US2653607A - Injection apparatus - Google Patents

Injection apparatus Download PDF

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Publication number
US2653607A
US2653607A US187277A US18727750A US2653607A US 2653607 A US2653607 A US 2653607A US 187277 A US187277 A US 187277A US 18727750 A US18727750 A US 18727750A US 2653607 A US2653607 A US 2653607A
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US
United States
Prior art keywords
cell
needle
cartridge
stopper
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US187277A
Inventor
Deans Sidney Alfred Vindin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada ULC
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Wyeth Canada ULC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to CA2653607X priority Critical
Application filed by Wyeth Canada ULC filed Critical Wyeth Canada ULC
Application granted granted Critical
Publication of US2653607A publication Critical patent/US2653607A/en
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Application status is Expired - Lifetime legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291Shafts with additional lateral openings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/03Medical

Description

Sept. 29,v 1953 s. A. v. DEANs INJECTION APPARATUS Filed sept. 28, 195o ATTORNEY Patented Sept. 29, 1953 INJECTION APPARATUS Sidney Alfred Vindin Deans, Rosemount, Quebec,

Canada, assignor to Ayerst, McKenna & Harrison, Limited, St. Laurent, Quebec, Canada Application September 28, 1950, Serial No. 187,277 In Canada September 16, 1950 (Cl. 12S-221) 1 Claim. 1

This invention relates to the art of injecting fluid medicinal substances into an organic subject and is particularly concerned with injecting iiuid containing a substance which is unstable in such iiuid, and also relates to improved apparatus for this purpose.

Various special types of cartridge or cartridgesyringe combinations have been developed for the direct injection by syringe of a component dry material and a component fluid in which the dry material is unstable. rlhese devices suffer from the disadvantage that they are not standard and special equipment must be purchased in addition to the normal injection equipment which the doctor already has.

Applicants development The applicant has now developed means by which the components of a uid mixture of which one is unstable can be packed in a standard-sized cartridge and administered by the use of a standard syringe. -One phase of the invention involves a special cartridge. This cartridge has the usual cylindrical case, generally of glass, the movable plunger-cap usually of rubber at the head, and the perforable resilient plug usually also of rubber at its base. f

According to the invention, the cartridge is divided into separate cells by a stopper. AOne cell contains the fluid, for example a suspension of procaine penicillin, and the other the fluid-unstable component, for example, dry potassium penicillin. The stopper is preferably of rubber and normally maintains a liquid-tight seal between the two cells.

The cartridge, according to .the invention, requires a special needle. This cartridge employs as the stopper-sealing member a relatively thick cylinder preferably of rubber. In this case, the needle is provided with a shank long enough to reach and go through the stopper as well as the base plug. The needle is designed to allow access oi the fluid from the head cell to the base cell where it mixes with the unstable component. The mixture then passes out through the injection channel in the needle. This needle is a feature of the invention.

The hollow shank of the needle is provided with a number of perforations which permit access of the fluid to the bore of the needle as it passes from the head cell to the base cell. There is a constriction in the bore of the needle in a position adapted to lie towards the base of the base cell and an opening in the needle on the -base side of the constriction. The uid passes into the bore of the needle on the head side of the dividing stopper, through the bore past the dividing stopper, and out through the openings to mix with the unstable component. The mixture then passes into the bore of the needle on the base side of the constriction and out through the injection channel past the base plug.

` Detailed description A detailed description follows in which the preferred form of the invention is illustrated. Reference is made to the accompanying drawing in which,

Figure 1 is a side elevation partly in section, showing a standard syringe in which one form of cartridge according to the invention is inserted ready for injection.

Figure 2 is a side elevation of a cartridge like that shown in Figure 1.

Figure 3 is an enlarged fragmentary vertical cross section through a syringe-cartridge combination showing the special form of syringe needle.

Figure 4 is an enlarged cross section along the line 4 4 of Figure 3.

Figure 5 is an enlarged cross section along the line 55 of Figure 4.

Figure 1 shows a cartridge in a syringe. The cartridge is made according to the invention. The syringe is of a standard type, but, the base shank of the needle is longer and perforated. As usual the syringe is made up of a barrel I0, a body I2 and a piston I5, slidably operating through the body I2 into the barrel IIJ. I6 is 1a finger rest. The barrel I0 is provided with a screw-threaded projecting perforated nub I9. The hub 22 of the needle is screwed on to the nub I9. The shank of the needle extends from a hole in the nub I9 up into the cartridge.

The cartridge, see Figure 2, includes a glass case 30. A rubber plunger plug 32 having an axially placed, screw-threaded metal projection 34 for engagement with the piston I5 of the syringe closes the head of the case. The other end of the case is closed by a rubber closure plug 36. This plug is cylindrical and has an axially formed depression 38 to leave a thin perforable portion 40. Spaced from the plug 36 is a rubber stopper 42, also provided with an axial depression 44 to provide a thin perforable portion 45. The stopper divides the case into two cells, A and B.

According to the invention, the cell B contains a iiuid, for example, a suspension of procaine penicillin, and the cell A a substance which is unstable in the uid, for example, potas- 3 sium penicillin. The contents of cell A must be kept apart from those of cell B until just before the injection, when they are mixed in accordance with the invention.

Operation The injection apparatus is operated as follows. The cartridge is placed in the syringe, as shown in Figure l. The elongated shank 20 of the needle penetrates both the closure plug 36 and the stopper 42. Fluid from cell B, for example, a suspension of procaine penicillin, can now pass through the bore channel in the needle past the stopper 42 into cell A. If potassium penicillin is present in cell A, it dissolves rapidly in the fluid from cell B. As the piston l5 is depressed, it moves the plunger plug 32 axially in the case 30. This forces the fluid from cell B through the bore of the needle into cell A and then out through the bore of the needle, through the injection shank 2| into the subject.

The form of needle shown in Figure l, is illustrated in more detail in Figures 3 and 4. The shank includes a point 20a and a plurality of orifices 20h. When the needle penetrates the stopper 42, the shank displaces the rubber of the stopper to maintain a passage between the two cells.

A constriction 225 is formed by indenting the needle.

The method and apparatus of the invention can be used to dispense and administer various solutions and uid mixtures, one component of which is unstable in solution or suspension. Examples of antibiotics which can be dispensed and administered in this manner are: dry potassium or sodium penicillin with procaine penicillin in aqueous suspension; dry potassium or sodium penicillin with water; dry potassium or sodium penicillin with procaine penicillin in water or other suspending medium (this medium might be, for example, water containing a suspending agent like carboxy methyl cellulose, a buier like sodium citrate and a preservative like phenol, or a mixture of methyl and propyl para-hydroxy benzoate).

Examples of hormone products which can be dispensed and administered in this manner are, any dry steroid, say testosterone or testosterone propionate, progresterone, oestrone, oestradiol benzoate in cell A with water or a suspending medium in cell B; dry anterior pituitary-like hormone or other gonadotrophin in cell A with water in cell B; estrogenic sulfates (water-soluble) in cell A with water in cell B.

Examples of vitamin products which can be dispensed and administered in this manner are water-soluble, water-labile vitamins in cell A with Water in cell B; water-insoluble vitamins in cell A With an aqueous suspending medium in cell B; vitamin B complex in cell A with a sterile diluent in cell B.

I claim:

A needle for a syringe adapted for use with a medicinal cartridge, comprising, a hub adapted to be connected to the end of the syringe, a hollow needle extending through said hub and having a part extending to one side of the hub for injection into the subject and a part integral with said iirst part extending to the other side of the hub for piercing the sealing member of a cartridge, the second-mentioned part being sunlciently long to pierce an end plug member in the cartridge and a sealing member within the cartridge spaced from the end plug and separating the cartridge into cells, a plurality of orices opening into the bore spaced apart at a position to open into the cell of the cartridge closest to the perforable end, and baille means constituted by inward deformations of the walls of the needle blocking the bore of the needle between said openings and the end adjacent to the plug, one of said orifices opening into the bore beyond said baille means.

SIDNEY ALFRED VINDIN DEAN S.

References Cited in the file of this patent UNITED STATES PATENTS Number Name Date 950,822 McElroy Mar. 1, 1910 1,263,793 Mulford Apr. 20, 1918 1,929,616 Vopata Oct. 10, 1933 2,193,322 Lozier et al. Mar. 12, 1940 FOREIGN PATENTS Number Country Date 282,622 Germany Mar. l1, 1915

US187277A 1950-09-16 1950-09-28 Injection apparatus Expired - Lifetime US2653607A (en)

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847996A (en) * 1953-08-13 1958-08-19 Miljam Instr Corp Hypodermic syringe
US2911123A (en) * 1956-07-23 1959-11-03 Saccomanno Geno Bottle cap
US3108591A (en) * 1962-05-29 1963-10-29 Bristol Mycrs Company Syringe
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3469572A (en) * 1966-08-18 1969-09-30 Becton Dickinson Co Apparatus for taking multiple fluid samples
US3552441A (en) * 1967-09-26 1971-01-05 Hartmut Luhleich Piercable closure diaphragm for a chamber
DE1491850B1 (en) * 1965-08-09 1971-06-24 Upjohn Co injection ampoule
US3837376A (en) * 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4413991A (en) * 1982-03-18 1983-11-08 Schmitz John B Dual dose ampule
WO1997047342A2 (en) * 1996-06-10 1997-12-18 Elan Corporation Plc. Needle for subcutaneous delivery of fluids
US20010012926A1 (en) * 1996-06-10 2001-08-09 Elan Medical Technologies Needle for subcutaneous delivery of fluids
DE20218493U1 (en) * 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Apparatus for producing medicinal foam
US20040092893A1 (en) * 2002-09-10 2004-05-13 Haider M. Ishaq Method and apparatus for epidermal delivery of a substance
WO2007149005A1 (en) * 2006-06-14 2007-12-27 Jury Anatoleivich Sukhonos Injection cannula
WO2010020800A1 (en) * 2008-08-18 2010-02-25 The Medical House Plc Autoinjector with mixing means
JP2013542023A (en) * 2010-11-03 2013-11-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Medicated module for the drug delivery device
US20140276450A1 (en) * 2011-08-30 2014-09-18 Novo Nordisk A/S Arrangement For Sequential Delivery of Fluid Volumes
JP2016506843A (en) * 2013-02-18 2016-03-07 ノボ・ノルデイスク・エー/エス Needle having a shield actuated valves
US20170007776A1 (en) * 2014-02-05 2017-01-12 Biontech Ag Cannula, an injection or infusion device and methods of using the cannula or the injection or infusion device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE282622C (en) *
US950822A (en) * 1909-04-30 1910-03-01 Randall Faichney Company Hypodermic needle.
US1263793A (en) * 1914-07-28 1918-04-23 H K Mulford Company Hypodermic needle.
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US2192322A (en) * 1939-03-11 1940-03-05 Nat Lock Co Lock washer screw and method of making the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE282622C (en) *
US950822A (en) * 1909-04-30 1910-03-01 Randall Faichney Company Hypodermic needle.
US1263793A (en) * 1914-07-28 1918-04-23 H K Mulford Company Hypodermic needle.
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US2192322A (en) * 1939-03-11 1940-03-05 Nat Lock Co Lock washer screw and method of making the same

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847996A (en) * 1953-08-13 1958-08-19 Miljam Instr Corp Hypodermic syringe
US2911123A (en) * 1956-07-23 1959-11-03 Saccomanno Geno Bottle cap
US3108591A (en) * 1962-05-29 1963-10-29 Bristol Mycrs Company Syringe
DE1491850B1 (en) * 1965-08-09 1971-06-24 Upjohn Co injection ampoule
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3469572A (en) * 1966-08-18 1969-09-30 Becton Dickinson Co Apparatus for taking multiple fluid samples
US3552441A (en) * 1967-09-26 1971-01-05 Hartmut Luhleich Piercable closure diaphragm for a chamber
US3837376A (en) * 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4413991A (en) * 1982-03-18 1983-11-08 Schmitz John B Dual dose ampule
WO1997047342A2 (en) * 1996-06-10 1997-12-18 Elan Corporation Plc. Needle for subcutaneous delivery of fluids
WO1997047342A3 (en) * 1996-06-10 1998-03-12 Haim Danon Needle for subcutaneous delivery of fluids
AU723947B2 (en) * 1996-06-10 2000-09-07 Alkermes Pharma Ireland Limited Needle for subcutaneous delivery of fluids
US6346095B1 (en) 1996-06-10 2002-02-12 Elan Corporation, Plc Needle and method for delivery of fluids
US20010012926A1 (en) * 1996-06-10 2001-08-09 Elan Medical Technologies Needle for subcutaneous delivery of fluids
US20040092893A1 (en) * 2002-09-10 2004-05-13 Haider M. Ishaq Method and apparatus for epidermal delivery of a substance
DE20218493U1 (en) * 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Apparatus for producing medicinal foam
WO2007149005A1 (en) * 2006-06-14 2007-12-27 Jury Anatoleivich Sukhonos Injection cannula
WO2010020800A1 (en) * 2008-08-18 2010-02-25 The Medical House Plc Autoinjector with mixing means
GB2462811B (en) * 2008-08-18 2012-08-15 Medical House Ltd Improved autoinjector
JP2013542023A (en) * 2010-11-03 2013-11-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Medicated module for the drug delivery device
US20140276450A1 (en) * 2011-08-30 2014-09-18 Novo Nordisk A/S Arrangement For Sequential Delivery of Fluid Volumes
US9919108B2 (en) * 2011-08-30 2018-03-20 Novo Nordisk A/S Arrangement for sequential delivery of fluid volumes
JP2016506843A (en) * 2013-02-18 2016-03-07 ノボ・ノルデイスク・エー/エス Needle having a shield actuated valves
US10034984B2 (en) 2013-02-18 2018-07-31 Novo Nordisk A/S Injection needle having shield activated valve
US20170007776A1 (en) * 2014-02-05 2017-01-12 Biontech Ag Cannula, an injection or infusion device and methods of using the cannula or the injection or infusion device

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