WO2021187516A1 - Animal growth promoter and livestock feed - Google Patents
Animal growth promoter and livestock feed Download PDFInfo
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- WO2021187516A1 WO2021187516A1 PCT/JP2021/010781 JP2021010781W WO2021187516A1 WO 2021187516 A1 WO2021187516 A1 WO 2021187516A1 JP 2021010781 W JP2021010781 W JP 2021010781W WO 2021187516 A1 WO2021187516 A1 WO 2021187516A1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Definitions
- the present invention relates to an animal growth promoter, livestock feed containing the same, and a method for raising livestock.
- Antibiotics are medicines originally developed for the treatment of biological diseases, but about 70 years ago, by adding some antibiotics to livestock feed, the health of livestock can be maintained. Not only that, it was discovered that the utilization efficiency of nutritional components was greatly increased. Since then, it has played a major role as an additive for all livestock feeds around the world (for example, Patent Document 1), and is now indispensable in the livestock industry, especially in developing countries where the feed environment is not favorable. It has become. Further, it is known that artificially bred early weaning pigs can be protected from intestinal pathogens and also have a growth promoting effect by feeding a feed containing an antibiotic.
- the present invention targets animal growth promoters.
- Animal growth promoter containing an extract of Rhus family tree ⁇ 2> The animal growth promoter according to ⁇ 1> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight;
- the animal growth-promoting agent according to any one of ⁇ 1> to ⁇ 3> above, which is balansae), schinopsis lorentzi, or a combination thereof.
- the present invention is intended for livestock feed containing the extract of the family Rhus family and a method for raising livestock, and for livestock, including an additive containing the extract of the family Rhus family. feed; ⁇ 6> The livestock feed according to ⁇ 5> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight; ⁇ 7> The livestock feed according to ⁇ 5> or ⁇ 6> above, wherein the extract is an extract extracted from the core material of a tree of the family Rhus family; ⁇ 8> The livestock feed according to any one of ⁇ 5> to ⁇ 7> above, wherein the lacquer tree is schinopsis balansae, schinopsis lorentzi, or a combination thereof; ⁇ 9> The livestock feed according to any one of ⁇ 5> to ⁇ 8>, wherein the content of the animal growth promoter is 0.2 to 1.0% by weight based on the total weight of the feed; ⁇ 10> The livestock feed according to any one of
- the animal growth promoter and livestock feed of the present invention can be applied to growing pigs and domestic pigs weighing 35 kg or more, in addition to the effect of improving constitution such as antidiarrhea obtained when the feed is given to piglets younger than 2 months old. It has an unprecedented effect that a growth promoting effect can be obtained by administration.
- the animal growth promoter of the present invention is characterized by containing an extract of a tree of the family Rhus family.
- extracts of lacquer trees have been mainly used for tanning in the leather industry because they are rich in plant tannins, but in the present invention, surprisingly, lacquer trees such as quebracho have been used. It has been found that the addition of the extract to the feed of livestock has an effect of promoting growth and the like.
- such an animal growth promoter is expected to be mainly used as an additive for livestock feed, but it is not necessarily limited to such a usage form as long as it is orally ingested by an animal. It is not something that can be done.
- the Rhus family tree can be widely used as long as the tannin component can be extracted, but is typically a schinopsis balansae, a schinopsis lotnzi, or a combination thereof. be able to. These are a type of tree widely called "Quebracho" and are known to be distributed in a vast area from northern Argentina to western Paraguay in South America. It is preferable that the trunk portion is hard and the specific gravity is about 1.1 to 1.4.
- the above extract is an extract extracted from the core material of a lacquer tree. Is preferable. In some cases, extracts extracted from other parts such as bark, branches, leaves, fruits, pods and roots can also be included. These extracts contain plant tannins as the main component. Plant tannins are a type of polyphenols contained in plants and are present in solution in the vacuoles of plant tissues (sometimes called catechins).
- the plant tannins contained in the extract of the lacquer tree belong to the condensed tannins called catechol type. These catechol-based tannins are characterized in that the color of the solution is red to reddish brown, the sugar content is relatively low, and the cohesive force is strong. Further, when it is boiled with formaldehyde or hydrochloric acid, it can precipitate to form a resinous solid substance.
- the extract of the Rhus family tree in the present invention can preferably contain the tannin component derived from the Rhus family tree in the range of 50 to 100% by weight, more preferably in the range of 70 to 100% by weight. Moreover, it is preferable that the extract is in the form of powder.
- an extract from a tree of the family Rhus family a known method can be used, but typically, a core material, bark or the like (preferably chipped) is boiled in water to remove insoluble components.
- An extract can be obtained by treating with sulfite for solubilization and then drying the resulting solution.
- the obtained dried product is preferably in the form of powder.
- vegetable oils and fats can be added before the drying step.
- the animal growth promoter of the present invention may consist only of an extract of the above-mentioned Rhus family tree extract, or may be a mixture containing one or more other carriers.
- examples of such carriers include soybean flour, wheat flour, calcium carbonate, rice bran, bran, corn flour, cornstarch, rice husks, fish meal, yeast cells and the like.
- animal fats and oils, or vegetable fats and oils such as soybean oil, coconut oil, canola oil, coconut oil, and olive oil can be added.
- the animal growth promoter of the present invention when administered to livestock, it may be directly orally administered. Can be taken in. Therefore, the animal growth-promoting agent of the present invention can be formulated and used by a conventional method in an appropriate oral dosage form such as tablets, capsules, granules, pills, pastes and syrups. In some cases, it may be administered as an injection.
- an aqueous solvent such as distilled water for injection, physiological saline, Ringer's solution or the like can be used.
- the present invention also relates to a livestock feed containing an additive containing the extract of the cashew family tree.
- the additive can act as an animal growth promoter capable of promoting the growth of the livestock to which the livestock feed is administered.
- livestock refers to agricultural animals or livestock animals such as pigs, horses, cows, sheep, or goats raised in farms, pastures, or agricultural environments, or zoos or zoological environments. Means animals that are bred in. It can also include so-called “poultry” such as chickens, quails, ducks and turkeys. Preferably, the livestock is a pig.
- the livestock feed of the present invention varies depending on the type, age, weight, sex, type of feed, etc. of the livestock, but is usually preferably 0.2% or more, more preferably 0.2% or more by weight, based on the total weight of the feed. It contains 0.2 to 1.0% by weight of the above additive.
- the livestock feed of the present invention preferably contains nutritional components such as protein, sugar, lipid, and dietary fiber, but grain raw materials or animal-derived raw materials usually used as livestock feed can be used.
- grain raw materials include wheat, barley, oats, corn, rice, and soybeans.
- additional nutrients such as vitamins and minerals can be added as needed.
- the present invention also relates to a method for raising livestock, which comprises administering the above-mentioned livestock feed to livestock.
- livestock includes various animals such as cows, sheep and horses, but pigs are preferable.
- the growth stage of the target livestock is not particularly limited, but for example, it can be a pig less than 2 months old during the lactation period, and a growing pig 2 months or more after the weaning period or a weight of 35 kg or more. And can be domestic pigs. Typically, it is preferable that the pig is 2 months old or more or has a body weight of 35 kg or more.
- the livestock feed of the present invention is given to piglets less than 2 months old, it is suitable for improving the constitution such as antidiarrhea.
- the elevation of blood leukocytes and the like was suppressed, and histological changes in the small intestine and large intestine were observed.
- the livestock feed of the present invention is given to a growing pig or a breeding pig having a body weight of 35 kg or more, it is suitable for promoting growth and improving feed efficiency. As shown in the examples, the growth promoting effect was confirmed.
- the dose of the livestock feed of the present invention is not particularly limited, and can be appropriately set according to the type, age, body weight, sex, type of feed, etc. of the livestock.
- livestock breeding method of the present invention in addition to the above-mentioned livestock feed, it can be administered in combination with other drugs or feed compounding agents.
- Quebracho Extract a powdered product purchased from UNITAN (Argentina) was used as it was.
- the quebracho extract is obtained by boiling the core material of quebracho (schinopsis balansae and schinopsis lorentzi) in water; then treating the solution with sulfite and then adding fats and oils; The resulting solution is dried and pulverized.
- the obtained dry powder contained about 50% or more of a tannin component.
- Example of administration to pigs 10 pigs 21 days old were divided into 2 groups (Duroc ⁇ Landrace ⁇ Yorkshire; average body weight 6.51 ⁇ 0.17 kg; experiment start date 21 ⁇ 1d), and the Kebracho extract obtained in 1 above was used.
- a feed added at 25 g / kg in the feed was prepared, and each group was administered for 110 days for breeding.
- a feed containing no quebracho extract was given as a control group.
- the composition of the feed used is shown in Table 1 below.
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Abstract
[Problem] To provide a novel antibiotic-free growth promoter for livestock that is usable as a substitute for conventional antibiotics, and a livestock feed. [Solution] An animal growth promoter comprising an anacardiaceous tree extract.
Description
本発明は、動物成長促進剤、これを含む家畜用飼料、及び家畜の飼育方法に関する。
The present invention relates to an animal growth promoter, livestock feed containing the same, and a method for raising livestock.
抗生物質は、本来、生物の疾病の治療を目的として開発された医薬品であるが、７０年前ほど前に、家畜の飼料にある種の抗生物質添加することによって、家畜の健康状態を維持できるのみならず、栄養成分の利用効率が大きく増大することが発見された。これ以降、世界中であらゆる家畜飼料の添加剤として大きな役割を果たしており（例えば、特許文献１）、現在では、特に飼料環境が恵まれていない発展途上国等の畜産業においては欠かせない存在となっている。また、人工的に飼育された早期離乳豚においては、抗生物質を含む飼料を与えることにより、腸内病原体から保護することができるとともに、成長促進効果も得られることが知られている。
Antibiotics are medicines originally developed for the treatment of biological diseases, but about 70 years ago, by adding some antibiotics to livestock feed, the health of livestock can be maintained. Not only that, it was discovered that the utilization efficiency of nutritional components was greatly increased. Since then, it has played a major role as an additive for all livestock feeds around the world (for example, Patent Document 1), and is now indispensable in the livestock industry, especially in developing countries where the feed environment is not favorable. It has become. Further, it is known that artificially bred early weaning pigs can be protected from intestinal pathogens and also have a growth promoting effect by feeding a feed containing an antibiotic.
一方で、近年、家畜の飼料に抗菌性物質を使用すると、病原菌に薬剤耐性が生じ、疾病治療の際に抗生物質等の効用が低くなるという問題が指摘されている。そのため、欧州諸国では、２００６年から飼料用抗生物質の使用が全面禁止となり、米国でも２０１５年から飼料効率改善と成長促進を目的とした抗生物質の飼料への添加が禁止されるに至っている。しかしながら、これまでの抗生物質の代替となる飼料添加物が未だ実用化に至っておらず、家畜の成長を即し得る代替物の開発が望まれている。
On the other hand, in recent years, it has been pointed out that the use of antibacterial substances in livestock feed causes drug resistance to pathogens and reduces the efficacy of antibiotics and the like in the treatment of diseases. Therefore, the use of feed antibiotics has been totally banned in European countries since 2006, and the addition of antibiotics to feeds for the purpose of improving feed efficiency and promoting growth has been banned in the United States from 2015. However, feed additives that can replace antibiotics have not yet been put into practical use, and the development of alternatives that can accelerate the growth of livestock is desired.
そこで、本発明は、従来の抗生物質の代替となり得る、抗生物質フリーの新規な家畜用成長促進剤及び家畜飼料を提供することを課題とするものである。
Therefore, it is an object of the present invention to provide a novel antibiotic-free growth promoter for livestock and livestock feed that can replace conventional antibiotics.
本発明者らは、上記課題を解決するべく鋭意検討を行った結果、ケブラチョに代表されるウルシ科樹木の抽出物を家畜飼料に添加することにより、家畜の成長促進或いは体質改善の効果が得られることを新規に見出し、本発明を完成するに至った。
As a result of diligent studies to solve the above problems, the present inventors have obtained the effect of promoting the growth of livestock or improving the constitution by adding an extract of a cashew tree represented by Quebracho to livestock feed. We have newly found that this is possible and have completed the present invention.
すなわち、本発明は、一態様において、動物成長促進剤を対象とし、
＜１＞ウルシ科樹木の抽出物を含む動物成長促進剤；
＜２＞前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、上記＜１＞に記載の動物成長促進剤；
＜３＞前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、上記＜１＞又は＜２＞に記載の動物成長促進剤；及び
＜４＞前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、上記＜１＞～＜３＞のいずれか１に記載の動物成長促進剤を提供するものである。 That is, in one aspect, the present invention targets animal growth promoters.
<1> Animal growth promoter containing an extract of Rhus family tree;
<2> The animal growth promoter according to <1> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight;
<3> The animal growth promoter according to <1> or <2> above, wherein the extract is an extract extracted from the core material of a lacquer tree; and <4> the lacquer tree is a schinopsis. The animal growth-promoting agent according to any one of <1> to <3> above, which is balansae), schinopsis lorentzi, or a combination thereof.
＜１＞ウルシ科樹木の抽出物を含む動物成長促進剤；
＜２＞前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、上記＜１＞に記載の動物成長促進剤；
＜３＞前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、上記＜１＞又は＜２＞に記載の動物成長促進剤；及び
＜４＞前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、上記＜１＞～＜３＞のいずれか１に記載の動物成長促進剤を提供するものである。 That is, in one aspect, the present invention targets animal growth promoters.
<1> Animal growth promoter containing an extract of Rhus family tree;
<2> The animal growth promoter according to <1> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight;
<3> The animal growth promoter according to <1> or <2> above, wherein the extract is an extract extracted from the core material of a lacquer tree; and <4> the lacquer tree is a schinopsis. The animal growth-promoting agent according to any one of <1> to <3> above, which is balansae), schinopsis lorentzi, or a combination thereof.
また、別の態様において、本発明は、上記ウルシ科樹木の抽出物を含む家畜用飼料及び家畜の飼育方法を対象とし
＜５＞ウルシ科樹木の抽出物を含有する添加剤を含む、家畜用飼料；
＜６＞前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、上記＜５＞に記載の家畜用飼料；
＜７＞前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、上記＜５＞又は＜６＞に記載の家畜用飼料；
＜８＞前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、上記＜５＞～＜７＞のいずれか１に記載の家畜用飼料；
＜９＞前記動物成長促進剤の含有量が、飼料全体重量に対して０．２～１．０重量％である、上記＜５＞～＜８＞のいずれか１に記載の家畜用飼料；
＜１０＞前記家畜がブタである、上記＜５＞～＜９＞のいずれか１に記載の家畜用飼料；
＜１１＞上記＜５＞～＜１０＞のいずれか１に記載の家畜用飼料を家畜に投与することを含む、家畜の飼育方法；及び
＜１２＞前記家畜が、生後２か月以上経過したブタ又は体重３５ｋｇ以上のブタである、上記＜１１＞に記載の飼育方法を提供するものである。 In another aspect, the present invention is intended for livestock feed containing the extract of the family Rhus family and a method for raising livestock, and for livestock, including an additive containing the extract of the family Rhus family. feed;
<6> The livestock feed according to <5> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight;
<7> The livestock feed according to <5> or <6> above, wherein the extract is an extract extracted from the core material of a tree of the family Rhus family;
<8> The livestock feed according to any one of <5> to <7> above, wherein the lacquer tree is schinopsis balansae, schinopsis lorentzi, or a combination thereof;
<9> The livestock feed according to any one of <5> to <8>, wherein the content of the animal growth promoter is 0.2 to 1.0% by weight based on the total weight of the feed;
<10> The livestock feed according to any one of <5> to <9> above, wherein the livestock is a pig;
<11> A method for raising livestock, which comprises administering the livestock feed according to any one of <5> to <10> to the livestock; and <12> The livestock has passed 2 months or more after birth. The breeding method according to <11> above, which is a pig or a pig having a body weight of 35 kg or more, is provided.
＜５＞ウルシ科樹木の抽出物を含有する添加剤を含む、家畜用飼料；
＜６＞前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、上記＜５＞に記載の家畜用飼料；
＜７＞前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、上記＜５＞又は＜６＞に記載の家畜用飼料；
＜８＞前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、上記＜５＞～＜７＞のいずれか１に記載の家畜用飼料；
＜９＞前記動物成長促進剤の含有量が、飼料全体重量に対して０．２～１．０重量％である、上記＜５＞～＜８＞のいずれか１に記載の家畜用飼料；
＜１０＞前記家畜がブタである、上記＜５＞～＜９＞のいずれか１に記載の家畜用飼料；
＜１１＞上記＜５＞～＜１０＞のいずれか１に記載の家畜用飼料を家畜に投与することを含む、家畜の飼育方法；及び
＜１２＞前記家畜が、生後２か月以上経過したブタ又は体重３５ｋｇ以上のブタである、上記＜１１＞に記載の飼育方法を提供するものである。 In another aspect, the present invention is intended for livestock feed containing the extract of the family Rhus family and a method for raising livestock, and for livestock, including an additive containing the extract of the family Rhus family. feed;
<6> The livestock feed according to <5> above, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight;
<7> The livestock feed according to <5> or <6> above, wherein the extract is an extract extracted from the core material of a tree of the family Rhus family;
<8> The livestock feed according to any one of <5> to <7> above, wherein the lacquer tree is schinopsis balansae, schinopsis lorentzi, or a combination thereof;
<9> The livestock feed according to any one of <5> to <8>, wherein the content of the animal growth promoter is 0.2 to 1.0% by weight based on the total weight of the feed;
<10> The livestock feed according to any one of <5> to <9> above, wherein the livestock is a pig;
<11> A method for raising livestock, which comprises administering the livestock feed according to any one of <5> to <10> to the livestock; and <12> The livestock has passed 2 months or more after birth. The breeding method according to <11> above, which is a pig or a pig having a body weight of 35 kg or more, is provided.
本発明によれば、従前の抗生物質の代替となり得る新規な動物成長促進剤を提供することができ、これにより抗生物質フリーの家畜飼料を提供することができる。
According to the present invention, it is possible to provide a novel animal growth promoter that can replace the conventional antibiotics, thereby providing an antibiotic-free livestock feed.
また、本発明の動物成長促進剤及び家畜飼料は、生後２か月未満の子豚へ与えた場合に得られる下痢止め等の体質改善効果に加えて、体重３５ｋｇ以上の成長豚や飼育豚に投与することで成長促進効果が得られるという、これまでにない効果を奏するものである。
In addition, the animal growth promoter and livestock feed of the present invention can be applied to growing pigs and domestic pigs weighing 35 kg or more, in addition to the effect of improving constitution such as antidiarrhea obtained when the feed is given to piglets younger than 2 months old. It has an unprecedented effect that a growth promoting effect can be obtained by administration.
以下、本発明の実施形態について説明する。本発明の範囲はこれらの説明に拘束されることはなく、以下の例示以外についても、本発明の趣旨を損なわない範囲で適宜変更し実施することができる。
Hereinafter, embodiments of the present invention will be described. The scope of the present invention is not limited to these explanations, and other than the following examples, the scope of the present invention can be appropriately modified and implemented as long as the gist of the present invention is not impaired.
１．本発明の動物成長促進剤
本発明の動物成長促進剤は、ウルシ科樹木の抽出物を含むことを特徴とするものである。これまで、ウルシ科樹木の抽出物は、植物タンニンを豊富に含むことから、主として皮革工業の鞣し加工用途に用いられていたが、本発明では、驚くべきことに、ケブラチョ等のウルシ科樹木の抽出物を家畜の飼料に添加することで、成長促進等の効果を有することを見出したものである。かかる動物成長促進剤は、後述のように、主として家畜用飼料の添加剤として利用されることが想定されているが、動物に経口摂取させる態様であれば、必ずしもそのような利用形態のみに限られるものではない。 1. 1. Animal Growth Promoter of the Present Invention The animal growth promoter of the present invention is characterized by containing an extract of a tree of the family Rhus family. Until now, extracts of lacquer trees have been mainly used for tanning in the leather industry because they are rich in plant tannins, but in the present invention, surprisingly, lacquer trees such as quebracho have been used. It has been found that the addition of the extract to the feed of livestock has an effect of promoting growth and the like. As will be described later, such an animal growth promoter is expected to be mainly used as an additive for livestock feed, but it is not necessarily limited to such a usage form as long as it is orally ingested by an animal. It is not something that can be done.
本発明の動物成長促進剤は、ウルシ科樹木の抽出物を含むことを特徴とするものである。これまで、ウルシ科樹木の抽出物は、植物タンニンを豊富に含むことから、主として皮革工業の鞣し加工用途に用いられていたが、本発明では、驚くべきことに、ケブラチョ等のウルシ科樹木の抽出物を家畜の飼料に添加することで、成長促進等の効果を有することを見出したものである。かかる動物成長促進剤は、後述のように、主として家畜用飼料の添加剤として利用されることが想定されているが、動物に経口摂取させる態様であれば、必ずしもそのような利用形態のみに限られるものではない。 1. 1. Animal Growth Promoter of the Present Invention The animal growth promoter of the present invention is characterized by containing an extract of a tree of the family Rhus family. Until now, extracts of lacquer trees have been mainly used for tanning in the leather industry because they are rich in plant tannins, but in the present invention, surprisingly, lacquer trees such as quebracho have been used. It has been found that the addition of the extract to the feed of livestock has an effect of promoting growth and the like. As will be described later, such an animal growth promoter is expected to be mainly used as an additive for livestock feed, but it is not necessarily limited to such a usage form as long as it is orally ingested by an animal. It is not something that can be done.
本明細書において、ウルシ科樹木は、タンニン成分を抽出可能なものであれば広く用いることができるが、典型的には、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせであることができる。これらは、広く「ケブラチョ（Ｑｕｅｂｒａｃｈｏ）」と呼ばれる種類の樹木であり、南米アルゼンチン北部からパラグアイ西部にかけの広大な地域に分布していることが知られている。幹部分が固く、比重が１．１～１．４程度のものが好ましい。
In the present specification, the Rhus family tree can be widely used as long as the tannin component can be extracted, but is typically a schinopsis balansae, a schinopsis lotnzi, or a combination thereof. be able to. These are a type of tree widely called "Quebracho" and are known to be distributed in a vast area from northern Argentina to western Paraguay in South America. It is preferable that the trunk portion is hard and the specific gravity is about 1.1 to 1.4.
ケブラチョに代表されるウルシ科樹木では、通常、その芯材（幹部分）にタンニンを豊富に含むことが知られているため、上記抽出物は、ウルシ科樹木の芯材から抽出したエキスであることが好ましい。場合により、樹皮や枝、葉、実、莢、根等のその他の部位から抽出したエキスを含むこともできる。これら抽出エキスには、主成分として植物タンニンが含まれる。植物タンニンは、植物中に含まれるポリフェノール類の一種であり、植物組織の液胞の中に溶液状態で存在している（カテキンと呼ばれる場合もある）。
Since it is known that the core material (trunk part) of a lacquer tree represented by Quebracho is usually rich in tannin, the above extract is an extract extracted from the core material of a lacquer tree. Is preferable. In some cases, extracts extracted from other parts such as bark, branches, leaves, fruits, pods and roots can also be included. These extracts contain plant tannins as the main component. Plant tannins are a type of polyphenols contained in plants and are present in solution in the vacuoles of plant tissues (sometimes called catechins).
ウルシ科樹木の抽出物に含まれる植物タンニンは、カテコール系と呼ばれる縮合型タンニンに属する。これらカテコール系タンニンは、溶液の色が赤～赤褐色であり、糖分が比較的少なく、凝集力が強いという特徴を有する。また、ホルムアルデヒドや塩酸で煮沸した際には、沈殿して樹脂状の固形物を形成することができる。
The plant tannins contained in the extract of the lacquer tree belong to the condensed tannins called catechol type. These catechol-based tannins are characterized in that the color of the solution is red to reddish brown, the sugar content is relatively low, and the cohesive force is strong. Further, when it is boiled with formaldehyde or hydrochloric acid, it can precipitate to form a resinous solid substance.
本発明におけるウルシ科樹木の抽出物は、好ましくは、当該ウルシ科樹木由来のタンニン成分を５０～１００重量％の範囲、より好ましくは、７０～１００重量％の範囲で含有することができる。また、当該抽出物は、粉末状であることが好ましい。
The extract of the Rhus family tree in the present invention can preferably contain the tannin component derived from the Rhus family tree in the range of 50 to 100% by weight, more preferably in the range of 70 to 100% by weight. Moreover, it is preferable that the extract is in the form of powder.
ウルシ科樹木から抽出物を得る手法としては、公知のものを用いることができるが、典型的には、芯材や樹皮等（好ましくは、チップ化したもの）を水で煮沸し、不溶性成分を水溶化するために亜硫酸で処理した後、得られた溶液を乾燥することで抽出物を得ることができる。得られた乾燥物は、粉末状であることが好ましい。なお、粉末化をし易くする目的で、乾燥工程前に、植物性油脂等を添加することができる。
As a method for obtaining an extract from a tree of the family Rhus family, a known method can be used, but typically, a core material, bark or the like (preferably chipped) is boiled in water to remove insoluble components. An extract can be obtained by treating with sulfite for solubilization and then drying the resulting solution. The obtained dried product is preferably in the form of powder. For the purpose of facilitating powdering, vegetable oils and fats can be added before the drying step.
本発明の動物成長促進剤は、上記ウルシ科樹木の抽出物の抽出物のみからなっていてもよいし、他の一種以上の担体を含む混合物であってもよい。かかる担体としては、例えば、大豆粉、小麦粉、炭酸カルシウム、米ぬか、ふすま、トウモロコシ粉、コーンスターチ、籾殻、魚粉、酵母菌体等を挙げることができる。また、油脂として、動物性油脂、或いは、大豆油、トウモロコシ油、カノーラ油、ヤシ油、オリーブ油等の植物性油脂を添加することもできる。
The animal growth promoter of the present invention may consist only of an extract of the above-mentioned Rhus family tree extract, or may be a mixture containing one or more other carriers. Examples of such carriers include soybean flour, wheat flour, calcium carbonate, rice bran, bran, corn flour, cornstarch, rice husks, fish meal, yeast cells and the like. Further, as the fats and oils, animal fats and oils, or vegetable fats and oils such as soybean oil, coconut oil, canola oil, coconut oil, and olive oil can be added.
また、本発明の動物成長促進剤を家畜に投与する際には、直接経口投与してもよいが、飼料あるいは飲料水に本剤を配合して、採餌あるいは飲水にともなって本剤が家畜に摂取されるようにすることができる。そのため本発明の動物成長促進剤は、錠剤、カプセル剤、顆粒剤、丸剤、ペースト、シロップ等の適宜の経口投与剤形に、常法により製剤化して使用することができる。また、場合により、注射剤として投与してもよい。この場合には溶剤としては、注射用蒸溜水、生理食塩水、リンゲル液等の水性溶剤等を用いることができる。
In addition, when the animal growth promoter of the present invention is administered to livestock, it may be directly orally administered. Can be taken in. Therefore, the animal growth-promoting agent of the present invention can be formulated and used by a conventional method in an appropriate oral dosage form such as tablets, capsules, granules, pills, pastes and syrups. In some cases, it may be administered as an injection. In this case, as the solvent, an aqueous solvent such as distilled water for injection, physiological saline, Ringer's solution or the like can be used.
２．本発明の家畜用飼料及び飼育方法
別の態様において、本発明は、上記ウルシ科樹木の抽出物を含有する添加剤を含む、家畜用飼料にも関する。好ましくは、当該添加剤は、家畜用飼料が投与される家畜の成長を促進し得る動物成長促進剤として作用することができる。 2. Livestock feed and breeding method of the present invention In another aspect, the present invention also relates to a livestock feed containing an additive containing the extract of the cashew family tree. Preferably, the additive can act as an animal growth promoter capable of promoting the growth of the livestock to which the livestock feed is administered.
別の態様において、本発明は、上記ウルシ科樹木の抽出物を含有する添加剤を含む、家畜用飼料にも関する。好ましくは、当該添加剤は、家畜用飼料が投与される家畜の成長を促進し得る動物成長促進剤として作用することができる。 2. Livestock feed and breeding method of the present invention In another aspect, the present invention also relates to a livestock feed containing an additive containing the extract of the cashew family tree. Preferably, the additive can act as an animal growth promoter capable of promoting the growth of the livestock to which the livestock feed is administered.
本明細書において「家畜」とは、飼育場、牧畜場もしくは農業環境で飼育されるブタ（豚）、馬、牛、羊、もしくは山羊等の農業動物もしくは家畜動物、または動物園もしくは動物学的環境で飼育される動物を意味する。また、鶏、うずら、家鴨、七面鳥等のいわゆる「家禽」も含むことができる。好ましくは、家畜は、ブタである。
As used herein, the term "livestock" refers to agricultural animals or livestock animals such as pigs, horses, cows, sheep, or goats raised in farms, pastures, or agricultural environments, or zoos or zoological environments. Means animals that are bred in. It can also include so-called "poultry" such as chickens, quails, ducks and turkeys. Preferably, the livestock is a pig.
本発明の家畜用飼料は、家畜の種類、年齢、体重、性別、飼料の種類等により異なるが、通常は、好ましくは、飼料全体重量に対して、０.２％重量以上、より好ましくは、０．２～１．０重量％の上記添加剤を含有する。
The livestock feed of the present invention varies depending on the type, age, weight, sex, type of feed, etc. of the livestock, but is usually preferably 0.2% or more, more preferably 0.2% or more by weight, based on the total weight of the feed. It contains 0.2 to 1.0% by weight of the above additive.
本発明の家畜用飼料は、好ましくは、タンパク質、糖質、脂質、食物繊維等の栄養成分を含むが、家畜用飼料として通常用いられる穀物原料又は動物由来の原料を使用することができる。穀物原料としては、例えば、小麦、大麦、オーツ麦、トウモロコシ、米、大豆などを挙げることができる。また、必要に応じて、ビタミンやミネラルなどの付加的な栄養素を添加することもできる。
The livestock feed of the present invention preferably contains nutritional components such as protein, sugar, lipid, and dietary fiber, but grain raw materials or animal-derived raw materials usually used as livestock feed can be used. Examples of the grain raw material include wheat, barley, oats, corn, rice, and soybeans. In addition, additional nutrients such as vitamins and minerals can be added as needed.
更なる態様において、本発明は、上記家畜用飼料を家畜に投与することを含む家畜の飼育方法にも関する。上述のように、家畜には、牛や羊、馬等の種々の動物を含まれるが、好ましくは、ブタ（豚）である。
In a further aspect, the present invention also relates to a method for raising livestock, which comprises administering the above-mentioned livestock feed to livestock. As described above, livestock includes various animals such as cows, sheep and horses, but pigs are preferable.
対象となる家畜の成長段階は特に限定されないが、例えば、授乳期にある生後２か月未満の豚であることができ、また、離乳期以降の生後２か月以上或いは体重３５ｋｇ以上の成長豚や飼育豚であることができる。典型的には、生後２か月以上経過したブタ又は体重３５ｋｇ以上のブタであることが好ましい。
The growth stage of the target livestock is not particularly limited, but for example, it can be a pig less than 2 months old during the lactation period, and a growing pig 2 months or more after the weaning period or a weight of 35 kg or more. And can be domestic pigs. Typically, it is preferable that the pig is 2 months old or more or has a body weight of 35 kg or more.
本発明の家畜用飼料を生後２か月未満の子豚へ与えた場合には、下痢止め等の体質改善に好適である。この場合、実施例に示すように、血中白血球などの上昇が抑制され、また、小腸や大腸における組織的変化が観測された。
When the livestock feed of the present invention is given to piglets less than 2 months old, it is suitable for improving the constitution such as antidiarrhea. In this case, as shown in the examples, the elevation of blood leukocytes and the like was suppressed, and histological changes in the small intestine and large intestine were observed.
また、本発明の家畜用飼料を体重３５ｋｇ以上の成長豚や飼育豚に与えた場合には、成長促進及び飼料効率の向上において好適である。実施例に示すように、成長促進効果が確認された。
Further, when the livestock feed of the present invention is given to a growing pig or a breeding pig having a body weight of 35 kg or more, it is suitable for promoting growth and improving feed efficiency. As shown in the examples, the growth promoting effect was confirmed.
本発明の家畜用飼料の投与量としては、特に限定されず、家畜の種類、年齢、体重、性別、飼料の種類等に応じて適宜設定することができる。
The dose of the livestock feed of the present invention is not particularly limited, and can be appropriately set according to the type, age, body weight, sex, type of feed, etc. of the livestock.
なお、本発明の家畜の飼育方法では、上記家畜用飼料に加えて、他の薬剤や飼料配合剤と組み合わせて投与することができる。
In the livestock breeding method of the present invention, in addition to the above-mentioned livestock feed, it can be administered in combination with other drugs or feed compounding agents.
以下、実施例により本発明をさらに詳細に説明するが、本発明はこれらによって限定されるものではない。
Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
１．ケブラチョ抽出物の調製
ケブラチョ抽出物は、ＵＮＩＴＡＮ社（アルゼンチン国）から購入した粉末化製品を、そのまま用いた。当該ケブラチョ抽出物は、ケブラチョ（バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）及びラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ））の芯材をチップ化したものを水中で煮沸し；次いで、溶液を亜硫酸で処理した後、油脂を添加し；得られた溶液を乾燥して粉末化したものである。得られた乾燥粉末は、約５０％以上のタンニン成分を含有していた。 1. 1. Preparation of Quebracho Extract As the Quebracho extract, a powdered product purchased from UNITAN (Argentina) was used as it was. The quebracho extract is obtained by boiling the core material of quebracho (schinopsis balansae and schinopsis lorentzi) in water; then treating the solution with sulfite and then adding fats and oils; The resulting solution is dried and pulverized. The obtained dry powder contained about 50% or more of a tannin component.
ケブラチョ抽出物は、ＵＮＩＴＡＮ社（アルゼンチン国）から購入した粉末化製品を、そのまま用いた。当該ケブラチョ抽出物は、ケブラチョ（バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）及びラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ））の芯材をチップ化したものを水中で煮沸し；次いで、溶液を亜硫酸で処理した後、油脂を添加し；得られた溶液を乾燥して粉末化したものである。得られた乾燥粉末は、約５０％以上のタンニン成分を含有していた。 1. 1. Preparation of Quebracho Extract As the Quebracho extract, a powdered product purchased from UNITAN (Argentina) was used as it was. The quebracho extract is obtained by boiling the core material of quebracho (schinopsis balansae and schinopsis lorentzi) in water; then treating the solution with sulfite and then adding fats and oils; The resulting solution is dried and pulverized. The obtained dry powder contained about 50% or more of a tannin component.
２．ブタへの投与例
生後２１日齢のブタ10頭を2群に分け（Duroc×Landrace×Yorkshire; 平均体重6.51±0.17kg; 実験開始日齢21±1d）、上記１で得たケブラチョ抽出物を飼料中２ 5ｇ／ｋｇで添加した飼料を調製し、各群に対して110日間投与して飼育した。また、対照群としてケブラチョ抽出物を含まない飼料を与えた。用いた飼料の配合を以下の表１に示す。 2. Example of administration to pigs 10 pigs 21 days old were divided into 2 groups (Duroc × Landrace × Yorkshire; average body weight 6.51 ± 0.17 kg; experiment start date 21 ± 1d), and the Kebracho extract obtained in 1 above was used. A feed added at 25 g / kg in the feed was prepared, and each group was administered for 110 days for breeding. In addition, a feed containing no quebracho extract was given as a control group. The composition of the feed used is shown in Table 1 below.
生後２１日齢のブタ10頭を2群に分け（Duroc×Landrace×Yorkshire; 平均体重6.51±0.17kg; 実験開始日齢21±1d）、上記１で得たケブラチョ抽出物を飼料中２ 5ｇ／ｋｇで添加した飼料を調製し、各群に対して110日間投与して飼育した。また、対照群としてケブラチョ抽出物を含まない飼料を与えた。用いた飼料の配合を以下の表１に示す。 2. Example of administration to pigs 10 pigs 21 days old were divided into 2 groups (Duroc × Landrace × Yorkshire; average body weight 6.51 ± 0.17 kg; experiment start date 21 ± 1d), and the Kebracho extract obtained in 1 above was used. A feed added at 25 g / kg in the feed was prepared, and each group was administered for 110 days for breeding. In addition, a feed containing no quebracho extract was given as a control group. The composition of the feed used is shown in Table 1 below.
１１０日間飼育後、１頭当りの増体量、飼料摂取量、飼料要求率を群毎に算出した。得られた結果を表２に示す。
After breeding for 110 days, the weight gain per animal, feed intake, and feed conversion ratio were calculated for each group. The results obtained are shown in Table 2.
表２の結果から、ケブラチョ抽出物を含む飼料の投与群では、1日当たり1頭豚の摂食量が４４６g増加し、1日当たりの豚の増体が１４０g改善された。ケブラチョ抽出物を含む飼料を投与する事により飼料要求率の改善は見られなかったものの、体重の増加が約１９.１％改善されたといえる。この結果は、食欲が改善され1日当たりの摂食量増加されることにより増体が増えたためと考えられる。
From the results in Table 2, in the feed group containing the quebracho extract, the daily intake of one pig increased by 446 g, and the daily gain of pigs was improved by 140 g. Although the feed conversion ratio was not improved by administering the feed containing the quebracho extract, it can be said that the weight gain was improved by about 19.1%. This result is considered to be due to an increase in body weight gain due to an improvement in appetite and an increase in daily food intake.
Claims (12)
- ウルシ科樹木の抽出物を含む動物成長促進剤。 Animal growth promoter containing an extract of Rhus family tree.
- 前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、請求項１に記載の動物成長促進剤。 The animal growth promoter according to claim 1, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight.
- 前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、請求項１又は２に記載の動物成長促進剤。 The animal growth promoter according to claim 1 or 2, wherein the extract is an extract extracted from the core material of a tree of the family Rhus family.
- 前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、請求項１～３のいずれか１に記載の動物成長促進剤。 The animal growth promoter according to any one of claims 1 to 3, wherein the lacquer tree is schinopsis balansae, schinopsis loannzi, or a combination thereof.
- ウルシ科樹木の抽出物を含有する添加剤を含む、家畜用飼料。 Livestock feed containing additives containing extracts of Rhus family trees.
- 前記抽出物が、ウルシ科樹木由来のタンニンを５０～１００重量％の範囲で含有する、請求項５に記載の家畜用飼料。 The livestock feed according to claim 5, wherein the extract contains tannin derived from a tree of the family Rhus family in the range of 50 to 100% by weight.
- 前記抽出物が、ウルシ科樹木の芯材から抽出したエキスである、請求項５又は６に記載の家畜用飼料。 The livestock feed according to claim 5 or 6, wherein the extract is an extract extracted from the core material of a tree of the family Rhus family.
- 前記ウルシ科樹木が、バランサエ（ｓｃｈｉｎｏｐｓｉｓ ｂａｌａｎｓａｅ）、ラレントジイ（ｓｃｈｉｎｏｐｓｉｓ ｌｏｒｅｎｔｚｉ）、又はそれらの組み合わせである、請求項５～７のいずれか１に記載の家畜用飼料。 The livestock feed according to any one of claims 5 to 7, wherein the lacquer tree is schinopsis balansae, schinopsis loannzi, or a combination thereof.
- 前記添加剤の含有量が、飼料全体重量に対して０．２～１．０重量％である、請求項５～８のいずれか１に記載の家畜用飼料。 The livestock feed according to any one of claims 5 to 8, wherein the content of the additive is 0.2 to 1.0% by weight based on the total weight of the feed.
- 前記家畜がブタである、請求項５～９のいずれか１に記載の家畜用飼料。 The livestock feed according to any one of claims 5 to 9, wherein the livestock is a pig.
- 請求項５～１０のいずれか１に記載の家畜用飼料を家畜に投与することを含む、家畜の飼育方法。 A method for raising livestock, which comprises administering the livestock feed according to any one of claims 5 to 10 to livestock.
- 前記家畜が、生後２か月以上経過したブタ又は体重３５ｋｇ以上のブタである、請求項１１に記載の飼育方法。 The breeding method according to claim 11, wherein the livestock is a pig that is 2 months old or more or a pig that weighs 35 kg or more.
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| JP2020-047491 | 2020-03-18 | ||
| JP2020047491A JP2023068206A (en) | 2020-03-18 | 2020-03-18 | Animal growth promoter and livestock feed |
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|---|---|---|---|---|
| WO2004089106A2 (en) * | 2003-04-07 | 2004-10-21 | Luigi Marenchino | Tannin mixture used as additives |
| JP2012184285A (en) * | 2011-03-03 | 2012-09-27 | Kagoshima Univ | Methods for producing highly viscous solution and gel of high molecular weight tannin |
| WO2019177171A1 (en) * | 2018-03-16 | 2019-09-19 | 味の素株式会社 | Animal feed additive and animal feed |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089106A2 (en) * | 2003-04-07 | 2004-10-21 | Luigi Marenchino | Tannin mixture used as additives |
| JP2012184285A (en) * | 2011-03-03 | 2012-09-27 | Kagoshima Univ | Methods for producing highly viscous solution and gel of high molecular weight tannin |
| WO2019177171A1 (en) * | 2018-03-16 | 2019-09-19 | 味の素株式会社 | Animal feed additive and animal feed |
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