EP1572336B1 - Device for producing medical foam - Google Patents

Device for producing medical foam Download PDF

Info

Publication number
EP1572336B1
EP1572336B1 EP03795826A EP03795826A EP1572336B1 EP 1572336 B1 EP1572336 B1 EP 1572336B1 EP 03795826 A EP03795826 A EP 03795826A EP 03795826 A EP03795826 A EP 03795826A EP 1572336 B1 EP1572336 B1 EP 1572336B1
Authority
EP
European Patent Office
Prior art keywords
foam
chamber
gas
connecting element
pistons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03795826A
Other languages
German (de)
French (fr)
Other versions
EP1572336A1 (en
EP1572336B2 (en
Inventor
Jan-Christoph Wollmann
Dorothee Schliephake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemische Fabrik Kreussler and Co GmbH
Original Assignee
Chemische Fabrik Kreussler and Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32103522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1572336(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chemische Fabrik Kreussler and Co GmbH filed Critical Chemische Fabrik Kreussler and Co GmbH
Publication of EP1572336A1 publication Critical patent/EP1572336A1/en
Publication of EP1572336B1 publication Critical patent/EP1572336B1/en
Application granted granted Critical
Publication of EP1572336B2 publication Critical patent/EP1572336B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/311—Injector mixers in conduits or tubes through which the main component flows for mixing more than two components; Devices specially adapted for generating foam
    • B01F25/3111—Devices specially adapted for generating foam, e.g. air foam
    • B01F25/31112—Devices specially adapted for generating foam, e.g. air foam with additional mixing means other than injector mixers, e.g. screen or baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4522—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube
    • B01F25/45221—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube the porous bodies being cylinders or cones which obstruct the whole diameter of the tube, the flow changing from axial in radial and again in axial

Definitions

  • the invention relates to a device for producing in particular reproducible medical foam or bubble suspension from a gaseous and a liquid medium.
  • the invention relates to a mixing device for the reproducible preparation and administration of injectables - such as e.g. Sclerosing agents, diagnostics, therapeutics, homeopathic remedies and autologous blood.
  • Sclerotherapy is the planed elimination of intra-, subcutaneous and / or transfascial varices and the sclerotherapy of subfascial vessels in venous malformations by injecting a sclerosing agent.
  • the various sclerosing agents cause damage to the endothelium of the vessels. This is followed by a secondary vascular occlusion and, in the longer term, the transformation of the veins into a connective tissue strand, to sclerosis.
  • the aim of the sclerotherapy is the definitive transformation into a fibrous strand. This can not recanalize and corresponds in its functional result to the surgical procedure for the removal of a varix.
  • the sclerotherapy with foamed sclerosants is becoming increasingly important.
  • the foam stays longer in the vein.
  • surface-active sclerosing agents such as polidocanol
  • polidocanol are usually brought into a foam-like state by reciprocating between two syringes or by shaking and then conventionally injected.
  • a mixing device for producing medical foam or for producing bubbles is known from EP 0 564 505.
  • a mixer with a helical mixing element is an additional element that can be permanently connected to a syringe.
  • the medium passes into the mixer, which contains the gas in a defined volume and type,
  • gas phase and liquid phase along the helical mixing element are mixed. This can produce a therapeutic and / or diagnostic foam.
  • the mixing device described in EP 0 564 505 has the disadvantage that the mixer, which is firmly connected to the syringe, in particular when the solution is moved back and forth, can easily be broken off or tilted due to the long lever. Furthermore, the mixer is a component which, due to the spiral-shaped mixing elements arranged in the mixer, can only be produced as an injection-molded part using elaborate injection molds.
  • a dual chamber syringe connected to a static mixer capable of producing foam is disclosed in US-A-3767085.
  • the object of the invention is to provide a device with which medical foam can be generated from a gaseous and a liquid medium in a simple manner.
  • the device according to the invention has an active substance chamber and a gas chamber. Both chambers are closed with one piston each. Furthermore, the device has a foam generator, which in particular has one or more screens. Both the drug chamber and the gas chamber are connected directly or indirectly to the foam generator. According to the invention, the two pistons are arranged displaceably in the respective chamber. In particular, the two pistons are connected together or connectable during actuation of the device, so that the two pistons are displaced together in each case in one of the two chambers. This results in an increase in the pressure in the chambers and thus conveying or transporting the active substance and the gas in the direction of the foam generator or through the foam generator therethrough.
  • the device according to the invention is thus very easy to handle, as moved by a movement both pistons and thus both media are pressed or transported in the direction of the foam generator.
  • the emerging from the foam generator medical foam then only needs to be collected, but can also be applied directly.
  • a reciprocation of a gas and a liquid or a gas and a detergent between two syringes is not required.
  • the production of a standardized sterile foam is thus considerably easier.
  • the provision of a compressed gas container in the device according to the invention is not required.
  • the two pistons are connected to one another via a connecting element.
  • the connecting element is in this case preferably configured such that one of the two chambers is opened during displacement of the connecting element.
  • the connection of the two pistons takes place only by the actuation of the device.
  • the connecting element is particularly preferred in this case to form the connecting element as a conveying channel, for example as a hollow needle.
  • a driving element which may be formed in particular as a bead or plate. This makes it possible, when moving the connecting element in the direction of one of the two chambers closing the piston after the example piercing or opening of the piston to push it into the corresponding chamber and thus to increase the pressure in the chamber, so that the located in the chamber Preferably, medium flows into the hollow needle and through it to the foam generator.
  • one of the two pistons is in particular firmly connected to the foam generator. Furthermore, one of the two pistons may also be loosely connected to the foam generator.
  • the medium flows through the piston into the foam generator. Furthermore, it is preferred that the medium from the second chamber through this piston flowing.
  • the two media mix in this preferred embodiment, preferably in the foam generator and / or immediately before the foam generator. It is particularly preferred to push the medium from the chamber further away from the generation of foam through a delivery channel provided in the connecting element and at least partially supply it directly to the foam generator. In this embodiment, a mixing of the two media takes place directly in the foam generator. Possibly.
  • This mixing element may be provided in or in front of the foam generator, a mixing element in which a premixing of the two media takes place before they are pressed by the foam generator.
  • This mixing element may, for example, be a type of sponge or a sintered material which simultaneously serves to decelerate the active substance. As a result, the foam generation is improved.
  • foam generator within the syringe, for example in the batch, e.g. also forms the luer lock to provide.
  • a foam outlet opening of the foam generator can be connected to a foam collecting container.
  • the foam collecting container may be a conventional syringe, which may then be connected to the foam outlet opening, for example via a Luer lock.
  • the device according to the invention is suitable because of its simple and inexpensive construction of preferably individually manufacturable simple parts, especially for disposable use. In particular, due to the disposable use, the required sterility can be ensured. Another advantage of the device according to the invention is that the drug and the gas come into contact with each other only immediately before the application.
  • the device according to the invention for the production of medical foam has an active substance chamber 10 and a gas chamber 12.
  • the active substance chamber 10 is designed as a carpule 14 (FIG. 4) and is sealed with a first piston 16, which may be a rubber stopper or the like.
  • the carpule 14 is held in a holder 18, in which the carpule 14 in the direction of an arrow 20 in the holder 18 in the in Figs. 1 - 3 shown position is inserted.
  • the carpule 14 is in this case fixed by latching elements 22 and with respect to the latching elements 22 arranged stops 24 (FIG. 4) in the position.
  • the holder 18, which receives in the cylindrical opening 26, which preferably also circular cylindrical trained carpule 14 is connected to a cylindrical projection 28. Within the cylindrical projection 28, the gas chamber 12 is formed.
  • the gas chamber 12 is also sealed by a second piston 30.
  • the gas chamber can optionally also be designed as a carpule.
  • the likewise cylindrical gas chamber 12 has a larger diameter than the active substance chamber 10.
  • the provision of active ingredient or gas in the two chambers can also be reversed. This is particularly useful for drugs in which only a small amount of gas is required for foaming, ie in the case of active substances which are already readily foamable themselves.
  • the height of the gas chamber 12 and the active substance chamber 10 is substantially the same, wherein preferably the gas chamber 12 is slightly higher in order to be able to completely empty both chambers 10, 12 if the pistons 16, 30 are fully depressed.
  • the piston 30 is designed as a hollow needle connecting element 32 is connected.
  • the piston 30 has a suitable, for example, cylindrical projection 34 (FIG. 4) into which the hollow needle 32 can be inserted and held, for example, by adhesive bonding.
  • a foam generator 38 fixed or loose and possibly releasably connected.
  • the foam generator 38 has, in particular, two screens 40, which cause a swirling and mixing of the two media and thus the generation of foam.
  • the foam generator 38 is connected via a holder 42 with the piston 30.
  • the foam generator 38 may for example also each have one or more sinter filters, propellers, helices and / or spirals.
  • a loose or detachable connection of the foam generator 38 with the piston 30 has the advantage that the foam generator 38 can be pulled out together with the syringe 46 from the cylindrical projection 38 of the device according to the invention. Upon squeezing the foam out of the syringe 46, it is again forced through the foam generator 38, so that the quality of the foam produced can be further improved. Further, it is possible that on the inside of the cylindrical projection 28 locking elements are provided, is prevented by the fact that the piston 30 can be pulled out of the cylindrical projection 28.
  • the piston 30 may comprise locking elements, for example, in recesses engage, which are provided on the projection 28 when the piston 30 is pulled too far out of the projection 28.
  • the holder 42 has a foam outlet opening 44 (FIG. 4) through which the foam produced in the foam generator 38 emerges.
  • the foam exit port is a luer to which a conventional syringe 46 can be connected.
  • the syringe 46 serves as a foam collecting container, as shown in FIGS. 2 and 3 can be seen.
  • the holder 18 is placed on a base, so that the device, as shown in FIGS. 1-3, is aligned vertically. Subsequently, the syringe body is e.g. by means of the lugs 48 in FIGS. pressed down in the direction of arrow 50. The syringe plunger or syringe plunger 52 is not changed in its position.
  • the foam generator 38 and the second piston 30 is moved downward. Together with the piston 30, the hollow needle 32 firmly connected to the piston 30 is pushed downwards. In this case pierces a tip 54 of the hollow needle 32, the first piston 16 and thus opens the drug chamber 10th
  • a driving element 56 such as a plate is firmly connected, the plate 56 pushes the first piston 16 in the drug chamber 10.
  • the plate 56 pushes the first piston 16 in the drug chamber 10.
  • drug is pressed through the hollow needle 32 into the foam generator 38.
  • gas from the gas chamber 12 is forced into the foam generator 38 through openings 58 located in the piston 30 and / or through transverse bores in the hollow needle 32.
  • the resulting foam passes through the foam outlet opening 44 of the Foam generator 38 in the free by the movement of the syringe body space 60 within the syringe body.
  • a significant advantage of the device according to the invention is that it can be achieved by a single piston stroke, i. that in the Fign. 1 - 3 down-pressing the two pistons 16, 30, a foam in the syringe 46 is generated. After the foam has been produced, the syringe 46 can be released again from the luer adapter, so that subsequently the foam can be applied directly.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A device for producing medical foam, for example, a sclerosing agent, a diagnostic agent, a therapeutic agent, etc. The device comprises an active ingredient chamber and a gas chamber. Both chambers are respectively closed by a piston and connected to a foam generator. Both pistons are interconnected, especially by a connecting element, and can be displaced together, in order to supply the active ingredient and the gas to the foam producer.

Description

Die Erfindung betrifft eine Vorrichtung zur Erzeugung von insbesondere reproduzierbarem medizinischem Schaum bzw. Bläschensuspension aus einem gasförmigen und einem flüssigen Medium. Insbesondere betrifft die Erfindung eine Mischvorrichtung für die reproduzierbare Zubereitung und Verabreichung von Injektabilia - wie z.B. Verödungsmittel, Diagnostika, Therapeutika, Homöopathika und Eigenblut.The invention relates to a device for producing in particular reproducible medical foam or bubble suspension from a gaseous and a liquid medium. In particular, the invention relates to a mixing device for the reproducible preparation and administration of injectables - such as e.g. Sclerosing agents, diagnostics, therapeutics, homeopathic remedies and autologous blood.

Unter der Verödungstherapie versteht man die planvolle Ausschaltung von intra-, subkutanen und/ oder transfascialen Varizen sowie die Verödung subfascialer Gefäße bei venösen Fehlbildungen durch das Einspritzen eines Verödungsmittels. Die verschiedenen Verödungsmittel führen zu einer Schädigung des Endothels der Gefäße. Im Anschluss kommt es zu einem sekundären Gefäßverschluss und längerfristig zur Umwandlung der Venen in einen bindegewebigen Strang, zur Sklerose. Ziel der Verödungsbehandlung ist die, definitive Umwandlung in einen fibrösen Strang. Dieser kann nicht rekanalisieren und entspricht in seinem funktionellen Ergebnis dem operativen Vorgehen zur Entfernung einer Varize. Neben der Verödung mit flüssigen Sklerosierungsmitteln gewinnt zunehmend die Verödung mit geschäumten Sklerosierungsmitteln an Bedeutung. Der Schaum verbleibt länger in der Vene. Hierbei werden oberflächenaktive Verödungsmittel, wie z.B. Polidocanol, meistens durch Hin- und Herpumpen zwischen zwei Spritzen oder durch Aufschütteln in einen schaumartigen Zustand gebracht und dann konventionell injiziert. Zur Zeit gibt es noch kein zugelassenes Verfahren, das die reproduzierbare Zubereitung eines standardisierten Schaums ermöglicht.Sclerotherapy is the planed elimination of intra-, subcutaneous and / or transfascial varices and the sclerotherapy of subfascial vessels in venous malformations by injecting a sclerosing agent. The various sclerosing agents cause damage to the endothelium of the vessels. This is followed by a secondary vascular occlusion and, in the longer term, the transformation of the veins into a connective tissue strand, to sclerosis. The aim of the sclerotherapy is the definitive transformation into a fibrous strand. This can not recanalize and corresponds in its functional result to the surgical procedure for the removal of a varix. In addition to the sclerotherapy with liquid sclerosizing agents, the sclerotherapy with foamed sclerosants is becoming increasingly important. The foam stays longer in the vein. In this case, surface-active sclerosing agents, such as polidocanol, are usually brought into a foam-like state by reciprocating between two syringes or by shaking and then conventionally injected. At present, there is still no approved process that allows the reproducible preparation of a standardized foam.

Ferner sind zahlreiche als Echokontrastmittel geeignete Zubereitungen bekannt, die z.T. oberflächenaktive Stoffe enthalten, die die Bildung von Mikrobläschen unterstützen und diese stabilisieren. Die Ultraschall reflektierenden Mikrobläschen bzw. ein Schaum sind das eigentliche Kontrastmittel und werden erst unmittelbar vor Verabreichung erzeugt.In addition, numerous preparations suitable as echo contrast agents are known, which are currently available. contain surface-active substances that support the formation of microbubbles and stabilize them. The ultrasound-reflecting microbubbles or a foam are the actual contrast agent and are only generated immediately before administration.

Eine Mischeinrichtung zur Herstellung von medizinischem Schaum bzw. zur Herstellung von Bläschen ist aus EP 0 564 505 bekannt. Hierin ist ein Mischer mit einem wendelförmigen Mischelement beschrieben. Bei dem Mischer handelt es sich um ein Zusatzelement, das mit einer Spritze unlösbar verbunden werden kann. Beim Herausdrücken von flüssigem und/oder gasförmigem Medium aus einer zweiten Spritze gelangt das Medium in den Mischer, welcher das Gas in definiertem Volumen und Art enthält, Hierbei werden Gasphase und Flüssigphase entlang des wendelfömigen Mischelements durchmischt. Hierdurch kann ein therapeutischer und/oder diagnostischer Schaum erzeugt werden.A mixing device for producing medical foam or for producing bubbles is known from EP 0 564 505. Herein is described a mixer with a helical mixing element. The mixer is an additional element that can be permanently connected to a syringe. When expressing liquid and / or gaseous medium from a second syringe, the medium passes into the mixer, which contains the gas in a defined volume and type, Here, gas phase and liquid phase along the helical mixing element are mixed. This can produce a therapeutic and / or diagnostic foam.

Die in EP 0 564 505 beschriebene Mischeinrichtung weist den Nachteil auf, dass der mit der Spritze fest verbundene Mischer, insbesondere beim Hin- und Herbewegen der Lösung, auf Grund des langen Hebels leicht abbrechen oder verkantet werden kann. Ferner handelt es sich bei dem Mischer um ein Bauteil, das auf Grund der in dem Mischer angeordneten spiralförmigen Mischelemente nur mit aufwändigen Spritzgussformen als Spritzgussteil hergestellt werden kann.The mixing device described in EP 0 564 505 has the disadvantage that the mixer, which is firmly connected to the syringe, in particular when the solution is moved back and forth, can easily be broken off or tilted due to the long lever. Furthermore, the mixer is a component which, due to the spiral-shaped mixing elements arranged in the mixer, can only be produced as an injection-molded part using elaborate injection molds.

Eine Doppelkammer Spritze verbunden mit einem Statikmischer die zum Schaum erzeugen geeignet ist, ist in der US-A-3767085 offenbart.A dual chamber syringe connected to a static mixer capable of producing foam is disclosed in US-A-3767085.

Aufgabe der Erfindung ist es, eine Vorrichtung zu schaffen, mit der auf einfache Weise medizinischer Schaum aus einem gasförmigen und einem flüssigen Medium erzeugt werden kann.The object of the invention is to provide a device with which medical foam can be generated from a gaseous and a liquid medium in a simple manner.

Die Lösung der Aufgabe erfolgt erfindungsgemäß durch die Merkmale des Anspruchs 1.The object is achieved according to the invention by the features of claim 1.

Die erfindungsgemäße Vorrichtung weist eine Wirkstoffkammer und eine Gaskammer auf. Beide Kammern sind mit jeweils einem Kolben verschlossen. Ferner weist die Vorrichtung einen Schaumerzeuger, der insbesondere ein oder mehrere Siebe aufweist, auf. Sowohl die Wirkstoffkammer als auch die Gaskammer sind mittelbar oder unmittelbar mit dem Schaumerzeuger verbunden. Erfindungsgemäß sind die beiden Kolben in der jeweiligen Kammer verschiebbar angeordnet. Insbesondere sind die beiden Kolben miteinander verbunden bzw. während des Betätigens der Vorrichtung verbindbar, so dass die beiden Kolben gemeinsam jeweils in einer der beiden Kammern verschoben werden. Hierdurch erfolgt eine Erhöhung des Drucks in den Kammern und somit ein Fördern bzw. Transportieren des Wirkstoffes und des Gases in Richtung des Schaumerzeugers bzw. durch den Schaumerzeuger hindurch. Die erfindungsgemäße Vorrichtung ist somit sehr einfach handhabbar, da durch eine Bewegung beide Kolben bewegt und somit beide Medien in Richtung des Schaumerzeugers gedrückt bzw. transportiert werden. Der aus dem Schaumerzeuger austretende medizinische Schaum muss sodann nur noch aufgefangen werden, kann jedoch auch unmittelbar appliziert werden.The device according to the invention has an active substance chamber and a gas chamber. Both chambers are closed with one piston each. Furthermore, the device has a foam generator, which in particular has one or more screens. Both the drug chamber and the gas chamber are connected directly or indirectly to the foam generator. According to the invention, the two pistons are arranged displaceably in the respective chamber. In particular, the two pistons are connected together or connectable during actuation of the device, so that the two pistons are displaced together in each case in one of the two chambers. This results in an increase in the pressure in the chambers and thus conveying or transporting the active substance and the gas in the direction of the foam generator or through the foam generator therethrough. The device according to the invention is thus very easy to handle, as moved by a movement both pistons and thus both media are pressed or transported in the direction of the foam generator. The emerging from the foam generator medical foam then only needs to be collected, but can also be applied directly.

Bei der erfindungsgemäßen Vorrichtung ist ein Hin- und Herbewegen eines Gases und einer Flüssigkeit bzw. eines Gases und eines Detergens zwischen zwei Spritzen nicht erforderlich. Die Herstellung eines standardisierten sterilen Schaums ist somit erheblich einfacher. Ferner ist das Vorsehen eines Druckgasbehälters bei der erfindungsgemäßen Vorrichtung nicht erforderlich.In the device according to the invention a reciprocation of a gas and a liquid or a gas and a detergent between two syringes is not required. The production of a standardized sterile foam is thus considerably easier. Furthermore, the provision of a compressed gas container in the device according to the invention is not required.

Vorzugsweise sind die beiden Kolben über ein Verbindungselement miteinander verbunden. Das Verbindungselement ist hierbei vorzugsweise derart ausgestaltet, dass beim Verschieben des Verbindungselementes eine der beiden Kammern geöffnet wird. Ferner kann durch das Verschieben des Verbindungselementes ein Verbinden der beiden Kolben erfolgen. Vorzugsweise erfolgt das Verbinden der beiden Kolben erst durch das Betätigen der Vorrichtung. Dies hat den Vorteil, dass die beiden Kammern vollständig voneinander getrennt sind und dicht abgeschlossen werden können. Besonders bevorzugt ist es hierbei, das Verbindungselement als Förderkanal, beispielsweise als Hohlnadel, auszubilden. Durch das Bewegen des Verbindungselements zusammen mit einem der beiden Kolben erfolgt ein Einführen des Verbindungskanals in eine der beiden Kammern. Sofern das Verbindungselement als Hohlnadel ausgebildet ist, erfolgt ein Aufstechen einer der beiden Kammern, indem die Hohlnadel beispielsweise durch den zweiten Kolben hindurch sticht.Preferably, the two pistons are connected to one another via a connecting element. The connecting element is in this case preferably configured such that one of the two chambers is opened during displacement of the connecting element. Furthermore, by moving the Connecting element connecting the two pistons done. Preferably, the connection of the two pistons takes place only by the actuation of the device. This has the advantage that the two chambers are completely separated from each other and can be sealed tightly. It is particularly preferred in this case to form the connecting element as a conveying channel, for example as a hollow needle. By moving the connecting element together with one of the two pistons, the connecting channel is inserted into one of the two chambers. If the connecting element is designed as a hollow needle, piercing one of the two chambers takes place in that the hollow needle pierces, for example, through the second piston.

Besonders bevorzugt ist es, an dem Verbindungselement ein Mitnahmeelement, das insbesondere als Wulst oder Teller ausgebildet sein kann, vorzusehen. Hierdurch ist es möglich, beim Bewegen des Verbindungselements in Richtung eines der beiden die Kammern verschließenden Kolben nach dem beispielsweise Durchstechen bzw. Öffnen des Kolbens diesen in die entsprechende Kammer einzudrücken und somit den Druck in der Kammer zu erhöhen, so dass das in der Kammer befindliche Medium vorzugsweise in die Hohlnadel und durch diese zu dem Schaumerzeuger strömt.It is particularly preferred to provide on the connecting element a driving element, which may be formed in particular as a bead or plate. This makes it possible, when moving the connecting element in the direction of one of the two chambers closing the piston after the example piercing or opening of the piston to push it into the corresponding chamber and thus to increase the pressure in the chamber, so that the located in the chamber Preferably, medium flows into the hollow needle and through it to the foam generator.

Anstelle eines gemeinsamen Verschiebens der beiden Kolben, die vorzugsweise über das Verbindungselement miteinander verbunden sind, ist auch ein Verschieben der beiden Kammern möglich. Relevant ist lediglich die Relativbewegung zwischen den Kammern und den Kolben.Instead of a common displacement of the two pistons, which are preferably connected to one another via the connecting element, a displacement of the two chambers is possible. Only the relative movement between the chambers and the pistons is relevant.

Vorzugsweise ist einer der beiden Kolben mit dem Schaumerzeuger insbesondere fest verbunden. Ferner kann einer der beiden Kolben auch lose mit dem Schaumerzeuger verbunden sein. Vorzugsweise strömt das Medium durch den Kolben hindurch in den Schaumerzeuger. Ferner ist es bevorzugt, dass auch das Medium aus der zweiten Kammer durch diesen Kolben hindurchströmt. Die beiden Medien mischen sich bei dieser bevorzugten Ausführungsform vorzugsweise im Schaumerzeuger und/ oder unmittelbar vor dem Schaumerzeuger. Besonders bevorzugt ist es, das Medium aus der von dem Schaumerzeugung weiter entfernten Kammer durch einen im Verbindungselement vorgesehenen Förderkanal hindurchzudrücken und zumindest teilweise unmittelbar dem Schaumerzeuger zuzuführen. Bei dieser Ausführungsform erfolgt ein Mischen der beiden Medien unmittelbar im Schaumerzeuger. Ggf. kann in oder vor dem Schaumerzeuger ein Mischelement vorgesehen sein, in dem ein Vormischen der beiden Medien erfolgt bevor diese durch den Schaumerzeuger gedrückt werden. Bei diesem Mischelement kann es sich beispielsweise um eine Art Schwämmchen oder ein Sintermaterial handeln, das gleichzeitig zum Abbremsen des Wirkstoffes dient. Hierdurch ist die Schaumerzeugung verbessert.Preferably, one of the two pistons is in particular firmly connected to the foam generator. Furthermore, one of the two pistons may also be loosely connected to the foam generator. Preferably, the medium flows through the piston into the foam generator. Furthermore, it is preferred that the medium from the second chamber through this piston flowing. The two media mix in this preferred embodiment, preferably in the foam generator and / or immediately before the foam generator. It is particularly preferred to push the medium from the chamber further away from the generation of foam through a delivery channel provided in the connecting element and at least partially supply it directly to the foam generator. In this embodiment, a mixing of the two media takes place directly in the foam generator. Possibly. may be provided in or in front of the foam generator, a mixing element in which a premixing of the two media takes place before they are pressed by the foam generator. This mixing element may, for example, be a type of sponge or a sintered material which simultaneously serves to decelerate the active substance. As a result, the foam generation is improved.

Ferner ist es möglich, den Schaumerzeuger innerhalb der Spritze, beispielsweise in dem Ansatz, der z.B. auch den Luer-Lock ausbildet, vorzusehen.Further, it is possible to use the foam generator within the syringe, for example in the batch, e.g. also forms the luer lock to provide.

Vorzugsweise ist eine Schaumaustrittsöffnung des Schaumerzeugers mit einem Schaumauffangbehälter verbindbar. Bei dem Schaumauffangbehälter kann es sich beispielsweise um eine herkömmliche Spritze handeln, die sodann beispielsweise über einen Luer-Lock mit der Schaumaustrittsöffnung verbunden werden kann.Preferably, a foam outlet opening of the foam generator can be connected to a foam collecting container. By way of example, the foam collecting container may be a conventional syringe, which may then be connected to the foam outlet opening, for example via a Luer lock.

Die erfindungsgemäße Vorrichtung ist auf Grund ihres einfachen und kostengünstigen Aufbaus aus vorzugsweise einzeln herstellbaren einfachen Teilen insbesondere für den Einweg-Gebrauch geeignet. Insbesondere auf Grund des Einweg-Gebrauchs kann die erforderliche Sterilität gewährleistet werden. Ein weiterer Vorteil der erfindungsgemäßen Vorrichtung besteht darin, dass das Arzneimittel und das Gas erst unmittelbar vor der Applikation miteinander in Kontakt kommen.The device according to the invention is suitable because of its simple and inexpensive construction of preferably individually manufacturable simple parts, especially for disposable use. In particular, due to the disposable use, the required sterility can be ensured. Another advantage of the device according to the invention is that the drug and the gas come into contact with each other only immediately before the application.

Nachfolgend wird die Erfindung anhand einer bevorzugten Ausführungsform unter Bezugnahme auf die anliegenden Zeichnungen näher erläutert.The invention will be explained in more detail with reference to a preferred embodiment with reference to the accompanying drawings.

Es zeigen:

Fig. 1 - 3
eine schematische, teilweise geschnittene Seitenansicht der Vorrichtung in drei unterschiedlichen Mischzuständen und
Fig.4
eine schematische Explosionszeichnung der erfindungsgemäßen Vorrichtung.
Show it:
Fig. 1-3
a schematic, partially sectioned side view of the device in three different mixed states and
Figure 4
a schematic exploded view of the device according to the invention.

Die erfindungsgemäße Vorrichtung zur Erzeugung von medizinischem Schaum weist eine Wirkstoffkammer 10 und eine Gaskammer 12 auf. Die Wirkstoffkammer 10 ist als Carpule 14 (Fig. 4) ausgebildet und mit einem ersten Kolben 16, bei dem es sich um einen Gummistopfen oder dgl. handeln kann, dicht verschlossen. Die Carpule 14 wird in einer Halterung 18 gehalten, in dem die Carpule 14 in Richtung eines Pfeils 20 in die Halterung 18 in die in den Fign. 1 - 3 dargestellte Lage eingeschoben wird. Die Carpule 14 wird hierbei durch Rastelemente 22 und gegenüber den Rastelementen 22 angeordneten Anschlägen 24 (Fig. 4) in der Lage fixiert. Die Halterung 18, die in der zylindrischen Öffnung 26, die vorzugsweise ebenfalls kreiszylindrisch ausgebildete Carpule 14 aufnimmt, ist mit einem zylindrischen Ansatz 28 verbunden. Innerhalb des zylindrischen Ansatzes 28 ist die Gaskammer 12 ausgebildet.The device according to the invention for the production of medical foam has an active substance chamber 10 and a gas chamber 12. The active substance chamber 10 is designed as a carpule 14 (FIG. 4) and is sealed with a first piston 16, which may be a rubber stopper or the like. The carpule 14 is held in a holder 18, in which the carpule 14 in the direction of an arrow 20 in the holder 18 in the in Figs. 1 - 3 shown position is inserted. The carpule 14 is in this case fixed by latching elements 22 and with respect to the latching elements 22 arranged stops 24 (FIG. 4) in the position. The holder 18, which receives in the cylindrical opening 26, which preferably also circular cylindrical trained carpule 14 is connected to a cylindrical projection 28. Within the cylindrical projection 28, the gas chamber 12 is formed.

Die Gaskammer 12 ist durch einen zweiten Kolben 30 ebenfalls dicht verschlossen. Die Gaskammer kann wahlweise auch als Carpule ausgebildet sein. Die ebenfalls zylindrisch ausgebildete Gaskammer 12 weist einen größeren Durchmesser als die Wirkstoffkammer 10 auf. Selbstverständlich kann das Vorsehen von Wirkstoff bzw. Gas in den beiden Kammern auch vertauscht werden. Dies ist insbesondere bei Wirkstoffen zweckmäßig, bei denen nur eine geringe Menge an Gas zum Aufschäumen erforderlich ist, d.h. bei Wirkstoffen, die bereits selbst leicht schäumbar sind. Die Höhe der Gaskammer 12 sowie der Wirkstoffkammer 10 ist im Wesentlichen gleich, wobei vorzugsweise die Gaskammer 12 geringfügig höher ist, um bei vollständig eingedrückten Kolben 16, 30 beide Kammern 10, 12 ggf. vollständig entleeren zu können.The gas chamber 12 is also sealed by a second piston 30. The gas chamber can optionally also be designed as a carpule. The likewise cylindrical gas chamber 12 has a larger diameter than the active substance chamber 10. Of course, the provision of active ingredient or gas in the two chambers can also be reversed. This is particularly useful for drugs in which only a small amount of gas is required for foaming, ie in the case of active substances which are already readily foamable themselves. The height of the gas chamber 12 and the active substance chamber 10 is substantially the same, wherein preferably the gas chamber 12 is slightly higher in order to be able to completely empty both chambers 10, 12 if the pistons 16, 30 are fully depressed.

Mit dem zweiten Kolben 30 ist ein als Hohlnadel ausgebildetes Verbindungselement 32 verbunden. Hierzu weist der Kolben 30 einen geeigneten, beispielsweise zylindrischen Ansatz 34 (Fig. 4) auf, in den die Hohlnadel 32 einsteckbar und beispielsweise durch Verkleben gehalten ist.With the second piston 30 is designed as a hollow needle connecting element 32 is connected. For this purpose, the piston 30 has a suitable, for example, cylindrical projection 34 (FIG. 4) into which the hollow needle 32 can be inserted and held, for example, by adhesive bonding.

Ferner ist mit dem Kolben 30, der an der Innenwandung 36 der Gaskammer 12 abdichtend anliegt, ein Schaumerzeuger 38 fest oder lose und ggf. lösbar verbunden. Der Schaumerzeuger 38 weist insbesondere zwei Siebe 40 auf, die ein Verwirbeln und Vermischen der beiden Medien und somit das Erzeugen von Schaum hervorrufen. Der Schaumerzeuger 38 ist über eine Halterung 42 mit dem Kolben 30 verbunden.Further, with the piston 30, which bears sealingly against the inner wall 36 of the gas chamber 12, a foam generator 38 fixed or loose and possibly releasably connected. The foam generator 38 has, in particular, two screens 40, which cause a swirling and mixing of the two media and thus the generation of foam. The foam generator 38 is connected via a holder 42 with the piston 30.

Zusätzlich oder anstatt eines oder mehrerer Siebe kann der Schaumerzeuger 38 beispielsweise auch jeweils einen oder mehrere Sinteifilter, Propeller, Wendeln und/ oder Spiralen aufweisen.In addition to or instead of one or more screens, the foam generator 38 may for example also each have one or more sinter filters, propellers, helices and / or spirals.

Ein loses bzw. lösbares Verbinden des Schaumerzeugers 38 mit dem Kolben 30 hat den Vorteil, dass der Schaumerzeuger 38 zusammen mit der Spritze 46 aus dem zylindrischen Ansatz 38 der erfindungsgemäßen Vorrichtung herausgezogen werden kann. Beim Herausdrücken des Schaums aus der Spritze 46 wird diese erneut durch den Schaumerzeuger 38 gedrückt, so dass die Qualität des hergestellten Schaums weiter verbessert werden kann. Ferner ist es möglich, dass an der Innenseite des zylindrischen Ansatzes 28 Rastelemente vorgesehen sind, durch die verhindert ist, dass der Kolben 30 aus dem zylindrischen Ansatz 28 herausgezogen werden kann. Ebenso kann der Kolben 30 Rastelemente aufweisen, die beispielsweise in Ausnehmungen einrasten, die an dem Ansatz 28 vorgesehen sind, wenn der Kolben 30 zu weit aus dem Ansatz 28 herausgezogen wird.A loose or detachable connection of the foam generator 38 with the piston 30 has the advantage that the foam generator 38 can be pulled out together with the syringe 46 from the cylindrical projection 38 of the device according to the invention. Upon squeezing the foam out of the syringe 46, it is again forced through the foam generator 38, so that the quality of the foam produced can be further improved. Further, it is possible that on the inside of the cylindrical projection 28 locking elements are provided, is prevented by the fact that the piston 30 can be pulled out of the cylindrical projection 28. Likewise, the piston 30 may comprise locking elements, for example, in recesses engage, which are provided on the projection 28 when the piston 30 is pulled too far out of the projection 28.

Die Halterung 42 weist eine Schaumaustrittsöffnung 44 (Fig. 4) auf, durch die der in dem Schaumerzeuger 38 erzeugte Schaum austritt. In dem dargestellten besonders bevorzugten Ausführungsbeispiel der Erfindung handelt es sich bei der Schaumaustrittsöffnung um einen Luer, mit dem eine herkömmliche Spritze 46 verbunden werden kann. Die Spritze 46 dient hierbei als Schaumauffangbehälter, wie anhand der Fign. 2 und 3 ersichtlich.The holder 42 has a foam outlet opening 44 (FIG. 4) through which the foam produced in the foam generator 38 emerges. In the illustrated particularly preferred embodiment of the invention, the foam exit port is a luer to which a conventional syringe 46 can be connected. The syringe 46 serves as a foam collecting container, as shown in FIGS. 2 and 3 can be seen.

Zur Herstellung von Schaum wird die Halterung 18 auf eine Unterlage gestellt, so dass die Vorrichtung, wie in den Fign. 1 - 3 dargestellt, vertikal ausgerichtet ist. Anschließend wird der Spritzenkörper z.B. mit Hilfe der Ansätze 48 in den Fign. nach unten in Richtung eines Pfeils 50 gedrückt. Der Spritzenkolben oder Spritzenstempel 52 wird hierbei in seiner Lage nicht verändert. Durch die Verschiebung des Spritzenkörpers nach unten in die Halterung 28 hinein wird insbesondere der Schaumerzeuger 38 sowie der zweite Kolben 30 nach unten verschoben. Zusammen mit dem Kolben 30 wird die mit dem Kolben 30 fest verbundene Hohlnadel 32 nach unten geschoben. Hierbei durchstößt eine Spitze 54 der Hohlnadel 32 den ersten Kolben 16 und öffnet somit die Wirkstoffkammer 10.For the production of foam, the holder 18 is placed on a base, so that the device, as shown in FIGS. 1-3, is aligned vertically. Subsequently, the syringe body is e.g. by means of the lugs 48 in FIGS. pressed down in the direction of arrow 50. The syringe plunger or syringe plunger 52 is not changed in its position. By the displacement of the syringe body down into the holder 28 in particular, the foam generator 38 and the second piston 30 is moved downward. Together with the piston 30, the hollow needle 32 firmly connected to the piston 30 is pushed downwards. In this case pierces a tip 54 of the hollow needle 32, the first piston 16 and thus opens the drug chamber 10th

Da mit dem Verbindungselement bzw. der Hohlnadel 32 ein Mitnahmeelement 56, wie ein Teller, fest verbunden ist, drückt der Teller 56 den ersten Kolben 16 in die Wirkstoffkammer 10. Durch die Verschiebung der beiden Kolben 30, 16 erfolgt sowohl eine Druckerhöhung in der Wirkstoffkammer 10 als auch in der Gaskammer 12. Hierdurch wird Wirkstoff durch die Hohlnadel 32 in den Schaumerzeuger 38 gedrückt. Ferner wird Gas aus der Gaskammer 12 durch Öffnungen 58, die sich in dem Kolben 30 befinden und/oder durch Querbohrungen in der Hohlnadel 32, in den Schaumerzeuger 38 gedrückt. Der hierbei entstehende Schaum gelangt durch die Schaumaustrittsöffnung 44 des Schaumerzeugers 38 in den durch die Bewegung des Spritzenkörpers frei werden Raum 60 innerhalb des Spritzenkörpers.Since with the connecting element or the hollow needle 32, a driving element 56, such as a plate is firmly connected, the plate 56 pushes the first piston 16 in the drug chamber 10. By the displacement of the two pistons 30, 16, both an increase in pressure in the drug chamber 10 as well as in the gas chamber 12. As a result, drug is pressed through the hollow needle 32 into the foam generator 38. Further, gas from the gas chamber 12 is forced into the foam generator 38 through openings 58 located in the piston 30 and / or through transverse bores in the hollow needle 32. The resulting foam passes through the foam outlet opening 44 of the Foam generator 38 in the free by the movement of the syringe body space 60 within the syringe body.

Ein wesentlicher Vorteil der erfindungsgemäßen Vorrichtung besteht darin, dass durch einen einmaligen Kolbenhub, d.h. das in den Fign. 1 - 3 nachunten-Drücken der beiden Kolben 16, 30 ein Schaum in der Spritze 46 erzeugt wird. Die Spritze 46 kann nach Erzeugen des Schaums wieder von dem Luer-Adapter gelöst werden, so dass anschließend der Schaum unmittelbar appliziert werden kann.A significant advantage of the device according to the invention is that it can be achieved by a single piston stroke, i. that in the Fign. 1 - 3 down-pressing the two pistons 16, 30, a foam in the syringe 46 is generated. After the foam has been produced, the syringe 46 can be released again from the luer adapter, so that subsequently the foam can be applied directly.

Claims (10)

  1. Device for producing medicinal foam, comprising:
    an active agent chamber (10) closed with a first piston (16),
    a gas chamber (12) closed with a second piston (30), and
    a foam producing means (38) connected with the active agent chamber (10) and the gas chamber (12),

    wherein both pistons (16, 30) may be interconnected and displaced in common to feed the active agent and the gas to the foam producing means (38)
    characterized in that
    the two pistons (16, 30) are interconnected through a connecting element (32) which opens one of the chambers (10) when it is displaced.
  2. Device of claim 1, wherein the connecting element (32) comprises a feed channel through which the active agent and/or the gas can flow towards the foam producing means (38).
  3. Device of claim 1 or 2, wherein the connecting element (32) comprises an entrainment element (56) for entraining one of the two pistons (16).
  4. Device of one of claims 1 - 3, wherein the feed channel connects the chamber (10) opened by the connecting element (32) immediately with the foam producing means (38) and/or the other chamber (12).
  5. Device of one of claims 1 - 4, wherein the chambers (10, 12) adjoin each other.
  6. Device of one of claims 1 - 5, wherein one of the two pistons (16, 30) is in particular rigidly connected to the foam producing means (38).
  7. Device of one of claims 1 - 6, wherein the foam producing means (38) has a foam exit opening (44) connectable to a foam collecting vessel (46) or an application aid.
  8. Device of one of claims 1-7, wherein the foam producing means (38) includes at least one, preferably at least two sieves (40) for producing foam.
  9. Device of one of claims 1 - 8, wherein a slow-down element is provided that is arranged upstream of the foam producing means (38) to cause, in particular, a slowing of the active agent and thus a pre-mixing of the active agent and the gas.
  10. Device of one of claims 1 - 9, wherein the connecting element (32) has openings for the active agent and/or the gas to exit from the feed channel of the connecting element (32) into a chamber (12).
EP03795826.1A 2002-11-28 2003-11-13 Device for producing medical foam Expired - Lifetime EP1572336B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE20218493U DE20218493U1 (en) 2002-11-28 2002-11-28 Device for producing medical foam
DE20218493U 2002-11-28
PCT/EP2003/012894 WO2004047969A1 (en) 2002-11-28 2003-11-13 Device for producing medical foam

Publications (3)

Publication Number Publication Date
EP1572336A1 EP1572336A1 (en) 2005-09-14
EP1572336B1 true EP1572336B1 (en) 2006-03-15
EP1572336B2 EP1572336B2 (en) 2018-01-24

Family

ID=32103522

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03795826.1A Expired - Lifetime EP1572336B2 (en) 2002-11-28 2003-11-13 Device for producing medical foam

Country Status (7)

Country Link
US (1) US7963938B2 (en)
EP (1) EP1572336B2 (en)
AT (1) ATE320304T1 (en)
AU (1) AU2003298123A1 (en)
DE (2) DE20218493U1 (en)
ES (1) ES2260686T3 (en)
WO (1) WO2004047969A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
GB0028692D0 (en) 2000-11-24 2001-01-10 Btg Int Ltd Generation of therapeutic microform
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
DE20218493U1 (en) 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Device for producing medical foam
DE602004024925D1 (en) 2003-11-17 2010-02-11 Btg Int Ltd PROCESS FOR PREPARING A LOOK WITH A SCLEROSING AGENT
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
DE102004048749B4 (en) * 2004-10-05 2007-03-29 Chemische Fabrik Kreussler & Co. Gmbh Device for producing a medical foam
DE102005011174B4 (en) 2005-03-09 2022-03-24 Chemische Fabrik Kreussler & Co. Gmbh Device for generating a medical foam
FR2883731B1 (en) * 2005-03-31 2008-03-14 Alain Monfreux DEVICE FOR THE PRODUCTION OF FORMED FOAM OF GAS BUBBLES AND A SURFACE LIQUID
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
GB0509845D0 (en) * 2005-05-13 2005-06-22 Btg Int Ltd Preparation of therapeutic foam
US8672879B2 (en) * 2005-10-13 2014-03-18 Argos Therapeutics, Inc. Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures
US20090318890A1 (en) * 2006-11-27 2009-12-24 Frank Levy Portable Medical Foam Apparatus
US9486594B2 (en) 2006-11-27 2016-11-08 Frank Levy Portable medical gas delivery system
US8876749B2 (en) 2006-11-27 2014-11-04 Frank Levy Apparatus and process for producing CO2 enriched medical foam
US9662435B2 (en) 2006-01-31 2017-05-30 Frank Levy System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid
US11833320B2 (en) 2006-11-27 2023-12-05 Frank Levy Apparatus and process for producing CO2 enriched medical foam
US10350399B2 (en) 2006-11-27 2019-07-16 Frank Levy Apparatus and method for producing an enriched medical suspension of carbon dioxide
US10149935B2 (en) 2006-11-27 2018-12-11 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
US11185671B2 (en) 2006-11-27 2021-11-30 Frank Levy Apparatus and process for producing CO2 enriched medical foam
US9427522B2 (en) 2006-11-27 2016-08-30 Frank Levy Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid
US10155093B2 (en) 2006-11-27 2018-12-18 Frank Levy Apparatus and method for producing CO2 enriched medical foam
US11712510B2 (en) 2006-11-27 2023-08-01 Frank Levy Delivery system and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid
US10322271B2 (en) 2006-11-27 2019-06-18 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
CA2678198A1 (en) * 2009-09-08 2011-03-08 Duoject Medical Systems Inc. Ez-linking device for fluid transfer
US8449494B2 (en) * 2009-12-16 2013-05-28 Cook Medical Technologies Llc Apparatus and method for preparing foam
EP2508219B1 (en) * 2011-04-05 2018-06-06 Kpr U.S., Llc Buffering agent delivery system for anesthetic syringe
GB201612948D0 (en) * 2016-07-26 2016-09-07 Provensis Ltd syringe for administering foam
RU2659632C1 (en) * 2017-04-04 2018-07-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Device for foaming and administering a medicament
CN107096406B (en) * 2017-05-11 2023-09-15 金宝医学科技(深圳)有限公司 Micro-foam generating device and method
WO2019233546A1 (en) * 2018-06-04 2019-12-12 Gemü Gmbh Applicator
CN111013423A (en) * 2020-01-06 2020-04-17 中国人民解放军陆军军医大学第一附属医院 Foaming device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425580A (en) 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
EP0695555A1 (en) 1992-12-01 1996-02-07 HIGASHIKAWA, Tetsuro Syringe
WO1996008227A1 (en) 1994-09-16 1996-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Mixing device for agents to be administered with a syringe
WO2000072821A1 (en) 1999-05-26 2000-12-07 Btg International Limited Generation of therapeutic microfoam
WO2002041872A1 (en) 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
GB2369996A (en) 2000-12-18 2002-06-19 S T D Pharmaceutical Products Method and apparatus for producing an injectable foam

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2630183A (en) * 1950-01-26 1953-03-03 Foutz Clinton Root Apparatus for forming and projecting a foam mixture
US2653607A (en) * 1950-09-16 1953-09-29 Ayerst Mckenna & Harrison Injection apparatus
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
US2772677A (en) * 1953-02-18 1956-12-04 Izaak A Ulert Syringe assembly
US3248014A (en) * 1964-10-07 1966-04-26 Orville N Greene Piston type dispenser
DE1278703B (en) * 1967-01-21 1968-09-26 Penicillin Ges Dauelsberg & Co Two-chamber syringe
US3767085A (en) * 1971-08-02 1973-10-23 J Cannon Mixing syringe
BE792131A (en) * 1972-02-15 1973-03-16 Sherwood Medical Ind Inc DEVICES FOR INJECTING MEDICINES
US4014463A (en) * 1975-11-28 1977-03-29 Kenics Corporation Plural component dispenser
US4059109A (en) † 1976-07-27 1977-11-22 Tischlinger Edward A Mixing and dispensing disposable medicament injector
US4538920A (en) * 1983-03-03 1985-09-03 Minnesota Mining And Manufacturing Company Static mixing device
DE3417182A1 (en) † 1984-05-09 1985-11-14 Gerald Dr. 8000 München Hauer Syringe set
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
DE8916222U1 (en) * 1988-09-29 1995-08-10 Afa Products Inc Foam nozzle arrangement
DE59105805D1 (en) 1990-12-28 1995-07-27 Byk Gulden Lomberg Chem Fab PHARMACEUTICAL FORM FOR MICROBUBBLE ECHOCONTRASTER.
CN1106189C (en) * 1993-09-07 2003-04-23 生物技术公司 Syringe device for mixing two compounds
DE4338553A1 (en) * 1993-11-08 1995-05-18 Ferring Arzneimittel Gmbh Injection syringe for mixing and applying injection substances
US5454805A (en) * 1994-03-14 1995-10-03 Brony; Seth K. Medicine vial link for needleless syringes
FR2775433A1 (en) * 1998-02-27 1999-09-03 Alain Monfreux DEVICE FOR PRODUCING FOAM IN A SYRINGE BODY
DE20015594U1 (en) * 2000-09-08 2001-06-21 Herrmann Frank Device for infinitely variable, quantity and pressure-controlled entry of gas into liquid media
US6592251B2 (en) * 2001-01-26 2003-07-15 Howmedica Osteonics Corp. Cement mixing and dispensing device
DE20218493U1 (en) 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Device for producing medical foam

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425580A (en) 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
EP0695555A1 (en) 1992-12-01 1996-02-07 HIGASHIKAWA, Tetsuro Syringe
WO1996008227A1 (en) 1994-09-16 1996-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Mixing device for agents to be administered with a syringe
WO2000072821A1 (en) 1999-05-26 2000-12-07 Btg International Limited Generation of therapeutic microfoam
WO2002041872A1 (en) 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
GB2369996A (en) 2000-12-18 2002-06-19 S T D Pharmaceutical Products Method and apparatus for producing an injectable foam

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.M. MACDONALD: "Chambers's Twentieth Century Dictionary", 1981, W. AND R. CHAMBERS, pages: 1258, XP055310159
MAYER H. ET AL.: "Zur Atiologie und Behandlung der V arizen . der unteren Extremitat", CHIRUGISHE PRAXIS, no. Issue 4, 1957, pages 521 - 528, XP055310155
WOLLMANN J-C G. R.: "The History of Sclerosing Foams", DERMATOL. SURG., vol. 30, 2004, pages 694 - 703, XP055310139

Also Published As

Publication number Publication date
US7963938B2 (en) 2011-06-21
DE20218493U1 (en) 2004-04-08
WO2004047969A1 (en) 2004-06-10
AU2003298123A1 (en) 2004-06-18
US20060178620A1 (en) 2006-08-10
DE50302685D1 (en) 2006-05-11
ES2260686T3 (en) 2006-11-01
ATE320304T1 (en) 2006-04-15
EP1572336A1 (en) 2005-09-14
EP1572336B2 (en) 2018-01-24

Similar Documents

Publication Publication Date Title
EP1572336B1 (en) Device for producing medical foam
DE69930615T2 (en) COMPOSITION AND METHOD FOR THE DISPERSION AND PROVISION OF FLUIDS
EP1796761B2 (en) Device for producing a medical foam
DE60209389T2 (en) Storage and dispensing device for biological sealant
EP1931405B1 (en) Automatic injection device for two-chamber ampullas
DE69820916T2 (en) Fibrin-based adhesive application device
DE69433044T2 (en) Production of an injection cartridge
DE60128713T2 (en) AUTOMATIC INJECTION DEVICE WITH WET AND DRY CHAMBER
DE60123237T2 (en) AUTOMATIC INJECTION DEVICE WITH DRYER AND LIQUID COMPONENT
EP1498073B1 (en) System and procedure for mixing of at least four components
EP3213707B1 (en) Storage and mixing system for pasty cement components and method therefor
EP3584005B1 (en) Bone cement applicator with retractable mixing rod and method for producing a bone cement
DE1491819B1 (en) Syringe rack assembly
DE10101932A1 (en) Suction piece for a device for administering an injectable product comprises a suction chamber which is placeable on the skin, and has a fluid connection to a product reservoir
DE69928012T2 (en) INJECTION DEVICE
CH691031A5 (en) Two-part device for the administration of drugs.
DE102010019217A1 (en) Cartridge system and discharge tube for such a cartridge system
DE102005041962B3 (en) Cartridge for storing e.g. dental casting compound, has discharge opening whose height in axial direction of cylindrical pipe is larger than axial length of interlocking plunger that is arranged in pipe
EP3584004B1 (en) Bone cement applicator with retractable mixing rod and method for producing a bone cement
DE69923198T2 (en) CATHETER, WHICH ALLOWS MIXING COMPONENTS
WO1997002060A1 (en) Automatic cannula withdrawing device for injection syringes
DE2206596A1 (en) Injection syringe
EP3219274A2 (en) Storage and mixing system for pasty cement components
DE2541377A1 (en) INJECTION SYRINGE WITH TWO CHAMBERS
DE3417182A1 (en) Syringe set

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

17P Request for examination filed

Effective date: 20050415

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20060315

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REF Corresponds to:

Ref document number: 50302685

Country of ref document: DE

Date of ref document: 20060511

Kind code of ref document: P

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20060517

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060615

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060615

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060816

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2260686

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20061130

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20061130

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

26 Opposition filed

Opponent name: BTG INTERNATIONAL LIMITED

Effective date: 20061215

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLAS Information related to reply of patent proprietor to notice(s) of opposition deleted

Free format text: ORIGINAL CODE: EPIDOSDOBS3

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

BERE Be: lapsed

Owner name: CHEMISCHE FABRIK KREUSSLER & CO. G.M.B.H.

Effective date: 20061130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060616

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071130

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20061113

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060916

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071130

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20060315

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20101119

Year of fee payment: 8

PLCK Communication despatched that opposition was rejected

Free format text: ORIGINAL CODE: EPIDOSNREJ1

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

APBM Appeal reference recorded

Free format text: ORIGINAL CODE: EPIDOSNREFNO

APBP Date of receipt of notice of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA2O

APBQ Date of receipt of statement of grounds of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA3O

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 320304

Country of ref document: AT

Kind code of ref document: T

Effective date: 20111113

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111113

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20121123

Year of fee payment: 10

Ref country code: ES

Payment date: 20121122

Year of fee payment: 10

Ref country code: GB

Payment date: 20121122

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20131119

Year of fee payment: 11

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20131113

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131113

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131113

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

R26 Opposition filed (corrected)

Opponent name: BTG INTERNATIONAL LIMITED

Effective date: 20061215

APBU Appeal procedure closed

Free format text: ORIGINAL CODE: EPIDOSNNOA9O

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20150709

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131114

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20150731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141201

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

PLBC Reply to examination report in opposition received

Free format text: ORIGINAL CODE: EPIDOSNORE3

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20180124

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R102

Ref document number: 50302685

Country of ref document: DE

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20191202

Year of fee payment: 17

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 50302685

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210601