EP1556128B1 - Dispositif d'imagerie pour applications de traitement par rayonnement - Google Patents

Dispositif d'imagerie pour applications de traitement par rayonnement Download PDF

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Publication number
EP1556128B1
EP1556128B1 EP03808034.7A EP03808034A EP1556128B1 EP 1556128 B1 EP1556128 B1 EP 1556128B1 EP 03808034 A EP03808034 A EP 03808034A EP 1556128 B1 EP1556128 B1 EP 1556128B1
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Prior art keywords
imaging
arm
source
target volume
treatment
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EP03808034.7A
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German (de)
English (en)
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EP1556128A4 (fr
EP1556128A2 (fr
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Stanley Mansfield
Robert Kopels
Ulrich Martin Graf
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Varian Medical Systems Inc
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Varian Medical Systems Inc
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Publication of EP1556128A4 publication Critical patent/EP1556128A4/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4429—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4007—Arrangements for generating radiation specially adapted for radiation diagnosis characterised by using a plurality of source units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/405—Source units specially adapted to modify characteristics of the beam during the data acquisition process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4233—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using matrix detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4266—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a plurality of detector units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4429—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
    • A61B6/4452—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit and the detector unit being able to move relative to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4429—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
    • A61B6/4458—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit or the detector unit being attached to robotic arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/482—Diagnostic techniques involving multiple energy imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/58—Testing, adjusting or calibrating thereof
    • A61B6/587—Alignment of source unit to detector unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/022—Stereoscopic imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/08—Auxiliary means for directing the radiation beam to a particular spot, e.g. using light beams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

Definitions

  • the present invention pertains in general to radiation medicine.
  • the invention involves imaging devices.
  • a technique to perform radiation therapy uses a radiotherapy device to target a radiation treatment beam onto a target volume (e.g., a tumor) of a patient.
  • a radiotherapy device to target a radiation treatment beam onto a target volume (e.g., a tumor) of a patient.
  • a radiation treatment beams emulate from a treatment radiation source, such as a megavoltage x-ray source.
  • the primary purpose of the x-ray source is to provide a sufficient dose of radiation to treat the target volume.
  • a radiotherapy device may include a separate imaging device used to image anatomy in the region of the target volume. This imaging device may use an imaging radiation source, such as a kilovoltage x-ray source.
  • a radiation imager or detector is also used to capture the radiation after it passes through the patient. Information obtained from this imager can be used to adjust or verify correct positioning of patient anatomy and particularly of the target volume relative to the treatment beam.
  • the imaging device including an x-ray source and imager may be attached to a gantry that houses the treatment radiation source.
  • a gantry that houses the treatment radiation source.
  • One such design is typically embedded in a wall in a treatment area.
  • the x-ray source and imager are attached inside a large diameter bearing (e.g., a cylinder) that the patient must enter for treatment.
  • the movement of the x-ray source and the imager are limited to the movement of the gantry. That is, the arms that attach the x-ray source and the imager to the gantry are rigidly attached (e.g., stationary) or have limited ability to move in relation to the gantry. Furthermore, they have limited ability to be moved or stored "out of the way" to allow a technician unrestricted access to the patient, especially if the patient is being treated inside the bearing housing the x-ray source and imager.
  • the inflexible manner in which the x-ray source and imager are attached to the gantry limits the movement of these treatment components independent from the movement of the gantry. For example, when the gantry is rotated to a specific position both components move with it, and the limited positions in which these components can be placed puts constraints on system movement and patient accessibility. Therefore, these designs limit the versatility of positioning an imaging beam and possibly even a treatment beam.
  • the invention provides an apparatus as defined in claim 1.
  • a radiotherapy clinical treatment machine having a rotatable gantry and an imaging device with articulating robotic arms to provide variable positioning and clearance for radiation treatment applications.
  • first and second robotic arms are pivotally attached to the rotatable gantry, allowing the robotic arms to maneuver independently from the rotatable gantry.
  • a radiotherapy clinical treatment machine having a rotatable gantry and imaging device with articulating robotic arms to provide variable positioning and clearance for radiation treatment applications. More specifically, a number of design configurations of the articulating robotic arms will be described that enable the positioning and re-positioning of a imaging source and a signal imager to provide versatility in placement and alignment to obtain imaging information useful in radiation treatment to a patient. Each device to be described has the ability to extend and retract the robotic arms to allow open access to the patient. Another aspect of some embodiments of the invention discloses how the variable real-time positioning of the robotic arms also provides improved targeting of the target volume by correcting for mechanical flexure of the device as will be described. In this way, imaging of the patient may be accomplished from a multitude of positions, orientations and directions as a result of the degrees of freedom given the articulating robotic arms, as will be described.
  • radiographic imaging techniques to analyze a target volume
  • other imaging techniques such as, for example, computed tomography (CT), fluoroscopy, computed laminar tomography, etc.
  • CT computed tomography
  • fluoroscopy fluoroscopy
  • computed laminar tomography etc.
  • known imaging techniques using other forms of radiated energy such as ultrasound RF or light
  • Figure 1 illustrates one embodiment of a radiotherapy clinical treatment machine with an imaging device having articulable robotic arms that swing laterally to/from a storing position from/to an imaging position.
  • Figure 2 illustrates one embodiment of a radiotherapy clinical treatment machine with an imaging device having robotic arms that swing downward to/from a storing position from/to a imaging position.
  • Figure 3 illustrates one embodiment of a radiotherapy clinical treatment machine with an imaging device having robotic arms that swing to/from a storing position from/to a imaging position.
  • Each design allows for various functional, cost, and/or storage benefits as will be further described below.
  • Preferred designs of the radiotherapy clinical treatment machine include a rotatable e.g. open gantry 202 that can be pivotably attached to a drive stand 203 of the radiotherapy clinical treatment machine 200.
  • the gantry 202 is capable of 360-degree rotation 215 about a centerline 216.
  • Each gantry 202 may also include one or more radiation sources and one or more imagers.
  • Each of figures 1 , 2 , and 3 show an imager 214 folded into the rotatable gantry 202 to provide more clearance.
  • the imager 214 may be unstowed and positioned beneath the patient (not shown), or more specifically, positioned opposite a treatment radiation source 212 to provide imaging of the patient using the treatment beam, as will be described.
  • Figure 1A is a perspective view-illustrating one embodiment of the rotatable open gantry 202 halving articulating robotic arms (205 and 207) each attached to pivot points 248 and 249 at the base of the rotatable gantry 202.
  • the opposite end of arm 205 is pivotally attached at a source end 251 to an imaging source 204.
  • the opposite end of arm 207 is pivotally attached at an imaging end 252 with an imaging detector 206.
  • the robotic arms (205 and 207) swing outward into an adjustable imaging position along a defined trajectory 272, as shown in figure 1B .
  • the robotic arms (205 and 207) can extend and retract for positioning and clearance.
  • the source end 251 and the imaging end 252 may contain any number of pivot points, from single plane pivots to ball joints, having 360 degrees of rotation for positioning the imaging source 204 and imaging detector 206.
  • the robotic arms (205 and 207) may be independently articulated into alignment for the imaging detector 206 to receive an image of the patient from the imaging source 204.
  • Figure 1B is a top view and Figure 1C is a side view of the machine 200 illustrating the swinging motion of robotic arms 205 and 207 to position the radiation source 204 and imager 206 for positioning and clearance.
  • Each arm (205 and 207) also includes pivot points 261 and 262 that add to the maneuverability and positioning of the arm.
  • Figure 1C also illustrates that each arm 205 and 207 may be curved to conform to the shape of the gantry 202 so as to maximize patient clearance.
  • Figure 2A is a perspective view illustrating one embodiment of the rotatable open gantry 202 having articulating robotic arms (305 and 307) each attached to a pivot point 348 and 349 at the base of the rotatable gantry 202.
  • the arm 305 is fixedly attached at a source end 351 to the radiation source 204.
  • the arm 307 is pivotally attached at an imaging end 352 with the imager 206.
  • the robotic arms 305 and 307 swing downward into an imaging position along a plane of motion (352), as shown in figure 2C .
  • the robotic arms (305 and 307) can extend and retract for positioning and clearance. It should be appreciated that because the arm 305 is fixedly attached to the radiation source 204, the design is simple and therefore less costly. However, in alterative embodiments, the arm 205 may be pivotally attached to the radiation source 204. In addition, the source end 351 and the imaging end 352 may contain any number of pivot points, from single plane pivots to ball joints, having 360 degrees of rotation for positioning the imaging source 204 and imaging detector 206. Therefore, the robotic arms (305 and 307) may be independently articulated into alignment for the imaging detector 206 to receive an image of the patient using the imaging source 204.
  • Figure 2B is a top view and Figure 2C is a side view of the machine 200 illustrating the swinging motion of robotic arms 305 and 307 to position the radiation source 204 and imager 206 from positioning and clearance.
  • Figure 3A is a perspective view illustrating one embodiment of the rotatable open gantry 202 having articulating robotic arms (405 and 407) each attached to a pivot point at a midsection (452) of the rotatable gantry 202.
  • the arm 405 is pivotally attached at a source end 451 to the radiation source 204.
  • the arm 407 is pivotally attached at an imaging end 452 to an imager 206.
  • Figure 3B is a top view and Figure 3C is a side view of the machine 200 illustrating the swinging motion of robotic arms 405 and 407 to position the radiation source 204 and imager 206.
  • the robotic arms 405 and 407 may pivot at three points 471, 472, and 473 along two independent axes in a plane.
  • the robotic arms 405 and 407 swing outward to an adjustable imaging position, as shown in figure 3C .
  • Each pivot point 248, 249, 261, 262, 348, 349, 471, 472, and 473 can be a set of sliding mechanisms that include gears and motors that are well known to one of ordinary skill in the art.
  • the result of such articulation can be to place the imaging detector 206 in alignment with, and at a distance from, the imaging source 204 with the target volume positioned in between.
  • each of the robotic arms may be positioned independently and/or in conjunction with the movement (or non-movement) and positioning of the rotatable gantry 202.
  • Figure 4 illustrates an exemplary process flow (500) of using the articulating robotic arms to provide a treatment.
  • the robotic arms are positioned to collect target volume information, such as the shape, size, and location of a tumor in the patient, or the position of an e.g. anatomical landmark or other marker.
  • the target volume information is captured and stored, for example, in a computer (that will be further described below).
  • one or more appropriate treatment positions for the device 200 may be determined to apply a radiation treatment beam to the target volume (at block 530).
  • the device 200 is maneuvered to the treatment position (at block 540) and the treatment beam is applied at the correct dosage to the target volume (at block 550).
  • FIG. 1 , 2 , and 3 allow imaging radiation source 204 to emit radiation at a first energy level to radiate a target volume along a first axis to provide target volume data to the imaging detector 206.
  • Target volume data from the imaging detector 206 can direct treatment radiation source 212 to emit radiation at a second energy level along a second axis to provide therapeutic radiation to the target volume and verification information to the treatment imaging detector 214.
  • Imagers can generally provide high quality imaging from one radiation energy range and lower quality imaging from other radiation energy ranges.
  • the first energy level for example, can be in the kilovolt energy range (kV) and the second energy level, for example, can be in the megavolt energy range (MV).
  • the radiation source 212 can generate an electron beam, generally in the 4 to 25 megavolt range, to provide electrons or X-rays to a volume within a patient undergoing treatment.
  • the imaging detector 214 can display radiographic information from the megavolt radiation sufficient to provide verification that the target volume is being radiated.
  • the imaging detector 206 can receive X-rays in the kV range to provide more accurate target volume data on the size, shape, and location of the target volume. Repeated X-ray shots with kV energy that alternate with MV radiation can reduce target error such as by directing a continuous adjustment of the beam shaping by a dynamic multileaf collimator and by providing targeting information to the MV radiation source.
  • the imaging detector 206 and the imaging radiation source 204 can be retracted for clearance via their respective robotic arms.
  • the gantry 202 can be rotated into position to administer a treatment beam from the radiation source 212, based on the target volume definition.
  • target volume information may be improved by placing internal seeds to act as markers for the target volume. Placement of these markers can be accomplished by performing a needle biopsy. This procedure is normally performed to gain tumor grading information to plan the therapy. These markers can provide higher contrast for the imaging detector 206 for some tissues that might otherwise be difficult to discern.
  • the use of internal seeds may determine a more accurate location of the target volume and/or edges of the target volume. The seeds may be placed away from the target in a location from which the target position and/or motion may be determined. Target volume data can be stored and recalled later to provide anatomical landmark definition to enhance position information on the target volume during radiotherapy.
  • a treatment bench (not shown) can be positioned adjacent to the gantry 202 to place the patient (and target volume) within the range of operation for the radiation sources 204 and 212, and the image detectors 206 and 214.
  • the bench can be capable of translating in multiple planes for positioning and re-positioning the patient and therefore the target volume, based on the target volume data.
  • Figure 5 illustrates a process flow (600) of using the articulating robotic arms to provide a treatment.
  • the robotic arms are positioned to collect target volume information, such as the shape, size, and location of a tumor in the patient, or the position of an e.g. anatomical landmark or other marker.
  • the target volume information is captured and stored, for example, in a computer (that will be further described below). As discussed, the target volume information may be captured by direct imaging of the target volume and/or by imaging the markers.
  • the treatment beam may be positioned and applied (at block 640) when the target is in the correct position (gating), or the treatment beam may be positioned and applied to the target volume while the treatment beam and/or the patient is moving to track tumor motion (at block 650).
  • Target volume data can be delivered and stored to a general or special purpose computer system.
  • the computer system may be coupled to the gantry 202 directly or across a network connection, and each of the translatable devices (radiation sources 204 and 212, and imagers 206 and 214,) and also, the treatment bench 218.
  • Software in the computer system can generate a representation of the target volume based on digital image data provided by the imaging detector 206. Following a predetermined treatment plan and/or the image data, irradiation of the target volume from selected radial locations can occur.
  • the control software in the computer can be used to operate the radiotherapy clinical treatment machine 200, such as, for example, to rotate and translate the above devices 202, 204, 206, 212, and 214, to position the target volume in line with the treatment beam that is shaped to the target volume.
  • the computer can merge the image data generated from at least two different radial locations into a stereoscopic representation of the target volume.
  • the stereoscopic representation can be used to determine, in 3-D, the location of the target volume, or some volume associated with it, such as an anatomical structure and/or marker. Thereby, allowing the target beam to target the target volume.
  • the articulable design and motion of the robotic arms provide independent positioning of the robotic arms to improve the treatment process.
  • the robotic arms may be positioned (via robotic notions) to extend the distance between a radiation source and an imager. That is, to extend the normal distance between the radiation source 204 and imaging unit 206 while performing target volume analysis and/or treatment (e.g., positioning the distance between source and imager to approximately 150 cm). This ability to extend the distance provides for varying needs of patient or equipment clearance and allows for different imaging resolutions and imaging field coverage.
  • the robotic arms may also be positioned (i.e., contracted) to provide higher resolution than would otherwise be possible using stationary arms.
  • the robotic arms may be maneuvered to shorten the distance between the imager 206 and radiation source 204 (e.g., to approximately 130 cm) to provide for high resolution imaging of the target volume.
  • the robotic arms may also be positioned to collect data from a location other than the target volume to perform treatment.
  • one or both of the imaging source 204 and the detector 206 may be off-set longitudinally from isocenter and thereby monitor intra-fraction motion away from isocenter (and the target volume).
  • the source and detector can be positioned to monitor chest wall or diaphragm motion associated with patient breathing while treating a volume in the upper thorax or lower abdomen. This motion information may be used to control the timing or positioning of the treatment beam while treatment proceeds.
  • the imaging source and imaging detector can be offset longitudinally and at any longitudinal position from the gantry can also be extended towards or retracted away from each other as described above.
  • the robotic arms may also be positioned at unequal distances from the gantry. At times it may be beneficial to have the arms an unequal distance from the gantry to provide additional versatility to the imaging process. For example, a first arm positioning an imaging detector 90 cm from the gantry may capture radiation from an imaging source, on a second arm, 130 cm from the gantry. This gives added flexibility in the types of images that may be taken. For example, in some cases this will allow simultaneous imaging of isocenter and another area of interest away from isocenter, such as the diaphragm.
  • the first and second arms may then be repositioned so that, for example, the imaging detector and the imaging source are at a first relative position for a first image, and then at a second relative position angularly offset from the first position for a second image.
  • a stereoscopic representation of the target volume may be generated to determine target location in three dimensions. This may be accomplished by motion of one or more pivot points on one or both arms.
  • one pivot point e.g. a pivot point nearest the imaging source and/or nearest the imaging detector may use a sliding mechanism.
  • the robotic arms may also be positioned to extend for a large field-of-view CT.
  • the imager may be off-set laterally, with an edge of active imager screen at the center of a source's axis.
  • the computer may use a combination of these positions to describe a large field-of-view cone beam computed tomography (CBCT).
  • CBCT cone beam computed tomography
  • CBCT cone beam computed tomography
  • the imaging source 204 can be rotated about the target volume for CT single slice or multiple CT images using a fan x-ray beam, or by using a cone x-ray beam where volumetric information can be constructed.
  • the arms can move such that the image detector and image source perform at least a partial rotation about the volume to obtain a CT reconstruction without necessarily moving the gantry. Also, if a partial data set is acquired from a limited number of images taken at specific angles around the target volume, enough information can be obtained with the help of previously acquired volumetric information to provide the three dimensional reconstruction of the anatomy of interest.
  • imaging from the radiation source 205 X-rays can provide targeting information to accurately direct the therapeutic X-rays to the target volume-from any angle while effectively excluding healthy tissue from injury.
  • the imaging radiation source 204 and detector 206 can be operated either in a continuous or pulsed manner to provide a real time or quasi-real time fluoroscopic image of moving internal anatomy.
  • This fluoroscopic image can also be used to provide information to track the motion of anatomy being treated. As is generally known, normal respiration or unwanted voluntary or involuntary patient movement may cause such motion.
  • This motion tracking information can in turn be used to adjust treatment parameters, track the target volume with the treatment beam, and/or gate the treatment beam off and on such that the anatomy intended to be treated is always in the intended position within the treatment beam.
  • each arm may have one or more of either or both of sources and/or image detectors.
  • the imaging sources and imaging detectors may be placed at any position on the arms.
  • both arms may have one of each, with the two imaging detectors placed in the position nearest the treatment source on both arms, and the two imaging sources placed in the lower position on each arm.
  • the number of image detectors and imaging sources to be used may be based on factors such as simplicity, cost, and versatility.
  • an arm attached to the gantry 202 may have two image detectors. These two detectors may capture radiation from one or more imaging sources.
  • the imaging source(s) and detectors may be off-set radially about the patient, to provide data to the computer to generate a stereoscopic representation of a target volume, as described above.
  • the imaging detector may be at a different distant from the gantry than the imaging source(s). Therefore, both the imaging detector and imaging source(s) are rotated at an angle, for the detector to capture the radiation of the imaging source.
  • one arm may have a single imaging detector that captures radiation from one or more imaging sources.
  • the imaging detector and/or imaging source might be repositioned to receive radiation from varying positions and angles. Thereby, providing target volume data to generate a stereoscopic representation of the target volume, as described.
  • a single imaging detector on one arm may also capture radiation from two spaced apart (possibly pulsing alternately) radiation sources on the other arm. Where the imaging detector is positioned and angled accordingly, to again, provide target volume data to generate a stereoscopic representation of the target volume.
  • an image from a single source/detector pair together with an image taken during treatment from e.g. imager 214 may be used to form a stereoscopic representation.
  • the image detector might be a multiple-energy imaging unit capable of receiving and displaying imaging information from multiple energy sources.
  • one of the energies can be a source of megavoltage x-ray energy and another a source of kilovoltage x-ray energy, both of which can alternately activate the multiple-energy imaging unit for high quality verification imaging and high quality target volume imaging, respectively.
  • the device 200 may also correct for mechanical flexure of the radiation source and imaging unit to improve image quality. Due to the weight of the radiation source and imager, the imaging beam may be misaligned causing error.
  • the imager-source stability is defined by projecting the x-ray beam past a set of markers of known fixed position, while rotating the gantry 360 degrees, and determining the difference from the ideal position by measuring the resulting, lateral and longitudinal shift in the image.
  • unwanted play or movement in any particular joint within the arm may be directly measured by a suitable sensor (for example encoder or potentiometer) incorporated in the mechanism associated to that joint. Either or both types of the foregoing information is used by a feedback control system to properly align the sagging radiation source and image detector in real-time during imaging.
  • a radiotherapy clinical treatment machine with a rotatable open gantry having articulating robotic arms
  • robotic arms provide variable positioning and clearance for e.g. effective administration of oncology radiation therapy to a patient.
  • the articulating robotic arms operating independently and/or in conjunction with the movement of the rotatable gantry.
  • the machine includes logic to detect and correct any mechanical flexure of the device in real-time before administrating the treatment beam. Thereby, providing better images for more accurate treatment and to minimize targeting of healthy tissue.
  • machine-readable medium shall be taken to include any medium that is capable of storing or encoding a sequence of instructions for execution by the machine and that cause the machine to perform any one of the methodologies of the present invention.
  • the term “machine-readable medium” shall accordingly be taken to included, but not be limited to, solid-state memories, optical and magnetic disks, and carrier wave signals.
  • one arm may have more pivot points than the other arm.

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  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Automation & Control Theory (AREA)
  • Robotics (AREA)
  • Mathematical Physics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Claims (27)

  1. Appareil de radiothérapie comprenant : un montant d'entraînement (203) ; un portique rotatif (202) couplé en pivotement au montant d'entraînement (203) et comprenant une source de traitement (212) ; un premier bras (205) couplé au portique rotatif (202) ; une source d'imagerie (204) couplée à une extrémité de source (251) du premier bras (205), un second bras (207) couplé au portique rotatif (202) ; et un détecteur d'image (206) couplé à l'extrémité d'imagerie (252) du second bras (207), caractérisé en ce que le premier bras (205) est couplé en pivotement au niveau de son point de couplage.
  2. Appareil selon la revendication 1, dans lequel le premier bras (205) et le second bras (207) sont agencés pour manoeuvrer indépendamment du portique rotatif (202).
  3. Appareil selon la revendication 1 ou 2, dans lequel le premier bras (205) et le second bras (207) sont agencés pour s'étendre jusqu'à une position d'imagerie depuis une position rétractée.
  4. Appareil selon la revendication 3, dans lequel le premier bras (205) et le second bras (207) sont agencés pour basculer latéralement dans la position d'imagerie depuis la position rétractée.
  5. Appareil selon la revendication 3, dans lequel le premier bras (205) et le second bras (207) sont agencés pour basculer vers le bas jusqu'à la position d'imagerie depuis la position rétractée.
  6. Appareil selon l'une quelconque des revendications précédentes, dans lequel la source d'imagerie (204) se situe à une distance différente du portique (202) que le détecteur d'image (206), la source d'imagerie (204) est positionnée de façon pivotante pour cibler le détecteur d'image (206), et le détecteur d'image (206) est positionné de façon pivotante pour capturer un faisceau d'imagerie depuis la source d'imagerie (204).
  7. Appareil selon l'une quelconque des revendications précédentes, dans lequel le détecteur d'image (206) fournit des informations de volume cible.
  8. Appareil selon la revendication 7, comprenant un ordinateur adapté pour positionner un faisceau de traitement basé sur les informations de volume cible.
  9. Appareil selon l'une quelconque des revendications précédentes, comprenant un ordinateur ayant un composant de commande à rétroaction de flexion mécanique afin de corriger la flexion mécanique de la source d'imagerie (204) et la flexion mécanique de l'imageur (206).
  10. Appareil selon la revendication 1, permettant de réaliser un traitement médical, dans lequel un moyen de positionnement est fourni pour positionner le premier bras (205) et le second bras (207) sur le portique rotatif (202) afin de recevoir des données de volume cible, le second bras (207) étant mobile jusqu'à une position depuis une position de débattement ; un moyen est fourni pour déterminer une position de traitement pour un faisceau de traitement d'après les informations de volume cible ; et un moyen est fourni pour appliquer le faisceau de traitement lors de la manoeuvre jusqu'à la position de traitement.
  11. Appareil selon la revendication 10, dans lequel les données de volume cible sont basées sur un rayonnement reçu par le détecteur d'image (206).
  12. Appareil selon la revendication 10 ou 11, dans lequel le moyen de positionnement comprend un moyen permettant d'étendre les premier et second bras (205, 207) afin de fournir une résolution plus élevée.
  13. Appareil selon la revendication 10, 11 ou 12, dans lequel le moyen de positionnement est agencé pour étendre les premier et second bras (205, 207) pour une tomographie assistée par ordinateur à grand champ de vision.
  14. Appareil selon l'une quelconque des revendications 10 à 13, dans lequel le moyen de positionnement comprend un moyen permettant de corriger la flexion mécanique.
  15. Appareil selon l'une quelconque des revendications 10 à 14, dans lequel les informations de volume cible sont basées sur un mouvement intrafractionnel en éloignement d'un volume cible.
  16. Appareil selon l'une quelconque des revendications 10 à 15, dans lequel le moyen de détermination de la position de traitement est agencé pour utiliser des informations stéréoscopiques générées.
  17. Appareil selon la revendication 1, comprenant un moyen de positionnement permettant de positionner la source d'imagerie (204) et le détecteur d'imagerie (206), dans lequel le moyen de positionnement est couplé de façon pivotante à la source d'imagerie et au moyen d'imagerie au niveau de points de couplage, le positionnement comprenant une transition entre une position de débattement et une position d'imagerie, et dans lequel le moyen de positionnement comprend lesdits premier et second bras.
  18. Appareil selon la revendication 17, dans lequel le moyen de positionnement est agencé pour faire basculer la source d'imagerie (204) vers l'extérieur jusqu'à la position d'imagerie.
  19. Appareil selon la revendication 17 ou 18, lequel le moyen de positionnement est agencé pour contracter le moyen d'imagerie (206) afin de fournir une résolution plus élevée.
  20. Appareil selon l'une quelconque des revendications 17, 18 ou 19, dans lequel le moyen de positionnement est agencé pour étendre le moyen d'imagerie (206) afin de fournir un plus grand champ de vision d'image.
  21. Appareil selon la revendication 20, comprenant un moyen de calcul agencé pour corriger une flexion mécanique de la source d'imagerie (204).
  22. Appareil selon la revendication 1, comprenant une pluralité de sources d'imagerie (204) couplées au premier bras (205), dans lequel le détecteur d'image (206) couplé au second bras (207) est agencé pour recevoir un rayonnement de la pluralité de sources de rayonnement (204).
  23. Appareil selon la revendication 22, dans lequel une première source de la pluralité de sources d'imagerie (204) est une source de rayonnement en kilovolt.
  24. Appareil selon la revendication 22 ou 23, dans lequel le détecteur d'image (206) est un imageur multiénergie.
  25. Appareil selon la revendication 22, 23 ou 24, dans lequel le second bras (207) est agencé pour s'étendre jusqu'à une position d'imagerie depuis une position de débattement.
  26. Appareil selon la revendication 1, dans lequel le point de couplage pour le premier bras (205) est un premier point de pivot, et le premier bras (205) comprend un deuxième point de pivot.
  27. Appareil selon la revendication 26, dans lequel le point de couplage pour le second bras (207) est un troisième point de pivot.
EP03808034.7A 2002-10-05 2003-07-22 Dispositif d'imagerie pour applications de traitement par rayonnement Expired - Lifetime EP1556128B1 (fr)

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EP11000084.1A EP2311528B1 (fr) 2002-10-05 2003-07-22 Dispositif d'imagerie pour applications de traitement de rayonnement

Applications Claiming Priority (3)

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US264630 1988-10-31
US10/264,630 US7657304B2 (en) 2002-10-05 2002-10-05 Imaging device for radiation treatment applications
PCT/US2003/022725 WO2004033026A2 (fr) 2002-10-05 2003-07-22 Dispositif d'imagerie pour applications de traitement par rayonnement

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EP11000084.1A Division EP2311528B1 (fr) 2002-10-05 2003-07-22 Dispositif d'imagerie pour applications de traitement de rayonnement

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EP1556128A2 EP1556128A2 (fr) 2005-07-27
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EP1556128B1 true EP1556128B1 (fr) 2014-09-03

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EP (2) EP2311528B1 (fr)
JP (1) JP5068426B2 (fr)
CN (1) CN100560022C (fr)
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WO (1) WO2004033026A2 (fr)

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US7657304B2 (en) 2010-02-02
EP1556128A4 (fr) 2008-10-22
US20040068169A1 (en) 2004-04-08
JP5068426B2 (ja) 2012-11-07
CN100560022C (zh) 2009-11-18
EP1556128A2 (fr) 2005-07-27
WO2004033026A2 (fr) 2004-04-22
WO2004033026A9 (fr) 2004-06-10
JP2006501933A (ja) 2006-01-19
CN1694647A (zh) 2005-11-09
EP2311528A2 (fr) 2011-04-20
AU2003254058A1 (en) 2004-05-04
AU2003254058A8 (en) 2004-05-04
EP2311528B1 (fr) 2016-02-10
WO2004033026A3 (fr) 2004-08-12
EP2311528A3 (fr) 2011-08-03

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