EP1711412B1 - Procede pour assembler un capuchon et un recipient - Google Patents

Procede pour assembler un capuchon et un recipient Download PDF

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Publication number
EP1711412B1
EP1711412B1 EP05700005A EP05700005A EP1711412B1 EP 1711412 B1 EP1711412 B1 EP 1711412B1 EP 05700005 A EP05700005 A EP 05700005A EP 05700005 A EP05700005 A EP 05700005A EP 1711412 B1 EP1711412 B1 EP 1711412B1
Authority
EP
European Patent Office
Prior art keywords
cap
receptacle
container
sealing
longitudinal axis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP05700005A
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German (de)
English (en)
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EP1711412A2 (fr
Inventor
Franz Konrad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Greiner Bio One GmbH Austria
Original Assignee
Greiner Bio One GmbH Austria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greiner Bio One GmbH Austria filed Critical Greiner Bio One GmbH Austria
Priority to EP10189757A priority Critical patent/EP2277625A1/fr
Publication of EP1711412A2 publication Critical patent/EP1711412A2/fr
Application granted granted Critical
Publication of EP1711412B1 publication Critical patent/EP1711412B1/fr
Active legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/04—Threaded or like caps or cap-like covers secured by rotation
    • B65D41/08—Threaded or like caps or cap-like covers secured by rotation engaging a threaded ring clamped on the external periphery of the neck or wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs

Definitions

  • the invention relates to a method for assembling a receiving device for blood, body fluids, tissue parts or tissue cultures, in which during the joining process, a closure device is screwed with an approximately cylindrical-shaped and an interior enclosing receptacle, as described in claim 1.
  • the WO 98/14373 or the parallel running US 5,858,141 A describe various devices for placing a cap with a thread on a bottle-shaped container, which also has a thread.
  • the pre-positioned on the bottle cap is supplied together with this by means of a conveyor of a pressing station, wherein a pressure force is exerted on the cap by reducing the distance.
  • a pressure force is exerted on the cap by reducing the distance.
  • the cap is pressed without any rotational movement due to the elastic deformation and expansion of the same over the threads on the bottle neck.
  • FIGS. 6 to 8 is another embodiment of a mounting device has become known, in which the cap is detected at its outer periphery of two opposing and specially driven drive wheels.
  • An adapter system for screwing a cap onto a container has become known in which the cap to be screwed is held in a cap holder. Between the cap holder and the spindle provided about a longitudinal axis and with a drive, an adapter element with a first and a second adapter element is additionally arranged.
  • the first adapter element stands with the one drive torque applying spindle via a threaded arrangement in drive connection.
  • the cap holder is connected via a further threaded arrangement with the second adapter element fixed in drive connection.
  • a rotational connection fixed in the form of a wedge connection with a keyway arranged in the second adapter element and a wedge arranged in the region of the first adapter element are formed.
  • the second adapter element is further associated with a spring element in the region of the rotatable spindle, with which the second adapter element is pressed into a position remote from the first adapter element. Due to the cooperating wedge connection, however, an axial longitudinal displacement between the first and second adapter element is possible within certain limits.
  • a container finish and double-threaded closure is proposed.
  • the thread consists of two threads, which extend over an angle of 240 ° to less than 360 °, which are additionally arranged offset by 180 ° to each other.
  • first portions and second portions are formed on the outer surface of the container finish.
  • the threads overlap in the vertical direction, wherein in the second sections in the vertical direction only one thread is arranged.
  • On the inner surface of the closure also first and second portions are formed.
  • the threads overlap in the vertical direction in the region of the first sections, with only one thread being provided in the region of the second sections.
  • at least one venting recess is arranged per thread, which interrupts the threads.
  • the pitch of the threads is in a range between 3 ° and 4 °, preferably at 3.5 °. Due to the circumferentially arranged threads in the specified angular ranges, in combination with a suitable choice of the vent recesses, an optimal venting behavior and a secure positive and frictional connection between the container finish and the closure are obtained. In such containers, improved venting properties are to be achieved between the container finish and the closure cap to reduce the internal pressure during the opening process of containers with carbonated beverages.
  • Various recording devices which describe from a receptacle and a coupling device can be coupled with it, are from the EP 867 378 B1 .
  • EP 1 174 085 B1 as well as the US 6,017,317 A1 known.
  • a coupling device in the form of a threaded arrangement is described between the closure device, in particular the cap, and the end of the receptacle to be closed, wherein the threaded arrangement in the region of the receptacle distributed over the circumference arranged thread segments, which are each arranged spaced apart in the circumferential direction.
  • the sealing device composed of a plurality of layers, which comprises a resealable layer, a connecting layer arranged between the latter and a gas barrier element, and a further connecting layer between the gas barrier element and the receiving container.
  • the resealable element is glued in the cap by means of a hot melt adhesive.
  • the connection or holding force of the further connection position between the gas barrier element and the receptacle is less than the connection force of the arranged between the resealable element and the cap hot melt adhesive.
  • closure devices of the same applicant are, for example, from EP 0 915 737 B1 have become known in which the conical sealing element used in the bottom region of the receptacle and held biased by means of engaging in the outer periphery of the receptacle cap so as to achieve sufficient tightness.
  • the coupling takes place via a pure snap action between the cap-like closure element and the receptacle.
  • the screwing-on movement takes place until the cap is applied far enough beyond the open front side of the receptacle, so that the guide extensions of the receptacle are moved in the free space between the end of the guide web or thread turn and the end wall of the cap.
  • a free rotation of the cap relative to the receptacle is possible without engagement of the coupling device is present.
  • the placement of the cap by a Aufschraubvorgang or a sliding over the cap with the guide web arranged thereon could be done on the or the guide extensions on the receptacle again. This is possible due to the elasticity of the cap.
  • a receiving device with a receptacle which has two spaced apart in a longitudinal axis ends of which at least one is formed with an opening.
  • the inner dimension of the receptacle in the region of the first open end in the plane aligned perpendicular to the longitudinal axis is greater than the inner dimension in the region of the further end in the plane aligned parallel thereto in the same spatial direction.
  • an annular component is used in the open end, which covers the open end side of the receptacle with a collar and a cylindrical wall portion projects into the interior of the receptacle at least partially.
  • the annular component has, following the cylindrical wall part, a shoulder and, connected thereto, a cross-sectional widening on which the elastic sealing element of the separating device is supported in the starting position.
  • the separator has a recess which is closed with a thin cover plate in the region of the upper end of the receptacle.
  • the filling of the interior is carried out by means of a puncture of the thin cover plate of the separator, the thin film and possibly the cap. Through this filling process, the vacuum is reduced in the interior, which also air is sucked into the interior. Subsequently, there is the centrifuging process, in which the separating device emerges from the annular member in the direction of the closed end and further comes with its sealing element on the inner surface of the receptacle to the plant. The rate of descent in the mixture or the already separated components is determined by the contact pressure of the elastic sealing element on the inner surface. By choosing the density of the entire separation device with respect to the components of the mixture to be separated, they float at the interface between the two different density media. A passage of the lighter medium during the centrifuging process is possible between the inner surface of the receptacle and the elastic sealing element.
  • Another receiving device with a separator is from the EP 1 005 910 A2 has become known, which has a cylindrical-shaped receptacle with a nearly constant inner diameter. At the open end of the receptacle is a arranged pierceable closure device on which even in the initial position, the separation device is arranged almost fitting.
  • This separator is formed of a flexible recoverable material, wherein on the outer periphery of the separator, a sealing device is provided for sealing with the inner surface of the receptacle.
  • a deformable element is still used in the interior, which is pressed during the application of the centrifugal force by the pressure exerted by the medium to the inner wall of the outer container and between the separator and the inserted deformed insert a flow channel is formed, which after removal of the Centrifugal force again assumes a sealing position with the arranged on the separator sealing elements, whereby the separated media remain separated from each other.
  • the other medium located between the closed end and the separating device can mix again with the medium separated therefrom, in one of the usual remaining amount of the other medium corresponding height is in the direction of the closed End cone-shaped widening end stop provided, with which the separator on the end stop, which penetrates through the aperture, runs up.
  • the separator remains in this position and it is thereby closed the breakthrough with the stop and there can be no exchange or re-mixing of the two media.
  • EP 1 106 250 A2 Other recording devices with therein separation devices are from the EP 1 106 250 A2 .
  • EP 1 106 253 A2 and the EP 1 107 002 A2 have become known, the separation devices are formed in a variety of embodiments and based on the principle of deformability of a component of the separation device during the centrifugation and the density of votes between the media to be separated.
  • the present invention has for its object to provide a method for assembling a closure device with one end of a receptacle to a receiving device, wherein the assembly or joining operation is simple and inexpensive in terms of the required mounting means feasible.
  • the object of the invention is achieved by a method for assembling a closure device with one end of a receptacle to a receiving device according to the features indicated in claim 1.
  • the resulting from the combination of features of the characterizing part of this claim advantages are that so in a single operation, a large number of receiving devices can be completed, which in short cycle times a large number of assembled receiving devices can be achieved. Likewise, so can be found even with a small footprint for the joint joining process Aus GmbH.
  • an intake of the goods to be filled into the interior, in particular blood, during the removal process is supported. Thus, otherwise occurring friction losses are compensated and it is subsequently possible a proper filling.
  • a tight closure device for the receptacle can be created, which can be introduced in a simple manner by a pure implementation of a linear movement in a rotary motion in the receptacle.
  • a uniform implementation of the axial compressive force is achieved in a rotary motion.
  • it is advantageous because it ensures a mutual leadership to reach the fully screwed position and the release over the entire rotational or pivotal movement.
  • Another advantage is that only by applying a directed in the direction of the longitudinal axis of the receptacle or the cap pressure force (F) in cooperation of arranged between these components of the assembly thread assembly, this axially acting pressure force (F) a relative pivoting or rotational movement between generates these components and so the screwing up or screwing is performed.
  • a procedure according to the features indicated in claims 2 to 4 is advantageous, because thereby the handling for the joining or mounting operation of the receiving device is better and easier to perform.
  • the predetermined retention of the cap or the receptacle can optionally be brought to the receptacle and / or the cap in the relative pivoting or rotational movement by the application of the predeterminable compressive force (F).
  • the cap loosely placed on the receptacle then the one or more receptacles fixedly held and by subsequent application of the compressive force (F) the cap are moved in a rotational movement relative to the receptacle, whereby the joining process performed and at corresponding Selection until fully unscrewed.
  • a multiple arrangement of recording devices to be screwed is possible, whereby in addition a simple and quick installation can be carried out at low machine cost.
  • a procedure according to the features specified in the claims 9 to 14 is advantageous because thereby the coating can be applied in a selective manner depending on the different friction conditions between the components to be joined and thereby depending on the application the corresponding friction values with a suitable choice of the coating can be reduced.
  • a receiving device 1 for example for a mixture 2 of at least two mutually different components or media 3, 4, such as body fluids, tissue parts or tissue cultures, shown.
  • the receiving device 1 consists of an approximately cylindrical receptacle 5 with two mutually distanced ends 6, 7, wherein in this embodiment, the end 6 is formed open and the end 7 is formed by an end wall 8 closed.
  • the open end 6 here is closed with a closure device 9 shown in a simplified manner, if necessary, and can, for example, according to the EP 0 445 707 B1 , of the EP 0 419 490 B1 , of the US 5,275,299 A , of the US 5,495,958 A as well as the US 5,522,518 A to avoid repetition, reference is made to the disclosure for the formation of the cap, the sealing device, the housing, the coupling device between the cap and the sealing device and the cap and the receptacle 5 and the arrangement of the retaining ring and is incorporated in the subject application.
  • a separator which is not shown here.
  • the procedural procedure for the assembly or assembly between the closure device 9 and the receptacle 5 will be described in more detail below.
  • This receptacle. 5 with the closure device 9 can also be designed or used, for example, as an evacuated blood sampling tube in various embodiments.
  • the receptacle 5 for example, bottle, vial, piston-shaped or the like. Formed and made of a variety of materials, such as plastic or glass, be formed. Is selected for the receptacle 5 as the material plastic, this may be liquid-tight, in particular waterproof and optionally gas-tight and for example of polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), polystyrene (PS), high-density polyethylene (PE -HD), acrylonitrile-butadiene-styrene copolymers (ABS) or the like or a combination thereof.
  • PET polyethylene terephthalate
  • PP polypropylene
  • PE polyethylene
  • PS polystyrene
  • PE -HD high-density polyethylene
  • ABS acrylonitrile-butadiene-styrene copolymers
  • the receptacle 5 has a container wall 11 with a wall thickness 12, wherein the container wall 11, starting from the one end 6 with an inner dimension 13 in a direction perpendicular to a running between the two ends 6, 7 longitudinal axis 14 level 15 out to a further, arranged in the region of the end 7 and extending parallel to the first plane 16 extending further level 16 with a smaller dimension 17 extends.
  • the container wall 11 of the receptacle 5 has an inner surface 18 facing the inner space 10 and an outer surface 18 facing away from it, which thus defines an outer circumference for the receptacle 5. Due to the inner surface of the container wall 11 with the inner clear dimension 13, 17 is thus an internal cross section, which has a variety of cross-sectional shapes, such as.
  • circular, elliptical, oval, polygonal, etc. may have.
  • the shape of the outer cross section may also be circular, elliptical, oval, polygonal, etc., but it is also possible to make the shape of the outer cross section different from the shape of the inner cross section.
  • the inner dimension 13 of the receptacle 5, starting from one end 6 to the distant from this further end 7 is continuously minimally reducing to the inner dimension 17 is formed, for example, the receptacle 5, if this plastic material in a Injection molding process is made to be able to easily remove from the injection molding tool. Further, through this tapered rejuvenation between the two planes 15, 16, the extent of the decrease in the internal dimension from the larger dimension 13 to the smaller dimension 17 is predetermined.
  • the taper or taper angle is, based on the inner opposite surfaces of the receptacle 5, between 0.1 ° and 3.0 °, preferably between 0.6 ° and 1.0 °.
  • the dimensions described are based on the distance between the opposing inner or outer surfaces 18 of the components, the diameter, the circumference along an envelope or a Hüll line and the cross-section or the cross-sectional area respectively in one of the aligned perpendicular to the longitudinal axis 14 planes and always the same spatial direction for determining the dimensions 13, 17 can relate.
  • the end 6 has an open front side 19, which can be closed by the closure device 9, which can be opened as required.
  • the closure device 9 consists of a cap 20 comprising the open end 19 and a sealing device 21 held therein, such as a sealing plug 22 made of a pierceable, highly elastic and self-sealing material, such as e.g. Pharmaceutical rubber, silicone rubber or bromobutyl rubber.
  • This cap 20 is usually arranged concentrically to the longitudinal axis 14 and formed by a cap-shaped annular jacket 23.
  • a coupling device 28 Between the cap 20 and the sealing device 21 are means for coupling, such as coupling parts 24 to 27 of a coupling device 28, consisting in the cap 20 from at least over the inner circumference partially arranged projections 29, 3 0, optionally a retaining ring 31, and in the sealing device 21 from an at least partially projecting beyond its outer periphery approach 32nd
  • the sealing device 21 is formed in the present embodiment by the sealing plug 22 and has a circumferential and approximately concentric with the longitudinal axis 15 arranged cylindrical sealing surface 33, which comes in its sealing position in the section of the end 6 on the inner surface of the receptacle 5 to the plant.
  • the inner surface of the receptacle 5 should be formed in its surface quality as a sealing surface 34 in this section.
  • the sealing device 21 has an approximately perpendicular to the longitudinal axis 14 aligned, further sealing surface, which in cooperation with the voltage applied to the inner surface or sealing surface 34 sealing surface 33, the inner space 10 of the receptacle 5 at the open end face 19 opposite the outer environment closes or seals.
  • the sealing device 21 may preferably have on the side facing the retaining ring 31, a recess 35 which has approximately the same cross-sectional area as an opening 36, wherein this opening 36 is formed in its dimension such that unimpeded passage of a not shown here Cannula and a subsequent piercing through the sealing device 21 is possible.
  • the coupling part 26 forming the projection 32 of the sealing plug 22, which protrudes over the sealing surface 33 at least in partial areas of the circumference flange is supported between the extensions 29 and 30 and optionally the retaining ring 31, the 1in two spaced apart in the direction of the longitudinal axis 14 and perpendicular arranged to this aligned planes and, for example, as at least partially or annular circumferential projections or Arretierfort instruments are formed which form a groove-shaped receiving area on the inside of the cap jacket 23 for the projection 32 of the sealing plug 22.
  • the retaining ring 31 has a larger outer diameter than a between the extensions 29 and 30 ausbil-forming inner dimension in the direction perpendicular to the longitudinal axis 14.
  • the diameter of the opening 36 of the retaining ring 31 is smaller than a largest outer dimension of the projection 32 in
  • this outer dimension of the sealing device 21 is dimensioned such that it is greater than the inner dimension 13 of the inner cross section and thus of the inner space 10 at least twice the wall thickness 12 of the receiving container 5 , which forms the coupling part 25, having an inner opening width which corresponds substantially to the inner dimension 13 of the receptacle 5 in its upper end 6, there is a very good support of the projection 32 in the cap 20 and a good seal between the Interior 10 of the receptacle 5 and the receiving device 1 surrounding atmosphere.
  • This inner opening width can also be chosen larger than the inner dimension 13 of the receptacle 5, whereby a lateral abutment of the extension 30 on the outer surface 18 of the receptacle 5 is possible.
  • the tightness of the closure device 9 for the open end face 19 of the receiving device 1 is further improved if an outer diameter of the sealing device 21 in the region of its sealing surface 33 in the relaxed state outside of the receptacle 5 is greater than the inner dimension 13 of the receptacle 5 in the sealing device 21 facing area.
  • a longitudinal or vertical extent of the projection 32 of the sealing device 21 in the direction of the longitudinal axis 14 is greater than a distance of a groove-shaped receiving area or a groove-shaped depression between the two extensions 29, 30 and optionally less a thickness of the retaining ring 31.
  • cap casing 23 is designed as a cylinder stump sheath or as a truncated cone casing, whereby an overstretching of the cap casing 23 in the region of the upper end face 19 is ensured.
  • the cap 20 has two spaced apart in the direction of the longitudinal axis 14 end portions 38, 39, wherein in the embodiment shown, the open end portion 39 is arranged across the open end face 19 of the receptacle 5 across and the end face 19 comes close to or even adjacent to the extension 30. In the position shown here, the end face 19 fits snugly against the surface of the extension 30 facing this.
  • a threaded assembly 40 is further provided between the cap 20 and the receptacle 5, a threaded assembly 40.
  • a first part of the thread assembly 40 is disposed on an inner surface 41 of the cap skirt 23 and a second part of the thread assembly 40 on the outer surface 18 of the receptacle 5 extending. It should be noted at this point that the threaded arrangement 40 or the parts forming it have only been shown schematically in this figure in a simplified manner.
  • Fig. 2 are the according to the Fig. 1 shown components for assembly to form the receiving device 1, namely the closure device 9 with the open here end 6 of the receptacle 5 in a still separated position, again to avoid unnecessary repetition, to the detailed description of the individual components on the previous Fig. 1 is referred to or referred to. Likewise, for the same parts the same component designation as in the previous Fig. 1 used.
  • a first part of the thread assembly 40 such as a thread 42
  • a further part of the thread assembly 40 such as another simplified thread 43 shown also shown.
  • the receptacle 5 is held by means of a holding device 44, shown in a preferred vertical position shown here, wherein it is additionally possible, the here closed end 7 of the receptacle 5 to a simplified illustrated Support surface 45.
  • the sealing plug 22 has been omitted for the sake of better clarity, in order to make the thread arrangement 40, in particular the thread 43 shown here, more readily apparent.
  • the cap 20 with the sealing plug 22 arranged therein can be applied to the end 6 of the receiving container 5 open here by means of devices or devices, not shown in detail. Automatic assembly or similar from the known prior art Fent Trents droveen be placed.
  • a part of a mounting device 46 is shown here in simplified manner above the cap 20, which in the direction of the longitudinal axis 14 according to the double arrow in the direction of the receptacle 5 or in the opposite direction by means of one or more adjustment means not shown here via adjusting means in its position relative to the stationary held receptacle 5 is designed to be adjustable or are.
  • This mounting means 46 may e.g. be formed by a corresponding pressure plate which by means of known actuating means, such. a cylinder-piston assembly, spindle drives, gear assembly, magnetic or hydraulic drives, etc. is placed in the predeterminable movement. Both a simple but also multiple arrangement is possible.
  • a thrust bearing 47 is shown, with which it is possible on the actuating means or the mounting means 46 impacted on the cap pressure force-in Cooperation with the threads 42, 43 of the threaded assembly 40 to bring the cap 20 in a relative to the receptacle 5 relative rotational or pivotal movement or to generate this and so to achieve the joining process or assembly of the closure device 9 with the receptacle 5.
  • several of these thrust bearing 47 may be kept in a corresponding division of the pressure plate, which can be done in a corresponding multiple arrangement of units to be mounted of the receiving devices 1 space saving the joining or assembly process.
  • the threads 42 project beyond the outer surface 18 of the receptacle 5 in the direction away from the longitudinal axis 14 direction.
  • the plug 48 of the sealing plug 22 inserted into the interior 10 has a larger outer dimension in its untensioned state than the receptacle 5 in the area to be used, whereby in selecting the pressure force to be used for overcoming the resistance due to the between the plug 48 and the inner wall of the interior 10 caused friction is considered.
  • the pressure force to be used for generating the relative rotational or pivoting movement between the closure device 9 and the receptacle 5 should be between 10 N and 50 N in size.
  • At least one component forming the receiving device 1 is applied at least in regions in the region of the coupling device 37 to a coating (not illustrated here).
  • this coating can be applied to the part of the thread arrangement 40 formed on the receptacle 5, and / or to the part of the thread arrangement 40 arranged in the cap 20 and / or to at least one of the mutually facing ones Sealing surfaces 33, 34 may be applied in the region of the plug 48 or receptacle 5.
  • This coating serves to reduce the friction between the components to be assembled. It is possible, for example, to choose different coatings in the area of the thread arrangement 40 or between the sealing plug 22 and the receptacle 5.
  • the coating can be applied to at least one component forming the receiving device 1 (closure device 9 with cap 20 and sealing device 21 or receiving container 5). This is preferably applied in the region of the coupling device 37 at least in regions, whereby this can be done on the part of the thread arrangement 40 formed on the receptacle 5 and / or in the cap 20. Not only the threads 42, 43 of the thread assembly 40 but also at least partially the inner surface 41 of the cap skirt 23 and / or at least partially the outer surface 18 of the receptacle 5 may be provided with the coating at least in the region of the thread assembly 40.
  • this coating can also be applied to the inner surface 18 of the receptacle 5 facing the sealing surface 33 of the plug 48 of the sealing device 21, which is facing the sealing surface 33 of the plug 48 of the sealing device 21. It is furthermore advantageous if the coating in the respective coating area is formed continuously or continuously preferably with a predeterminable layer thickness.
  • the compressive force (F) is one of the components to be assembled (closure device 9, in particular cap 20, or receptacle 5) relative to the other of the components to be assembled (receptacle 5 and closure device 9, in particular cap 20) relative to this by free rotation to pre-position the common longitudinal axis 14. This is done by holding one of the two components, wherein in the interaction of the threads 42, 43, the mutual alignment takes place and so a perfect repeatable Aufschraubvorgang until reaching the end position can be achieved. During the relative rotational or pivotal movement about the common longitudinal axis 14, the threads 42, 43 of the thread assembly 40 are engaged over the entire length of the Einschraubweges until reaching the fully screwed position with each other.
  • the coating for facilitating the insertion movement of the sealing plug 22 of the sealing device 21
  • silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides can be used.
  • lubricants or lubricant additives can also be mixed into or introduced into the coating and applied to the cap 20 and / or the receptacle 5 and / or the sealing device 21 for reducing the frictional forces.
  • the coating comprises at least one lubricant or lubricant additive.
  • lubricant or a lubricant additive already intended for the preparation of the cap 5 mixture or granules and melt the lubricant together with the mixture or granules to form the plastic melt in a known form or soften , whereby the lubricant or the lubricant is or are already part of the cap material.
  • the coating and / or the lubricant additives or the lubricant (s) mixed or incorporated therein and / or dissolved therein can be designed such that they not only greatly reduce the sliding friction between the components to be joined but also increase the static friction prevent accidental release of the components during normal use.
  • a specific opening movement of the closure device 9, in particular the cap 20 from the receptacle 5, can also be carried out simply for a later access to the interior 10, as is described, for example. is necessary for sampling from the collected medium.
  • this plane 49 is oriented perpendicular to the longitudinal axis 14 a pitch angle 50 from a selected range with a lower limit of 2 °, preferably 3 °, in particular 5 °, preferably 8 °, 10 °, 13 °, 15 ° and with an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably of 16 °, 13 ° or 12 °.
  • pitch angles 50 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable.
  • the cap 20 is shown to form the receiving device 1 in different views, again with the same parts with the same reference numerals, as in the preceding Fig. 1 and 2 be designated.
  • the thread assembly 40 is designed to be more continuous in the region of the cap 20.
  • three threads 42 distributed over the inner surface 41 are preferably provided, wherein thread starts 51 to 53 of the individual threads 43 are arranged offset to one another in the circumferential direction by approximately 120 °.
  • a thread length of the individual threads or threads 43 forming the thread arrangement 40 is equal to or smaller than an inner circumference of the cap jacket 23 in the region of the thread arrangement 40 in the plane 49 aligned perpendicular to the longitudinal axis 14. This is due to the above-described three-start thread advantageous if a thread 43 extends approximately over half the inner circumference of the cap skirt 23. Furthermore, from the presentation, in particular the 3 and 4 to see that the one or more threads 43 on the inner surface 41 of the cap skirt 23 in the direction are formed projecting on the longitudinal axis 14. To reduce the friction between the threads 43 shown here in the region of the cap 20 and the previously briefly in the Fig.
  • the thread assembly 40 in particular the threads 42 and / or 43, at least partially provided with a coating not shown here. In this case, only the mutually interacting sections of the individual threads 42 and / or 43 may be provided with this coating, not shown.
  • the individual thread starts 51 to 53 are arranged close to the open and the receptacle 5 facing or cross-end portion 39 and extend due to their above-described slope or the pitch angle 50 to close to the extension 30 zoom.
  • the pitch angle 50 and the circumferential extent of the individual threads 43 is described in the present embodiment for the cap 20 of the receptacle 5 for a nominal size of 13 mm, as this represents a common standard size for the receiving device 1 at the present time.
  • the holder of the sealing plug 22, in particular of the projection 32 between the two extensions 29 and 30 may optionally be made with the interposition of the retaining ring 31 but other mounting options are not excluded.
  • the description for the formation of the threads 42 relates to a receptacle 5, in particular blood sampling tube, with a nominal size in its diameter of 13 mm. In the event of deviations, in particular in diameter, the values described here must be correspondingly transferred to other nominal sizes.
  • the individual threads 42 are arranged to form the threaded assembly 40 on the outer surface 18 of the receptacle 5 evenly distributed.
  • thread starts 54 to 56 and threaded ends 57 to 59 limit the individual threads 42 in their longitudinal extent over the circumference. So is from a synopsis of Fig.
  • a lead angle 60 of the threads 42 for forming the thread assembly 40 relative to a plane 49 oriented perpendicular to the longitudinal axis 14 is preferred from a selected range having a lower limit of 2 °, preferably 3 °, especially 5 ° of 8 °, 10 °, 13 °, 15 ° and having an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably 16 °, 13 ° or 12 °.
  • pitch angle 60 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable.
  • the thread arrangement 40 is designed to be more continuous, wherein the second part of the thread arrangement 40 likewise comprises three threads 42 distributed over the outer surface 18 or outer surface.
  • the two selected pitch angles 50, 60 are in the same limits and, in order to achieve a perfect Aufschraubvorgang, each chosen the same size.
  • preferred pitch angles 50, 60 values with lower or upper limits of 3 ° and 20 °, 5 ° and 16 °, 8 ° and 13 ° and 10 ° and 12 ° have also been found, wherein the size of the selected pitch angle 50, 60 of the material combination of the receptacle 5, the cap 20 and the sealing device 21 and the proposed coating is dependent.
  • the thread starts 54 to 56 of the individual threads 42 are arranged offset in the circumferential direction to each other approximately at 120 °.
  • the same also applies to the threaded ends 57 to 59.
  • immediately adjacent to each other arranged thread roots 54 to 56 and threaded ends 57 to 59 are each spaced apart in the circumferential direction, whereby a sum of the thread lengths of the threads 42 forming the thread arrangement 40 in the plane perpendicular to the longitudinal axis 14 oriented plane 49 seen over the circumference equal to or smaller than an outer circumference of the receptacle 5 in the region of the thread assembly 40.
  • each arranged in the circumferential direction immediately adjacent Threads 42 arranged spaced apart in the circumferential direction.
  • the threads 42 extend between their thread beginning 54 to 56 and their threaded end 57 to 59 seen over the circumference over an angle 61, which may be for example between 50 ° and 80 °.
  • this angle 61 is selected to be in about 65 °.
  • the threads 42 have their full thread height 62, as shown in the enlarged view of Fig. 9 best seen.
  • the thread 42 in the section of its thread beginning 54 to 56 starting from the full thread height 62 towards the outer surface 18 of the receiving container 5, has a threaded outlet 63 which is designed to be steadily decreasing in height.
  • the thread or threads 42 in the section of their threaded ends 57 to 59, starting from their full thread height 62, toward the outer surface 18 of the receptacle 5 have a further threaded outlet 64, which is also formed in its height steadily decreasing.
  • the threaded outlet 63 and / or 64 is formed by a transition radius 65. But this thread outlet can also have any other form technical training to facilitate the joining process. This can also be selected differently depending on the material.
  • the manufacturing process in particular the Injection molding process to arrange the mold parting plane to form the receptacle 5 in the threads in each case at their highest point or the highest line thereof and between the immediately adjacent threaded starts 54 to 56 and threaded ends 57 to 59 this through a connecting line in the region of the outer surface 18 running connect to each other and further form the mold parting plane in this connection line.
  • the manufacturing process in particular the Injection molding process to arrange the mold parting plane to form the receptacle 5 in the threads in each case at their highest point or the highest line thereof and between the immediately adjacent threaded starts 54 to 56 and threaded ends 57 to 59 this through a connecting line in the region of the outer surface 18 running connect to each other and further form the mold parting plane in this connection line.
  • Such an arrangement of the mold parting plane for the formation of external threads is for example from the US 3,926,401 A as well as the US 2001/0055632 A1 known.
  • a similar training for internal thread is from the DE 30 47 856 C2 .
  • US 4,188,178 A such as US 5,667,870 A known.
  • the thread 42 has seen or seen in its cross section, ie in a parallel to and centrally through the longitudinal axis 14 extending plane, starting from its full thread height 62, toward the outer surface 18 of the receptacle 5 iron mutually different transition region , whereby a thread cross section of the thread 42 is formed asymmetrically in this plane.
  • the thread 42 has in the region of the outer surface 18 in a nearly parallel direction to the longitudinal axis 14 or in the reference plane described above, a base width 66, which may be 1.3 mm in the present embodiment. Starting from this base width 66, the thread 42 in the considered plane on the open end 19 of the receptacle 5 side facing an exclusive radius 67, which leads, starting from the outer surface 18 toward full thread height 62. In the section of full thread height 62, the thread 42 also has one parallel to the longitudinal axis 14 extending vertex width 68, in the region of the mold parting plane may be arranged to extend. This vertex width 68 is approximately 0.6 mm in the above-described base width 66 of 1.3 mm.
  • the first radius 67 in this embodiment 0.7 mm and passes from starting the outer surface 18 to the parallel vertex width 68 of the thread 42 via.
  • This vertex width 68 of the thread 42 may also be referred to as a vertex surface 72.
  • the apex surface 72 and the transition surface 69, in a view of the thread cross-section can also be referred to as a crest line or transition line or boundary line.
  • FIG. 10 is another and possibly independent solution for joining or mounting the receiving device 1 similar to the training as in the Fig. 2 shown.
  • illustrated components for assembly to form the receiving device 1, namely the closure device 9 are shown with the open end 6 of the receptacle 5 in a still separate position, in turn, to avoid unnecessary repetition, to the detailed description of the individual components on the previous one Fig. 1 to 9 is referred to or referred to.
  • the cap 20 is simplified in half section and shown without sealing device 21, wherein the cap 20 is still seen in a distant position from the receptacle 5 in the direction of the longitudinal axis 14.
  • the thread assembly 40 is shown simplified.
  • the reference numerals were analogous to those in Fig. 2 Registered training, wherein, in order to avoid unnecessary repetition, here omitted a detailed description and reference is made to the preceding embodiments and reference is made.
  • the receptacle 5 is rotatably supported in this embodiment via the thrust bearing 47 on the support surface 45 about the longitudinal axis 14, wherein the axial alignment or pre-positioning of the same with respect to the cap 20 and closure device 9 this is associated with a positioning device 75.
  • a positioning device 75 a guide hole 76 shown in simplified form is arranged, which ensures, for example, a vertical orientation of the receptacle 5 for the assembly or Fügelage.
  • This guide opening 76 has a sufficient clearance to the outer surface 18 of the receptacle 5 so as to be able to perform about the fixed cap 20 generated rotational or pivotal movement about the longitudinal axis 14 can.
  • different coatings may be provided on the outer surface 18 facing the inner surface of the guide opening 76, which are not shown here.
  • the thrust bearing 47 or on a movable mounting base being filled in a separate filling the mounting bracket with a corresponding number of receptacles 5, in a further station to be joined closure devices 9 also in a separate mounting support on which the support plate 74 is required to pivot or rotatably supported, also to load or insert them into the receptacles 73, then subsequently to move the so pre-filled mounting bracket to its own assembly station, in which the joining process according to the invention, namely Application of a pure compressive force to screw together.
  • the placement process of the closure device 9 takes place on the receptacle 5 by a pure implementation of acting in the direction of the longitudinal axis 14 axial force in a relative rotational or pivotal movement between the components to be joined until the maximum Einschraubweg For example, by a mechanical stop between the receptacle 5 and the cap 20 and / or the sealing device 21 is limited.
  • This unscrewing operation is controlled by the at least partially co-operating threads 42, 43, wherein in addition also held on the coupling device 28 in the cap 20 sealing device 21 also mitentfernt simultaneously removed from the receptacle 5 and is lifted.
  • a simultaneous secure decrease or separation of the closure device 9 from the receptacle 5 is possible.
  • a jerky opening or loosening of the sealing device 21 is avoided by the cooperating threads 42, 43 from the receptacle 5, wherein an inadvertent leakage of stored in the interior 10 of media 3, 4 and the mixture 2 is avoided.
  • the handling of the operating personnel is safer, which possible infection by leaking subsets and thus possible connected infections are ignored.
  • FIG. 11 different training options of the receptacle 5 are shown simplified in a single figure, but these can also be arbitrarily combined with each other as well as with any of the training options described above.
  • the illustration of the closure device 9 is omitted in this figure.
  • the detailed description in the preceding Fig. 1 to 10 referred or referred.
  • same reference numerals or component names are used as in the preceding figures.
  • a separating device 77 is provided, which is to be inserted into the receptacle 5 before closing the inner space 10 and is shown here in a position distant from the receptacle 5.
  • this separating device 77 according to the statements, as shown in the WO 02/078848 A2 the same applicant is described to be formed.
  • the receptacle and the closure device is on the aforementioned WO 02/078848 A2 Reference is made and incorporated this disclosure in the present application. The selected terms are analogously to the terms and representations chosen here.
  • the separating device 77 is inserted into the inner space 10 or a receiving space 78 in the region of the open end face 19 in the receptacle 5 and is there in the so-called starting position, in which after completion of the receptacle 5 with the closure device 9 also additionally simultaneously or even before the interior 10 is lowered to a lower pressure relative to the ambient pressure, in particular evacuated is.
  • the filling of the receiving device 1 is carried out in a conventional manner, for example in the form of a blood sample, with the associated piercing of the sealing device 21 with a cannula, not shown here, whereby the in the Fig. 1 Dargesllte mixture 2 from the media 3 and 4, in particular blood, flows through the flow channel or connection opening through the separator 77.
  • the separation of the mixture by centrifuging as already described in detail in the WO 02/078848 A2 has been described.
  • this is in the so-called working position, which is dependent on the total filling volume of the receptacle and the volume proportion of the components of the mixture to be separated 2.
  • the working position is approximately in half of the longitudinal extent be selected of the available receiving space 78 of the receptacle 5.
  • the retaining device 79 In the region of the starting position adjacent to the end 6 of the receptacle 5 for the separating device 77 to be inserted into the inner space 10 or the receiving space 78, different embodiments of the retaining device 79 are shown for the latter. It is shown here in the right part of the figure that the retaining device 79 by at least one over the circumference of an inner surface 80 in the direction of the longitudinal axis 14 projecting projection 81 and / or by at least partially over the circumference of the inner surface 80 in the direction the longitudinal axis 14 projecting web 82 is formed. In this case, both the projection 81 and / or the web 82 can only be arranged in a continuous manner over the circumference and possibly also continuously over the entire circulation of the inner surface 80 over certain regions.
  • a further embodiment of the retaining device 79 is shown, which is formed by a reduction of the inner dimension 13 of the receiving space 78, starting from the open end face 19, the sealing surface 34 for the sealing device 21, not shown here, in particular the sealing surface 33 of the sealing plug 22, is trained.
  • This reduction can be effected by, for example, starting from the end 6 of the receptacle 5 to the retaining device 79, the normal wall thickness 12 of the receptacle 5 and from the retainer 79 in the direction of the other end 7 has a greater wall thickness, the magnification of the Wall thickness 12 by an offset of the inner surface 80 in the direction of the longitudinal axis 14 takes place.
  • the wall thickness 12 of the receptacle 5 between the starting position and the other end 7 in the range of the usual wall thickness 12 and only the wall thickness between the starting position and the open end 6 of the receptacle 5 form less.
  • a positional positioning of the separating device 77 in the direction of the longitudinal axis 14 until reaching a predeterminable centrifugal force in which the restraining forces are overcome and the displacement of the separating device 77 relative to the receptacle 5 takes place up to reaching the working position can be predetermined.
  • a positioning device 83 can be arranged between the receiving container 5 and the separating device 77, which is preferably formed by a mechanically acting stop.
  • This positioning device 83 may, for example, by a reduction of an inner dimension 84 of the receiving space 78 or interior space 10, optionally to form an approximately perpendicular be formed to the longitudinal axis 14 aligned stop surface 85.
  • both the sealing device arranged in the first end region of the separating device 77, in particular the sealing lips, and the further end region thereof or its components can be brought into abutment.
  • This positioning device 83 thus forms a mechanical stop for the separating device 77 for terminating the relative adjustment movement relative to the receiving container 5 in the direction of the longitudinal axis 14 toward the further end 7.
  • the rejuvenation of the receiving container 5 described above in its inner space 10 or receiving space 78 between the two mutually spaced-apart planes 15, 16 can be between 0.1 and 3.0 °, preferably between 0.6 ° and 1.0 °.
  • This conical or cone angle is chosen to be constant over the entire outer longitudinal extent between the two ends 6, 7.
  • the conical or cone angle of the inner surface 80, also with respect to the longitudinal axis 14, can also be 0.46 in the first partial area between the first end 6 and the positioning device 83, for example 0.46 ° and between the positioning device 83 and the plane 16 ° amount.
  • Fig. 12 to 16 is another possible and possibly independent training of the receptacle 5 for forming a closable with a closure device 9 receiving means 1 for body fluids, tissue parts or tissue cultures shown, again for like parts, the same reference numerals or component names, as in the preceding Fig. 1 to 11 be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 11 referred or referred. It need not be emphasized that this embodiment of the receptacle 5 described here but also with all other forms contained in this description can be combined with each other arbitrarily.
  • This receptacle 5 in turn serves as a receptacle 1 for body fluids, tissue parts or tissue cultures, in particular for the use of a mixture to be separated 2, consisting of at least the, a different density having media 3, 4, as already in the Fig. 1 has been shown simplified and described.
  • a mixture to be separated 2 consisting of at least the, a different density having media 3, 4, as already in the Fig. 1 has been shown simplified and described.
  • the thread arrangement 40 described above in the area of the open end 19 in the region of the first end 6, evenly distributed over the circumference are several, in the present case three, the outer surface 18 in the direction away from the longitudinal axis 14 protruding extensions 86 än167 how this can already be deduced from the known state of the art.
  • the extensions 86 instead of the extensions 86, to use the previously described threads 42 in connection with the threads 43 in the cap 20, as already described in detail in the preceding Fig. 1 to 10 has been explained.
  • the sealing surface 34 which serves to bear the sealing surface 33 of the sealing stopper 22 of the sealing device 21 not shown here.
  • the further area of the interior 10 for the insertion of in the Fig. 11 simplified illustrated separating device 77 provided as best of the Fig. 13 can be seen.
  • at least one through-flow channel 87 in the region between the container wall 11 of the receptacle in the starting position of the inserted or deployable separation device 77 5 and the separator 77 is formed.
  • This flow-through channel 87 serves to spend the remaining in the interior 10 between the separator 77 and the other end 7 remaining amount of air to the separator 77 over into the interior 10 between the separator 77 and sealed by the sealing device 21 interior 10.
  • the flow-through channels 87 can also serve to retain remainders of the mixture 2 which have not passed through the flow channel or the connection opening in the region of the separating device 77, likewise into that between the separating device 77 and the other end 7 formed interior 10 of the receptacle 5 to spend.
  • the flow-through channel 87 is formed by at least one recessed 88 formed in the inner surface 80 of the container wall 11.
  • This recess 88 recessed in relation to the inner surface 80, has, starting from the inner surface 80 in the radial direction towards the outer surface 18, a depth 89 between 0.1 mm and 1.0 mm, preferably between 0.2 mm and 0.5 mm , on.
  • a plurality of distributed over the inner circumference arranged recesses 88 are provided, in which case a symmetrical division in relation to the longitudinal axis 14 over the inner circumference is advantageous.
  • the recess 88 has a coaxial with the sealing surface 34 arranged base surface 90, which thus limits the recess 88 in depth. Between the base surface 90 and at least one of those in the direction of the longitudinal axis 14 spaced from each other boundary surfaces 91, 92 each have a first transition surface 93 is arranged. Furthermore, at least one further transition surface 94 can be arranged between one of the boundary surfaces 91, 92 of the recess 88, distanced from one another in the direction of the longitudinal axis 14, and the inner surface 80. These two transition surfaces 93, 94 may be selected such that they already form the mutually distanced boundary surfaces 91, 92.
  • boundary surfaces 91, 92 are in the direction of the longitudinal axis 14 as viewed across a longitudinal extent 95 distanced from each other.
  • the longitudinal extent 95 ends before the sealing surface 33 of the sealing plug 22 zuwendbaren sealing surface 34.
  • this is chosen to be shorter, only to form the flow passage 87 in the region of the inner surface 80 and the separator 77 during the filling process and only after a slight adjustment of the separator 77 towards its working position, only a passage of a component of the mixture through the To allow flow channel or the connection opening in the region of the separator 77. Otherwise, a sealing contact of the sealing lips of the separator 77 on the inner surface 80 of the receptacle 5 to achieve a perfect Trennergebriisses to prefer.
  • five recesses 88 are provided in the receptacle 5 over the inner periphery, which have a size or extent in the circumferential direction of 1.9 mm seen at a depth of 0.4 mm. These recesses have in the direction of the longitudinal axis 14, the longitudinal extent 95 of 3 mm. It is essential in the choice of the depth 89 of the recess 88, that in this area, the container wall 11 still has sufficient strength that is sufficient to ensure the shelf life of the receiving device 1 in its unused state (maintenance of the vacuum). Here, depending on the manufacturer, a period of e.g. Guaranteed 18 months, within which the interior 10 preset vacuum is maintained. With this design, attention must be paid to the oxygen and water vapor permeability of the material, especially in this area.
  • a flow cross-section 98 is limited or fixed, which is dimensioned such that both subsets of the mixture 2 and residual amounts of air can flow simultaneously, but in the opposite direction, without a Clogging or laying of this flow-through channel 87 and the flow-through channels 87 associated therewith.
  • the minimum flow cross-section 98 of the at least one flow-through channel 87 in the plane 49 oriented perpendicular to the longitudinal axis 14 is at least 0.4 mm 2 .
  • This size represents the minimum extent of that cross-sectional area which is necessary when using the receiving device 1 as a blood sampling tube to allow a proper flow of a portion of the mixture or medium to be filled and a simultaneous displacement of residual amounts of air in the opposite direction of flow.
  • boundary surfaces 91, 92 and / or 96 or 97 it is advantageous if at least one of these boundary surfaces 91, 92, 96, 97 and transition surfaces 93, 94 is concavely curved. But it would also be possible, one of these boundary surfaces 91, 92, 96, 97 and / or transition surfaces 93, 94 planar form.
  • boundary surface 91 closer to the open end 19 or the transition surfaces 93, 94 form a relatively shallow transition towards the sealing surface 34 or inner surface 80 like this best of all Fig. 15 can be seen.
  • the boundary surface 91 is planar and the transition surface 94 arranged between the latter and the sealing surface 34 or inner surface 80 is convex, in particular by a radius, and the transition surface 93 formed between the base surface 90 and the boundary surface 91 is concave, preferably also by a radius. educated.
  • this surface has a surface structure which impedes or prevents adhesion ,
  • a surface structure according to the "lotus flower effect” can be used.
  • this repellent surface structure can also be provided on the sealing device 21, the sealing surfaces 33, 34, the cap 20 and the separating device 77, wherein only a region-wise arrangement is possible.
  • FIGS. 17 and 18 In each case, a further and possibly independent training of the cap 20 and the receptacle 5 is shown in simplified form, again in order to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 16 is referred to or referred to. Likewise, the same reference numerals and component names for the same parts, as in the preceding Fig. 1 to 16 , used.
  • Fig. 18 is the thread 42 on the receptacle 5 also seen over its longitudinal course formed by a plurality of circumferentially successively arranged and spaced from each other further thread segments 100.
  • These thread segments 100 can in turn have a wide variety of spatial forms and project beyond the outer surface 18 of the receptacle 5 in the direction away from the longitudinal axis direction.
  • the previously described in detail coating or a lubricant or a lubricant additive can be stored in at least one recess 101 in the region of the thread 43.
  • the depressions 101 are shown only schematically simplified and can be arranged, for example, between the individual thread segments 99 in the cap casing 23 and / or also directly in the region of the thread 43.
  • several recesses 101 distributed over the circumference in the cap casing 23 and the threads 43 may be arranged, which serve to receive the coating and / or the lubricant or a lubricant additive.
  • Fig. 19 is another, possible and possibly independent training of the cap 20 shown in conjunction with the sealing device 21 inserted therein, again to avoid unnecessary repetition, to the previously detailed description in the Fig. 1 to 18 is referred to or referred to. Likewise, the same reference numerals and the same component designations are used for the same parts, as in the preceding Fig. 1 to 18 used.
  • at least one penetration 102 is arranged in the cap casing 23, which forms an opening or an opening or can also form only one recess in the cap casing 23.
  • this enforcement 102 projects in the inserted or assembled state of the sealing device 21, a projection 32 superior projection 103 into it, which in addition to the holder or coupling of the sealing device 21 in the direction of the longitudinal axis 14 against rotation or further coupling of the sealing device 21 against the cap 20 forms about the longitudinal axis 14.
  • This enforcement 102 may have a variety of cross-sectional shapes and be formed, for example, round, polygonal, oval, etc., wherein the enforcement is preferably a window-like opening in the cap jacket 23. If, viewed over the circumference, a plurality of openings 102 are provided in the cap casing 23, it is advantageous if they are distributed uniformly over the circumference.
  • the individual projections 103 projecting through the penetrations 102 may also project beyond the outer surface of the cap skirt 23 and at the same time be used as a prevention for rolling or rotating the entire receptacle while lying on a flat or sloping surface. If the projections 103 protrude beyond the outer surface of the cap jacket 23 to a certain extent, they can also simultaneously serve as a handle or grip element for unscrewing the entire closure device 9 from the receptacle 5 and thus improve handling or even make it safer.
  • FIG. 19 Another additional and possibly independent training of the cap 20 is simplified in the Fig. 19 represented here, in which the receptacle 5 zuwendbaren and cross-end portion 39 of the cap 20 is a preferably all-round, and the end portion 39 superior apron-shaped protective element 104 is shown simplified.
  • This apron-shaped protective element 104 can only be arranged or formed on the cap jacket 23 in regions over the circumference, but preferably all around. It is possible to form the protective element 104 as a separate component on the cap casing 23 or to form the protective element 104 as an integral part of the cap casing 23. As shown in simplified form here, the protective element 104 has a continuously decreasing cross section with increasing distance from the end region 39.
  • An inner diameter 105 of the protective element 104 may be approximately the outer diameter or the outer dimension of the receptacle 5, optionally in addition; the projection of the threads 42 on the outer surface 18 of the receptacle 5 correspond.
  • This protective element 104 serves to form an additional leakage protection or splash protection for a user of the receiving device 1 in order to avoid unwanted contact when taking off the closure device 9, which is possible by ejecting the contents from the receiving container 5. As a result, contagions or infection of the operating personnel can be reduced or avoided at all.
  • Fig. 20 is another possible and possibly independent training of the receptacle 5 is shown, again to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 19 is referred to or referred to. Likewise, the same reference numerals and component names are used for the same parts, as in the preceding Fig. 1 to 19 , used.
  • the receptacle 5 shown here is again preferably designed for insertion of a separation device 77, not shown here, and instead has the in the Fig. 12 to 16
  • at least one, but preferably several, of the inner surface 80 of the receptacle 5 projecting ribs 106 projecting in the direction of the longitudinal axis 14 are shown and described.
  • the ribs 106 are web-shaped and are preferably aligned parallel to the longitudinal axis 14 , In most cases, a plurality of ribs 106 distributed over the circumference are arranged on the inner surface 80 of the container wall 11 and form between them - so seen in the circumferential direction, the flow-through channels 87.
  • the separation device 77 abuts the boundary surfaces of the ribs closer to the longitudinal axis 14 and thus faces, whereby between the separating device 77, the circumferentially spaced apart ribs 106 and the inner surface 80 of the container wall 11 or the flow channels 87th is limited or are.
  • a minimum cross-section of this flow-through channel 87 can again amount to at least 0.4 mm 2 , but can also be made larger.
  • Fig. 21 and 22 are possible and possibly independent embodiments for applying the coating already described above, in turn, for the same parts the same reference numerals or the same component designations as in the Fig. 1 to 20 be used. Likewise, to avoid unnecessary repetition, the detailed description of the Fig. 1 to 20 referred or referred.
  • Fig. 21 a possibility for applying the coating to the sealing surface 33 of the sealing device 21, in particular of the plug 48, which is the inner surface 18 of the receptacle 5 in the inserted state facing and thereby seals the inner space 10 from the outside atmospheric environment.
  • the projection 32 of the sealing device 21 may be held in a holder 107 shown here only in a simplified manner, wherein the sealing surface 33 to be coated is assigned a coating element 108 shown in a simplified manner. This is independently rotatable about a simple axis of rotation about its own axis and / or also additionally coupled with a drive.
  • the holder 107 with the sealing device 21 performs a rotational movement and it is by the system of the coating element 108 on the surface to be coated - here the sealing surface 33 - transferred the coating material from the coating member 108 from.
  • On the presentation of the drive was omitted for better clarity. However, it would also be possible to drive the coating element 108 and to let the sealing device 21 held in the holder 107 rotate together with it through the system. It is also a superposition of the rotational movement with a movement gem. Registered double arrow in the direction of the longitudinal axis 14 of the sealing device 21 possible.
  • a supply device 109 is assigned to the coating element 108 for storing the coating agent.
  • a liquid coating agent such as silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides or the like used, this is stored in a container 110 and fed via a feed line 111, in which also a metering element 112 may be arranged.
  • the thereby supplied amount may be supplied dropwise in dependence on the number of pieces and the surface to be coated of the sealing plug 22 to be coated. In this case, cycle times can be selected in the supply line between 50 and 300 pieces, which means that after reaching the coated number of sealing plug 22 again a predeterminable Quantity unit of the coating agent, for example, a drop or more, is supplied.
  • the coating element 108 stores the coating agent supplied to it and delivers it to the surface or body to be coated in order to form the coating.
  • the sealing surface 33 - receiving openings 113 such. Pores, distributed over the sealing surface 33 are provided in order to bring in these additional coating agent for forming the coating can. This causes after the first insertion of the plug 48 into the receptacle 5 and a first removal, if the coating on the sealing surface 33 is already partially scraped, further coating agent is stored for a further easy insertion process.
  • the sealing device 21 in a preferably rectilinear guide rail such that the projection 32 rests on the guide rail, the plug 48 projects through the guide rail and the sealing surface 33 is brought into contact with the coating element 108 and thus transfers the coating agent becomes.
  • the coating element 108 may be formed as a strip-shaped component, which rests on the sealing surface 33 on one side and by a parallel movement of the coating member 108 to the guide rail a combined rotational and longitudinal movement of the sealing device 21 is effected relative to the guide rail.
  • the sealing device 21 rotates on the one hand about its longitudinal axis 14 and on the other hand it is moved along the guide slot.
  • a plurality of sealing devices 21 may preferably be arranged at a distance from each other in succession in the guide slot, whereby then a plurality of sealing devices 21 can be beschiehtet in a coating movement simultaneously.
  • a possibility for applying the coating on the inner surface 18 of the receptacle 5 in the region of the open end face 19 is shown.
  • the surface to be coated, in particular the sealing surface 34, may correspond to that which faces the sealing surface 33 of the plug 48 in its inserted state.
  • the mandrel 114 radially projecting coating element 108 is arranged at approximately trained receptacle 5, wherein this in his outside dimension to the inner dimension 13 of the receptacle 5 is tuned.
  • the coating element 108 is held fixed in a groove-shaped recess 115 on the mandrel 114 and projects beyond the mandrel 114 in the radial direction.
  • the coating element 108 is tubular in this case.
  • the feed and the quantitative dosage can be as described in the Fig. 21 respectively.
  • the application of the coating on the outer surface 18 of the receptacle 5 in the region of the thread arrangement 40 can be carried out analogously to the coating on the inner surface 18, in which case the coating element has an opening adapted to the outer dimension of the receptacle 5.
  • a silicone amount of between 0.1 mg and 0.001 mg, preferably between 0.07 mg and 0.04 mg, in particular of 0.055583 mg, may be applied.
  • a silicon amount of between 0.6 mg and 0.1 mg, preferably between 0.4 mg and 0.2 mg, in particular of 0.27917 be applied mg.
  • These weights refer to a nominal size of the receptacle 5 of 13 mm and only those surface areas which are also provided with the coating.
  • the coated surface area on the receiving container 5 is at a dipping depth of between 1 to 2 minutes ca. 75 mm 2 and on the outer surface of about 70 mm 2 on the inner surface.
  • an area of about 146 mm 2 is coated.
  • Fig. 23 and 24 is a further possible and possibly independent training of the receiving device 1, in particular the closure device 9 for the receptacle 5, shown in an enlarged, schematically simplified representation, in turn, the same parts the same reference numerals or component names, as in the previous Fig. 1 to 22nd be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 22nd referred or referred.
  • the extension 30 is arranged laterally next to the outer surface 18 of the receptacle 5 in the region of the open end face 19 and may also be formed adjacent thereto.
  • the plug 48 of the sealing plug 22 has in its central region - ie in the region of the longitudinal axis 14 - in the direction of the same thickness or thickness of about 3.0 to 4.0 mm, said thickness depends on the selected material of the sealing plug 22, in particular of the plug 48, is.
  • This is, as described above, formed from a re-closing after the piercing process material, so as to prevent the closure of the passage opening of the cannula or needle and thus a passage of liquid or gaseous substances secured over a predeterminable period of time even after the puncture.
  • the plug 48 has the sealing surface 33 facing or facing the inner sealing surface 34 of the receptacle 5, which in this embodiment is shorter in the direction of the longitudinal axis 14 relative to the previously described embodiments.
  • the sealing surface 33 can be formed shorter in its longitudinal extent in the direction of the longitudinal axis 14, for example, by half. But it is also an extent in this direction between 1.0 mm and 2.5 mm, preferably 1.5 mm possible.
  • a further sealing surface 116 is provided in the region of the radially projecting shoulder 32 at the end face 19 facing the open end 19 of the receptacle 5 in the fully inserted position of the sealing plug 22 cooperates in the interior 10 of the receptacle 5. This makes it possible, at least partially, to compensate for the reduction of the sealing surface 33 in the region of the plug 48.
  • This has in the inserted state of the sealing plug 22 has the advantage that despite the reduction of the inner surface 18 and the sealing surface 34 of the receptacle 5 facing sealing surface 33 an additional sealing surface 116 in the region of the open end face 19 is created. Furthermore, the shortening of the sealing surface 33 on the stopper 48, the relative displacement between the receptacle 5 and the closure device 9 is reduced so far that, as best of the Fig. 24 can be seen, with still engaged threads 42, 43 of the thread assembly 40 between the plug 48, in particular the sealing surface 34, and the open end 6 of the receptacle 5 in the region of the sealing surface 34 and the end face 19 at least one channel 117 is formed or is released.
  • At least one channel 117 is formed between the sealing device 21 and the open end 6 of the receptacle 5 in still engaged threads 42, 43 of the threaded assembly 40 on the receptacle 5 and the cap 20.
  • a pressure equalization between the inner space 10 of the receptacle 5 and the outer atmospheric environment is still possible in overlapping position between the cap 20 and the receptacle 5, as shown schematically by a wavy arrow in the Fig. 24 is shown.
  • the extension 30, which is preferably arranged to run continuously over the entire inner circumference of the cap jacket 23, has in this embodiment shown here a clear inner width 118, which corresponds approximately to an outer dimension 119 of the receptacle 5 in the region of the open end 6.
  • the extension 30 may also be adjacent to the outer surface 18 of the receptacle 5 may be formed, in which case the inner clear width 118 of the extension 30 corresponds to the outer dimension 119 of the receptacle 5. If, however, the inner clear width 118 of the extension 30 slightly smaller the outer dimension 119 of the receptacle 5 is selected, there is a slight interference fit between the cap 20 and the receptacle 5. In these cases, then the formation of the or the channels 117, the extension 30 seen over the circumference at least partially interrupted form or to provide recesses on the receiving container 5 facing or adjacent surface.
  • a tapered in the direction of the longitudinal axis 14 bevel 120th is at the stopper 48 of the sealing device 21 between the receptacle 5 facing or zuwendbaren sealing surface 33 and the aligned approximately perpendicular to the longitudinal axis 14 and the interior 10 facing further sealing surface, a tapered in the direction of the longitudinal axis 14 bevel 120th arranged.
  • the bevel 120 may be formed, for example, as part of a conical surface. However, any other forms of space for forming the bevel 120 would also be possible.
  • the sealing surface 33 which is preferably formed cylindrical to the longitudinal axis 14, reduced in size or their size, in which case, for example, the sealing surface 33 on the plug 48 in the direction of the longitudinal axis 14, a longitudinal extent or an extent 121 between 1 , 0 mm and 2.5 mm, preferably 1.5 mm.
  • This length in the direction of the longitudinal axis 14 and the extent 121 is to be selected such that when fully inserted sealing plug 22, the facing sealing surfaces 33, 34 and 116 and the open end 19 ensure adequate gas tightness and liquid tightness over a predeterminable period of storage and Also a plant of the same over the circumference is continuous.
  • Fig. 23 is indicated in dash-dotted lines in the region of the chamfer 120 that instead of this it is possible to form the channel or channels 117 by at least one groove-shaped recess 122 arranged in the region of the sealing surface 33 of the plug 48. It is also possible for a plurality of groove-shaped recesses 122 distributed over the circumference of the plug 48 or sealing surface 33 to be provided.
  • This depression 122 extends or extends from an edge region 123 facing the interior 10 of the receptacle 5 in the direction of the projection 32 and ends or ends at a distance 124 in front of the projection 32.
  • the distance 124 can also be between 1 , 0 mm and 2.5 mm, preferably 1.5 mm, while the extent of 121 correspond.
  • the sealing surface 33 passing over the circumference is formed on the stopper 48.
  • the interior 10 after closing with the closure device 9 has a relation to the local atmospheric pressure lower pressure, that is evacuated.
  • the interior 10 is filled only sterile, or in this one for the treatment of the material to be filled stocked active ingredient, and this is not evacuated. But it can also be filled in the evacuated interior 10 only or the active ingredients.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Closures For Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
  • Closing Of Containers (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)

Claims (14)

  1. Procédé pour l'assemblage d'un dispositif de réception (1) pour le sang, des liquides corporels, des parties de tissu ou des cultures de tissu, ledit dispositif de réception (1) étant formé par un dispositif d'obturation (9), constitué d'un capuchon (20), ainsi que d'un dispositif d'étanchéité (21), inséré dans ce dernier avant le vissage et réalisé dans un matériau apte à être transpercé, hautement élastique et auto-refermable, et par un récipient (5) sensiblement cylindrique, entourant un volume intérieur (10) et muni d'une extrémité (6, 7) ouverte, sachant que pendant le processus d'assemblage, une face frontale (19) ouverte du récipient (5) est enserrée par le dessus par une paroi latérale (23) du capuchon (20) avec sa zone d'extrémité (39) ouverte et orientée vers le récipient (5) et, en outre, une surface d'étanchéité (33) du dispositif d'étanchéité (21) est insérée dans la zone ouverte du volume intérieur (10) du récipient (5), un système fileté (40) avec des pas de vis (42, 43) coopérant entre eux étant prévu entre le capuchon (20) et le récipient (5) et un mouvement relatif de rotation ou de pivotement autour d'un axe longitudinal (14) commun étant effectué, en vue de l'assemblage, entre le dispositif d'obturation (9) et le récipient (5), caractérisé en ce que simultanément plusieurs dispositifs d'obturation (9) sont amenés, conjointement avec les récipients (5) à assembler, dans un dispositif de montage (46) commun pour former les dispositifs de réception (1), à la suite de quoi, avant l'assemblage des pièces (5, 9) à assembler, les volumes intérieurs (10) des récipients (5) sont abaissés à une pression plus faible que le pression atmosphérique, et, pour les processus d'assemblage, respectivement l'une des pièces (5, 9) à assembler est mise en appui sur un palier de pression (47) du dispositif de montage (46) de manière à pouvoir tourner autour de son axe longitudinal (14), sachant qu'une force de pression (F), orientée sensiblement dans la direction de l'axe longitudinal (14), est exercée par le dispositif de montage (46) sur au moins l'une des pièces (5, 9) à assembler, et dans ce cas, sous l'effet des pas de vis (42, 43) coopérant entre eux, la force de pression (F) pour générer le mouvement relatif est transformée en un mouvement relatif de rotation ou de pivotement autour de l'axe longitudinal (14) commun et, pendant le mouvement relatif de rotation et de pivotement, les pas de vis (42, 43) du système fileté (40) engrènent l'un dans l'autre sur toute la longueur de la distance de vissage jusqu'à ce que la position totalement vissée soit atteinte.
  2. Procédé selon la revendication 1, caractérisé en ce que la force de pression (F) est exercée sur le capuchon (20) du dispositif d'obturation (9).
  3. Procédé selon la revendication 1 ou 2, caractérisé en ce que pendant l'application de la force de pression (F), le capuchon (20) est maintenu immobile par rapport au récipient (5) et le récipient (5) est amené à effectuer le mouvement relatif de rotation ou de pivotement.
  4. Procédé selon la revendication 1 ou 2, caractérisé en ce que pendant l'application de la force de pression (F), le récipient (5) est maintenu immobile par rapport au capuchon (20).
  5. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que le mouvement relatif de rotation ou de pivotement est induit par la force de pression (F) avec une valeur entre 10 N et 50 N.
  6. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que, avant l'application de la force de pression (F), l'une des pièces (5, 20) à assembler par rapport à l'autre des pièces (20, 5) à assembler est pré-positionnée par rapport à celle-ci par une rotation libre autour de l'axe longitudinal (14) commun.
  7. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que, avant l'assemblage, un revêtement est appliqué sur au moins une des pièces (9, 5) formant le dispositif de réception (1).
  8. Procédé selon la revendication 7, caractérisé en ce que le revêtement est appliqué au moins par zones dans une zone d'un dispositif de couplage (37) entre le capuchon (20) et le récipient (5).
  9. Procédé selon la revendication 7 ou 8, caractérisé en ce que le revêtement est appliqué sur la partie du système fileté (40), formée sur le récipient (5).
  10. Procédé selon l'une quelconque des revendications 7 à 9, caractérisé en ce que le revêtement est appliqué sur la partie du système fileté (40), formée dans le capuchon (20).
  11. Procédé selon l'une quelconque des revendications 7 à 10, caractérisé en ce que le revêtement est appliqué sur la surface d'étanchéité (33), orientée vers le récipient (5), d'un bouchon (48) du dispositif d'étanchéité (21).
  12. Procédé selon l'une quelconque des revendications 7 à 11, caractérisé en ce que le revêtement est appliqué sur une surface intérieure (18) du récipient (5), orientée vers la surface d'étanchéité (33) du bouchon (48) du dispositif d'étanchéité (21).
  13. Procédé selon l'une quelconque des revendications 7 à 12, caractérisé en ce que le revêtement est appliqué en continu ou sans interruption dans la zone de revêtement respective.
  14. Procédé selon l'une quelconque des revendications 7 à 13, caractérisé en ce que le frottement, généré pendant le processus d'assemblage, entre les pièces à assembler est diminué par le revêtement.
EP05700005A 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient Active EP1711412B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10189757A EP2277625A1 (fr) 2004-01-23 2005-01-14 Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus

Applications Claiming Priority (2)

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AT0008004A AT500459B1 (de) 2004-01-23 2004-01-23 Verfahren zum zusammenbau einer kappe mit einem aufnahmebehälter
PCT/AT2005/000004 WO2005070781A2 (fr) 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient

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EP1711412A2 EP1711412A2 (fr) 2006-10-18
EP1711412B1 true EP1711412B1 (fr) 2010-11-17

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EP05700005A Active EP1711412B1 (fr) 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient

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US (1) US8448800B2 (fr)
EP (2) EP2277625A1 (fr)
KR (1) KR101146711B1 (fr)
CN (1) CN1997455B (fr)
AT (2) AT500459B1 (fr)
AU (2) AU2005206216B2 (fr)
BE (1) BE1016618A5 (fr)
BR (1) BRPI0506975B8 (fr)
DE (1) DE502005010549D1 (fr)
FR (1) FR2865457A1 (fr)
RU (1) RU2336948C2 (fr)
WO (1) WO2005070781A2 (fr)

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Publication number Priority date Publication date Assignee Title
WO2015051389A1 (fr) 2013-10-11 2015-04-16 Greiner Bio-One Gmbh Module de prélèvement, en particulier d'échantillons sanguins
US10004444B2 (en) 2013-10-11 2018-06-26 Greiner Bio-One Gmbh Collection assembly, in particular for blood samples
US10618049B2 (en) 2015-05-04 2020-04-14 Greiner Bio-One Gmbh Sampling assembly, in particular for collecting a relatively small quantity
US11305286B2 (en) 2017-05-02 2022-04-19 Greiner Bio-One Gmbh Collection assembly or test tube for a small amount of a body fluid, comprising an extender element
WO2020012252A1 (fr) * 2018-07-11 2020-01-16 Agrawal Parth Rajeshkumar Appareil de collecte d'échantillons et procédé d'assemblage automatisé de celui-ci

Also Published As

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RU2006130370A (ru) 2008-02-27
AU2005206216A1 (en) 2005-08-04
BRPI0506975A (pt) 2007-07-03
WO2005070781A8 (fr) 2005-11-24
DE502005010549D1 (de) 2010-12-30
CN1997455B (zh) 2011-07-20
RU2336948C2 (ru) 2008-10-27
KR101146711B1 (ko) 2012-05-17
BE1016618A5 (fr) 2007-03-06
KR20070004645A (ko) 2007-01-09
AU2010202765A1 (en) 2010-07-22
EP1711412A2 (fr) 2006-10-18
WO2005070781A2 (fr) 2005-08-04
BRPI0506975B8 (pt) 2017-11-14
AT500459B1 (de) 2010-08-15
BRPI0506975B1 (pt) 2017-06-27
US20080223815A1 (en) 2008-09-18
EP2277625A1 (fr) 2011-01-26
WO2005070781A3 (fr) 2006-10-12
AU2005206216B2 (en) 2010-04-01
CN1997455A (zh) 2007-07-11
ATE488445T1 (de) 2010-12-15
AT500459A1 (de) 2006-01-15
FR2865457A1 (fr) 2005-07-29
AU2010202765B2 (en) 2012-06-28
US8448800B2 (en) 2013-05-28

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