with the plasma by the outlet channel 33.
  • the ends of the outlet channels 32, 33 are intended to be connected to flexible bags, not shown, for collecting the blood components.
  • these outputs are respectively connected to a means for re-injecting the washed component to the patient and to a bag containing washing waste.
  • the connections between these bags and the channels of the centrifuge device are hermetic and performed under the required sterility conditions.
  • these connections are made in advance, following the manufacture of the centrifugation device, so that this assembly can be packaged in a preferably hermetic and sterile packaging for marketing.
  • such a package may also be porous to allow subsequent sterilization with steam or gas, before use of the device.
  • the static member 30 further comprises at least one inlet channel 34 of a gaseous fluid under pressure opening inside the centrifugation chamber, preferably in the upper part 3 thereof.
  • This fluid may be pre-sterilized air from a source allowing at least to deliver this gas under a specific pressure, preferably at an adjustable flow rate.
  • the gaseous fluid enters the inlet channel 34, in accordance with the direction of flow indicated by the arrow 34a, before emerging at the mouth 35 of this channel in the centrifugation chamber, preferably slightly below the neck 12 of the centrifuge chamber. it.
  • the static admission / discharge member 30 comprises a plurality of collectors 37 for capturing the constituents. blood. These collectors extend radially until they reach the different zones of stratification 3a, 3b of these constituents. By these capture channels, these can be extracted simultaneously or successively from the centrifugation chamber via the outlet channels 32, 33 of the static member 30.
  • zone 3a corresponds to that in which red blood cells of higher density are accumulated than the plasma which will be located in zone 3b, closer to the axis of revolution 2 than the preceding one. This distribution occurs naturally under the effect of the centrifugal force applied to the blood spilled in the centrifuge chamber.
  • the collectors 37 for capturing red blood cells have been represented. Similar collectors will also be used to capture plasma or wash waste. Because these collectors are located below the previous ones, they do not appear in the illustrations of the figures attached to this description.
  • a gap 38 is formed in the opening 11 of the chamber, between the latter and the static member 30 of admission / evacuation.
  • This gap is intended to constitute an escape route for the gaseous fluid introduced under pressure into the centrifuge chamber. From the inlet channel 34, this gaseous fluid arrives in the chamber through the mouth 35. It fills the space available in this chamber by putting it under pressure. The pressure results from the pressure loss created by the flow through the gap 38. The latter will therefore be dimensioned so as to generate a measurable and sufficient overpressure in the centrifuge chamber. Thanks to this calibrated gap, the gaseous fluid escapes from this chamber in a controlled manner in a continuous flow in accordance with the direction given by the arrow 34b.
  • the main function performed by this gas flow is to repel any infiltration of germs thus protecting the centrifuge chamber and its contents from any contamination via gas escape through the gap 38.
  • This function acts as a barrier against the infiltration of microorganisms into the device.
  • no rise in temperature of the blood or its constituents will be observed. This is due to the fact that there is no longer any contact between the static member 30 and the spinning chamber 10 rotatable.
  • the arrangement of this gap makes it possible to guarantee the absence of any wear between the rotating part and the non-rotating part of the device of the present invention. According to the preferred embodiment, it will be ensured that the opening 11 and the static member 30 are, around the neck 12, circular and concentric with the axis of revolution 2 so that the distribution of the gas flow through gap 38 can be as homogeneous as possible.
  • the inlet channel 34 may be provided with at least one filter 39, for single use, sterilization of the gaseous fluid as clearly visible on the figure 1 .
  • the arrangement of such a filter may have the purpose of ensuring the sterility of the gaseous fluid so as not to contaminate the blood or its constituents.
  • such a filter can also serve as a sterile barrier preventing any microorganism from entering the inlet channel 34 when no other means closes the latter upstream.
  • it also makes it possible to guarantee the flawless state of the fluid filtration means because it is part of the single-use disposable device of the present invention.
  • the fluid used may be either a sterile gas or a gas pre-filtered at the source, or a gas that is intended to be purified by one or more filters 39 arranged in the upstream portion of the inlet channel 34
  • filters 39 any conventional device which allows the resulting fluid to destroy, inactivate, trap or reduce the microorganisms it contains at a level of sterility in accordance with the standards imposed in the field of transfusions and other blood manipulations.
  • the device is provided with a hermetic sealing means 40 of the gap 38.
  • a hermetic sealing means 40 may consist of a shoulder 41 and / or a bearing 42 , of conical rounded or cylindrical shape, which can fit into the opening 11 of the centrifugation chamber or around the neck 12, more precisely fit tightly against this neck, for example in the gap 38 by translation of the one or the other of the mobile and non-mobile parts in rotation of the device.
  • the hermetic closure of this means against the opening in the neck of the centrifugation chamber could if necessary be improved by the arrangement of an O-ring, not shown, secured to either the static member 30 or the collar 12 of the centrifuge chamber.
  • the centrifugation chamber 10 and / or the static admission / discharge member 30 can slide along the axis of revolution 2, between a closed position of the gap 38 and an open position thereof, and secondly hold in this open position by means of a means for automatically opening the gap 38.
  • a means of opening the gap 38 may be constituted by the pressure exerted by the gaseous fluid on the closure means 40, more particularly on the shoulder 41.
  • the overpressure within the chamber will allow to expel sufficiently, or the chamber 10 downwards in the case where the static member 30 is held fixed along the axis of revolution 2, or the static member 30 upwards in the opposite case where it is the centrifugation chamber which is kept fixed along its axis of revolution.
  • the opening means may be constituted by a conical portion 60 adjacent to the tread 13.
  • a conical portion 60 adjacent to the tread 13.
  • FIG 2a shows in detail an illustration of the neck 12 in which the guiding means 22 are already engaged with the tread 13.
  • the conical portion 60 preferably a conical trunk portion, located just below the tread 13.
  • the operation of this opening means according to the second embodiment is as follows.
  • the automatic opening of the gap 38 is obtained by a slight sliding down of the centrifugation chamber 10 along its axis of revolution 2. This sliding is obtained automatically when the guide means 22 come into contact with the room in a room first time in contact with the opening means consisting of the conical portion 60. Indeed, the support and clamping of the guide means 22 against this conical portion will push the latter down until the means of guideway are engaged with the tread 13, as shown in FIG. figure 2a . By this slight displacement of the sliding chamber downwards, the gap 38 will be released, the lower part 4 of the chamber will be able to engage the shaft 21 of the drive means 20, and the device will be soon ready to operate.
  • the opening means 40 also allows the gap 38 to be maintained in its open position, thus avoiding its inadvertent closing during the time necessary for using the device.
  • the filter 39, the closure means 40 and the possible sliding of one or the other of the two main parts 30, 10 of the device between two relatively close positions it is possible to condition and then sterilize, in the closed position , the device of the present invention in its packaging and to ensure the sterility of this device until its use.
  • the inlet channel 34 can be connected to a common, and therefore not shown, control or pressure regulation member within this channel.
  • this member could be supplemented or replaced by a control member or regulating the flow of the gaseous fluid.
  • control means make it possible to ensure the proper functioning of the centrifugation chamber by detecting for example a possible uncontrolled leak or an abnormal throttling, or even a total obstruction or blockage of the opening 11.
  • the overpressure within the centrifuge chamber can typically be of the order of 0.1 to 100 millibars for the main function of the gaseous fluid can be filled correctly.
  • the inlet channel 34 of the gaseous fluid terminates upstream by a protective membrane 45 which at least partially closes this channel.
  • this membrane Made of a flexible and elastic material, this membrane can be in two possible configurations.
  • the protective membrane 45 hermetically closes the inlet channel 34 in order to guarantee the sterility of the entire device when it is not yet connected to the source of gaseous fluid for which it is intended.
  • the protective membrane 45 and the closure device 40 make it possible to ensure the non-contamination of the device of the present invention as soon as it is removed from its sterile packaging, not shown, and until it is is connected to the source of gaseous fluid via the inlet channel 34.
  • this protective membrane can be pierced as is referred to in FIG. figure 3 .
  • this protective membrane may, if necessary, also be applied to a lining 46 secured to the upstream end portion of the inlet channel 34.
  • the device of the present invention can be connected to a machine 50 treatment of blood fluids.
  • the wall of the machine will then comprise, for example, a tubular tip 51 for perforating the protective membrane 45. After perforation of this membrane, the insertion of this circular tip through the membrane will cause a natural deformation thereof until 'to present an elastic lip 47. This lip will surround the tubular tip and come to be plated by acting as joint sealing. Usefully, such a seal will prevent the gaseous fluid from escaping out of the liner 46.
  • This same machine is equipped with the means necessary to produce or connect to a source of gaseous fluid under pressure, preferably sterile or pre-sterilized.
  • this membrane According to the second possible configuration of this membrane, it is expected that it is provided with a circular opening of diameter smaller than that of the tubular nozzle 51, and that it therefore only partially closes the inlet channel 34
  • the seal 46 will be sealed only after insertion of the tubular nozzle through the circular opening formed in advance within this membrane, thanks to the elastic lip 47 that constitutes the part peripheral of the circular opening.
  • this lip will be automatically pressed against the tubular end because of the diameter of the latter which is greater than that of the circular opening previously formed in the membrane.
  • this membrane is then above all to ensure the seal between the tubular nozzle 51 and the device during its operation. It makes it possible to prevent the gaseous fluid injected into the channel 34a from escaping from the device before being passed through the centrifugation chamber 10.
  • the tubular nozzle 51 When connecting the disposable device to the machine 50, the tubular nozzle 51 on the one hand allows the piercing of the membrane 45 or the widening of its existing circular opening, and on the other hand acts as a delivery channel of the gaseous fluid within the intake channel 34.
  • this figure 4 schematically represents an enlargement of the central portion of a variant of the device of the present invention. More precisely, this figure shows a detail of a second mode embodiment of the neck 12 of the centrifuge chamber, in which is engaged the static member 30 of admission / evacuation. The latter is illustrated in an initial position, called the closed position, which corresponds for example to the position in which the device is located when it leaves its packaging packaging.
  • the leakage path of the gaseous fluid out of the centrifugation chamber is via a gap 38 with sinuous shapes.
  • the labyrinth shape given to this gap is defined by the arrangement of baffles 36 which occupy at least part of the space of this interstice. These baffles may be integral with either the static member 30 or the neck 12 of the centrifugation chamber, or still partly of the static member 30 and partly of this chamber as shown in FIG. figure 4 .
  • the arrangement of these baffles makes it possible, for the same gas flow rate, to increase the pressure drop within the exhaust channel formed by the gap 38.
  • the overpressure in the centrifugation chamber in will be even more important.
  • the arrangement of such baffles improves the sealing of the disposable device, particularly where the static member 30 passes through the neck 12 of the centrifuge chamber.
  • the shape that the gap 38 takes can be more or less complex depending on the number, the position and the shape of the baffles 36.
  • the parts of this device are intended to be made by injection of a plastic material into a mold.
  • the dimensions of the centrifugation chamber are of the order of 20 to 200 mm in length for a diameter of between 10 and 100 mm approximately.
  • the parts that constitute this device are mainly cylindrical in shape which facilitates their injection. The realization of such a device by the An injection method is therefore perfectly suited to this type of implementation because of its small size, its single-use nature and the imperatives to obtain limited manufacturing costs.
  • the subject of the present invention could also be used for blood analysis purposes from samples or else to perform other blood manipulations such as the washing of red blood cells, for the purpose of autotransfusion in particular, or deglycerolization of frozen red blood cells.

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Claims (12)

  1. Einwegvorrichtung zur Blutzentrifugation zum Trennen oder auch Waschen von Blutbestandteilen mit einer Zentrifugierkammer (10), die eine Drehachse (2) sowie eine Öffnung (11) aufweist, die von der letztgenannten durchquert wird und in einem oberen Teil (3) der Zentrifugierkammer (10) angeordnet ist, mit Drehführungsmitteln (22) der Zentrifugierkammer (10), die dazu eingerichtet sind, mit der letztgenannten gegen eine Abrollbande (13) in Eingriff zu kommen, mit Drehantriebsmitteln (20) der Zentrifugierkammer um die Drehachse (2) herum, mit wenigstens einem statischen Teil (30) zum Einlass/Auslass, das durch seine Öffnung (11) mit der Zentrifugierkammer (10) verbunden ist und wenigstens einen Zuführkanal (31) für das Blut und wenigstens einen Ausleitkanal (32, 33) für einen Bestandteil des Bluts aufweist, wobei das statische Teil (30) zum Einlass/Auslass wenigstens einen Einlasskanal (34) für ein unter Druck stehendes, gasförmiges Fluid aufweist, der in das Innere der Zentrifugierkammer (10) mündet, und ein Spalt (38) in der Öffnung (11) zwischen der Zentrifugierkammer (10) und dem statischen Teil (30) zum Einlass/Auslass zum Ausströmen des gasförmigen Fluids aus der Zentrifugierkammer (10) eingerichtet ist, dadurch gekennzeichnet, dass die Zentrifugierkammer (10) oder/und das statische Teil (30) zum Einlass/Auslass entlang der Drehachse (2) zwischen einer Schließstellung des Spalts (38) und einer geöffneten Stellung des letztgenannten verschiebbar ist/sind.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass sie ein hermetisches Verschlussmittel (40) des Spalts (38) aufweist.
  3. Vorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass das Verschlussmittel (40) eine Schulter (41) und/oder eine Anlagefläche (42) aufweist, die in die Öffnung (11) der Zentrifugierkammer (10) einpassbar ist/sind.
  4. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass sie ein automatisches Öffnungsmittel des Spalts (38) aufweist.
  5. Vorrichtung nach Anspruch 4, dadurch gekennzeichnet, dass das Öffnungsmittel durch den Druck gebildet ist, der das gasförmige Fluid auf das Verschlussmittel (40) ausübt.
  6. Vorrichtung nach Anspruch 4, dadurch gekennzeichnet, dass das Öffnungsmittel durch einen der Abrollbande (13) benachbarten Kegelabschnitt (60) gebildet ist.
  7. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass Leitstege (36) wenigstens einen Teil des Raums des Spalts (38) einnehmen.
  8. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der Einlasskanal (34) des gasförmigen Fluids wenigstens einen Einmalfilter (39) zur Sterilisation des gasförmigen Fluids aufweist.
  9. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass eine Schutzmembran (45) den Einlasskanal (34) wenigstens teilweise stromaufwärts von diesem verschließt.
  10. Vorrichtung nach Anspruch 9, dadurch gekennzeichnet, dass die Schutzmembran (45) das Einfügen eines röhrenartigen Endstücks (51) in sie erlaubt.
  11. Vorrichtung nach Anspruch 10, dadurch gekennzeichnet, dass die Schutzmembran (45) eine elastische Lippe (47) bildet, die das röhrenartige Endstück (51) umgibt, wenn die Schutzmembran durch das letztgenannte durchquert wird.
  12. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der Einlasskanal (34) des gasförmigen Fluids mit einem Kontroll- oder Steuerelement für den im Inneren des Kanals herrschenden Druck und/oder mit einem Kontroll- oder Steuerelement für die Ausströmmenge des gasförmigen Fluids verbunden ist.
EP06817753A 2005-12-21 2006-12-14 Entsorgbare vorrichtung zum zentrifugieren von blut Ceased EP1965925B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06817753A EP1965925B1 (de) 2005-12-21 2006-12-14 Entsorgbare vorrichtung zum zentrifugieren von blut

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05405717A EP1800754A1 (de) 2005-12-21 2005-12-21 Einweg-Blutzentrifuge
PCT/CH2006/000701 WO2007071086A1 (fr) 2005-12-21 2006-12-14 Dispositif jetable de centrifugation sanguine
EP06817753A EP1965925B1 (de) 2005-12-21 2006-12-14 Entsorgbare vorrichtung zum zentrifugieren von blut

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EP1965925A1 EP1965925A1 (de) 2008-09-10
EP1965925B1 true EP1965925B1 (de) 2012-02-08

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EP05405717A Withdrawn EP1800754A1 (de) 2005-12-21 2005-12-21 Einweg-Blutzentrifuge
EP06817753A Ceased EP1965925B1 (de) 2005-12-21 2006-12-14 Entsorgbare vorrichtung zum zentrifugieren von blut

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EP05405717A Withdrawn EP1800754A1 (de) 2005-12-21 2005-12-21 Einweg-Blutzentrifuge

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US (1) US8070666B2 (de)
EP (2) EP1800754A1 (de)
AT (1) ATE544524T1 (de)
WO (1) WO2007071086A1 (de)

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Publication number Priority date Publication date Assignee Title
EP1683579A1 (de) * 2005-01-25 2006-07-26 Jean-Denis Rochat Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren
EP1800754A1 (de) * 2005-12-21 2007-06-27 Jean-Denis Rochat Einweg-Blutzentrifuge
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ATE544524T1 (de) 2012-02-15
WO2007071086A1 (fr) 2007-06-28
EP1965925A1 (de) 2008-09-10
US8070666B2 (en) 2011-12-06
EP1800754A1 (de) 2007-06-27
US20080264841A1 (en) 2008-10-30

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