EP1778257A1 - The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics - Google Patents
The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnicsInfo
- Publication number
- EP1778257A1 EP1778257A1 EP05768231A EP05768231A EP1778257A1 EP 1778257 A1 EP1778257 A1 EP 1778257A1 EP 05768231 A EP05768231 A EP 05768231A EP 05768231 A EP05768231 A EP 05768231A EP 1778257 A1 EP1778257 A1 EP 1778257A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- portulaca
- extracts
- aerial parts
- animals
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to the use of extracts of aerial parts of plants of the Portulaca genus, in particular Portulaca oleracea, for the preparation of growth promoters for use in livestock.
- Bacterial antibiotic resistance is an increasing problem which affects public health, including the veterinary field.
- Portulaca is a annual herbaceous plant present in all temperate and warm regions.
- Aerial parts of plants of the Portulaca genus have been used for a long time, as they are or in the form of aqueous or water-ethanol extracts, in Chinese traditional medicine for arresting hemorrage of various origin (hemorrhoids, uterus), and for the treatment of sores, eczema, snake or insect bites.
- compositions for the veterinary or zootechnical use comprising as active ingredients aerial parts ground or extracts of aerial parts of Portulaca, preferably Portulaca oleracea, admixed with suitable carriers or in the form of feed supplements.
- compositions proved capable of promoting growth in livestock, in particular swine, bovine, ovine and equine, more particularly swine, without inducing the drawbacks and side effects of growth-promoting antibiotics.
- Dosages will depend on a number of factors, such as species, size, weight and age of the animal. In principle, a typical dosage will range from 0.1 g to 1O g of extract/aerial parts per animal/day.
- the extracts usable according to the invention can be prepared by a process which comprises the repeated extraction of Portulaca oleracea aerial parts with a solvent, of preferably at room temperature.
- the solvent used for the extraction preferably consists of a hydro-alcoholic ethanol/water 1 : 1 mixture.
- Group 1 control was treated with standard feed free from additives.
- Group 2 antibiotic was treated with medicated feed containing 2 g of apramycin and 1 g of colistin per kg of feed.
- Group 3 was treated with standard feed added with 2 g/Kg of Portulaca extract.
- Group 4 was treated with standard feed added with 5 g/kg of finely ground Portulaca aerial parts.
- Table 2 Mean daily intake: amount of feed daily intake, expressed in kg, between days 22 and 41 of treatment.
- Table 4 Effect of administration of the tested substances on different bacterial populations (log Ufc/g) from faeces samples taken on day 41.
Abstract
The present invention relates to the use of the aerial parts of plants of the Portulaca genus and extracts thereof, in particular Portulaca oleracea, for the preparation of growth promoters for use in livestock.
Description
THE USE OF MEDICINAL PLANTS AND EXTRACTS THEREOF FOR THE WELL BEING OF ANIMALS IN VETERINARY MEDICINE AND ZOOTECHNICS
The present invention relates to the use of extracts of aerial parts of plants of the Portulaca genus, in particular Portulaca oleracea, for the preparation of growth promoters for use in livestock.
TECHNOLOGICAL BACKGROUND Bacterial antibiotic resistance is an increasing problem which affects public health, including the veterinary field.
The use in veterinary medicine of antibiotics that are mostly the same as or strictly related to those used in human medicine, and the established practice of use of antibiotics at sub-therapeutical doses as growth promoters and mass metaphylactic agents, are the main causes of diffusion of acquired antibiotic resistance by a number of bacterial species responsible for pathologies in domestic animals and often even in -humans. The presence of antibiotic residues in meat and, indirectly, the selection of antibiotic-resistant bacteria, which can transfer the resistance genes to bacteria pathogenic to humans, can be a hazard to human health.
Approximately 25% of the total antibiotic production is intended for use in livestock, the 90% of them being used at sub-therapeutical doses for both the prevention of diseases and the promotion of growth. Antimicrobials have been added to feed and extensively used in zootechnics since the '50s to improve productive performances. In swine breeding, for instance, weaning of piglets is the most delicate step, as the distressing events related to the transfer and mixing of different groups of animals and the changes of feed induce alterations in the intestinal microbial flora of the animal, making it more susceptible to infections. The use of antibiotics in the prophylaxis of endemic
diseases occurring during weaning has lead to a generalized use of antibiotics which are included in feed for times which can be protracted until the animal is even 70-80 day old.
As a consequence of antibiotic-resistance emergency, the European Union has followed a restricted approach concerning the use of antibiotics as growth promoters, antimicrobial prophylaxis, multi-therapies, mass medication through feed and water. In particular, EU is withdrawing all authorizations concerning the use of antibiotics as growth promoters by 2006.
However, the prohibition of use of antibiotics as growth promoters and prophylactic agents will involve a deterioration of animals health, with an increase in diarrhoea, weight loss and mortality.
Different approaches exist for reducing the dependency of zootechnics, more particularly swine breeding, on the use of antibiotics: the choice one is the development of alternatives acting through the control of bacteria and promoting the natural reactivity of the animal, thereby inducing an improvement in health as well as the optimization of performances. Mandatory characteristics for such alternative solutions are safety of use and cheapness for producers, and hence for consumers.
Portulaca is a annual herbaceous plant present in all temperate and warm regions.
Aerial parts of plants of the Portulaca genus have been used for a long time, as they are or in the form of aqueous or water-ethanol extracts, in Chinese traditional medicine for arresting hemorrage of various origin (hemorrhoids, uterus), and for the treatment of sores, eczema, snake or insect bites. DISCLOSURE OF THE INVENTION
It has now been found that the administration of parts of plants, particularly the ground aerial parts or the extracts of the aerial parts of plants
of the Portulaca genus, in particular Portulaca oleracea, to livestock, is at least as much as active as the administration of growth-promoting antibiotics.
Therefore, the present invention relates to compositions for the veterinary or zootechnical use, comprising as active ingredients aerial parts ground or extracts of aerial parts of Portulaca, preferably Portulaca oleracea, admixed with suitable carriers or in the form of feed supplements.
Said compositions proved capable of promoting growth in livestock, in particular swine, bovine, ovine and equine, more particularly swine, without inducing the drawbacks and side effects of growth-promoting antibiotics. Dosages will depend on a number of factors, such as species, size, weight and age of the animal. In principle, a typical dosage will range from 0.1 g to 1O g of extract/aerial parts per animal/day.
The extracts usable according to the invention can be prepared by a process which comprises the repeated extraction of Portulaca oleracea aerial parts with a solvent, of preferably at room temperature. The solvent used for the extraction preferably consists of a hydro-alcoholic ethanol/water 1 : 1 mixture.
The resulting extracts are combined and concentrated under reduced pressure.
The following examples illustrate the invention in further detail.
EXAMPLE 1: Portulaca oleracea aerial parts extract for the zootechnical use
Preparation of the extract
1000 g of dry ground aerial parts of Portulaca oleracea are placed in percolator. The material is covered with a mixture ethanol/water mixture 1 : 1 v/v and left at RT for 3 hours. The solvent is then percolated and the material is covered with a further portion of ethanol/water mixture 1 : 1 v/v. The procedure is repeated 6 times using about 7700 ml of solvent totally. The 6 percolates are filtered, combined and concentrated under reduced pressure, thereby obtaining a dark hygroscopic grindable solid (241 g; yield 24.1% w/w).
EXAMPLE 2: In vivo test
Experiments were carried out on 120 piglets divided into 4 groups of 30 animals each.
Group 1 (control) was treated with standard feed free from additives. Group 2 (antibiotic) was treated with medicated feed containing 2 g of apramycin and 1 g of colistin per kg of feed. Group 3 was treated with standard feed added with 2 g/Kg of Portulaca extract. Group 4 was treated with standard feed added with 5 g/kg of finely ground Portulaca aerial parts.
All animals were treated during weaning from day 22 to day 41. The animal well being was evaluated by the total weight increase, the feed daily intake and the percentage of diarrhoeic animals. Moreover, from day 41, faeces samples were microbiologically analysed for bacterial counts of total mesophyte charge, total Coliform and Lactobacilli. All parameters were evaluated with standard methods known to those skilled in the art. Results reported in the following Tables prove that the addition to standard feed of Portulaca in the form of both finely ground aerial parts and water-ethanol extract, although being devoid of per se in vitro antibacterial activity, can be a valuable replacement for antibiotic growth promoters in weaning foodstock. Table 1. Piglets weights and Mean Weight Increase (MWI) on day 41.
Table 2. Mean daily intake: amount of feed daily intake, expressed in kg, between days 22 and 41 of treatment.
Table 3. Effect of treatment on diarrhoea onset in the various treated groups.
Table 4. Effect of administration of the tested substances on different bacterial populations (log Ufc/g) from faeces samples taken on day 41.
Claims
1. The use of parts or extracts of plants of the Portulaca genus for the preparation of growth promoters for feedstock.
2. The use as claimed in claim 1 wherein the plant of the Portulaca genus is Portulaca oleracea.
3. The use as claimed in claim 1 or 2 in which the parts of Portulaca are the aerial parts.
4. The use as claimed in claim 1 or 2 in which the extract is a aerial parts hydro-alcoholic extract.
5. Veterinary or zootechnical compositions comprising parts or extracts of plants of the Portulaca genus in admixture with suitable carriers.
6. Compositions as claimed in claim 5 comprising aerial parts or extracts idro-alcholic of the aerial parts of Portulaca oleracea.
7. Feed added with aerial parts or aerial parts extracts of plants of the Portulaca genus, in particular Portulaca oleracea.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001629A ITMI20041629A1 (en) | 2004-08-06 | 2004-08-06 | USE OF MEDICINAL PLANTS AND THEIR EXTRACTS FOR ANIMAL WELFARE IN VETERINARY AND ZOOTECHNICS |
PCT/EP2005/007897 WO2006013001A1 (en) | 2004-08-06 | 2005-07-20 | The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1778257A1 true EP1778257A1 (en) | 2007-05-02 |
Family
ID=35149346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05768231A Withdrawn EP1778257A1 (en) | 2004-08-06 | 2005-07-20 | The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1778257A1 (en) |
JP (1) | JP2008509098A (en) |
KR (1) | KR20070039114A (en) |
CN (1) | CN101010092A (en) |
AU (1) | AU2005269016A1 (en) |
CA (1) | CA2576103A1 (en) |
IL (1) | IL181161A0 (en) |
IT (1) | ITMI20041629A1 (en) |
NO (1) | NO20070661L (en) |
RU (1) | RU2007104345A (en) |
WO (1) | WO2006013001A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX354530B (en) * | 2013-02-27 | 2018-02-19 | Univ Autonoma Del Estado De Morelos | Compositions comprising immp for contributing to the development, growth and improvement of the productive parameters of animals of zootechnical interest, and use of same. |
CN107397805B (en) * | 2017-07-07 | 2018-06-08 | 山东统盛医药科技有限公司 | Improve oral hygiene, prevention and the composition and preparation method for the treatment of mouth disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1053729A (en) * | 1990-02-05 | 1991-08-14 | 徐芝庭 | A kind of antimicrobial and preparation method thereof |
JP2583382B2 (en) * | 1992-10-30 | 1997-02-19 | 中部飼料株式会社 | Livestock and poultry feed containing purslane |
US5688508A (en) * | 1995-02-21 | 1997-11-18 | Virginia State University | Feed compositions comprising purslane leaves and methods of using thereof |
CA2191923C (en) * | 1996-12-03 | 2000-10-24 | Ji-Won Yoon | Portulaca oleracea and tumor cell growth |
CN1081445C (en) * | 1998-06-02 | 2002-03-27 | 归顺龙 | Additive for feed for piglets |
-
2004
- 2004-08-06 IT IT001629A patent/ITMI20041629A1/en unknown
-
2005
- 2005-07-20 CA CA002576103A patent/CA2576103A1/en not_active Abandoned
- 2005-07-20 KR KR1020077002506A patent/KR20070039114A/en not_active IP Right Cessation
- 2005-07-20 RU RU2007104345/13A patent/RU2007104345A/en not_active Application Discontinuation
- 2005-07-20 JP JP2007524215A patent/JP2008509098A/en active Pending
- 2005-07-20 WO PCT/EP2005/007897 patent/WO2006013001A1/en not_active Application Discontinuation
- 2005-07-20 CN CNA2005800265904A patent/CN101010092A/en active Pending
- 2005-07-20 AU AU2005269016A patent/AU2005269016A1/en not_active Abandoned
- 2005-07-20 EP EP05768231A patent/EP1778257A1/en not_active Withdrawn
-
2007
- 2007-02-05 NO NO20070661A patent/NO20070661L/en not_active Application Discontinuation
- 2007-02-05 IL IL181161A patent/IL181161A0/en unknown
Non-Patent Citations (1)
Title |
---|
See references of WO2006013001A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006013001A1 (en) | 2006-02-09 |
IL181161A0 (en) | 2007-07-04 |
RU2007104345A (en) | 2008-08-10 |
CN101010092A (en) | 2007-08-01 |
AU2005269016A1 (en) | 2006-02-09 |
KR20070039114A (en) | 2007-04-11 |
JP2008509098A (en) | 2008-03-27 |
ITMI20041629A1 (en) | 2004-11-06 |
NO20070661L (en) | 2007-03-06 |
CA2576103A1 (en) | 2006-02-09 |
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AX | Request for extension of the european patent |
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17Q | First examination report despatched |
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Effective date: 20070926 |