EP1613259B1 - Ampulle - Google Patents

Ampulle Download PDF

Info

Publication number
EP1613259B1
EP1613259B1 EP20040704206 EP04704206A EP1613259B1 EP 1613259 B1 EP1613259 B1 EP 1613259B1 EP 20040704206 EP20040704206 EP 20040704206 EP 04704206 A EP04704206 A EP 04704206A EP 1613259 B1 EP1613259 B1 EP 1613259B1
Authority
EP
European Patent Office
Prior art keywords
ampoule
annular channel
neck
neck part
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20040704206
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1613259A1 (de
Inventor
Bernd Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1613259A1 publication Critical patent/EP1613259A1/de
Application granted granted Critical
Publication of EP1613259B1 publication Critical patent/EP1613259B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/902—Vent

Definitions

  • the invention relates to an ampoule made of plastic, comprising a container part for receiving a predeterminable fluid, such as a pharmaceutical liquid, a neck portion, which is substantially cylindrical, adjoining an upper side of the container part, a neck opening for removing fluid from the container part and at least one Has channel-like entry point for air in the interior of the container part.
  • a predeterminable fluid such as a pharmaceutical liquid
  • a neck portion which is substantially cylindrical, adjoining an upper side of the container part, a neck opening for removing fluid from the container part and at least one Has channel-like entry point for air in the interior of the container part.
  • a dimensionally stable ampoule of plastic for a fluid which can be removed from the ampoule by means of a syringe body having at its end to be inserted into the ampoule neck a sampling neck in the manner of a cone, wherein the inner wall of the ampoule neck in the for the Appendix of the cone certain area is provided with a passage of liquid between the conical wall and the inner wall of the ampoule neck preventing sealing zone, which results in an investment along a circular line.
  • the free end of the neck of the ampoule is formed as a contact surface for a cone-bearing end face of the syringe body and in the longitudinal direction of the neck has a distance from the sealing zone, so that upon contact of the end face of the syringe body to the contact surface of the Neck, the contact pressure of the cone is limited to the inner wall of the neck to a value which, while maintaining the barrier for the passage of liquid ensures an entry of air between the conical wall and the inner wall of the neck, In a normal mounting of the syringe on the syringe plunger by hand, a smooth liquid removal is possible, even if the ampoule for the removal process as usual is upside down, so their neck part facing down.
  • US 5,716,346 discloses a method of transferring injectable fluids from a supply vial to a syringe or cannula, the syringe being provided with a first coupling member and an opening having an inner cylindrical cavity the syringe (Luer-Lock system) is connected such that liquid flows past the first coupling element and through the opening into the cylindrical cavity and the syringe or cannula fills, in such a liquid-tight locked connection is made and the ampoule is accordingly with elastic walls to be provided, which collapse under the negative pressure during the removal process by means of the syringe or cannula body and thus ensure the removal process.
  • the syringe being provided with a first coupling member and an opening having an inner cylindrical cavity the syringe (Luer-Lock system) is connected such that liquid flows past the first coupling element and through the opening into the cylindrical cavity and the syringe or cannula fills, in such a liquid-tight locked connection is made
  • the pertinent airtight removal method to be carried out with the known device can thus not be transferred to rigid ampoules and due to the "collapsible ampoules walls" within the ampoule to a negative pressure with the result that the removal process by means of the syringe, the content back into the ampule inevitably is sucked back.
  • US-A-3 630 199 is a kind of set with a generic ampoule known, consisting of a container part made of plastic for receiving a predetermined amount of fluid to which a cannula body in the form of a Aufziehspritze is connected in the initial state of the set, which receives a further fluid in a predeterminable amount.
  • Said set consisting of container part and cannula body, serves for at least partial mixing of the quantities of fluid stored so far together with subsequent delivery of the mixed fluid quantity via the cannula or syringe body.
  • a connecting body with an external thread is mounted, which remains on removal of the cannula body from the set arrangement thereon.
  • the external thread of the connecting part engages in an internal thread of the container part in the region of its free open end form-fitting and distance-free one, wherein the container part to the outside has no separable via a separation head part, so as to release in the region of the neck after removal of the head part neck opening for the removal of the container contents can.
  • a ventilation of the interior of the container part is provided, via at least one radially introduced ventilation opening in the container wall.
  • the present invention seeks to further improve the generic type ampoule solution mentioned above, that a safe storage possibility of fluid in ampoule bodies is created and beyond the same at each removal rate by means of the syringe or cannula body reaches a secure filling is.
  • a pertinent object solves an ampoule with the features of claim 1 in its entirety.
  • the invention further comprises a removal device, comprising an ampoule according to the invention and a cannula body with a substantially cylindrically shaped fixing part for fixing on the neck part of the ampoule.
  • a removal device comprising an ampoule according to the invention and a cannula body with a substantially cylindrically shaped fixing part for fixing on the neck part of the ampoule.
  • the respective annular channel is arranged helically on the neck part via a predeterminable threaded section.
  • the helical annular channel on an inlet and a discharge point, so that in such a way only conical extraction nozzle according to the content of DE 39 16 840 C2 on the ampoule, which relates to a Luer-Lock connection, as defined in ISO standard 594/1 First edition of 15 June 1986.
  • ampoule but also connections of syringe bodies and cannulas can be defined, as described in the ISO standard 594/2 First edition of May 1, 1991 under Part 2 Lock fittings.
  • the respective annular channel with its groove-shaped recess is at least partially interrupted by longitudinal webs which lie in the shaping plane of the container part.
  • the ampoule according to the invention is on the outer peripheral side of the neck portion and outside the respective Ring channel arranged a stop member as over-rotation protection.
  • fittings according to Part 2 of said ISO standard can then be safely determined in such a way to the ampoule with her neck part and remove after the removal process also without inhibition by twisting off the neck part.
  • the Fig.1 shows the upper part of a dimensionally stable ampoule made of plastic blow-molding process, which contains a removable by means of a syringe or a cannula pharmaceutical liquid.
  • the container part 12 of a pertinent ampoule for example, completely in the Fig.1 and 2 of the DE 39 16 840 C2 shown.
  • a substantially cylindrically shaped neck portion 14 which may be provided to its free side and conical with a slight inclination (not shown).
  • the neck portion 14 of the ampoule is followed by a head piece 16 formed integrally therewith; which in turn is formed integrally with an integrally formed toggle part 18.
  • the neck portion 14, the head portion 16 and the Knebeiteil 18 are formed in a known manner following the filling of the container part 12, wherein simultaneously with the mold, the container part 12 is closed sterile with its container contents in the form of the fluid.
  • a Halsteilöff opening 20 see. Fig.2
  • a separation point 22 is formed between the neck portion 14 and head portion 16, wherein the neck portion 14 and the head portion 16 tapers conically on their sides facing each other to form the separation point 22. If the toggle part 18 is rotated by hand relative to the container part 12, the head part 16 shears off the neck part 14 at the separation point 22, and the neck part opening 20 is then released for a fluid removal process.
  • the neck portion 14 is provided with a generally designated 24 channel-like entry point for air for their supply into the interior 26 of the container part 12.
  • the said entry point 24 for air consists of two annular channels 28,30, wherein the annular channel 28 is arranged on the outer peripheral side of the neck portion 14 and the further annular channel 30 on the inner circumference (see. Fig.2 ).
  • the respective annular channel 28,30 is arranged helically in the manner of a screw thread over a predetermined threaded distance on the neck portion 14.
  • the respective helical annular channel 28, 30 has an inlet point 32 and an outlet point 34.
  • the profile shape of the respective annular channel 28,30 is trapezoidal and the single-thread allows full rotation of the screw about 360 °.
  • a stop member 36 as over-rotation protection for the syringe or cannula body to be screwed.
  • Corresponding stop members may also be provided with respect to the inner annular channel 30 on the inside of the neck portion 14 in order to form an over-rotation protection on the inside circumference.
  • the respective outer annular channel 28 is interrupted with its groove-shaped recess via two longitudinal webs 38 which form the extension of form webs 40 on the neck portion 14 diametrically opposite each other, which form the parting plane arranged in the same plane on the container part 12, at which the mold halves one not closer shown form of the blow molding machine abut, which serves to produce the ampoule.
  • the annular channel 28 and thus also the neck portion 14 can be stiffened, so that even with a high Aufschraubmoment the thread is maintained.
  • the thread, formed by the respective annular channel 28,30, can be from his screw-in specify and in the embodiment of the Figure 3 is approximately in the middle of the neck portion 14 a shortened in the circumferential direction thread visible in the direction of the Figure 3 seen overlying stop member 36 as overspeed protection.
  • the Figure 4 shows now the front end of a cannula body 42 according to the ISO standard 594-2 first edition of May 1, 1991, part 2.
  • the pertinent cannula body 42 has at its free end a fixing part 44 with an internal thread 46 and the center is the fixing part 44th penetrated by a removal opening 48, the front end with a predetermined projection, the free abutment end 50 of the fixing member 44 engages over and otherwise the removal opening 48 is provided with a central channel 52, which allows the liquid removal from the ampoule 10 via the neck opening 20, if not shown in detail Piston part of the cannula body 42 is pulled from its front to its rear position.
  • the neck part 14 is released with its adhesive part opening 20.
  • the internal thread 46 of the fixing part 44 of the cannula body 42 can then be screwed for a removal operation in a clockwise direction on the helical annular channel 28 on the outer circumference of the neck portion 14 of the ampoule. The screwing takes place until either the free end stop 50 comes into abutment with the top 54 of the container part 12, which tapers slightly conically, and / or until a part of the internal thread 46 abuts the stopper part 36 of the neck part 14 limiting and so the screwing movement stops.
  • the stop end 50 is designed in the manner of a planar stop ring, which extends transversely to the longitudinal axis 56 of the cannula body 52 and ampoule, a gap results through the air into the annular channel 28 of the neck portion 14 flows in and passes due to the generously sized cross-sectional shape in the manner of a trapezoidal thread profile a relatively large amount of air via the inlet point 32 of the annular channel 28 in the peripheral region of the neck portion 20 and from there into the same and into the interior 26 of the container part 12.
  • the pertinent removal process is further promoted if, in the sense of a swirl guide, the amount of air supplied via the annular channel 28 and the neck opening 20 along the inner annular channel 30 into the interior 26 of the container part 12 is conveyed.
  • the groove-shaped threaded recesses of the outer annular channel 28 and the inner annular channel 30 extend in an alternating sequence along the neck portion 14.
  • the outer annular channel 28 is used to serve as a counterpart to the internal thread 46 of the cannula body 42, the free annular channel cross sections are still dimensioned such that substantially unhindered, preferably in the manner of a swirl guide, air from the outside can flow into the interior of the container part 12 for a removal process.
  • the arrangement according to the invention is suitable for such cannula body, which have no internal thread 46 on the fixing part 44, but there have a smooth stop surface (not shown).
  • the ampoule according to the invention can also be used for Luer connections according to ISO 594/1, first edition of June 15, 1986, in which only a conical removal pin is comparable to the removal opening 48 as shown in FIG Figure 4 is exclusively available.
  • a corresponding air guide is then accomplished via the inner annular channel 30 of the neck portion 14.
  • the pertinent extraction device for an ampoule is inexpensive to produce, so that there are no additional costs compared to the other known solutions, but with respect to the known solutions with the ampoule according to the invention a safe and rapid removal process Fluid is reached via a cannula or syringe body.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Saccharide Compounds (AREA)
EP20040704206 2003-04-17 2004-01-22 Ampulle Expired - Lifetime EP1613259B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003117665 DE10317665A1 (de) 2003-04-17 2003-04-17 Ampulle
PCT/EP2004/000473 WO2004091472A1 (de) 2003-04-17 2004-01-22 Ampulle

Publications (2)

Publication Number Publication Date
EP1613259A1 EP1613259A1 (de) 2006-01-11
EP1613259B1 true EP1613259B1 (de) 2011-12-28

Family

ID=33154269

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20040704206 Expired - Lifetime EP1613259B1 (de) 2003-04-17 2004-01-22 Ampulle

Country Status (16)

Country Link
US (1) US7516846B2 (es)
EP (1) EP1613259B1 (es)
JP (1) JP4643562B2 (es)
KR (1) KR101075813B1 (es)
CN (1) CN100431514C (es)
AT (1) ATE538770T1 (es)
AU (1) AU2004229139B2 (es)
BR (1) BRPI0409335B8 (es)
CA (1) CA2520503C (es)
DE (1) DE10317665A1 (es)
ES (1) ES2376754T3 (es)
HK (1) HK1089651A1 (es)
MX (1) MXPA05011143A (es)
PL (1) PL214241B1 (es)
PT (1) PT1613259E (es)
WO (1) WO2004091472A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898812B1 (fr) * 2006-03-24 2008-06-13 Technoflex Sa Connecteur luer, connecteur medical et set de transfert comportant un tel connecteur
US9700710B2 (en) 2006-06-22 2017-07-11 Excelsior Medical Corporation Antiseptic cap equipped syringe
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
GB0623320D0 (en) 2006-11-22 2007-01-03 Breath Ltd Ampoules
CN101455615B (zh) * 2007-12-14 2012-02-29 山东省药用玻璃股份有限公司 色环安瓿
DE102008025012A1 (de) * 2008-05-24 2009-11-26 Tecpharma Licensing Ag Nadeleinheit mit Drehanschlag
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
US20120267335A1 (en) * 2010-10-19 2012-10-25 Chris Cindrich Ampoule with protective sleeve for contamination prevention
US10016587B2 (en) 2011-05-20 2018-07-10 Excelsior Medical Corporation Caps for needleless connectors
US9867975B2 (en) 2011-05-23 2018-01-16 Excelsior Medical Corporation Antiseptic line cap
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
WO2013009998A2 (en) 2011-07-12 2013-01-17 Pursuit Vascular, Inc. Device for delivery of antimicrobial agent into trans-dermal catheter
WO2015036536A1 (de) 2013-09-12 2015-03-19 Fresenius Kabi Deutschland Gmbh Ampulle für eine medizinische flüssigkeit und verfahren zum herstellen einer ampulle
EP3137122B1 (en) 2014-05-02 2019-09-04 Excelsior Medical Corporation Strip package for antiseptic cap
JP6822978B2 (ja) 2015-05-08 2021-01-27 アイシーユー・メディカル・インコーポレーテッド 治療薬のエミッタを受け入れるように構成された医療用コネクタ
CA3040277A1 (en) 2016-10-14 2018-04-19 Icu Medical, Inc. Sanitizing caps for medical connectors
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
DE102017009012A1 (de) * 2017-09-26 2019-03-28 Kocher-Plastik Maschinenbau Gmbh Behälter sowie Verbindungs- und Herstellvorrichtung
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
AU2019384564B2 (en) 2018-11-21 2023-11-23 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
CA3204371A1 (en) 2020-12-07 2022-06-16 Icu Medical, Inc. Peritoneal dialysis caps, systems and methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1938864A1 (de) * 1968-08-01 1970-02-05 Nosco Plastics Injektionsspritze und Verfahren zu deren Herstellung
US3630199A (en) * 1970-05-26 1971-12-28 Louis P Gangarosa Unitized injection system
FR2288455A1 (fr) * 1974-06-28 1976-05-21 Jougla Ets Supports metalliques perfectionnes pour espaliers, utilises en cultures fruitieres
FR2288445A7 (fr) 1974-10-14 1976-05-14 Goiffon Ets Leon Recipient tel que flacon, ampoule ou analogue, pour projection ou injection de produit liquide ou pulverulent
US4055282A (en) * 1976-04-19 1977-10-25 Automatic Liquid Packaging, Inc. Container with one-piece neck and discharge controller
US4176755A (en) * 1979-01-26 1979-12-04 Baxter Travenol Laboratories, Inc. Resealable pour bottle with severing ring
US4405053A (en) * 1981-04-27 1983-09-20 Abbott Laboratories Tamperproof closure system for plastic containers
GB8801655D0 (en) * 1988-01-26 1988-02-24 Waverley Pharma Ltd Ampoules
DE3916840A1 (de) * 1988-09-21 1990-03-29 Bernd Hansen Ampulle
GB9012041D0 (en) * 1990-05-30 1990-07-18 Beeson & Sons Ltd Improvements in or relating to containers
JPH0636939U (ja) * 1992-10-23 1994-05-17 ポップリベット・ファスナー株式会社 アクセルペダル等のためのストッパの取付構造
US5716346A (en) 1993-07-02 1998-02-10 Farris; Barry Method and apparatus for loading syringes without the need for hypodermic needles
GB9316834D0 (en) * 1993-08-13 1993-09-29 Beeson & Sons Ltd Container closure assembly
US6105831A (en) * 1999-07-20 2000-08-22 Finezilber; Gedaliahu Pitcher-style reusable bottle holder
JP4472137B2 (ja) * 2000-09-07 2010-06-02 株式会社アルテ 容器兼用注射器

Also Published As

Publication number Publication date
PL214241B1 (pl) 2013-07-31
BRPI0409335B1 (pt) 2016-02-23
PL377792A1 (pl) 2006-02-20
CN1771018A (zh) 2006-05-10
EP1613259A1 (de) 2006-01-11
ES2376754T3 (es) 2012-03-16
KR20060003883A (ko) 2006-01-11
CA2520503C (en) 2010-09-28
ATE538770T1 (de) 2012-01-15
PT1613259E (pt) 2012-01-12
JP2006523475A (ja) 2006-10-19
BRPI0409335A (pt) 2006-04-25
BRPI0409335B8 (pt) 2021-06-22
US20060163109A1 (en) 2006-07-27
CN100431514C (zh) 2008-11-12
DE10317665A1 (de) 2004-11-11
US7516846B2 (en) 2009-04-14
KR101075813B1 (ko) 2011-10-25
AU2004229139A1 (en) 2004-10-28
AU2004229139B2 (en) 2009-10-08
WO2004091472A1 (de) 2004-10-28
HK1089651A1 (en) 2006-12-08
JP4643562B2 (ja) 2011-03-02
MXPA05011143A (es) 2006-01-24
CA2520503A1 (en) 2004-10-28

Similar Documents

Publication Publication Date Title
EP1613259B1 (de) Ampulle
DE69623268T2 (de) Vorgefüllte spritze zur verabreichung von medikamenten
DE68905752T2 (de) Zum Ändern der Zusammensetzung einer Flüssigkeit bestimmte Verpackung.
EP0312725B1 (de) Tropferflasche und Verfahren zu ihrer Herstellung
DE69515885T2 (de) Behälter für pharmazeutische Produkte mit zwei gesonderten Komponenten, mit Mitteln zu deren Mischung und dosierter Ausgabe sowie Verfahren zum Zusammenstellen des Behälters
DE4230645C2 (de) Ampulle
DE3916840C2 (es)
DE60012270T2 (de) Vebindungsvorrichtungen für Katheter, Perfusionseinrichtungen oder Flüssigkeitsabsaugsysteme
EP3044104B1 (de) Ampulle für eine medizinische flüssigkeit und verfahren zum herstellen einer ampulle
DE4434644A1 (de) Behältnis zur Lagerung und Verabreichung von Injektions-, Infusions- und Diagnostikpräparaten
DE102007007474B3 (de) Behältnis
CH692194A5 (de) Verpackung.
DE2922706A1 (de) Vorrichtung zur vorbereitungsfreien herstellung einer loesung unter sterilen bedingungen
DE69504649T2 (de) Injektionsspritze
EP2155140B1 (de) Durchstossvorrichtung und verfahren zum entnehmen einer flüssigkeit aus einem beutel oder zuführen einer substanz in einen beutel
EP3687474A1 (de) Behälter sowie verbindungs- und herstellvorrichtung
EP3638357B1 (de) Spritze mit luer-lock-anschluss
DE2200007A1 (de) Vorrichtung zur Verabreichung eines medizinischen Mittels durch den Anus
DE69218727T2 (de) Medikamentenbehälter
DE69030117T2 (de) Behälter für einheitsdosis
DE102009040016A1 (de) Vorrichtung zur Applikation von fluidalen Medikamenten
EP1064961A1 (de) Spritze für medizinische Zwecke
DE60118840T2 (de) Verfahren zur Herstellung eines zylinderförmigen Fläschchenbehälters mit konischem Boden
DE2149550A1 (de) Vorrichtung zum eingiessen von fluessigkeiten in koerperhoehlen oder gefaesse oder zum ansaugen von fluessigkeiten aus solchen
DE69110375T2 (de) Spender mit abnehmbarer einteiliger verschlusskappe sowie übergreifender schraubkappe.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050628

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20081219

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER & PEDRAZZINI AG

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20111229

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 538770

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120115

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502004013186

Country of ref document: DE

Effective date: 20120223

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2376754

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20120316

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20120400632

Country of ref document: GR

Effective date: 20120417

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20111228

REG Reference to a national code

Ref country code: SK

Ref legal event code: T3

Ref document number: E 11267

Country of ref document: SK

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20111228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20111228

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120328

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20111228

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20111228

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20121001

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502004013186

Country of ref document: DE

Effective date: 20121001

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120122

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20040122

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SK

Payment date: 20191120

Year of fee payment: 17

Ref country code: PT

Payment date: 20191113

Year of fee payment: 17

Ref country code: IE

Payment date: 20191203

Year of fee payment: 17

Ref country code: CZ

Payment date: 20191120

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20191122

Year of fee payment: 17

Ref country code: GR

Payment date: 20191113

Year of fee payment: 17

Ref country code: BE

Payment date: 20191212

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20200113

Year of fee payment: 17

Ref country code: NL

Payment date: 20200129

Year of fee payment: 17

Ref country code: DE

Payment date: 20200131

Year of fee payment: 17

Ref country code: AT

Payment date: 20200122

Year of fee payment: 17

Ref country code: FI

Payment date: 20200107

Year of fee payment: 17

Ref country code: ES

Payment date: 20200203

Year of fee payment: 17

Ref country code: SE

Payment date: 20200122

Year of fee payment: 17

Ref country code: GB

Payment date: 20191114

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20200113

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20200116

Year of fee payment: 17

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502004013186

Country of ref document: DE

REG Reference to a national code

Ref country code: FI

Ref legal event code: MAE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20210201

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 538770

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210122

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20210122

REG Reference to a national code

Ref country code: SK

Ref legal event code: MM4A

Ref document number: E 11267

Country of ref document: SK

Effective date: 20210122

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20210131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210201

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

Ref country code: CZ

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210805

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210131

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210123

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210722

Ref country code: SK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210131

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210803

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210123

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210122