EP1572336B1 - Dispositif permettant de produire une mousse medicale - Google Patents
Dispositif permettant de produire une mousse medicale Download PDFInfo
- Publication number
- EP1572336B1 EP1572336B1 EP03795826A EP03795826A EP1572336B1 EP 1572336 B1 EP1572336 B1 EP 1572336B1 EP 03795826 A EP03795826 A EP 03795826A EP 03795826 A EP03795826 A EP 03795826A EP 1572336 B1 EP1572336 B1 EP 1572336B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- foam
- chamber
- gas
- connecting element
- pistons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006260 foam Substances 0.000 title claims abstract description 76
- 239000013543 active substance Substances 0.000 claims description 16
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 9
- 239000003229 sclerosing agent Substances 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 7
- 238000006073 displacement reaction Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000007632 sclerotherapy Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 206010046996 Varicose vein Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 208000027185 varicose disease Diseases 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 101100390736 Danio rerio fign gene Proteins 0.000 description 1
- 101100390738 Mus musculus Fign gene Proteins 0.000 description 1
- 229920001363 Polidocanol Polymers 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- -1 diagnostics Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229960002226 polidocanol Drugs 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 201000009371 venous hemangioma Diseases 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/311—Injector mixers in conduits or tubes through which the main component flows for mixing more than two components; Devices specially adapted for generating foam
- B01F25/3111—Devices specially adapted for generating foam, e.g. air foam
- B01F25/31112—Devices specially adapted for generating foam, e.g. air foam with additional mixing means other than injector mixers, e.g. screen or baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
- B01F25/4522—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube
- B01F25/45221—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube the porous bodies being cylinders or cones which obstruct the whole diameter of the tube, the flow changing from axial in radial and again in axial
Definitions
- the invention relates to a device for producing in particular reproducible medical foam or bubble suspension from a gaseous and a liquid medium.
- the invention relates to a mixing device for the reproducible preparation and administration of injectables - such as e.g. Sclerosing agents, diagnostics, therapeutics, homeopathic remedies and autologous blood.
- Sclerotherapy is the planed elimination of intra-, subcutaneous and / or transfascial varices and the sclerotherapy of subfascial vessels in venous malformations by injecting a sclerosing agent.
- the various sclerosing agents cause damage to the endothelium of the vessels. This is followed by a secondary vascular occlusion and, in the longer term, the transformation of the veins into a connective tissue strand, to sclerosis.
- the aim of the sclerotherapy is the definitive transformation into a fibrous strand. This can not recanalize and corresponds in its functional result to the surgical procedure for the removal of a varix.
- the sclerotherapy with foamed sclerosants is becoming increasingly important.
- the foam stays longer in the vein.
- surface-active sclerosing agents such as polidocanol
- polidocanol are usually brought into a foam-like state by reciprocating between two syringes or by shaking and then conventionally injected.
- a mixing device for producing medical foam or for producing bubbles is known from EP 0 564 505.
- a mixer with a helical mixing element is an additional element that can be permanently connected to a syringe.
- the medium passes into the mixer, which contains the gas in a defined volume and type,
- gas phase and liquid phase along the helical mixing element are mixed. This can produce a therapeutic and / or diagnostic foam.
- the mixing device described in EP 0 564 505 has the disadvantage that the mixer, which is firmly connected to the syringe, in particular when the solution is moved back and forth, can easily be broken off or tilted due to the long lever. Furthermore, the mixer is a component which, due to the spiral-shaped mixing elements arranged in the mixer, can only be produced as an injection-molded part using elaborate injection molds.
- a dual chamber syringe connected to a static mixer capable of producing foam is disclosed in US-A-3767085.
- the object of the invention is to provide a device with which medical foam can be generated from a gaseous and a liquid medium in a simple manner.
- the device according to the invention has an active substance chamber and a gas chamber. Both chambers are closed with one piston each. Furthermore, the device has a foam generator, which in particular has one or more screens. Both the drug chamber and the gas chamber are connected directly or indirectly to the foam generator. According to the invention, the two pistons are arranged displaceably in the respective chamber. In particular, the two pistons are connected together or connectable during actuation of the device, so that the two pistons are displaced together in each case in one of the two chambers. This results in an increase in the pressure in the chambers and thus conveying or transporting the active substance and the gas in the direction of the foam generator or through the foam generator therethrough.
- the device according to the invention is thus very easy to handle, as moved by a movement both pistons and thus both media are pressed or transported in the direction of the foam generator.
- the emerging from the foam generator medical foam then only needs to be collected, but can also be applied directly.
- a reciprocation of a gas and a liquid or a gas and a detergent between two syringes is not required.
- the production of a standardized sterile foam is thus considerably easier.
- the provision of a compressed gas container in the device according to the invention is not required.
- the two pistons are connected to one another via a connecting element.
- the connecting element is in this case preferably configured such that one of the two chambers is opened during displacement of the connecting element.
- the connection of the two pistons takes place only by the actuation of the device.
- the connecting element is particularly preferred in this case to form the connecting element as a conveying channel, for example as a hollow needle.
- a driving element which may be formed in particular as a bead or plate. This makes it possible, when moving the connecting element in the direction of one of the two chambers closing the piston after the example piercing or opening of the piston to push it into the corresponding chamber and thus to increase the pressure in the chamber, so that the located in the chamber Preferably, medium flows into the hollow needle and through it to the foam generator.
- one of the two pistons is in particular firmly connected to the foam generator. Furthermore, one of the two pistons may also be loosely connected to the foam generator.
- the medium flows through the piston into the foam generator. Furthermore, it is preferred that the medium from the second chamber through this piston flowing.
- the two media mix in this preferred embodiment, preferably in the foam generator and / or immediately before the foam generator. It is particularly preferred to push the medium from the chamber further away from the generation of foam through a delivery channel provided in the connecting element and at least partially supply it directly to the foam generator. In this embodiment, a mixing of the two media takes place directly in the foam generator. Possibly.
- This mixing element may be provided in or in front of the foam generator, a mixing element in which a premixing of the two media takes place before they are pressed by the foam generator.
- This mixing element may, for example, be a type of sponge or a sintered material which simultaneously serves to decelerate the active substance. As a result, the foam generation is improved.
- foam generator within the syringe, for example in the batch, e.g. also forms the luer lock to provide.
- a foam outlet opening of the foam generator can be connected to a foam collecting container.
- the foam collecting container may be a conventional syringe, which may then be connected to the foam outlet opening, for example via a Luer lock.
- the device according to the invention is suitable because of its simple and inexpensive construction of preferably individually manufacturable simple parts, especially for disposable use. In particular, due to the disposable use, the required sterility can be ensured. Another advantage of the device according to the invention is that the drug and the gas come into contact with each other only immediately before the application.
- the device according to the invention for the production of medical foam has an active substance chamber 10 and a gas chamber 12.
- the active substance chamber 10 is designed as a carpule 14 (FIG. 4) and is sealed with a first piston 16, which may be a rubber stopper or the like.
- the carpule 14 is held in a holder 18, in which the carpule 14 in the direction of an arrow 20 in the holder 18 in the in Figs. 1 - 3 shown position is inserted.
- the carpule 14 is in this case fixed by latching elements 22 and with respect to the latching elements 22 arranged stops 24 (FIG. 4) in the position.
- the holder 18, which receives in the cylindrical opening 26, which preferably also circular cylindrical trained carpule 14 is connected to a cylindrical projection 28. Within the cylindrical projection 28, the gas chamber 12 is formed.
- the gas chamber 12 is also sealed by a second piston 30.
- the gas chamber can optionally also be designed as a carpule.
- the likewise cylindrical gas chamber 12 has a larger diameter than the active substance chamber 10.
- the provision of active ingredient or gas in the two chambers can also be reversed. This is particularly useful for drugs in which only a small amount of gas is required for foaming, ie in the case of active substances which are already readily foamable themselves.
- the height of the gas chamber 12 and the active substance chamber 10 is substantially the same, wherein preferably the gas chamber 12 is slightly higher in order to be able to completely empty both chambers 10, 12 if the pistons 16, 30 are fully depressed.
- the piston 30 is designed as a hollow needle connecting element 32 is connected.
- the piston 30 has a suitable, for example, cylindrical projection 34 (FIG. 4) into which the hollow needle 32 can be inserted and held, for example, by adhesive bonding.
- a foam generator 38 fixed or loose and possibly releasably connected.
- the foam generator 38 has, in particular, two screens 40, which cause a swirling and mixing of the two media and thus the generation of foam.
- the foam generator 38 is connected via a holder 42 with the piston 30.
- the foam generator 38 may for example also each have one or more sinter filters, propellers, helices and / or spirals.
- a loose or detachable connection of the foam generator 38 with the piston 30 has the advantage that the foam generator 38 can be pulled out together with the syringe 46 from the cylindrical projection 38 of the device according to the invention. Upon squeezing the foam out of the syringe 46, it is again forced through the foam generator 38, so that the quality of the foam produced can be further improved. Further, it is possible that on the inside of the cylindrical projection 28 locking elements are provided, is prevented by the fact that the piston 30 can be pulled out of the cylindrical projection 28.
- the piston 30 may comprise locking elements, for example, in recesses engage, which are provided on the projection 28 when the piston 30 is pulled too far out of the projection 28.
- the holder 42 has a foam outlet opening 44 (FIG. 4) through which the foam produced in the foam generator 38 emerges.
- the foam exit port is a luer to which a conventional syringe 46 can be connected.
- the syringe 46 serves as a foam collecting container, as shown in FIGS. 2 and 3 can be seen.
- the holder 18 is placed on a base, so that the device, as shown in FIGS. 1-3, is aligned vertically. Subsequently, the syringe body is e.g. by means of the lugs 48 in FIGS. pressed down in the direction of arrow 50. The syringe plunger or syringe plunger 52 is not changed in its position.
- the foam generator 38 and the second piston 30 is moved downward. Together with the piston 30, the hollow needle 32 firmly connected to the piston 30 is pushed downwards. In this case pierces a tip 54 of the hollow needle 32, the first piston 16 and thus opens the drug chamber 10th
- a driving element 56 such as a plate is firmly connected, the plate 56 pushes the first piston 16 in the drug chamber 10.
- the plate 56 pushes the first piston 16 in the drug chamber 10.
- drug is pressed through the hollow needle 32 into the foam generator 38.
- gas from the gas chamber 12 is forced into the foam generator 38 through openings 58 located in the piston 30 and / or through transverse bores in the hollow needle 32.
- the resulting foam passes through the foam outlet opening 44 of the Foam generator 38 in the free by the movement of the syringe body space 60 within the syringe body.
- a significant advantage of the device according to the invention is that it can be achieved by a single piston stroke, i. that in the Fign. 1 - 3 down-pressing the two pistons 16, 30, a foam in the syringe 46 is generated. After the foam has been produced, the syringe 46 can be released again from the luer adapter, so that subsequently the foam can be applied directly.
Claims (10)
- Dispositif de production d'une mousse médicale, avec
une chambre à principe actif (10) fermée par un premier piston (16),
une chambre à gaz (12) fermée par un deuxième piston (30) et
un générateur de mousse (38) raccordé sur la chambre à principe actif (10) et sur la chambre à gaz (12),
les deux pistons (16, 30) étant reliés entre eux et mobiles ensemble, pour transporter du principe actif et du gaz vers le générateur de mousse (38),
caractérisé en ce que
les deux pistons (16, 30) sont reliés entre eux par l'intermédiaire d'un élément de liaison (32) qui, lorsqu'il se déplace, ouvre l'une des deux chambres (10). - Dispositif selon la revendication 1, caractérisé en ce que l'élément de liaison (32) comporte une canalisation de transport à travers laquelle le principe actif et/ou le gaz peut s'écouler en direction du générateur de mousse (38).
- Dispositif selon la revendication 1 ou 2, caractérisé en ce que l'élément de liaison (32) comporte un élément d'entraînement (56) pour entraîner l'un des deux pistons (16).
- Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce que la canalisation de transport relie directement la chambre (10) ouverte par l'élément de liaison (32) avec le générateur de mousse (38) et/ou avec l'autre chambre (12).
- Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce que les chambres (10, 12) sont adjacentes.
- Dispositif selon l'une quelconque des revendications 1 à 5, caractérisé en ce que l'un des deux pistons (16, 30) est relié au générateur de mousse (38) de façon particulièrement fixe.
- Dispositif selon l'une quelconque des revendications 1 à 6, caractérisé en ce que le générateur de mousse (38) comporte un orifice de sortie de mousse (44) pouvant être relié avec un récipient collecteur de mousse (46) ou avec un applicateur.
- Dispositif selon l'une quelconque des revendications 1 à 7, caractérisé en ce que le générateur de mousse (38) comporte au moins un, de préférence au moins deux cribles (40) pour la génération de mousse.
- Dispositif selon l'une quelconque des revendications 1 à 8, caractérisé par un élément de freinage, qui est monté en amont du générateur de mousse (38), pour assurer notamment un freinage du principe actif et donc un mélange préalable du principe actif et du gaz.
- Dispositif selon l'une quelconque des revendications 1 à 9, caractérisé en ce que l'élément de liaison (32) comporte des orifices pour la sortie du principe actif et/ou du gaz hors de la canalisation de transport de l'élément de liaison (32) vers une chambre (12).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20218493U DE20218493U1 (de) | 2002-11-28 | 2002-11-28 | Vorrichtung zur Erzeugung von medizinischem Schaum |
DE20218493U | 2002-11-28 | ||
PCT/EP2003/012894 WO2004047969A1 (fr) | 2002-11-28 | 2003-11-13 | Dispositif permettant de produire une mousse medicale |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1572336A1 EP1572336A1 (fr) | 2005-09-14 |
EP1572336B1 true EP1572336B1 (fr) | 2006-03-15 |
EP1572336B2 EP1572336B2 (fr) | 2018-01-24 |
Family
ID=32103522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03795826.1A Expired - Lifetime EP1572336B2 (fr) | 2002-11-28 | 2003-11-13 | Dispositif permettant de produire une mousse medicale |
Country Status (7)
Country | Link |
---|---|
US (1) | US7963938B2 (fr) |
EP (1) | EP1572336B2 (fr) |
AT (1) | ATE320304T1 (fr) |
AU (1) | AU2003298123A1 (fr) |
DE (2) | DE20218493U1 (fr) |
ES (1) | ES2260686T3 (fr) |
WO (1) | WO2004047969A1 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
GB0028692D0 (en) | 2000-11-24 | 2001-01-10 | Btg Int Ltd | Generation of therapeutic microform |
US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
DE20218493U1 (de) | 2002-11-28 | 2004-04-08 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung von medizinischem Schaum |
EP1791519B1 (fr) | 2003-11-17 | 2017-07-19 | BTG International Limited | Mousses thérapeutiques avec un sclérosant et avec un agent améliorant la viscosité, méthodes pour leur production |
US8052669B2 (en) | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
US9238127B2 (en) | 2004-02-25 | 2016-01-19 | Femasys Inc. | Methods and devices for delivering to conduit |
US8048101B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US8048086B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
DE102004048749B4 (de) * | 2004-10-05 | 2007-03-29 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung eines medizinischen Schaums |
DE102005011174B4 (de) | 2005-03-09 | 2022-03-24 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung eines medizinischen Schaums |
FR2883731B1 (fr) * | 2005-03-31 | 2008-03-14 | Alain Monfreux | Dispositif pour la production d'une mousse formee de bulles de gaz et d'un liquide tensioactif |
GB0509824D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
GB0509845D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Preparation of therapeutic foam |
US8672879B2 (en) * | 2005-10-13 | 2014-03-18 | Argos Therapeutics, Inc. | Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures |
US9486594B2 (en) | 2006-11-27 | 2016-11-08 | Frank Levy | Portable medical gas delivery system |
US9662435B2 (en) | 2006-01-31 | 2017-05-30 | Frank Levy | System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
US20090318890A1 (en) * | 2006-11-27 | 2009-12-24 | Frank Levy | Portable Medical Foam Apparatus |
US8876749B2 (en) | 2006-11-27 | 2014-11-04 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
US11712510B2 (en) | 2006-11-27 | 2023-08-01 | Frank Levy | Delivery system and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
US11833320B2 (en) | 2006-11-27 | 2023-12-05 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
US10149935B2 (en) | 2006-11-27 | 2018-12-11 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
US10155093B2 (en) | 2006-11-27 | 2018-12-18 | Frank Levy | Apparatus and method for producing CO2 enriched medical foam |
US10350399B2 (en) | 2006-11-27 | 2019-07-16 | Frank Levy | Apparatus and method for producing an enriched medical suspension of carbon dioxide |
US11185671B2 (en) | 2006-11-27 | 2021-11-30 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
US9427522B2 (en) | 2006-11-27 | 2016-08-30 | Frank Levy | Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid |
US10322271B2 (en) | 2006-11-27 | 2019-06-18 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
US9554826B2 (en) | 2008-10-03 | 2017-01-31 | Femasys, Inc. | Contrast agent injection system for sonographic imaging |
US10070888B2 (en) | 2008-10-03 | 2018-09-11 | Femasys, Inc. | Methods and devices for sonographic imaging |
CA2678198A1 (fr) * | 2009-09-08 | 2011-03-08 | Duoject Medical Systems Inc. | Dispositif de liaison facile pour transfer de fluide |
US8449494B2 (en) * | 2009-12-16 | 2013-05-28 | Cook Medical Technologies Llc | Apparatus and method for preparing foam |
CA2773480C (fr) * | 2011-04-05 | 2014-12-30 | Tyco Healthcare Group Lp | Systeme d'administration d'un agent tampon pour seringue renfermant un anesthesique |
GB201612948D0 (en) * | 2016-07-26 | 2016-09-07 | Provensis Ltd | syringe for administering foam |
RU2659632C1 (ru) * | 2017-04-04 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Устройство для вспенивания и введения лекарственного препарата |
CN107096406B (zh) * | 2017-05-11 | 2023-09-15 | 金宝医学科技(深圳)有限公司 | 一种微泡沫生成装置及方法 |
WO2019233546A1 (fr) * | 2018-06-04 | 2019-12-12 | Gemü Gmbh | Applicateur |
Citations (6)
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US5425580A (en) | 1990-12-28 | 1995-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dosage form for micro-bubble echo contrast agents |
EP0695555A1 (fr) | 1992-12-01 | 1996-02-07 | HIGASHIKAWA, Tetsuro | Seringue |
WO1996008227A1 (fr) | 1994-09-16 | 1996-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dispositif de melange pour substances a administrer avec une seringue |
WO2000072821A1 (fr) | 1999-05-26 | 2000-12-07 | Btg International Limited | Generation de micromousse therapeutique |
WO2002041872A1 (fr) | 2000-11-24 | 2002-05-30 | Btg International Limited | Production de micromousse therapeutique |
GB2369996A (en) | 2000-12-18 | 2002-06-19 | S T D Pharmaceutical Products | Method and apparatus for producing an injectable foam |
Family Cites Families (22)
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US2630183A (en) * | 1950-01-26 | 1953-03-03 | Foutz Clinton Root | Apparatus for forming and projecting a foam mixture |
US2653607A (en) * | 1950-09-16 | 1953-09-29 | Ayerst Mckenna & Harrison | Injection apparatus |
US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
US2772677A (en) * | 1953-02-18 | 1956-12-04 | Izaak A Ulert | Syringe assembly |
US3248014A (en) * | 1964-10-07 | 1966-04-26 | Orville N Greene | Piston type dispenser |
DE1278703B (de) * | 1967-01-21 | 1968-09-26 | Penicillin Ges Dauelsberg & Co | Zweikammerspritze |
US3767085A (en) | 1971-08-02 | 1973-10-23 | J Cannon | Mixing syringe |
BE792131A (fr) * | 1972-02-15 | 1973-03-16 | Sherwood Medical Ind Inc | Dispositifs pour l'injection de medicaments |
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DE3417182A1 (de) † | 1984-05-09 | 1985-11-14 | Gerald Dr. 8000 München Hauer | Spritzen-set |
US4743229A (en) * | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
DE8916222U1 (de) * | 1988-09-29 | 1995-08-10 | Afa Products Inc | Schaumdüsenanordnung |
DE59105805D1 (de) * | 1990-12-28 | 1995-07-27 | Byk Gulden Lomberg Chem Fab | Darreichungsform für mikrobläschen-echokontrastmittel. |
WO1995007066A1 (fr) * | 1993-09-07 | 1995-03-16 | Debiotech S.A. | Dispositif de seringue pour le melange de deux composes |
DE4338553A1 (de) * | 1993-11-08 | 1995-05-18 | Ferring Arzneimittel Gmbh | Injektionsspritze zum Mischen und Applizieren von Injektionssubstanzen |
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FR2775433A1 (fr) * | 1998-02-27 | 1999-09-03 | Alain Monfreux | Dispositif pour la production de mousse dans un corps de seringue |
DE20015594U1 (de) * | 2000-09-08 | 2001-06-21 | Herrmann Frank | Vorrichtung zum stufenlosen, mengen- und druckregulierten Eintragen von Gas in flüssige Medien |
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DE20218493U1 (de) | 2002-11-28 | 2004-04-08 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung von medizinischem Schaum |
-
2002
- 2002-11-28 DE DE20218493U patent/DE20218493U1/de not_active Expired - Lifetime
-
2003
- 2003-11-13 EP EP03795826.1A patent/EP1572336B2/fr not_active Expired - Lifetime
- 2003-11-13 AT AT03795826T patent/ATE320304T1/de active
- 2003-11-13 AU AU2003298123A patent/AU2003298123A1/en not_active Abandoned
- 2003-11-13 ES ES03795826T patent/ES2260686T3/es not_active Expired - Lifetime
- 2003-11-13 DE DE50302685T patent/DE50302685D1/de not_active Expired - Lifetime
- 2003-11-13 WO PCT/EP2003/012894 patent/WO2004047969A1/fr not_active Application Discontinuation
- 2003-11-13 US US10/536,862 patent/US7963938B2/en not_active Expired - Fee Related
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US5425580A (en) | 1990-12-28 | 1995-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dosage form for micro-bubble echo contrast agents |
EP0695555A1 (fr) | 1992-12-01 | 1996-02-07 | HIGASHIKAWA, Tetsuro | Seringue |
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Also Published As
Publication number | Publication date |
---|---|
AU2003298123A1 (en) | 2004-06-18 |
EP1572336B2 (fr) | 2018-01-24 |
ATE320304T1 (de) | 2006-04-15 |
ES2260686T3 (es) | 2006-11-01 |
US20060178620A1 (en) | 2006-08-10 |
US7963938B2 (en) | 2011-06-21 |
DE50302685D1 (de) | 2006-05-11 |
EP1572336A1 (fr) | 2005-09-14 |
DE20218493U1 (de) | 2004-04-08 |
WO2004047969A1 (fr) | 2004-06-10 |
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