EP1594761B1 - Primärverpackung als applikator - Google Patents

Primärverpackung als applikator Download PDF

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Publication number
EP1594761B1
EP1594761B1 EP04706135.3A EP04706135A EP1594761B1 EP 1594761 B1 EP1594761 B1 EP 1594761B1 EP 04706135 A EP04706135 A EP 04706135A EP 1594761 B1 EP1594761 B1 EP 1594761B1
Authority
EP
European Patent Office
Prior art keywords
foil
joining
zone
film
joining zone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP04706135.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1594761A1 (de
Inventor
Christian Falkenhausen Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP1594761A1 publication Critical patent/EP1594761A1/de
Application granted granted Critical
Publication of EP1594761B1 publication Critical patent/EP1594761B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5855Peelable seals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture

Definitions

  • the invention relates to a film bag comprising at least one carrier film and at least one cover film, wherein between the carrier film and the cover film, so the adherends, a film or sheet-like, active ingredient-containing product gas and moisture sealed - surrounded by a closed, strip-shaped joining zone - is included, wherein the strength of the joint in the joint zone is less than the strength of the joint parts, wherein at least one joining zone section, which is not arranged transversely to the tear-peeling direction and lies laterally next to the product, narrows at least in sections transversely to the tear-peeling direction, wherein at least the first quarter of the non-transverse to Aufr GmbHCulraum Fügezonenabitess has no narrowing.
  • Such a film bag is for example off Patent abstracts of Japan vol. 2000, no. 15, 6 April 2011 (2001-04-06 ) - & JP 2000, 335574, A , (Fujimori Kogyo co Itd), December 5, 2000 (2000-12-05).
  • Such a film bag is known as primary packaging.
  • This foil bag also serves to store foil or sheet-like products.
  • the film bags are stored stacked in a secondary packaging.
  • the provision of the foil or sheet-like products takes place via a hand-operated mechanism integrated in the secondary packaging. If one were to open a single film bag simply by tearing it open - ie without the aid of the secondary packaging - the packaged product would largely uncontrollably detach from the parts of the film bag. As a result, it would then be necessary to grasp the product by gripping it in order to subsequently apply it to the respective destination.
  • surface pharmaceutical forms such as mucoadhesive systems are applied to a tissue surface such as the mucosa.
  • the user should avoid direct skin contact with the appropriate drug form, since under certain circumstances, the integrated there, often highly potent agents represent a danger for him.
  • the present invention is therefore based on the problem to develop a film bag for film or sheet-like products, which makes the use of aids such as gloves, tweezers or the like for the application of drug-containing systems superfluous.
  • the joining zone section has one or two inwardly oriented notches.
  • a two-dimensional dosage form or the product is enclosed between two films, wherein the closure-like joining zone between the films is designed, for example, by a peeling movement rupturable.
  • the joining zone has a widening or narrowing or a combination of these width changes in a region located behind the front edge and in front of the rear edge of the packaged dosage form.
  • This change in width represents a disruption during the rupturing peeling motion in the form of an at least short-term change in rupture force requirement. Because of this perturbation, the user recognizes that he or she ripped the package one-third, one-half, or two-thirds, depending on the location of the width change Has.
  • the partially torn-open package will now be attached to the not yet torn portion, e.g. held between thumb and forefinger.
  • the peeled cover film area lies folded back on the untapped packaging part region.
  • the thumb presses him against the still closed packaging section.
  • the film bag With the exposed product area in advance, the film bag is brought to the point of the recipient to be applied. After a first contact with this point, the foil bag is pressed.
  • the index finger tip presses the exposed product area against the application site via the substantially uncut carrier film. Due to the immediate adhesion of the product at this point, the product remains at the intended location when the film bag that is being emptied is removed.
  • the cover sheet can be completely removed before the now torn over the entire length of the film bag is removed.
  • FIG. 10 shows a film pocket according to the invention with a joining zone with at least one inner notch.
  • the Figures 1 and 2 show a foil bag (10) with an inserted foil or sheet-like product (1).
  • the latter is, for example, a film which may contain a pharmaceutically active substance, eg a selective analgesic.
  • the film bag (10) is also referred to as primary packaging.
  • the film bag (10) consists for example of two films, between which the film-like product (1) is inserted over the entire surface.
  • the two foils (11, 12) are glued, sealed, welded or the like at a small distance from the edges of the film.
  • the film (1) is therefore in a gas and moisture-proof cavity.
  • the foils (11, 12) are connected to one another only by way of example by means of an applied adhesive (13).
  • the materials from which the film bag parts are made are, for example, polyethylene (PE), polyethylene terephthalate (PET), fluorinated hydrocarbons such as Aclar, polypropylene (PP), OPA, polyacrylate (PA), EVOH, ethylene vinyl acetate copolymers (EVA), EC, Barex, Surlyn, paper, aluminum and related combinations of these substances. These and similar substances are u.a. used for sealed bags and blister packs.
  • the films may be at least partially transparent.
  • the films (11) or (12) can also be constructed in each case as composite materials from two or more layers of the materials mentioned and, if appropriate, further materials.
  • the carrier film (11) is a substantially rectangular film whose length corresponds to, for example, twice its width. In the Figures 2-11 the support film (11) is widened on both sides by approximately the width of the adhesive strip. On the carrier film (11), the film (1) is placed. Around the film (1) around the carrier film (11) is printed eg strip-shaped with adhesive (13). The adhesive (13) does not come into contact with the film (1). On the film (1) and the adhesive (13) is the cover sheet (12) - in FIG. 2 shown in dashed lines - laid down firmly. The strength of the connection in the joining zone (30) is always smaller than the strength of the joining parts (11, 12), so that the film pocket (10) tears exclusively controllable along the joining zone (30) during opening.
  • the cover film (12) here has the same width dimensions as the carrier film (11). However, it is shorter. Your For example, semi-elliptical leading edge (27) is offset to the rear, for example, by a few millimeters. Between the front edge (27) and the front portion (31) of the adhesive (13) is about a third of the length of a gap space (21), see. FIG. 1 , In this area, the films (11, 12) do not adhere to each other.
  • the primary packaging may also consist of films which have a recess in the contact area with the filling (1). Even a depression in only one of the slides is conceivable.
  • the corresponding foil is designed as a deep-drawn blister base. In both cases, then the edge regions of the films are in spite of the inserted product (1) over the entire surface on each other, so that the height of the gap space (21) is almost infinitely small.
  • the carrier film (11) and the cover film (12) consist of a strip which is folded together during packaging of the product (1) such that a sealing or bonding takes place at the rear film edge.
  • the film bag (10) in the plan view also have a polygonal, round, elliptical, oval or any other conceivable contour, provided that it is suitable for separating the films (11, 12) by a Aufr composerClamba.
  • the joining zone (30) is broadened at least in regions.
  • the Figures 2-8 show different ways of broadening.
  • a joining zone (30) is shown in plan view. It encloses - as well as the joining zones of the others Figures 3-11 completely the product.
  • the joining zone (30) here consists of a front (31), a rear (32) and four lateral joining zone sections (33, 34, 43, 44).
  • the sections (33, 34, 43, 44) are here parallel to the AufrönClraum (9), while the sections (31) and (32) extend transversely to this direction.
  • the sections (31-33, 43) have a constant width of, for example, about 3 mm. Depending on the size and type of film pocket and the type of connection between the films (11, 12), the width can vary between 1 and 10 mm.
  • the sections (34) and (44) have after FIG. 2 compared to the sections (31-33, 43) twice the width.
  • the joining zone (30) in the central region (29) at the spacers (35) and (45) changes the width on both sides.
  • the required tearing force in the example shown abruptly to at least twice the value.
  • the required tearing force at the given geometrical dimensions is about 0.4 N.
  • This value increases in sections (34) and (44), for example to 1.4 N. This change in force is peeling off when opened manually Separation of the films (11, 12) clearly felt or felt.
  • the joining zone can also be double-sealed in order to increase the tearing force, ie, for example, a partial area of the joining zone is sealed twice or more times.
  • a partial area of the joining zone is sealed twice or more times.
  • the broadening of the sections (34) and (44) extends transversely to the tear direction (9) to the outside.
  • the chamfer (46) widening towards the end of the film bag (10) includes a 60 ° angle with the tear-open direction (9). Possibly.
  • the outer transition may be staircase-shaped to achieve a stepped increase in the required tearing force.
  • FIGS. 3 and 4 show film pockets (10) with joining zones (30), which have over their entire extent an at least almost constant average width (DB).
  • DB average width
  • the length (L) corresponds to the average width of the joining zone (30).
  • the double bend (35) is designed so that the section (34) is offset from the section (33) by the average width (DB). This offset can also between half and three times the average width (DB).
  • FIG. 5 a joining zone (30) is shown, whose double bend (36) has a length (L) which is greater than the average width (DB).
  • the length (L) corresponds to twice the average width (DB).
  • the Figures 6-11 show joining zones (30), which surrounds the product (1) - without double angulation (35) - as a substantially rectangular frame in the embodiment.
  • To FIG. 6 is the joining zone (30) in the central region (29), cf. FIG. 2 , widened between sections (33, 34).
  • the broadening (37) projects, for example, at a right angle and web-shaped outwards over the outer edge of the sections (33, 34).
  • the supernatant here corresponds, for example, the average width (DB).
  • the broadening (37) can also extend inwards towards the product.
  • the broadening can also extend on both sides of the edges of the sections (33, 34), for example like a circular broadening located in the middle (29) in the region (29), whose diameter corresponds, for example, to twice the average width (DB).
  • the widenings are designed as additional joining zones (38) and (39).
  • the toasthegezone (38) for example, a circular area with a diameter corresponding to the average width (DB). She is in middle area (29), cf. FIG. 2 , arranged outside the joining zone (30).
  • the minimum distance between the joining zone (30) and the circular additional joining surface (38) is one fifth of the average width (DB).
  • the sum of the widths (B1) and (B2) represents the total broadening.
  • the toasthegezone (38, 39) can be prepared by a different method than the regular joint zone (30).
  • a plurality of equal or non-uniform additional joining zones (40) can also be arranged, see FIG. 7 , There is shown as a further archhed, unshaded circle (40).
  • a dashed, unshaded circle 40.
  • the gap (48) has, for example, a minimum length which corresponds to half the average width (DB).
  • FIG. 8 shows as forme tannin (39) an adhesive or sealing strip, for example, as a so-called double seal parallel to the section (34) is oriented.
  • the distance between the section (34) and the additional joining zone (39) is one fifth of the average width (DB).
  • DB average width
  • the Figures 9-11 show joining zones (30), in which the conscious disturbance during the tearing process is caused by a reduction of the joining zone width.
  • the narrowing is generated by a notch (55).
  • the notch (55) which protrudes into the joining zone (30) from the outside, has, for example, an approximately semicircular groove bottom and two flanks leading away from the notch base in a V-shape.
  • the joining zone (30) is reduced, for example, to one quarter of the average width (DB).
  • an inwardly oriented notch (56) in the illustrated area has straight flanks which are oriented transversely to the tear direction (9).
  • a joining zone (30) is shown in which the narrowing is produced by a recess (58).
  • the recess (58) for example, has the shape of a slot, has a length corresponding to, for example, the average width (DB).
  • the width of the slot is chosen so that the local residual width of the joint zone (30) is about 50% of the average width.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packaging Of Annular Or Rod-Shaped Articles, Wearing Apparel, Cassettes, Or The Like (AREA)
  • Bag Frames (AREA)
EP04706135.3A 2003-02-22 2004-01-29 Primärverpackung als applikator Expired - Lifetime EP1594761B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10307583A DE10307583A1 (de) 2003-02-22 2003-02-22 Primärverpackung als Applikator
DE10307583 2003-02-22
PCT/EP2004/000767 WO2004074131A1 (de) 2003-02-22 2004-01-29 Primärverpackung als applikator

Publications (2)

Publication Number Publication Date
EP1594761A1 EP1594761A1 (de) 2005-11-16
EP1594761B1 true EP1594761B1 (de) 2015-04-08

Family

ID=32841804

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04706135.3A Expired - Lifetime EP1594761B1 (de) 2003-02-22 2004-01-29 Primärverpackung als applikator

Country Status (13)

Country Link
US (1) US7594908B2 (zh)
EP (1) EP1594761B1 (zh)
JP (1) JP4292200B2 (zh)
KR (1) KR101029401B1 (zh)
CN (1) CN1750978B (zh)
AU (1) AU2004213109B2 (zh)
BR (1) BRPI0407439A (zh)
CA (1) CA2513582C (zh)
DE (1) DE10307583A1 (zh)
ES (1) ES2534722T3 (zh)
MX (1) MXPA05008858A (zh)
WO (1) WO2004074131A1 (zh)
ZA (1) ZA200505697B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004047445B4 (de) 2004-09-30 2007-05-31 Lts Lohmann Therapie-Systeme Ag Nichtwiederverschließbare Verpackung für gesundheitsgefährdende Erzeugnisse, Verwendung der Verpackung, sowie Verfahren zu deren Herstellung
DE102004047447B4 (de) 2004-09-30 2008-01-03 Lts Lohmann Therapie-Systeme Ag Peelfähige, kindesichere Verpackung für flache, biegsame Objekte, Verwendung dieser Verpackungen und Verfahren zum Verpacken von flachen, biegsamen Objekten
US8622206B2 (en) * 2006-09-08 2014-01-07 The Procter & Gamble Company Peel-to-open packages
RU2503603C2 (ru) * 2008-09-08 2014-01-10 Лтс Ломанн Терапи-Зюстеме Аг Недоступная для открывания детьми индивидуальная упаковка для чрескожных терапевтических систем или лекарственных форм пленочного и пластинчатого типа
JP5260697B2 (ja) * 2011-03-11 2013-08-14 池田機械産業株式会社 四方シール包装体の製造装置
CN105143061B (zh) * 2013-03-26 2017-11-03 京洛株式会社 包装袋
JP6033720B2 (ja) * 2013-03-26 2016-11-30 キョーラク株式会社 包装袋及びその製造方法
US20190099234A1 (en) * 2017-10-03 2019-04-04 Depuy Ireland Unlimited Company Packaged article
JP7256023B2 (ja) * 2019-02-06 2023-04-11 朝日インテック株式会社 包装体

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US2998880A (en) * 1958-06-19 1961-09-05 Bard Parker Company Inc Sterile surgical instrument and assembly
US2997770A (en) 1958-09-29 1961-08-29 Charles R Beltz Method for manufacture of an encasement structure
US3342326A (en) * 1965-10-22 1967-09-19 Johnson & Johnson Sterile flexible package
US3507087A (en) * 1969-02-24 1970-04-21 Pratt Mfg Corp Article-separating packages for flat articles such as surgical supplies
US4150744A (en) * 1976-02-27 1979-04-24 Smith & Nephew Pharmaceuticals Ltd. Packaging
JPS61196961U (zh) * 1985-05-31 1986-12-09
DE3611935A1 (de) * 1986-04-09 1987-10-22 Dixie Union Verpackungen Gmbh Verpackung fuer chirurgische instrumente
IL91560A0 (en) * 1988-10-04 1990-04-29 Roussel Uclaf Package
US5389686A (en) * 1989-02-20 1995-02-14 Jouveinal Sa Analgesic properties of fedotozine
JPH03111267A (ja) * 1989-09-27 1991-05-13 Terumo Corp 包装体
CN2145019Y (zh) * 1992-12-30 1993-11-03 陈哲 一次性外用药品袋
GB2281274B (en) * 1993-08-31 1997-04-09 Johnson & Johnson Medical Wound dressing package
DE4412754C2 (de) * 1994-04-13 1999-09-30 Via Log Medikalprodukte Gmbh K Verpackung eines medizinischen Instruments
FR2750399B1 (fr) * 1996-06-28 1998-08-14 Instr Medecine Veterinaire Sachet de conditionnement de substances liquides a ouverture pelable pour introduction de canules, tubes et sondes
BE1011681A5 (fr) * 1997-06-10 1999-12-07 Techy Int Sa Emballage et procede d'emballage.
DE19817206B4 (de) * 1998-04-17 2004-10-21 Schleicher & Schuell Gmbh Schutzverpackung für sterile Artikel und Verwendung einer solchen Schutzverpackung
US6568533B1 (en) * 1998-06-16 2003-05-27 Takeda Chemical Industries, Ltd. Peelable package and peelable packaging method
JP2000272659A (ja) * 1998-12-15 2000-10-03 Takeda Chem Ind Ltd ピール性包装体及びピール性包装方法
JP4022022B2 (ja) * 1999-05-28 2007-12-12 オリンパス株式会社 内視鏡用クリップ包装体およびその包装箱
JP4577700B2 (ja) 1999-05-28 2010-11-10 藤森工業株式会社 包装体
DE10159746B4 (de) 2001-12-05 2006-05-18 Lts Lohmann Therapie-Systeme Ag Spendevorrichtung für flächenförmige Darreichungsformen
US7329240B2 (en) * 2003-01-02 2008-02-12 Meridian Medical Technologies, Inc. Protective packaging for medicament dispenser

Also Published As

Publication number Publication date
CN1750978A (zh) 2006-03-22
EP1594761A1 (de) 2005-11-16
ZA200505697B (en) 2006-05-31
KR101029401B1 (ko) 2011-04-14
MXPA05008858A (es) 2005-10-05
KR20050103948A (ko) 2005-11-01
AU2004213109B2 (en) 2010-01-14
JP2006518313A (ja) 2006-08-10
ES2534722T3 (es) 2015-04-27
WO2004074131A1 (de) 2004-09-02
US7594908B2 (en) 2009-09-29
CA2513582C (en) 2010-10-26
WO2004074131A8 (de) 2005-09-22
US20060200098A1 (en) 2006-09-07
CA2513582A1 (en) 2004-09-02
AU2004213109A1 (en) 2004-09-02
BRPI0407439A (pt) 2006-01-31
DE10307583A1 (de) 2004-09-09
CN1750978B (zh) 2010-08-25
JP4292200B2 (ja) 2009-07-08

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