EP1761242A2 - Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol - Google Patents

Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol

Info

Publication number
EP1761242A2
EP1761242A2 EP05747659A EP05747659A EP1761242A2 EP 1761242 A2 EP1761242 A2 EP 1761242A2 EP 05747659 A EP05747659 A EP 05747659A EP 05747659 A EP05747659 A EP 05747659A EP 1761242 A2 EP1761242 A2 EP 1761242A2
Authority
EP
European Patent Office
Prior art keywords
medicament according
estriol
medicament
film
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05747659A
Other languages
German (de)
English (en)
Inventor
Joachim Moormann
Walter Elger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HF Arzneimittelforschung GmbH and Co KG
Original Assignee
HF Arzneimittelforschung GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HF Arzneimittelforschung GmbH and Co KG filed Critical HF Arzneimittelforschung GmbH and Co KG
Publication of EP1761242A2 publication Critical patent/EP1761242A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Definitions

  • the present invention relates to orally administered, film-shaped medicaments for the transmucosal administration of estriol and / or at least one of its pharmacologically acceptable esters, alone or in combination with at least one gestagen.
  • the present invention also relates to the use of estriol and / or at least one of its pharmacologically acceptable esters, alone or in combination with at least one gestagen, for the production of a fil-shaped, orally administered medicament for the treatment of menopausal symptoms.
  • menopause is a phase of life that separates the fertile phase and the time in which reproduction is no longer possible.
  • the menopause is characterized by a permanent decrease in the hormone production in the ovaries as well as the associated decrease and finally the absence of the monthly menstrual period.
  • the level of progestin in the blood drops and, after a few years, less estrogen is produced until the body completely stops producing hormones.
  • the organic complaints can be accompanied by neurovegetative complaints such as hot flashes, sweating, sleep disorders, dizziness, rapid heartbeat or headache. These symptoms shape the picture of climacteric complaints for about 2 to 3 years.
  • Psychological complaints can also occur. These include anxiety, irritability and aggressiveness, inner tension, disaffection, nervousness, mood swings and depressions, tiredness and lack of drive, forgetfulness, a reduced ability to concentrate and an altered sexuality. These symptoms usually subside when the organism has got used to the hormone deficiency.
  • hormone replacement therapy In order to compensate for the hormone deficit and to treat the symptoms associated with the menopause, so-called hormone replacement therapy (HRT) combines estrogens with progestogens administered.
  • HRT hormone replacement therapy
  • hormone replacement therapy can also have undesirable side effects.
  • the most common side effects include increased edema formation, an increased risk of thrombosis, an increased risk of developing endometrial cancer, chest tightness, weight gain, nausea, hyperpigmentation and spotting.
  • hormones that act as hormones promotes the proliferation of vaginal epithelial cells and increases the risk of endometrial hyperplasia.
  • estriol instead of estradiol as part of a hormone replacement therapy, which hardly induces proliferation of the endometrium.
  • Estriol ((16 ⁇ , 17ß) -Estra-1, 3, 5 (10) -triene-3, 16,17-triol) is the final and usually predominant urine metabolite of estrogen metabolism.
  • estriol is also much less hormonally effective than estradiol.
  • estriol when taken orally in the form of coated tablets, capsules or tablets, estriol is quickly inactivated in the liver by forming its glucoronide derivative. Only 1 to 2% of the administered estriol dose gets into the bloodstream in bioavailable form.
  • estriol when estriol was given orally, a dose of 2 mg per day was found to be optimal for preventing vaginal atrophy and effective in treating hot flashes, sleep disorders and some other climacteric problems.
  • side effects such as nausea and mastalgia can also occur.
  • vaginal administration of estriol was also tested in order to be able to reduce the amount of hormone to be administered with the same systemic effect.
  • a lower dose also has the advantage of less deflection of estrogen-modulated liver functions.
  • Vaginal administration proved to be more effective than oral administration, since intravaginally administered estriol was initially quickly absorbed and is therefore basically suitable for local and systemic hormone replacement therapy.
  • the cornification of the vaginal epithelium that occurs during prolonged use speaks against vaginal application of estriol, which has a negative effect on the absorption of estriol.
  • vaginal administration of estriol was not accepted by the subjects.
  • estriol administered transdermally is also suitable for the therapy of climacteric osteoporosis.
  • the very high amounts of estriol (12 mg per 24 hours) that are continuously administered transdermally to the male test subjects are to be regarded as disadvantageous to reach a serum level of free estriol that corresponds to the physiological concentrations of estrogen hormones in the woman's cycle (50 to 350 ⁇ g / ml).
  • estriol should lead to a largely constant blood level of estriol, which has a beneficial effect on the bones, but which also promotes the undesirable effects in the uterine mucosa.
  • estriol and / or the pharmacologically acceptable ester (s) of estriol can be used in combination.
  • combination with at least one gestagen can be contained in the film-shaped medicament.
  • the film-like medicaments according to the invention enable the transmucosal absorption of estriol and / or the pharmacologically acceptable ester (s) of estriol and optionally the progestogen (s) additionally contained in the medicinal product via the oral mucosa by applying the medicinal product sublingually or buccally becomes.
  • the active substance contained in the film-shaped medicament or the active substances contained in the film-shaped medicinal product are released from the film-shaped medicinal product due to the action of saliva and can / can subsequently be resorbed via the oral mucosa. In this way, the so-called "first pass effect", which is responsible for the rapid inactivation of orally administered estriols, is avoided.
  • the dose of estriol or estriol ester to be administered with the film-like medicament according to the invention can be based on the known dosage forms for estriol, can be reduced to less than 2 mg / 24 h, preferably to about 200 ⁇ g per 24 h, which the medicament according to the invention releases in order to achieve the same systemic effects as with significantly higher doses of orally or transdermally administered estriols.
  • the film-like dosage forms according to the invention are medicaments of small thickness.
  • the thickness of these film-shaped pharmaceuticals is 0.01 mm to 5 mm, preferably 0.03 mm to 3 mm, particularly preferably 0.05 mm to 2 mm and very particularly preferably 0.1 mm to 1 mm.
  • the area of the pharmaceuticals according to the invention is between 0.5 and 20 cm 2 , preferably the area is 1 to 10 cm 2 .
  • each drug can vary. They can have a round, oval, triangular, quadrangular or polygonal shape.
  • the medicaments according to the invention are also referred to as “wafers”. They are able to adapt to the irregular surface contour of the oral mucosa after absorbing moisture.
  • the medicaments according to the invention can be gellable or swellable.
  • the film-like pharmaceutical preparations according to the invention are flexible before they are applied and can absorb moisture from the saliva.
  • the active substance content of a film-like pharmaceutical preparation according to the invention is 0.5 to 40% by weight, preferably 1 to 30% by weight, and particularly preferably 5 to
  • the film-like medicaments consist of one or have at least one polymer-containing layer which serves as an active substance reservoir.
  • This layer contains the active ingredient and can release it under the influence of saliva.
  • the polymer content in this polymer-containing reservoir layer is 10 to 90% by weight, preferably 20 to 70% by weight, and particularly preferably 30 to 60% by weight.
  • the polymers suitable for the production of the active substance reservoir layer can be selected from the group consisting of polyvinyl alcohols, polyvinyl pyrrolidones, polyvinyl acetates, polyethylene glycol, polyethylene oxide polymers, polyurethanes, polyacrylic acids, polyacrylates, polymethacrylates, poly (methyl vinyl ether-maleic anhydrides), starch, starch , natural gums, alginates, pectins and gelatin pullulan, gel-forming proteins, chitosan, agar-agar, agarose, carragenan, xanthan, tragacanth, dextran and cellulose ethers such as ethyl cellulose, hydroxyethyl cellulose, propyl cellulose, carboxylmethyl cellulose, Na Carboxy ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl ethyl cellulose, cellulose acetate.
  • the polymers can be used individually or in combination with one another to produce a medicament according to the invention with desired properties such as adhesion, release or disintegration properties.
  • the film-shaped medicament according to the invention consists of a single polymer layer.
  • Other embodiments relate to film-shaped medicaments which have a two- or multi-layer structure, at least one of the layers containing active substance. If several layers of these embodiments contain the active substance (s), they can differ from one another with regard to their active substance content and their active substance composition, but also with regard to their polymer composition and thus their adhesion and / or disintegration properties.
  • the pharmaceuticals according to the invention can additionally contain one or more auxiliary substances which are known to the person skilled in the art.
  • the auxiliaries can be selected from one or more of the following groups: emulsifiers comprising polyethoxylated
  • Sorbitan fatty acid esters polyethoxylated fatty alcohols and lecithin
  • Plasticizers including polyethylene glycol, glycerin and other polyalcohols, higher alcohols such as dodecanol, undecanol or octanol, sorbitol, mannitol and other sugar alcohols, dexpanthenol and triglycerides
  • Fillers comprising highly disperse silicon dioxide, titanium dioxide, zinc oxide, chalk and starch; dyes; Sweeteners and flavors; Wetting agents; Preservatives; pH regulators and antioxidants; Disintegrating; Permeation accelerators which improve the mucosal absorption of estradiol, for example fatty acids and fatty acid esters, polyhydric alcohols such as propanediol, tocopherols or essential oils such as menthol.
  • the proportion of these auxiliaries can be up to 60% by weight, based on the total weight of the drug.
  • the proportion of auxiliaries is preferably 5 to 40% by weight.
  • the film-shaped pharmaceuticals are intended to enable a longer-lasting, time-delayed release of active ingredient.
  • the active ingredient is preferably released over a period of 4 h, particularly preferably over a period of 6 h, and very particularly preferably over a period of 8 h.
  • a pulse-like release of the active ingredient within 4 h, 6 h or 8 h once a day can generate effects in the central nervous system, in the vaginal epithelium and the genitourinary tissue that are therapeutically desirable, without atrophy in the vagina or genitourinary tissue that is embryologically the same Have origin to induce.
  • pulsed administration could contribute to improved utero / vaginal dissociation.
  • the medicament according to the invention can improve the tissue specificity of estriol or the estriol ester (s) in the treatment of climacteric complaints.
  • the active substance (s) is released over a period of 24 hours or longer. This allows a largely constant blood level to be achieved, which is particularly suitable for treating osteoporosis due to its beneficial effect in the bone.
  • At least one of the polymer layers containing the active substance has a delayed release of active substance.
  • the film-shaped medicaments can preferably be formulated as slowly soluble or slowly disintegrating films which have completely disintegrated or have dissolved only after several hours. They preferably only completely disintegrated after 4 hours, particularly preferably only after 6 hours, and very particularly preferably only after 8 hours or even only after more than 24 hours, or have completely dissolved.
  • the film-shaped medicaments according to the invention are mucoadhesive.
  • An embodiment is particularly preferred which has only one mucoadhesive surface. This will create a The medication can adhere to the oral mucosa during the application period and the active ingredient (s) can be resorbed directly at the application site via the oral mucosa.
  • the mucoadhesive medicament has a layer on the side opposite the mucoadhasive surface which is impermeable to the active substance, so that a directed release of active substance can be achieved when applied to the oral mucosa.
  • the film-shaped medicament to be administered orally, containing estriol and / or at least one pharmacologically acceptable ester of estriol can additionally contain at least one further active ingredient from the group of gestagens, which is also administered transmucosal when the medicament is administered, so that in hormone replacement therapy a combination of estriol with at least one progestogen only needs to be administered a single pharmaceutical preparation.
  • the film-shaped medicaments according to the invention can be produced by a person skilled in the art by processes which are basically known, for example by coating an inert base with a liquid composition which comprises polymer (s), active ingredient (s) and, if appropriate, excipient (s) and solvent, for example using a doctor blade , Spraying or extrusion processes.
  • a liquid composition which comprises polymer (s), active ingredient (s) and, if appropriate, excipient (s) and solvent, for example using a doctor blade , Spraying or extrusion processes.
  • the thin film layer contained in this way is dried.
  • one or more coatings can be made in the same way applied to the existing film layer or produced separately and then laminated on.
  • the film-shaped medicinal products according to the invention to be administered orally, containing estriol and / or at least one pharmaceutically acceptable ester of estriol, alone or in combination with at least one gestagen, can be used for the treatment of climacteric complaints and / or in the course of hormone replacement therapy.
  • the hormone replacement therapy or treatment of climacteric complaints can advantageously be carried out with an estriol dose of less than 2 mg / 24 h, preferably with an active substance dose of about 200 ⁇ g / 24 h.
  • the pulse-shaped administration of estriol and its pharmacologically acceptable esters which is possible with the medicament according to the invention, once a day over a period of 4 h, preferably 6 h, or particularly preferably 8 h, enables not only the administration of lower doses but also an improved tissue specificity compared to transdermal administration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne des agents pharmaceutiques à administration orale, notamment buccale, en forme de film, destinés au traitement de troubles climatériques, ledit agent pharmaceutique contenant, en tant qu'agents actifs, de l'oestriol et/ou au moins un ester pharmaceutiquement acceptable de l'oestriol, seul ou en combinaison avec au moins un gestagène.
EP05747659A 2004-05-14 2005-05-06 Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol Withdrawn EP1761242A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004023984A DE102004023984A1 (de) 2004-05-14 2004-05-14 Filmförmiges, oral zu verabreichendes Arzneimittel, enthaltend Estriol
PCT/EP2005/004894 WO2005110358A2 (fr) 2004-05-14 2005-05-06 Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol

Publications (1)

Publication Number Publication Date
EP1761242A2 true EP1761242A2 (fr) 2007-03-14

Family

ID=34977101

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05747659A Withdrawn EP1761242A2 (fr) 2004-05-14 2005-05-06 Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol

Country Status (16)

Country Link
US (1) US20070243217A1 (fr)
EP (1) EP1761242A2 (fr)
JP (1) JP2007537178A (fr)
KR (1) KR20070040753A (fr)
CN (1) CN1997349A (fr)
AR (1) AR048958A1 (fr)
AU (1) AU2005244409A1 (fr)
BR (1) BRPI0510855A (fr)
CA (1) CA2566325A1 (fr)
DE (1) DE102004023984A1 (fr)
IL (1) IL179014A0 (fr)
MX (1) MXPA06012890A (fr)
NO (1) NO20065657L (fr)
RU (1) RU2006140649A (fr)
TW (1) TW200536547A (fr)
WO (1) WO2005110358A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010008940A (es) * 2008-02-13 2010-10-05 Bayer Schering Pharma Ag Sistemas de administracion de drogas que contienen estradiol.
US20110052699A1 (en) * 2008-02-13 2011-03-03 Adrian Funke Drug delivery system with stabilising effect
CN102083418A (zh) * 2008-04-24 2011-06-01 伊万斯彻有限公司 口服避孕药剂及其制备方法
WO2010033832A2 (fr) * 2008-09-19 2010-03-25 Evestra, Inc. Formulations à base d’oestriol
DE102009007771B4 (de) * 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
KR102044515B1 (ko) * 2019-08-20 2019-11-14 이영환 구강점막 부착력이 우수한 서방형 구강붕해용 필름 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO301689B1 (no) * 1987-09-24 1997-12-01 Jencap Research Ltd Kontraseptivt preparat i form av en forpakning
JPH07504672A (ja) * 1992-03-21 1995-05-25 エンテック　ゲゼルシャフト　フュア　エンドクリノロギッシェ　テヒノロギー　エム．ベー．ハー． 更年期骨粗鬆症の処置に対するエストリオールの使用
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
DE19832169A1 (de) * 1998-07-17 2000-01-27 Jenapharm Gmbh Lokal anwendbare pharmazeutische Präparate zur Prophylaxe und Therapie atrophischer Erscheinungen in der Mundhöhle
US6117446A (en) * 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
DE19932603A1 (de) * 1999-07-13 2001-01-25 Gruenenthal Gmbh Wirkstoffhaltiger Mehrschichtfilm aus in situ vernetzten hydrophilen Polymeren
NZ520630A (en) * 2000-01-18 2004-09-24 Schering Ag Drospirenone for hormone replacement therapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005110358A2 *

Also Published As

Publication number Publication date
AU2005244409A1 (en) 2005-11-24
JP2007537178A (ja) 2007-12-20
WO2005110358A2 (fr) 2005-11-24
WO2005110358A3 (fr) 2007-03-15
MXPA06012890A (es) 2007-07-19
CN1997349A (zh) 2007-07-11
NO20065657L (no) 2006-12-07
KR20070040753A (ko) 2007-04-17
RU2006140649A (ru) 2008-05-27
IL179014A0 (en) 2007-03-08
TW200536547A (en) 2005-11-16
DE102004023984A1 (de) 2005-12-08
CA2566325A1 (fr) 2005-11-24
BRPI0510855A (pt) 2007-12-26
US20070243217A1 (en) 2007-10-18
AR048958A1 (es) 2006-06-14

Similar Documents

Publication Publication Date Title
DE60006692T2 (de) Pharmazeutische kombination von ethinylestradiol und drospirenone als empfängnisverhütendes mittel
DE60113809T2 (de) Pharmazeutische kombination aus mikronisiertem drospirenon und einen estrogen für die hormonersatztherapie
US5422119A (en) Transdermal hormone replacement therapy
EP0370220B1 (fr) Composition de Gestoden à application transdermique
DE60130147T2 (de) Verwendung oraler formulierungen zur behandlung der weiblichen sexuellen störung
DE102005015128B4 (de) Wafer enthaltend Steroidhormone
WO2007124250A2 (fr) Méthode de traitement des bouffées de chaleur par des préparations transdermiquea ou transmucosiques
EP1485072B1 (fr) Systeme therapeutique transdermique contenant des hormones, comportant un reservoir d'agents actifs a base de copolymere de vinylacetate-vinylpyrrolidone presentant une meilleure cohesion
DE102007011486A1 (de) Arzneimittel umfassend wenigstens ein Gestagen
EP1761242A2 (fr) Agent pharmaceutique a administration orale, en forme de film, contenant de l'oestriol
EP0587047B1 (fr) Composition pharmaceutique contenant des gestagènes
DE102006027796A1 (de) Estrogen-Gestagen-Kombinationen
WO2001049273A2 (fr) Composition pharmaceutique pour administration transdermique d'hormones avec un additif ameliorant la permeation
EP1093361B1 (fr) Emplatre contenant des steroides, procede permettant de le produire et son utilisation
WO1998018474A1 (fr) Utilisation d'acide ursodeoxycholique pour le traitement topique de maladies inflammatoires des muqueuses
DE69819503T2 (de) Verwendung eines 7-alpha-methyl-17-alpha-ethinyl-östran-derivats zur behandlung von arteriosklerose
DE10025970C2 (de) Estrogenhaltiges Pflaster mit einem Wirkstoffreservoir auf der Basis von Ethylcellulose und einem Ethylen-Vinylacetat-Vinylpyrrolidon-Copolymer und seine Verwendung
DE102008033254B4 (de) Verfahren zur Herstellung eines einphasischen pharmazeutischen Präparates zur oralen Therapie der Regulierung des Blutdruckes
WO2003045358A1 (fr) Systeme therapeutique transdermique concu pour administrer de l'oestradiol 17$g(a)
EP1350541A1 (fr) Emploi de déhydro-épiandrosterone et d'un dérivé d'estradiol pour préparer un médicament pour le traitement des troubles climactériques de la postménopause
EP0966289A1 (fr) Budesonide pour le traitement d'affections hepatiques cholestatiques
EP0675720A1 (fr) Therapie de substitution hormonale transcutanee multiphase
WO2009015766A1 (fr) Préparation pharmaceutique combinée monophasique (diénogest et éthinylestradiol) pour la thérapie orale de régulation de la pression artérielle
DE102007008231A1 (de) Pharmazeutische Zubereitung zur Behandlung der Migräne

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20061020

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR LV MK YU

PUAK Availability of information related to the publication of the international search report

Free format text: ORIGINAL CODE: 0009015

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 5/30 20060101ALI20070329BHEP

Ipc: A61K 31/565 20060101ALI20070329BHEP

Ipc: A61K 9/00 20060101AFI20070329BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1095763

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20070531

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1095763

Country of ref document: HK