EP1830947A4 - Purification d'immunoglobulines - Google Patents

Purification d'immunoglobulines

Info

Publication number
EP1830947A4
EP1830947A4 EP05815565A EP05815565A EP1830947A4 EP 1830947 A4 EP1830947 A4 EP 1830947A4 EP 05815565 A EP05815565 A EP 05815565A EP 05815565 A EP05815565 A EP 05815565A EP 1830947 A4 EP1830947 A4 EP 1830947A4
Authority
EP
European Patent Office
Prior art keywords
immunoglobulins
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05815565A
Other languages
German (de)
English (en)
Other versions
EP1830947A1 (fr
Inventor
Hans Berg
Hans J Johansson
Gunnar Malmquist
Per-Mikael Aaberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
GE Healthcare Bio Sciences AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36588164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1830947(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE0403057A external-priority patent/SE0403057D0/sv
Application filed by GE Healthcare Bio Sciences AB filed Critical GE Healthcare Bio Sciences AB
Publication of EP1830947A1 publication Critical patent/EP1830947A1/fr
Publication of EP1830947A4 publication Critical patent/EP1830947A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
EP05815565A 2004-12-14 2005-12-12 Purification d'immunoglobulines Withdrawn EP1830947A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0403057A SE0403057D0 (sv) 2004-12-14 2004-12-14 Purification of immunoglobulins
US63831604P 2004-12-22 2004-12-22
PCT/SE2005/001900 WO2006065208A1 (fr) 2004-12-14 2005-12-12 Purification d'immunoglobulines

Publications (2)

Publication Number Publication Date
EP1830947A1 EP1830947A1 (fr) 2007-09-12
EP1830947A4 true EP1830947A4 (fr) 2012-04-18

Family

ID=36588164

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05815565A Withdrawn EP1830947A4 (fr) 2004-12-14 2005-12-12 Purification d'immunoglobulines

Country Status (5)

Country Link
EP (1) EP1830947A4 (fr)
JP (1) JP5787461B2 (fr)
AU (1) AU2005317279C1 (fr)
CA (1) CA2586803C (fr)
WO (1) WO2006065208A1 (fr)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
US10011858B2 (en) 2005-03-31 2018-07-03 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
ES2654040T3 (es) 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
DK3056568T3 (da) 2006-03-31 2021-11-01 Chugai Pharmaceutical Co Ltd Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
CN106422418B (zh) * 2006-09-29 2022-03-01 思拓凡生物工艺研发有限公司 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
CL2008002886A1 (es) 2007-09-26 2009-12-04 Chugai Pharmaceutical Co Ltd Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende.
US8277649B2 (en) * 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
US10435458B2 (en) 2010-03-04 2019-10-08 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variants with reduced Fcgammar binding
JP5917417B2 (ja) 2010-03-05 2016-05-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体の選択的強化
US8859294B2 (en) 2010-03-17 2014-10-14 Panasonic Corporation Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate
WO2011114405A1 (fr) * 2010-03-17 2011-09-22 Panasonic Corporation Méthode de liaison au substrat d'une protéine constituée de la protéine a ou constituée d'au moins un domaine des domaines a à e de la protéine a
KR20130055569A (ko) 2010-03-31 2013-05-28 제이에스알 가부시끼가이샤 친화성 크로마토그래피용 충전제
US9162161B2 (en) 2010-03-31 2015-10-20 Jsr Corporation Filler for affinity chromatography
TR201802772T4 (tr) 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül.
WO2015030094A1 (fr) 2013-08-30 2015-03-05 株式会社カネカ PEPTIDE SE LIANT À LA RÉGION Fab
US9448243B2 (en) * 2013-09-04 2016-09-20 Sten Ohlson Weak affinity chromatography
JP6230853B2 (ja) * 2013-09-06 2017-11-15 株式会社日立製作所 タンパク質の精製方法及び精製装置
BR112016006197B1 (pt) 2013-09-27 2023-04-11 Chugai Seiyaku Kabushiki Kaisha Método para produzir um anticorpo biespecífico de polipeptídeos
EP3076170B1 (fr) 2013-11-27 2023-09-06 JSR Corporation Support de phase solide et procédé de production pour charge pour chromatographie d'affinité
EP3160982B1 (fr) 2014-06-24 2020-10-28 Cytiva BioProcess R&D AB Procédé de chromatographie
EP3162809B1 (fr) 2014-06-27 2021-08-04 JSR Corporation Support pour chromatographie d'affinité
US20170334947A1 (en) * 2014-08-28 2017-11-23 Kaneka Corporation Affinity separation matrix for fab region-containing peptide
CN108064286A (zh) 2015-01-26 2018-05-22 株式会社钟化 突变型免疫球蛋白κ链可变区结合性肽
WO2016121701A1 (fr) 2015-01-26 2016-08-04 株式会社カネカ Matrice pour séparation par affinité destinée à la purification de protéines contenant la région variable de la chaîne kappa des immunoglobulines
EP3279216A4 (fr) 2015-04-01 2019-06-19 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production d'un hétéro-oligomère polypeptidique
WO2017115773A1 (fr) 2015-12-28 2017-07-06 中外製薬株式会社 Procédé pour favoriser l'efficacité de purification d'un polypeptide contenant une région fc
WO2017195638A1 (fr) 2016-05-09 2017-11-16 株式会社カネカ Procédé de purification d'un anticorps ou d'un fragment d'anticorps comportant une région variable de chaîne κ
WO2017195641A1 (fr) * 2016-05-11 2017-11-16 株式会社カネカ Matrice de séparation par affinité, et procédé de fabrication de celle-ci
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies

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US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5089605A (en) * 1987-03-13 1992-02-18 Repligen Corporation Immobilized immunoglobulin-binding proteins
US5445732A (en) * 1992-06-19 1995-08-29 Sepracor Inc. Passivated porous polymer supports and methods for the preparation and use of same
EP0693085B1 (fr) * 1993-03-29 2001-10-31 Minnesota Mining And Manufacturing Company Procede de couplage de ligands au sein de supports poreux (p.e. azlactone) et ses utilisations
SE9503925D0 (sv) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
DE69835275T2 (de) * 1997-01-07 2007-07-19 Kaneka Corp. Absorbens zum reinigen von körperflüssigkeiten
SE9700383D0 (sv) * 1997-02-04 1997-02-04 Pharmacia Biotech Ab An adsorption/separation method and a medium for adsorption/separation
SE0004929D0 (sv) * 2000-12-29 2000-12-29 Apbiotech Ab A method for producing liquid chromatography matrices
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
SE0300482D0 (sv) * 2003-02-21 2003-02-21 Amersham Biosciences Ab Inorganic beads with hierarchical pore structures
US7700743B2 (en) * 2003-07-22 2010-04-20 Millipore Corporation Immobilised affinity medium and its use in separation
WO2006024497A1 (fr) * 2004-08-30 2006-03-09 Lonza Biologics Plc. Chromatographie par echange d'ions et affinite pour la purification d'anticorps

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "MabSelect Xtra - Recombinant protein A-based, high-capacity affinity medium", 1 November 2004 (2004-11-01), Uppsala, pages 1 - 8, XP055015044, Retrieved from the Internet <URL:http://www.gelifesciences.co.jp/catalog/pdf/11001157.pdf> [retrieved on 20111216] *
ANONYMOUS: "Protein A Agarose Kit Catalogue No. 553-50-00", 1 September 2004 (2004-09-01), Gaithersburg, MD, pages 1 - 3, XP055014986, Retrieved from the Internet <URL:http://web.archive.org/web/20040901150500/http://www.kpl.com/docs/datasheet/5535000.PDF> [retrieved on 20111215] *
See also references of WO2006065208A1 *

Also Published As

Publication number Publication date
AU2005317279A1 (en) 2006-06-22
CA2586803C (fr) 2012-12-11
AU2005317279B2 (en) 2011-02-24
WO2006065208A1 (fr) 2006-06-22
JP2008523140A (ja) 2008-07-03
EP1830947A1 (fr) 2007-09-12
JP5787461B2 (ja) 2015-09-30
AU2005317279C1 (en) 2014-07-17
CA2586803A1 (fr) 2006-06-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20070514

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20120320

RIC1 Information provided on ipc code assigned before grant

Ipc: B01D 15/38 20060101ALI20120314BHEP

Ipc: B01J 2/00 20060101AFI20120314BHEP

Ipc: C07K 1/22 20060101ALI20120314BHEP

17Q First examination report despatched

Effective date: 20130118

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Effective date: 20130730