EP1923022B1 - Sprunggelenksendoprothesenelemente - Google Patents

Sprunggelenksendoprothesenelemente Download PDF

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Publication number
EP1923022B1
EP1923022B1 EP08001262A EP08001262A EP1923022B1 EP 1923022 B1 EP1923022 B1 EP 1923022B1 EP 08001262 A EP08001262 A EP 08001262A EP 08001262 A EP08001262 A EP 08001262A EP 1923022 B1 EP1923022 B1 EP 1923022B1
Authority
EP
European Patent Office
Prior art keywords
inlay
component
talus
tibial
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08001262A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1923022A3 (de
EP1923022A2 (de
Inventor
Michael Prof. Dr. Fellinger
Ernst Prim. Doz. Dr. Orthner
Robert Prim. Dr. Siorpaes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alphamed Medizintechnik Fischer GmbH
Original Assignee
Alphamed Medizintechnik Fischer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphamed Medizintechnik Fischer GmbH filed Critical Alphamed Medizintechnik Fischer GmbH
Priority to PL08001262T priority Critical patent/PL1923022T3/pl
Priority to SI200531266T priority patent/SI1923022T1/sl
Publication of EP1923022A2 publication Critical patent/EP1923022A2/de
Publication of EP1923022A3 publication Critical patent/EP1923022A3/de
Application granted granted Critical
Publication of EP1923022B1 publication Critical patent/EP1923022B1/de
Priority to CY20111100368T priority patent/CY1111385T1/el
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/42Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4202Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/42Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30405Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by screwing complementary threads machined on the parts themselves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604Special structural features of bone or joint prostheses not otherwise provided for modular
    • A61F2002/30616Sets comprising a plurality of prosthetic parts of different sizes or orientations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/3069Revision endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/42Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4202Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
    • A61F2002/4205Tibial components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/42Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4202Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
    • A61F2002/4207Talar components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00029Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Definitions

  • the present invention relates to ankle prosthesis elements, more particularly a talar component, for a multi-part ankle prosthesis.
  • the first ankle prostheses were cemented metal-polyethylene joints.
  • the most well-known prosthesis of this generation the so-called St. Georg endoprosthesis, had a sled-like talar component, congruent with a downwards, i.e. concave-shaped tibial component articulated.
  • the endoprostheses used today can be divided essentially into single and multi-axial two-component endoprostheses and three-component endoprostheses.
  • the three-component endoprostheses generally consist of a tibia and a talus component and an intermediate Gleitkem.
  • a three-component prosthesis HINTEGRA ®; Newdeal SA, Vienne, France
  • HINTEGRA ® Newdeal SA, Vienne, France
  • the tibial component has a metal plate with tibial-side small anchoring pyramids and a ventral plate, which allows a screw fixation through two oval holes and prevents the ingrowth of scar tissue and thus movement restriction.
  • the talar component has a shape similar to a cone having a narrower medial side radius. One side edge on the medial and lateral side guides the PE gliding core.
  • This mobile and felted slide core has a flat surface to the tibial component and a concave surface to the talar component.
  • the tibial component consists of a metal plate with an intraoperatively attachable keel, while the talus component is configured as part of a cylindrical surface having a central trough-shaped incision in the circumferential direction the talus apparatus correspondingly shaped inlay slides.
  • the top of the inlay is the tibial component designed to be planar.
  • the tibial component of another known prosthesis (LINK STAR® , Waldemar Link GmbH & Co. KG) consists of a metal plate with a highly polished flat articulation surface, which has two cylindrical fixation webs arranged at the back for anchoring in the tibial bone.
  • the talar component is a convex metal cap that converges on its underside at a rounded obtuse angle.
  • At the center of the convex surface of the talar component there is a rib for guiding the PE inlay, A / P extending, which accordingly has a concave surface with a groove.
  • a two-part and a three-part ankle prosthesis are from the US 3,975,778 or the WO 00/69373 A1 known.
  • the present invention has the object to provide ankle prosthesis elements or ankle prosthesis, which have an optimal fit of the talar prosthesis portion with simultaneous low bone resection.
  • lateral protrusion of the slide core and thus the formation of impingement should be prevented.
  • a talar component for a multi-part ankle prosthesis which Taluskomponente has a bottom, which faces the bony talus after implantation, achieved in that the bony talus facing underside is designed as a concave spherical segment.
  • a means for anchoring in the bone is provided on the underside designed as a concave spherical segment.
  • the means comprises a centrally disposed tubular stem and a pin arranged ventrally thereto.
  • the invention also provides a three-part ankle prosthesis with a talar component, an inlay and a tibial component, which is characterized in that a talar component according to the invention is provided.
  • a tibial component inlay combination for a multipart ankle prosthesis wherein the tibial component comprises a plate and anchoring means in the bone and the inlay has a planar tibial surface.
  • a substantially central elevation and in the tibial surface of the inlay for the survey provided a recess on the side facing the inlay, wherein the recess is designed such that the inlay relative to the tibial component allows rotation and an AP crimping is and a lateral occupancy of the inlay is prevented.
  • the elevation may be formed Kugelgegnentförmig and the recess may be configured as a segment of a cylinder with spherical segment-shaped ends, wherein the axis of the cylinder is aligned in the A / P direction.
  • the means for anchoring in the bone comprises a ventrally curved wedge.
  • a metal pin 5 is formed. This has for example a diameter of about 3 mm and is arranged in the representation parallel to the direction of the central stem 4.
  • the pin 5 is used for primary anti-rotation of the introduced talar prosthesis element.
  • tibial prosthesis element consists of a 3 mm thick metal plate 7, for example, which carries on the side of the inlay a spherical segment-shaped elevation 8, which forms a part of the necessary positive guidance of the polyimide.
  • the elevation 8 is provided substantially centrally on the underside 9 of the metal plate 7, such as 4 and 5 demonstrate.
  • This wedge 10 is significantly flattened at its lower boundary side 11 to the insertion of the Tibial component 6 easier.
  • the cranial wedge portion tapers continuously and is thus intended to contribute to the impaction of the cancellous bone.
  • the longest revision wedge preferably carries 2 holes for receiving locking bolts.
  • a fastening mechanism for the modular Tibia wedges can be integrated.
  • Fig. 6 shows a view of the tibial surface 13 of the PE inlay 12, which may be made, for example, from Chirulen ISO 5834.
  • the configuration of the inlay 12 is oriented with respect to the shape on the metal plate 7 of the tibial component 6.
  • the size of the inlay 12 to be used is based, in principle, on the talar component.
  • the tibial surface 13 consists of a planar surface, in the center of which in the longitudinal direction, ie A / R direction, a recess 14 in the form of a groove is provided, which is designed as a cylinder segment with spherical segment-shaped ends.
  • This shape of the recess 14 can be made of the in FIGS. 7 and 8 illustrated cross sections along the line BB and AA of Fig. 6 detect.
  • the recess 14 receives the survey 8 of the tibial component 6 closed. In interaction thus the necessary A / P sliding and the rotation of the inlay 12 with respect to the tibial component 6 is ensured.
  • the lateral displacement relative to the tibial component 6, however, is limited. This prevents with respect to the metal plate 7 of the tibial component 6 a lateral projection and thus the formation of an impingement through the inlay 12th
  • the talc component 1 facing surface 15 of the inlay 12 is, as in Fig. 7 shown, this formed as a concave cylinder surface accordingly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Finger-Pressure Massage (AREA)
EP08001262A 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente Active EP1923022B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL08001262T PL1923022T3 (pl) 2004-11-08 2005-11-08 Element endoprotezy stawu skokowgo
SI200531266T SI1923022T1 (sl) 2004-11-08 2005-11-08 Endoprotetični elementi za skočni sklep
CY20111100368T CY1111385T1 (el) 2004-11-08 2011-04-08 Στοιχεια ενδοπροθεσης ποδοκνημικης αρθρωσης

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0186204A AT502926B1 (de) 2004-11-08 2004-11-08 Sprunggelenksprothesenelemente
EP05801610A EP1824426B1 (de) 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP05801610.6 Division 2005-11-08
EP05801610A Division EP1824426B1 (de) 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente

Publications (3)

Publication Number Publication Date
EP1923022A2 EP1923022A2 (de) 2008-05-21
EP1923022A3 EP1923022A3 (de) 2008-08-20
EP1923022B1 true EP1923022B1 (de) 2011-01-19

Family

ID=36319529

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08001262A Active EP1923022B1 (de) 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente
EP05801610A Active EP1824426B1 (de) 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP05801610A Active EP1824426B1 (de) 2004-11-08 2005-11-08 Sprunggelenksendoprothesenelemente

Country Status (24)

Country Link
US (1) US20080097617A1 (el)
EP (2) EP1923022B1 (el)
JP (1) JP4675968B2 (el)
KR (1) KR101338572B1 (el)
CN (1) CN101098666B (el)
AT (3) AT502926B1 (el)
AU (1) AU2005301078B2 (el)
BR (1) BRPI0517692A (el)
CA (1) CA2586662C (el)
CY (2) CY1108433T1 (el)
DE (2) DE502005010896D1 (el)
DK (2) DK1923022T3 (el)
EA (2) EA014723B1 (el)
ES (2) ES2360474T3 (el)
HK (2) HK1108349A1 (el)
IL (1) IL183030A (el)
NO (1) NO333958B1 (el)
NZ (1) NZ555047A (el)
PL (2) PL1923022T3 (el)
PT (1) PT1824426E (el)
SG (1) SG154447A1 (el)
SI (2) SI1923022T1 (el)
WO (1) WO2006047805A2 (el)
ZA (1) ZA200704138B (el)

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US8668743B2 (en) 2010-11-02 2014-03-11 Adam D. Perler Prosthetic device with multi-axis dual bearing assembly and methods for resection
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CN107374788B (zh) * 2017-08-29 2023-08-29 中国人民解放军第三军医大学 一种解剖型固定衬垫踝关节假体
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ZA200704138B (en) 2008-09-25
EA014723B1 (ru) 2011-02-28
WO2006047805A3 (de) 2006-10-05
PL1824426T3 (pl) 2009-01-30
AU2005301078B2 (en) 2010-09-09
IL183030A0 (en) 2007-09-20
DK1923022T3 (da) 2011-04-26
EA200701021A1 (ru) 2007-10-26
HK1108349A1 (en) 2008-05-09
CN101098666A (zh) 2008-01-02
CN101098666B (zh) 2012-11-14
NZ555047A (en) 2010-06-25
JP4675968B2 (ja) 2011-04-27
DE502005004841D1 (de) 2008-09-04
NO20072277L (no) 2007-08-07
AT502926A2 (de) 2007-06-15
US20080097617A1 (en) 2008-04-24
ES2310850T3 (es) 2009-01-16
SI1824426T1 (sl) 2008-12-31
AT502926A3 (de) 2011-01-15
PL1923022T3 (pl) 2011-11-30
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HK1117376A1 (en) 2009-01-16
CY1108433T1 (el) 2013-09-04
AT502926B1 (de) 2011-04-15
EP1923022A3 (de) 2008-08-20
NO333958B1 (no) 2013-10-28
BRPI0517692A (pt) 2008-10-14
JP2008518692A (ja) 2008-06-05
AU2005301078A1 (en) 2006-05-11
IL183030A (en) 2011-12-29
PT1824426E (pt) 2008-10-30
ATE495716T1 (de) 2011-02-15
SI1923022T1 (sl) 2011-08-31
EA200900585A1 (ru) 2009-08-28
ES2360474T3 (es) 2011-06-06
ATE401845T1 (de) 2008-08-15
KR20070094730A (ko) 2007-09-21
EA012197B1 (ru) 2009-08-28
CA2586662A1 (en) 2006-05-11
CY1111385T1 (el) 2015-08-05
EP1923022A2 (de) 2008-05-21
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