JP2008509098A - Use of medicinal plants and their extracts for animal health in animal medicine and livestock - Google Patents

Abstract

The present invention relates to the use of an above-ground part of a plant of the genus Suveruhi, particularly of the purslane, or an extract thereof for the production of a growth promoter for use in livestock.

Description

  The present invention relates to the use of an aerial part of a plant body of the genus Portulaca, in particular, Portulaca oleracea, or an extract thereof for producing a growth promoter for use in livestock.

  Bacterial antibiotic resistance is increasing as a problem affecting public health, including in the field of livestock.

  The practice of using antibiotics in veterinary medicines that are almost the same or very similar to those used in human medicine, and the use of antibiotics at sub-therapeutic doses as growth promoters or mass metaphylactic agents is It is a major cause of spreading antibiotic resistance acquired by many bacterial species associated with livestock and often human lesions. The presence of antibiotic residues in meat and, indirectly, the selection of antibiotic-resistant bacteria that can transfer resistance genes to bacteria that cause disease to humans is detrimental to human health.

  About 25% of all antibiotic products are for use in livestock, of which 90% are used in sub-therapeutic doses for disease prevention and growth promotion. Antibacterial agents are added to feed to improve productivity and have been widely used in livestock since the 1950s. In pig farming, for example, weaning of piglets is the stage with the most attention. This is because the hard events associated with the movement and mixing of different animal groups and changes in feeds induce changes in the intestinal microflora of animals, making them more susceptible to infections. The use of antibiotics to prevent species-specific illnesses that develop during weaning has led to the widespread use of antibiotics. The antibiotic is placed in the feed for a period that is extended until the animal is just 70-80 days old.

  Due to the crisis of antibiotic resistance, the European Union has taken a limited stance on the use of antibiotics as growth promoters, antibacterial prophylaxis, multi-therapies and mass medications through diet and water. I came. In particular, the EU has withdrawn all approvals for the use of antibiotics as growth promoters by 2006. However, withholding the use of antibiotics as growth promoters and prophylaxis results in a deterioration of animal health with diarrhea, weight loss and increased mortality.

  There are various ways to reduce the dependence of livestock, more specifically pig farming, on antibiotic use. One option is to develop alternative substances that act through controlling bacteria and promote the natural activity of animals, thereby achieving health enhancement and maximizing performance. Essential properties for such alternatives are safety to use and low cost for producers and thus for consumers.

  The genus Berberis is an annual leafy plant that exists in all temperate zones and the tropics.

  The above-ground part of the plant of the genus Prunus is intact or in the form of an aqueous or water-ethanol extract to stop bleeding of various causes (hemorrhoids, uterus) as well as ulcers, eczema, snake bites or insect bites. For treatment, it has been used for a long time in Chinese traditional medicine.

  It has now been found that the administration of plant parts of the genus Purslane, especially the purslane, especially ground ground or aboveground extracts to livestock, is at least as effective as the administration of growth-promoting antibiotics. .

  Thus, the present invention provides for use in veterinary or animal husbandry comprising, as an active ingredient, a spruce genus, preferably ground ground part of purslane, or an extract thereof mixed with a suitable carrier or in the form of a supplementary feed. Relates to the composition.

  The composition has been shown to be able to promote the growth of livestock, especially pigs, cows, sheep and horses, and more particularly pigs, without the disadvantages and side effects of growth-promoting antibiotics.

  The dose depends on several factors such as animal species, size, weight and age. As a general rule, typical doses range from 0.1 g to 10 g of extract / abovehead per day per animal.

  The usable extract of the present invention can be produced by a process comprising repeatedly extracting the above-ground part of purslane with a solvent, preferably at room temperature. As a solvent used for extraction, a mixture of ethanol / water 1: 1 hydrous alcohol is preferable. The resulting extracts are combined and concentrated under reduced pressure.

  The following examples illustrate the invention in more detail.

Example 1: Preparation of an extract of the above-ground part of purslane for use in livestock production 1000 g of the above-ground part of dry-spotted purslane is placed in a percolator. The material is covered with an ethanol / water mixture with a 1: 1 v / v mixture and placed at RT for 3 hours. The solvent is then filtered and the material is immersed in a further ethanol / water mixture 1: 1 v / v. This procedure is repeated 6 times using a total of about 7700 ml of solvent. The 6 leachates are filtered, combined, and concentrated under reduced pressure, thereby obtaining a brown hygroscopic solid (241 g, 24.1% w / w yield) that can be ground.

Example 2: In vivo test The experiment was performed with 120 piglets divided into 4 groups of 30 animals each.

  Group 1 (control) was bred using a standard diet without additives. Group 2 (antibiotics) was raised on a diet containing a drug with 2 g apramycin and 1 g colistin per kg diet. Group 3 was bred with a standard diet supplemented with 2 g / Kg extract of the genus Amaranthus. Group 4 was bred with a standard feed supplemented with 5 g / kg above ground portion of the finely ground genus Amaranthus.

  All animals were raised during the weaning period from 22 days to 41 days of age.

  Healthy animals were assessed by overall weight gain, daily feed intake and percentage of animals with diarrhea symptoms. In addition, from day 41, stool samples were microbiologically analyzed for total mesophyte charge, total coliforms and total lactobacilli. All parameters were evaluated by standard methods well known to those skilled in the art.

  The results reported in the table below show that the addition of Agaricus to the standard feed in the form of both finely ground aerial and water-ethanol extracts is not in itself antibacterial activity, but in weaned feed It shows that it can be a useful alternative to antibiotic growth promoters.

Claims (7)

  Use of a plant part or an extract of the plant of the genus Pleurotus for the production of a growth promoter for feed.   The use according to claim 1, wherein the plant of the genus Prunus is Prunus.   The use according to claim 1 or 2, wherein the part of the purslane is the above-ground part.   Use according to claim 1 or 2, wherein the extract is an above-ground hydroalcoholic extract.   A composition for veterinary or animal husbandry comprising a plant part or an extract of the genus Suveruyu mixed with a suitable carrier.   The composition according to claim 5, comprising an aerial part of purslane or an aqueous alcoholic extract thereof.   Feeds to which the above-ground part of the plant of the genus Purslane, especially the purslane, or an extract thereof is added.