EP1830947A4 - Reinigung von immunoglobulinen - Google Patents
Reinigung von immunoglobulinenInfo
- Publication number
- EP1830947A4 EP1830947A4 EP05815565A EP05815565A EP1830947A4 EP 1830947 A4 EP1830947 A4 EP 1830947A4 EP 05815565 A EP05815565 A EP 05815565A EP 05815565 A EP05815565 A EP 05815565A EP 1830947 A4 EP1830947 A4 EP 1830947A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- immunoglobulins
- purification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Fodder In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0403057A SE0403057D0 (sv) | 2004-12-14 | 2004-12-14 | Purification of immunoglobulins |
US63831604P | 2004-12-22 | 2004-12-22 | |
PCT/SE2005/001900 WO2006065208A1 (en) | 2004-12-14 | 2005-12-12 | Purification of immunoglobulins |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1830947A1 EP1830947A1 (de) | 2007-09-12 |
EP1830947A4 true EP1830947A4 (de) | 2012-04-18 |
Family
ID=36588164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05815565A Withdrawn EP1830947A4 (de) | 2004-12-14 | 2005-12-12 | Reinigung von immunoglobulinen |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1830947A4 (de) |
JP (1) | JP5787461B2 (de) |
AU (1) | AU2005317279C1 (de) |
CA (1) | CA2586803C (de) |
WO (1) | WO2006065208A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI544076B (zh) | 2005-03-31 | 2016-08-01 | Chugai Pharmaceutical Co Ltd | A method of manufacturing a polypeptide that controls assembly |
EP2009101B1 (de) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antikörpermodifikationsverfahren für die aufreinigung eines bispezifischen antikörpers |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
CA2664530C (en) | 2006-09-29 | 2015-11-17 | Ge Healthcare Bio-Sciences Ab | Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation |
SG149759A1 (en) * | 2007-07-10 | 2009-02-27 | Millipore Corp | Media for affinity chromatography |
AU2008304778B9 (en) | 2007-09-26 | 2014-05-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
US8277649B2 (en) * | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
US10435458B2 (en) | 2010-03-04 | 2019-10-08 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variants with reduced Fcgammar binding |
CN102791728B (zh) * | 2010-03-05 | 2015-04-01 | 贝林格尔.英格海姆国际有限公司 | 抗体的选择性富集 |
JP4987165B2 (ja) * | 2010-03-17 | 2012-07-25 | パナソニック株式会社 | プロテインa、またはプロテインaのa〜eドメインの少なくとも1つからなるタンパク質を基板の表面に結合させる方法 |
US8859294B2 (en) | 2010-03-17 | 2014-10-14 | Panasonic Corporation | Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate |
CN102834407B (zh) | 2010-03-31 | 2016-01-20 | Jsr株式会社 | 亲和色谱用填充剂 |
US9162161B2 (en) | 2010-03-31 | 2015-10-20 | Jsr Corporation | Filler for affinity chromatography |
KR101962483B1 (ko) | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
CN105518023A (zh) | 2013-08-30 | 2016-04-20 | 株式会社钟化 | Fab区域结合性肽 |
EP3042192A4 (de) * | 2013-09-04 | 2017-04-26 | Sten Ohlson | Schwache affinitätschromatografie |
JP6230853B2 (ja) * | 2013-09-06 | 2017-11-15 | 株式会社日立製作所 | タンパク質の精製方法及び精製装置 |
RU2758952C1 (ru) | 2013-09-27 | 2021-11-03 | Чугаи Сейяку Кабусики Кайся | Способ получения полипептидного гетеромультимера |
JP6387015B2 (ja) | 2013-11-27 | 2018-09-05 | Jsr株式会社 | 固相担体、固相担体の製造方法、アフィニティ精製用担体、アフィニティクロマトグラフィー用充填剤の製造方法、アフィニティクロマトグラフィー用充填剤、クロマトグラフィーカラムおよび精製方法 |
EP3160982B1 (de) | 2014-06-24 | 2020-10-28 | Cytiva BioProcess R&D AB | Chromatographieverfahren |
CN106459141B (zh) | 2014-06-27 | 2019-09-13 | Jsr株式会社 | 亲和色谱用载体 |
US20170334947A1 (en) * | 2014-08-28 | 2017-11-23 | Kaneka Corporation | Affinity separation matrix for fab region-containing peptide |
CN108064286A (zh) | 2015-01-26 | 2018-05-22 | 株式会社钟化 | 突变型免疫球蛋白κ链可变区结合性肽 |
JPWO2016121701A1 (ja) | 2015-01-26 | 2017-11-09 | 株式会社カネカ | 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス |
US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
SG11201803989WA (en) * | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
WO2017195638A1 (ja) | 2016-05-09 | 2017-11-16 | 株式会社カネカ | 抗体またはκ鎖可変領域含有抗体断片の精製方法 |
WO2017195641A1 (ja) * | 2016-05-11 | 2017-11-16 | 株式会社カネカ | アフィニティ分離マトリックスの製造方法およびアフィニティ分離マトリックス |
GB201703116D0 (en) * | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
US5089605A (en) * | 1987-03-13 | 1992-02-18 | Repligen Corporation | Immobilized immunoglobulin-binding proteins |
US5445732A (en) * | 1992-06-19 | 1995-08-29 | Sepracor Inc. | Passivated porous polymer supports and methods for the preparation and use of same |
JP3607289B2 (ja) * | 1993-03-29 | 2005-01-05 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | 多孔質支持体(p.e.アズラクトン)の内部にリガンドをカップリングする方法及びその使用法 |
SE9503925D0 (sv) * | 1995-11-07 | 1995-11-07 | Pharmacia Biotech Ab | Separationsmedium för IgG |
SE9601368D0 (sv) * | 1996-04-11 | 1996-04-11 | Pharmacia Biotech Ab | Process for the production of a porous cross-linked polysaccharide gel |
EP1693402A3 (de) * | 1997-01-07 | 2009-05-27 | Kaneka Corporation | Zellulolische Partikel, vernetzte Polymerteilchen enthaltender sphärischer Gegenstand und Absorbent zum Reinigen von Körperflüssigkeiten |
SE9700383D0 (sv) * | 1997-02-04 | 1997-02-04 | Pharmacia Biotech Ab | An adsorption/separation method and a medium for adsorption/separation |
SE0004929D0 (sv) * | 2000-12-29 | 2000-12-29 | Apbiotech Ab | A method for producing liquid chromatography matrices |
SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
SE0300482D0 (sv) * | 2003-02-21 | 2003-02-21 | Amersham Biosciences Ab | Inorganic beads with hierarchical pore structures |
US7700743B2 (en) * | 2003-07-22 | 2010-04-20 | Millipore Corporation | Immobilised affinity medium and its use in separation |
KR20070072510A (ko) * | 2004-08-30 | 2007-07-04 | 론자 바이올로직스 피엘씨 | 항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피 |
-
2005
- 2005-12-12 CA CA2586803A patent/CA2586803C/en active Active
- 2005-12-12 JP JP2007546603A patent/JP5787461B2/ja active Active
- 2005-12-12 WO PCT/SE2005/001900 patent/WO2006065208A1/en active Application Filing
- 2005-12-12 AU AU2005317279A patent/AU2005317279C1/en active Active
- 2005-12-12 EP EP05815565A patent/EP1830947A4/de not_active Withdrawn
Non-Patent Citations (3)
Title |
---|
ANONYMOUS: "MabSelect Xtra - Recombinant protein A-based, high-capacity affinity medium", 1 November 2004 (2004-11-01), Uppsala, pages 1 - 8, XP055015044, Retrieved from the Internet <URL:http://www.gelifesciences.co.jp/catalog/pdf/11001157.pdf> [retrieved on 20111216] * |
ANONYMOUS: "Protein A Agarose Kit Catalogue No. 553-50-00", 1 September 2004 (2004-09-01), Gaithersburg, MD, pages 1 - 3, XP055014986, Retrieved from the Internet <URL:http://web.archive.org/web/20040901150500/http://www.kpl.com/docs/datasheet/5535000.PDF> [retrieved on 20111215] * |
See also references of WO2006065208A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP5787461B2 (ja) | 2015-09-30 |
CA2586803A1 (en) | 2006-06-22 |
AU2005317279A1 (en) | 2006-06-22 |
AU2005317279C1 (en) | 2014-07-17 |
AU2005317279B2 (en) | 2011-02-24 |
EP1830947A1 (de) | 2007-09-12 |
JP2008523140A (ja) | 2008-07-03 |
WO2006065208A1 (en) | 2006-06-22 |
CA2586803C (en) | 2012-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070514 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20120320 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: B01D 15/38 20060101ALI20120314BHEP Ipc: B01J 2/00 20060101AFI20120314BHEP Ipc: C07K 1/22 20060101ALI20120314BHEP |
|
17Q | First examination report despatched |
Effective date: 20130118 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130730 |