EP1875966A1 - Dispositif de pipetage - Google Patents

Dispositif de pipetage Download PDF

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Publication number
EP1875966A1
EP1875966A1 EP07011005A EP07011005A EP1875966A1 EP 1875966 A1 EP1875966 A1 EP 1875966A1 EP 07011005 A EP07011005 A EP 07011005A EP 07011005 A EP07011005 A EP 07011005A EP 1875966 A1 EP1875966 A1 EP 1875966A1
Authority
EP
European Patent Office
Prior art keywords
piston
pipetting device
rod
piston head
cylinder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07011005A
Other languages
German (de)
English (en)
Other versions
EP1875966B1 (fr
Inventor
Jens Wilmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of EP1875966A1 publication Critical patent/EP1875966A1/fr
Application granted granted Critical
Publication of EP1875966B1 publication Critical patent/EP1875966B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices

Definitions

  • the invention relates to a pipetting device for dosing liquids.
  • Bubble pipettes have at least one integrated displacer unit comprising a cylinder and a piston arranged longitudinally displaceable therein.
  • the cavity of the cylinder is connected via a connecting channel to a through hole in a seat for a pipette tip.
  • an air column is displaceable in order to suck sample liquid into a pipette tip sealingly arranged on the seat and to eject it out of it.
  • the displacer unit does not come in Contact with the liquid. Only the pipette tip, which is usually made of plastic, becomes contaminated and can be replaced after use.
  • the piston is connected to a drive for displacing the piston within the cylinder. It is known to couple a piston actuating rod, which can be driven manually or by means of an electromotive linear drive, with the piston rod.
  • the piston rod is inserted into a receptacle of the piston actuating rod.
  • a bending or spiral spring is inserted into the receptacle, which bears under prestress against the piston spring in order to avoid play.
  • the present invention seeks to provide a pipetting device, in which the assembly and disassembly of piston actuating rod and displacer unit is associated with less effort.
  • the piston has an elastic body, which is not or partially elastically compressed for the purpose of clearance compensation when the piston head is arranged in the receptacle.
  • the elastic body rests against the abutment surface of the receptacle and the piston head is supported with the underside at the bottom.
  • the elastic body has a significantly greater elasticity than the piston or the piston head, on which the elastic body is arranged.
  • the elastic body is not a separate part, but is arranged on the piston and can be mounted together with this or the displacer on the piston actuating rod. This eliminates the handling of a separate, particularly small spring, so that assembly and dismantling costs saved and incorrect assembly can be avoided.
  • the supernatant which has the elastic body in the non-compressed state on the bottom in the axial direction of the piston rod, equal to or greater than the distance of the bottom of the contact surface.
  • the pipetting device according to the invention is e.g. a hand pipette or a pipetting device at a dosing station or workstation.
  • the pipetting device is a single-channel pipetting device, i. it has only a single displacement unit connected to a single seat for a pipette tip.
  • the pipetting device is a multi-channel pipetting device, i. it has one or more displacement units connected to multiple seats for multiple pipette tips.
  • the piston actuating rod has a transversely aligned to its longitudinal axis traverse with a plurality of juxtaposed receptacles for piston heads and a plurality of parallel cylinders with a plurality of guided therein, arranged with their piston heads in the receptacles piston.
  • the piston head and through hole have a cross-section so formed that the piston head in a certain rotational position to the passage opening axially into the receptacle can be inserted and after a subsequent rotational movement (eg of 90 °) can not be pulled out because it rests on the ground. It is also possible to guide the piston in this secured rotational position between small projections which protrude axially from the ground and over which the piston head is rotatable only under pressure against the contact surface and further axial compression of the elastic body.
  • the bottom is formed by a plate, which is releasably connectable to the end of the piston-actuating rod (eg by a thread on the circumference of a circular disc-shaped plate or by means of additional screws) to form the bottom with the passage opening of the receptacle or the Remove soil from the receptacle.
  • a plate which is releasably connectable to the end of the piston-actuating rod (eg by a thread on the circumference of a circular disc-shaped plate or by means of additional screws) to form the bottom with the passage opening of the receptacle or the Remove soil from the receptacle.
  • the receptacle has a transversely extending to the piston actuating rod insertion opening for the piston head and the piston rod.
  • the piston can be easily inserted or removed from the insertion opening with piston head and piston rod. When displacing the piston, the power transmission is perpendicular to the insertion, so that the piston does not slip out.
  • the piston can be secured by the partially compressed elastic body in the receptacle.
  • the insertion opening for securing the piston can be covered by a removable housing part of the pipetting device.
  • the piston head is possible, e.g. with a spherical, flat or conical bottom.
  • the piston head is supported with an annular disk on the floor.
  • the piston head has a cone between annular disk and piston rod.
  • the elastic body may be attached to the piston in various ways.
  • the attachment can be done by positive engagement and / or friction and / or material connection.
  • the elastic body outside a rim which engages around an edge of the piston head outside and is secured in this way on the piston head.
  • a positive connection of the elastic body is buttoned by means of protruding elements on the bottom in corresponding recesses in the top of the piston head.
  • the piston at the top of the piston head to a blind hole in which the elastic body is partially arranged.
  • the elastic body is fixed for example by pressing or frictional engagement in the blind hole.
  • the blind hole at an interval from its opening an extension and the elastic body is fixed by engagement in the extension positively in the blind hole.
  • the blind hole diametrically opposed extensions on.
  • the radial expansions start from a depression at the bottom of the blind hole.
  • the elastic body has a crowned portion projecting from the piston head.
  • the crowned section promotes gradual elastic deformation with gentle increase in elastic return forces.
  • the piston has a cone at the end remote from the piston head and the cylinder and / or the connecting channel has a corresponding conicity on the inside. This favors a complete emptying of the cylinder. Due to the elastic coupling of the piston and piston actuating rod, a pressing in or clamping of the cone in the conicity is avoided.
  • the piston can be sealed in different ways in the cylinder. It is possible that it is sealed with an outer periphery directly on the inner circumference of the cylinder. According to one embodiment, the piston has at least one circumferential piston seal at the end remote from the piston head. The piston seal has a greater elasticity than the piston. A secure seal is achieved, even if the piston and cylinder are not precisely matched.
  • the piston seal is a piston sealing ring inserted in an annular groove on the circumference of the piston.
  • the cylinder is connected to the seat via a tube or hose.
  • the cylinder is formed integrally with the seat.
  • the seat is e.g. a receptacle for inserting a pipette tip.
  • the pipette tip is secured in the receptacle by pinching its upper edge area.
  • the seat is a cylindrical projection on which a pipette tip is attachable, so that it is fixed by clamping on the seat.
  • the seat is a cone for attaching a pipette tip.
  • the pipette tip can be fixed directly sealingly on the seat.
  • the seat has at least one circumferential seat seal for sealing against an inserted or inserted pipette tip.
  • the seat seal is inserted into a further annular groove on the periphery of the seat seat seal.
  • the elastic body and / or the piston seal and / or the seat seal comprises an elastomer, i. consists entirely or partially of the elastomer.
  • the elastic body and / or the piston seal and / or the seat seal made of silicone and / or of a thermoplastic elastomer.
  • the elastic body and the piston are manufactured separately, for example, and then connected together.
  • the piston is made of plastic, in particular by injection molding.
  • the elastic body is molded onto the piston. By injecting the elastic body on the piston elastic body and piston can be positively and / or frictionally and / or materially connected to each other, the latter e.g. if the materials are chosen so that they fuse together in the contact area.
  • piston and elastic body are produced in the multi-component injection molding process.
  • the pipetting device has a housing which comprises the piston actuating rod, the at least one cylinder with the at least one piston and the at least one seat on an externally accessible side of the housing.
  • the pipetting device is provided for example with its own manual or electric drive device, which is also arranged in the housing.
  • the end of the piston-actuating rod on one side of the housing is accessible from the outside.
  • the pipetting device then forms a pipetting tool which can be connected to a drive device.
  • the drive device may in turn be a hand-operated drive device or an electric motor-driven drive device.
  • the piston actuating rod protrudes from the side of the housing to be coupled to a drive member of a drive device.
  • an axially outwardly spring-loaded piston actuating rod abuts axially against a linearly displaceable actuating member of the drive device.
  • the piston actuating rod has at the end remote from the receiving means a coupling device for connecting to a drive device.
  • the housing has a fastening device for fastening the pipetting device to a drive device.
  • the fastening device is e.g. a screw thread and / or a bayonet connection and / or a flange or radially projecting edge for fixing to pivotable gripping or clamping devices of the drive device.
  • the pipetting device has a basic structure 1 with a U-shape, which has a base 2 and two legs 3, 4 which project perpendicularly at the edges. From the base 2 is outwardly a hollow cylindrical fastening device 5 before.
  • the basic structure 1 is made for example of metal or of a rigid and solid plastic.
  • a fastening sleeve 6 with an external thread 7 is arranged so as to be rotatable and axially immovable.
  • the mounting sleeve 6 is also made of metal or a rigid and solid plastic.
  • a through hole 8 extends coaxially with the fastening device 5.
  • a piston actuating rod 9 extends coaxially through the fastening device 5 and through the through hole 8.
  • the piston actuating rod 9 has at a outwardly of the fastening means 5 projecting end a coupling device 10 for connection to a drive device, the two rotating, circular disk-shaped shaft coils 11, 12 with a Groove 13 between them.
  • the piston actuating rod 9 is connected on the inside of the base 2 with a cross member 14, which is aligned transversely to the piston actuating rod 9.
  • a coil spring 15 is arranged, which is supported at one end on the outside of the base 2 and the other end to an abutment 16 in the form of a screw ring which is screwed close to an opening of the fastening device 5 on the piston actuating rod 9.
  • the Coil spring 15 is in the position shown under bias, so that it presses the cross member 14 against the inside of the base 2.
  • the traverse 14 has on the side remote from the base 2 side a plurality of parallel receptacles 17 for each piston head.
  • Each receptacle 17 is accessible on the side facing away from the base 2 by a passage opening 18 in a bottom 19 from the outside.
  • the bottom 19 thus forms a the passage opening 18 bounding edge, which protrudes with respect to the overlying part of the receptacle 17 inwardly.
  • Each receptacle 17 is also accessible from the outside by a perpendicular to the piston actuation rod 9 and the traverse 14 (or perpendicular to the plane) extending insertion opening 21 axially opposite the passage opening 18.
  • the piston actuating rod 9 and the cross member 14 are e.g. made of a metallic material or of a rigid and solid plastic.
  • a multi-part housing 22 is fixed on the basic structure 1, a multi-part housing 22 is fixed.
  • the housing 22 is relatively flat, i. its external dimensions perpendicular to the plane of the drawing are only a fraction of the external dimensions shown in the drawing plane.
  • housing 22 is directly adjacent to the ends of the legs 3, 4 a parallel to the base 2 extending perforated plate 23 with extending in the axial direction of the piston actuating rod 9, aligned on the through holes 18 guide holes 24 are provided.
  • a further perforated plate 25 is arranged with coaxial with the guide holes 24 threaded holes 26.
  • the further perforated plate 25 terminates the housing 22 at this end face.
  • the housing 22 is made of a rigid and solid plastic or of a metallic material.
  • the pipetting device comprises a plurality of cylinders 27 with a cylindrical cavity 28, which are integrally connected to a seat 29 in the form of a cone for a pipette tip.
  • the cylindrical cavity 28 is connected via a conical passage 30 with a through hole 31 in an end face of the seat 29.
  • Each cylinder 27 has a circumferential flange 32. Further, each cylinder 27 on the side of the seat 29 adjacent to the flange 32 has an external thread 33.
  • the cylinder 26 is made of a metallic material or of a rigid and solid plastic.
  • Each cylinder 27 is inserted into a guide bore 24 and screwed into a threaded bore 26 coaxial therewith, so that the flange 32 is seated on the inside of the further perforated plate 25. Instead, the cylinder 27 may be executed without external thread 33 and be inserted into a threadless hole of the further perforated plate 25.
  • a spring may hold the flange 32 in abutment with the further perforated plate 25. In this position, the seat 29 protrudes outwardly beyond the adjacent end face of the housing 22.
  • annular groove 34 runs around, in which a seat sealing ring 35 is arranged.
  • Each piston 36 has a piston head 38 at the end of a protruding from the cylinder 27 piston rod 37.
  • Each piston head 38 comprises an annular disc 39 and a cone 40 arranged between annular disc 39 and piston rod 37 (compare FIGS. 2 and 3).
  • the piston head 38 On the side of the piston rod 37, the piston head 38 has a bottom 41 and on the opposite side a flat top 42nd
  • the piston has a blind hole 43 which has a recess 44 at the bottom.
  • This has radial extensions 45, 46 which extend perpendicular to the plane of the drawing of Fig. 1 to the sheath of the cone 40 (see Fig .. 2).
  • An elastic body 47 is disposed in the blind hole 43.
  • the elastic body 47 is cylindrical in the region of the blind hole 43 and crowned in an area projecting beyond the upper side 42.
  • the area 48 of the elastic body 47 beyond the upper side 42 has the shape of a hemisphere.
  • the piston head 38 opposite end of the piston 36 has a slender cone 50 whose cone angle corresponds to that of the passage channel 30. Between cone 50 and piston rod 37, a circumferential annular groove 51 is present, which receives a piston seal 52 in the form of a piston sealing ring.
  • the piston 36 is manufactured in a two-component injection molding process.
  • the piston 36 is made of a hard plastic, for example of a thermoplastic such as Fortron (glass fiber reinforced polyvinyl sulfide from Hoechst).
  • the elastic body 47 is molded onto the piston 36 in a second injection cycle of silicone (rubber) or of a thermoplastic elastomer.
  • Each piston 36 is disposed with the cone 50 and the piston seal 52 in the cylindrical cavity 28, even if the piston 36 is pulled out of the cylinder 27 maximum (Fig. 1).
  • Each piston head 38 is located in a receptacle coaxial with the cylinder 27. In this case, the piston rod 37 extends through the through hole 18.
  • the piston head 38 is seated in the region of the circular disc 30 with the bottom 41 on the bottom 19.
  • the crowned region 48 of the elastic body 47 sits on the contact surface 20.
  • the elastic body 47 is compressed somewhat elastically in the crowned area 48.
  • Each piston 36 can be connected by simply inserting the piston head 38 through the insertion opening 21 into the receptacle 17 with the traverse 14. by virtue of the elastic compression of the elastic body 47 it is held in a defined position in the receptacle 17 and a clearance between the piston head 38 and receptacle 17 is thereby compensated. Conversely, the piston 36 is extremely easy to disassemble.
  • the pipetting device is connected to a drive device 53.
  • a drive device 53 For this purpose, it is used with the fastening device 5 in a mounting receptacle 54 of the drive device 53 and connected by screwing the mounting ring 6 in an internal thread 55 of the mounting receptacle 54 with this.
  • the fastening device 5 sits with its front end on the bottom of the fastening receptacle 54.
  • the coupling device 10 is connected to a matched further coupling device 56 of a linear drive 57 of the drive device 53.
  • the piston actuating rod 9 and the associated piston 36 is displaceable.
  • the pistons 36 displace air columns within the cavities 28 and the connecting channels 30 in order to eject or suck liquid from pipette tips plugged onto the seats 29.
EP07011005A 2006-07-07 2007-06-05 Dispositif de pipetage Active EP1875966B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006031460A DE102006031460B4 (de) 2006-07-07 2006-07-07 Pipettiervorrichtung

Publications (2)

Publication Number Publication Date
EP1875966A1 true EP1875966A1 (fr) 2008-01-09
EP1875966B1 EP1875966B1 (fr) 2010-11-03

Family

ID=38578640

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07011005A Active EP1875966B1 (fr) 2006-07-07 2007-06-05 Dispositif de pipetage

Country Status (5)

Country Link
US (1) US7673532B2 (fr)
EP (1) EP1875966B1 (fr)
JP (1) JP5213155B2 (fr)
CN (1) CN101138742B (fr)
DE (2) DE102006031460B4 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108970661A (zh) * 2018-07-23 2018-12-11 中冶武汉冶金建筑研究院有限公司 一种手动移液器
CN110193388A (zh) * 2019-07-08 2019-09-03 昆山汇先医药技术有限公司 一种多通道自动移液枪
EP3932557A1 (fr) 2020-07-02 2022-01-05 Eppendorf AG Tête de pipetage à canaux multiples

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009051654B4 (de) 2009-10-30 2013-01-03 Eppendorf Ag Dosiervorrichtung für Flüssigkeiten und Verfahren zum Dosieren von Flüssigkeiten
US8466335B2 (en) * 2010-04-26 2013-06-18 The Procter & Gamble Company Personal care product
US9815053B2 (en) 2013-01-15 2017-11-14 Mettler-Toledo Rainin, LLC Liquid end assembly for a multichannel air displacement pipette
EP3302800B1 (fr) 2015-06-05 2019-08-14 Mimetas B.V. Plaque microfluidique
US11167282B2 (en) * 2017-01-31 2021-11-09 HighRes Biosolutions, Inc. Auto-pipetting apparatus and method
JP6865510B2 (ja) * 2017-06-01 2021-04-28 株式会社エー・アンド・デイ マルチチャンネルピペット
CN108745432B (zh) * 2018-07-19 2023-10-03 北京百泰克生物技术有限公司 移液枪用移液机构
EP3934809A4 (fr) * 2019-03-08 2023-01-25 Rarecyte, Inc. Dispositif, système et procédé permettant de sélectionner un analyte cible
CN110215945B (zh) * 2019-07-08 2024-03-15 江苏汇先医药技术有限公司 一种自动褪吸头的移液枪
TWD218529S (zh) * 2020-09-30 2022-05-01 富佳生技股份有限公司 核酸檢測儀之圖形化使用者介面
EP4331725A1 (fr) 2022-08-30 2024-03-06 Eppendorf SE Tige de piston et procédé de fabrication d'une telle tige de piston

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2330456A1 (fr) * 1975-11-05 1977-06-03 Eppendorf Geraetebau Netheler Dispositif de pipetage
EP0181957A1 (fr) * 1984-11-20 1986-05-28 HTL High-Tech Lab Herstellung und Vertrieb medizinisch technischer Erzeugnisse GmbH Pipette à dose réglable
DD239539A1 (de) * 1985-07-19 1986-10-01 Univ Schiller Jena Hohlkolbenpipette
DE19708151A1 (de) * 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipettiervorrichtung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392791A (en) * 1972-02-10 1975-04-30 Suovaniemi Oa Multiple pipette
GB1442439A (en) 1972-09-07 1976-07-14 Santerre Orsan Method of making l-aspartic acid from fumaric acid
US4258761A (en) * 1979-05-03 1981-03-31 Bennett John T Jr Rehydrator
FR2521724B1 (fr) * 1982-02-16 1988-03-25 Data Packaging Corp Doseur a pipette a tubes multiples
JPS60222571A (ja) * 1984-04-18 1985-11-07 Toshiba Corp シリンダ−ポンプ
DD260571B5 (de) * 1987-05-04 1998-02-19 Opal Jena Ges Fuer Optische An Mehrkanaldosiervorrichtung zum diskreten simultanen Abmessen von definierten Volumina
DE4330562A1 (de) * 1993-09-09 1995-03-16 Behringwerke Ag Kunststoffpipette
JP3699749B2 (ja) * 1995-06-09 2005-09-28 セーラー万年筆株式会社 ピペット
US6499363B1 (en) * 1997-12-12 2002-12-31 The Sailor Pen Co., Ltd. Tip for pipette and pipette with the same
JP3473409B2 (ja) * 1998-06-11 2003-12-02 松下電器産業株式会社 分注装置
CH695544A5 (de) * 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
FI20010972A0 (fi) * 2001-05-09 2001-05-09 Thermo Labsystems Oy Kärkisäiliöpipetti

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2330456A1 (fr) * 1975-11-05 1977-06-03 Eppendorf Geraetebau Netheler Dispositif de pipetage
EP0181957A1 (fr) * 1984-11-20 1986-05-28 HTL High-Tech Lab Herstellung und Vertrieb medizinisch technischer Erzeugnisse GmbH Pipette à dose réglable
DD239539A1 (de) * 1985-07-19 1986-10-01 Univ Schiller Jena Hohlkolbenpipette
DE19708151A1 (de) * 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipettiervorrichtung

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108970661A (zh) * 2018-07-23 2018-12-11 中冶武汉冶金建筑研究院有限公司 一种手动移液器
CN108970661B (zh) * 2018-07-23 2021-04-27 中冶武汉冶金建筑研究院有限公司 一种手动移液器
CN110193388A (zh) * 2019-07-08 2019-09-03 昆山汇先医药技术有限公司 一种多通道自动移液枪
CN110193388B (zh) * 2019-07-08 2023-12-15 江苏汇先医药技术有限公司 一种多通道自动移液枪
EP3932557A1 (fr) 2020-07-02 2022-01-05 Eppendorf AG Tête de pipetage à canaux multiples

Also Published As

Publication number Publication date
US7673532B2 (en) 2010-03-09
JP2008012533A (ja) 2008-01-24
DE102006031460B4 (de) 2008-10-30
JP5213155B2 (ja) 2013-06-19
DE102006031460A1 (de) 2008-01-10
DE502007005526D1 (de) 2010-12-16
CN101138742A (zh) 2008-03-12
US20080006100A1 (en) 2008-01-10
CN101138742B (zh) 2012-11-14
EP1875966B1 (fr) 2010-11-03

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