EP1580271A3 - Recepteurs humains couples à la protéine G sans ligands connus - Google Patents

Recepteurs humains couples à la protéine G sans ligands connus Download PDF

Info

Publication number
EP1580271A3
EP1580271A3 EP05005946A EP05005946A EP1580271A3 EP 1580271 A3 EP1580271 A3 EP 1580271A3 EP 05005946 A EP05005946 A EP 05005946A EP 05005946 A EP05005946 A EP 05005946A EP 1580271 A3 EP1580271 A3 EP 1580271A3
Authority
EP
European Patent Office
Prior art keywords
protein
coupled receptors
human orphan
orphan
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP05005946A
Other languages
German (de)
English (en)
Other versions
EP1580271A2 (fr
Inventor
Ruoping Chen
Huong T. Dang
Chen W. Liaw
I-Lin Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arena Pharmaceuticals Inc
Original Assignee
Arena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals Inc filed Critical Arena Pharmaceuticals Inc
Publication of EP1580271A2 publication Critical patent/EP1580271A2/fr
Publication of EP1580271A3 publication Critical patent/EP1580271A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP05005946A 1998-11-20 1999-10-13 Recepteurs humains couples à la protéine G sans ligands connus Ceased EP1580271A3 (fr)

Applications Claiming Priority (47)

Application Number Priority Date Filing Date Title
US10921398P 1998-11-20 1998-11-20
US109213P 1998-11-20
US12041699P 1999-02-16 1999-02-16
US120416P 1999-02-16
US12185299P 1999-02-26 1999-02-26
US121852P 1999-02-26
US12394999P 1999-03-12 1999-03-12
US12394699P 1999-03-12 1999-03-12
US123946P 1999-03-12
US123949P 1999-03-12
US13713199P 1999-05-28 1999-05-28
US13656799P 1999-05-28 1999-05-28
US13712799P 1999-05-28 1999-05-28
US13643699P 1999-05-28 1999-05-28
US13643799P 1999-05-28 1999-05-28
US13643999P 1999-05-28 1999-05-28
US136437P 1999-05-28
US136436P 1999-05-28
US136567P 1999-05-28
US137131P 1999-05-28
US136439P 1999-05-28
US137127P 1999-05-28
US14144899P 1999-06-29 1999-06-29
US141448P 1999-06-29
US15655599P 1999-09-29 1999-09-29
US15663499P 1999-09-29 1999-09-29
US15665399P 1999-09-29 1999-09-29
US15663399P 1999-09-29 1999-09-29
US156634P 1999-09-29
US156633P 1999-09-29
US156555P 1999-09-29
US156653P 1999-09-29
US15729499P 1999-10-01 1999-10-01
US15728199P 1999-10-01 1999-10-01
US15728299P 1999-10-01 1999-10-01
US15728099P 1999-10-01 1999-10-01
US15729399P 1999-10-01 1999-10-01
US157294P 1999-10-01
US157282 1999-10-01
US157280P 1999-10-01
US157281P 1999-10-01
US157293P 1999-10-01
US41676099A 1999-10-12 1999-10-12
US41704499A 1999-10-12 1999-10-12
US417044 1999-10-12
US416760 1999-10-12
EP99972682A EP1133559B1 (fr) 1998-11-20 1999-10-13 Recepteur humain orphelin rup3 couple a une proteine g

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP99972682A Division EP1133559B1 (fr) 1998-11-20 1999-10-13 Recepteur humain orphelin rup3 couple a une proteine g

Publications (2)

Publication Number Publication Date
EP1580271A2 EP1580271A2 (fr) 2005-09-28
EP1580271A3 true EP1580271A3 (fr) 2006-01-18

Family

ID=27586698

Family Applications (8)

Application Number Title Priority Date Filing Date
EP07008841A Expired - Lifetime EP1849866B1 (fr) 1998-11-20 1999-10-13 Récepteur humain orphelin RUP3 couplé à une protéine g
EP10008862A Withdrawn EP2295572A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g
EP05003040A Expired - Lifetime EP1584683B1 (fr) 1998-11-20 1999-10-13 Récepteur humaine orphelin RUP3 couplé à une protéine g
EP10010303A Withdrawn EP2295573A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g
EP10010658A Withdrawn EP2295574A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g
EP05005946A Ceased EP1580271A3 (fr) 1998-11-20 1999-10-13 Recepteurs humains couples à la protéine G sans ligands connus
EP99972682A Expired - Lifetime EP1133559B1 (fr) 1998-11-20 1999-10-13 Recepteur humain orphelin rup3 couple a une proteine g
EP07001452A Ceased EP1780280A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine G

Family Applications Before (5)

Application Number Title Priority Date Filing Date
EP07008841A Expired - Lifetime EP1849866B1 (fr) 1998-11-20 1999-10-13 Récepteur humain orphelin RUP3 couplé à une protéine g
EP10008862A Withdrawn EP2295572A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g
EP05003040A Expired - Lifetime EP1584683B1 (fr) 1998-11-20 1999-10-13 Récepteur humaine orphelin RUP3 couplé à une protéine g
EP10010303A Withdrawn EP2295573A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g
EP10010658A Withdrawn EP2295574A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine g

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP99972682A Expired - Lifetime EP1133559B1 (fr) 1998-11-20 1999-10-13 Recepteur humain orphelin rup3 couple a une proteine g
EP07001452A Ceased EP1780280A1 (fr) 1998-11-20 1999-10-13 Récepteurs humains orphelins couplés à une protéine G

Country Status (13)

Country Link
EP (8) EP1849866B1 (fr)
JP (5) JP2003534767A (fr)
KR (5) KR20080104062A (fr)
AT (3) ATE301673T1 (fr)
AU (2) AU770056B2 (fr)
CA (2) CA2348377C (fr)
DK (3) DK1849866T3 (fr)
ES (3) ES2243095T3 (fr)
HK (2) HK1037675A1 (fr)
IL (2) IL142538A0 (fr)
NZ (3) NZ537625A (fr)
PT (3) PT1133559E (fr)
WO (1) WO2000031258A2 (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1690939B8 (fr) 1998-03-12 2010-10-13 Astellas Pharma Inc. Nouvelles protéines du récepteur couplé à la protéine G
US6071722A (en) * 1998-04-24 2000-06-06 Smithkline Beecham Corporation Nucleic acids encoding a G-protein coupled 7TM receptor (AXOR-1)
JP2002512780A (ja) * 1998-04-24 2002-05-08 スミスクライン ビーチャム コーポレーション 新規７ｔｍ受容体ａｘｏｒ−２のクローニング
WO2000026339A2 (fr) * 1998-11-03 2000-05-11 Smithkline Beecham Corporation Recepteur couple aux proteines g, dit axor-14
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
WO2000050458A1 (fr) * 1999-02-26 2000-08-31 Smithkline Beecham Corporation Clonage du recepteur 7tm (axor 17) du type p2y
US6620615B1 (en) * 1999-04-23 2003-09-16 Curagen Corporation G-protein coupled receptor—encoding nucleic acids
EP1189944A4 (fr) * 1999-06-21 2002-09-11 Smithkline Beecham Corp Axor16, r cepteur coupl une prot ine g
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WO2001009313A1 (fr) * 1999-07-30 2001-02-08 Merck Patent Gmbh Recepteur couple g-proteine et sequences adn de celui-ci
EP1207169A4 (fr) * 1999-08-27 2003-03-19 Takeda Chemical Industries Ltd Nouvelle proteine receptrice couplee a une proteine g, et son adn
US6998255B1 (en) 1999-09-24 2006-02-14 Solvay Pharmaceuticals B.V. Human G-protein coupled receptor
GB9923177D0 (en) * 1999-09-30 1999-12-01 Pfizer Ltd Novel polypeptide
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GB9923890D0 (en) * 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
GB9923893D0 (en) * 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
GB9924956D0 (en) * 1999-10-21 1999-12-22 Pfizer Ltd Novel polypeptide
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CA2386509A1 (fr) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company Recepteurs couples par des proteines g exprimes dans le cerveau
ATE375390T1 (de) * 1999-10-29 2007-10-15 Pfizer G-protein-gekoppelter rezeptor-ähnliche proteine
EP1226250A2 (fr) * 1999-11-03 2002-07-31 MERCK PATENT GmbH Nouveaux polypeptides de type gpcr-kd5 et sequences d'adn correspondantes
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BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
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WO2012170702A1 (fr) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulateurs du récepteur gpr119 et traitement de troubles associés à celui-ci
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CN116850181A (zh) 2015-01-06 2023-10-10 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
MX2017016530A (es) 2015-06-22 2018-03-12 Arena Pharm Inc Sal cristalina de l-arginina del acido (r)-2-(7-(4-ciclopentil-3-( trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3- il)acetico (compuesto1) para ser utilizada en transtornos asociados con el receptor de esfingosina-1-fosfato 1 (s1p1).
WO2018026890A1 (fr) 2016-08-03 2018-02-08 Cymabay Therapeutics Composés d'aryle d'oxyméthylène pour le traitement de maladies gastro-intestinales inflammatoires ou de troubles gastro-intestinaux
WO2018236896A1 (fr) 2017-06-19 2018-12-27 Arena Pharmaceuticals, Inc. Composés et procédés pour le traitement de nafld et de nash

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