EP1551838B1 - Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid - Google Patents
Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid Download PDFInfo
- Publication number
- EP1551838B1 EP1551838B1 EP03809127A EP03809127A EP1551838B1 EP 1551838 B1 EP1551838 B1 EP 1551838B1 EP 03809127 A EP03809127 A EP 03809127A EP 03809127 A EP03809127 A EP 03809127A EP 1551838 B1 EP1551838 B1 EP 1551838B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valacyclovir hydrochloride
- residual process
- ppm
- contacting
- process alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 92
- ZCDDBUOENGJMLV-QRPNPIFTSA-N Valacyclovir hydrochloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 ZCDDBUOENGJMLV-QRPNPIFTSA-N 0.000 title claims abstract description 43
- 229940064636 valacyclovir hydrochloride Drugs 0.000 title claims abstract description 43
- 150000001298 alcohols Chemical class 0.000 title description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 59
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229960004592 isopropanol Drugs 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 7
- 230000003068 static effect Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 abstract description 22
- -1 isopropanol) Chemical compound 0.000 abstract description 5
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 11
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 description 10
- 229960004150 aciclovir Drugs 0.000 description 9
- 229940093257 valacyclovir Drugs 0.000 description 8
- 239000008186 active pharmaceutical agent Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000010626 work up procedure Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical class CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 239000013557 residual solvent Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000002777 nucleoside Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 0 CC(C)C(*)C(OCCOC*(C1*C(**)=*2)C=*C1C2=O)=O Chemical compound CC(C)C(*)C(OCCOC*(C1*C(**)=*2)C=*C1C2=O)=O 0.000 description 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N Guanine Natural products O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- UYLWKSJTHLRFBX-UHFFFAOYSA-N purin-6-one Chemical compound O=C1N=CN=C2N=CN=C12 UYLWKSJTHLRFBX-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229940108442 valtrex Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Definitions
- Valacyclovir is an L-valyl ester prodrug of acyclovir.
- Acyclovir is an acyclic analog of a natural nucleoside which has been found to have high anti-viral activity.
- Acyclovir is widely used in the treatment and prophylaxis of viral infections in humans, particularly infections caused by the herpes group of viruses. See Goodman and Gilman's, The Pharmacological Basis of Therapeutics 1193-1198 (9th ed. 1996).
- Acyclovir is an acyclic guanine nucleoside analog that lacks a 3'-hydroxyl on the side chain.
- Acyclovir has the chemical name 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]. (CAS Registry No. 59277-89-3.)
- Acyclovir as the sodium salt is currently marketed as ZOVIRAX® .
- Valacyclovir has the chemical name 1-valine, 2-[(2-amino-1,6-dihydro-6-oxo -9H-purin-9-yl)methoxy]ethyl ester. (CAS Registry No. 124832-26-4.) Valacyclovir is currently marketed as VALTREX® . The chemical structure of valacyclovir is shown as Formula I.
- valacyclovir For oral administration, it is advantageous to administer valacyclovir rather than acyclovir because acyclovir is poorly absorbed from the gastrointestinal tract after oral administration in both animals and humans. In contrast, valacyclovir is rapidly absorbed from the gastrointestinal tract after oral administration. Moreover, valacyclovir is converted rapidly and virtually completely to acyclovir after oral administration in healthy adults. The conversion of valacyclovir is thought to result from first-pass intestinal and hepatic metabolism through enzymatic hydrolysis.
- valacyclovir hydrochloride can and frequently do use solvents that are or that contain alcohols such as methanol, ethanol or iso -propanol.
- United States Patent 4,957,924 discloses one such crystallization procedure that uses ethanol.
- the valacyclovir hydrochloride can contain 5000 ppm or more of excess residual process alcohol.
- the presence of unnecessary foreign substances, for example excess residual process alcohols, in any active pharmaceutical ingredient (API) is undesirable.
- API active pharmaceutical ingredient
- the solvents may be toxic and can produce undesirable effects in the patient receiving valacyclovir hydrochloride. Since there is no therapeutic benefit from residual process solvents, all residual solvents should be removed to the extent possible to meet quality-based requirements.
- the present invention relates to a method of reducing excess residual process alcohol (> 5000 ppm) in valacyclovir hydrochloride having excess residual process alcohol, including the step of statically or dynamically contacting the valacyclovir hydrochloride having excess residual process alcohol with a humid gas, especially humid air.
- the present invention relates to a method of reducing excess residual process alcohol, especially excess residual process isopropanol, in valacyclovir hydrochloride having excess residual process alcohol including the step of dynamically contacting such valacyclovir hydrochloride with humid air, especially humid air of ⁇ 50% relative humidity, more especially ⁇ 75% relative humidity, in a fluiduzed bed apparatus.
- solvents e.g. alcohols
- traces, sometimes substantial traces, of these solvents can remain in the compound synthesized.
- the remaining solvents which can be referred to as residual process solvents, can be difficult to remove.
- Residual process solvents in pharmaceutical compounds serve no therapeutic purpose and can be harmful to the patient.
- governmental regulatory agencies and international advisory organizations have promulgated regulations and guidelines for residual (process) solvents in pharmaceutical compounds.
- Excess residual process solvent in valacyclovir hydrochloride is defined in relation to the concentration limits set for class 3 solvents, of which iso -propanol is on example, by the ICH Guidelines.
- excess process alcohol in valacyclovir hydrochloride refers to process alcohol, especially ethanol and iso-propanol, in excess of 5000 ppm on a weight basis.
- Valacylcovir hydrochloride having excess residual process alcohol refers to valacyclovir hydrochloride having 5000 ppm or more, on a weight basis, residual process alcohol.
- Alcohols can be used as solvents in the synthesis, work-up, and purification of valacyclovir hydrochloride.
- the present invention provides a method for reducing the excess residual process alcohol content of crystalline valacyclovir hydrochloride having excess residual process alcohols, for example ethanol, n-propanol, or iso -propanol, remaining from, for example, work-up, isolation, or other treatment procedures, for example recrystallization.
- Valacyclovir hydrochloride is considered to have excess residual process alcohol if the residual process alcohol is ⁇ 5000 ppm on a weight basis.
- the present method includes the step of contacting (exposing) particles (e.g. crystals) of valacyclovir hydrochloride having excess residual process alcohol with a humid gas, at ambient atmospheric pressure (750 to 765 mm Hg).
- the valacyclovir hydrochloride having excess residual process alcohol or process alcohol can be from any source.
- the valacyclovir hydrochloride will be obtained from a process in which an alcohol or alcohol-containing solvent is used, for example from a crystallization procedure in which an alcohol is used.
- valacyclovir hydrochloride having excess residual process alcohol can be obtained directly from a synthesis process in which an alcohol is used. In such cases, the excess residual process alcohol can be more than 5000 ppm.
- Humid gas has a relative humidity (RH) of at least 15%, preferably at least 50%, more preferably at least 75%.
- RH relative humidity
- Relative humidity refers to the ratio (times 100) of the actual vapor pressure of water in a gas to the saturation vapor pressure of water in the gas at a particular temperature and pressure.
- the contacting is conducted at ambient pressure and a temperature of 10°C to 60°C.
- the contacting can be static or it can be dynamic.
- Static contacting particles (e.g. crystals) of valacyclovir hydrochloride are at rest. That is, they are not mechanically or otherwise agitated or stirred.
- Static contacting can be carried out, for example, by contacting particles of valacyclovir hydrochloride having excess residual process alcohol on a tray, preferably in a thin layer, with humid gas in a suitable enclosure such as, for example, a constant humidity chamber.
- particles of valacyclovir hydrochloride are in motion induced by mechanical or other agitation whilst being contacted with humid gas.
- Mechanical agitation can be provided by, for example, a ribbon-type blender through which humid gas is passed.
- the valacyclovir hydrochloride having excess residual process alcohol is contacted with humid gas in a fluidized bed apparatus wherein the valacyclovir hydrochloride is fluidized with humid gas.
- Fluidized bed apparatus is well-known in the art.
- suitable fluidized bed apparatus is a Retsch model TG-100
- Valacyclovir hydrochloride having excess residual process alcohol is contacted with humid air for a contacting time sufficient to reduce the excess residual process alcohol to less that 5000 ppm, preferably to 1000 ppm or less.
- the skilled artisan will know to optimize the contacting time by routine experimentation, taking into consideration factors such as the amount of excess residual process alcohol initially present, the size of the particles of valacyclovir hydrochloride, and the humidity of the humid gas.
- the lower the initial amount of excess residual process alcohol and the higher the humidity of the humid gas the shorter, in general, will be the contacting time.
- the excess residual process alcohol in valacyclovir hydrochloride is reduced to ⁇ 5000 ppm, preferably to 1000 ppm or less.
- Alcohol in valacyclovir hydrochloride can be measured by any means known in the art, for example by gas chromatography (GC).
- Valacyclovir hydrochloride (about 10g), crystallized from isopropanol/water and having about 6000 ppm excess residual process solvent, were dried in a fluidized bed drier at about 40°C for about 4 hours in a stream of humid air (ca. 80% RH). After drying, the material so treated contained less than about 300 ppm residual process solvent and about 9% by weight water.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Claims (19)
- Verfahren zum Reduzieren von überschüssigem restlichem Prozeßalkohol in Valacyclovir-Hydrochlorid mit überschüssigem restlichem Prozeßalkohol, welches die Stufe umfaßt, bei der man Partikel von Valacyclovir-Hydrochlorid mit überschüssigem restlichem Prozeßalkohol bei Umgebungsdruck mit einem feuchten Gas in Kontakt bringt.
- Verfahren nach Anspruch 1, wobei das feuchte Gas feuchte Luft ist.
- Verfahren nach Anspruch 2, wobei die feuchte Luft eine relative Feuchte von wenigstens 15% hat.
- Verfahren nach Anspruch 3, wobei die feuchte Luft eine relative Feuchte von wenigstens 50% hat.
- Verfahren nach Anspruch 4, wobei die feuchte Luft eine relative Feuchte von wenigstens 75% hat.
- Verfahren nach Anspruch 1, wobei das Inkontaktbringen statisch erfolgt.
- Verfahren nach Anspruch 1, wobei das Inkontaktbringen dynamisch erfolgt.
- Verfahren nach Anspruch 7, wobei das Inkontaktbringen in einem Wirbelschichtapparat stattfindet.
- Verfahren nach Anspruch 1, wobei nach der Stufe des Inkontaktbringens die Menge an restlichem Prozeßalkohol in dem kontaktierten Valacyclovir-Hydrochlorid auf Basis des Gewichts weniger als 5000 ppm beträgt.
- Verfahren nach Anspruch 9, wobei die Menge an restlichem Prozeßalkohol in dem kontaktierten Valacyclovir-Hydrochlorid auf Basis des Gewichts 1000 ppm oder weniger beträgt.
- Verfahren nach Anspruch 1, wobei der Prozeßalkohol Ethanol ist.
- Verfahren nach Anspruch 1, wobei der Prozeßalkohol Isopropanol ist.
- Verfahren nach Anspruch 1, wobei der Prozeßalkohol Isopropanol ist und wobei das Verfahren die Stufe umfaßt, bei der man Valacyclovir-Hydrochlorid mit überschüssigem restlichem Prozeß-Isopropanol bei Umgebungsdruck in einem Wirbelschichtapparat mit feuchter Luft in Kontakt bringt, wobei die relative Feuchte der Luft wenigstens 15% beträgt.
- Verfahren nach Anspruch 13, wobei die relative Feuchte der Luft wenigstens 50% beträgt.
- Verfahren nach Anspruch 13, wobei die Menge an restlichem Isopropanol in dem kontaktierten Valacyclovir-Hydrochlorid auf Basis des Gewichts 5000 ppm oder weniger beträgt.
- Verfahren nach Anspruch 15, wobei die Menge an restlichem Isopropanol in dem kontaktierten Valacyclovir-Hydrochlorid auf Basis des Gewichts 1000 ppm oder weniger beträgt.
- Verfahren nach Anspruch 1 zum Reduzieren der Menge an restlichem Prozeßalkohol in Valacyclovir-Hydrochlorid, welches auf Basis des Gewichts mehr als 1000 ppm an restlichem Prozeßalkohol enthält, auf 1000 ppm oder weniger auf Basis des Gewichts, wobei das Verfahren die Stufe umfaßt, bei der man das Valacyclovir-Hydrochlorid mit mehr als 1000 ppm restlichem Prozeßalkohol auf Basis des Gewichts bei Umgebungsdruck mit feuchtem Gas, welches eine relative Feuchte von wenigstens 15% hat, in Kontakt bringt.
- Verfahren nach Anspruch 17, wobei das feuchte Gas eine relative Feuchte von wenigstens 50% hat.
- Verfahren nach Anspruch 18, wobei das Inkontaktbringen in einem Wirbelschichtapparat stattfindet.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41927002P | 2002-10-16 | 2002-10-16 | |
US419270P | 2002-10-16 | ||
US42732002P | 2002-11-18 | 2002-11-18 | |
US427320P | 2002-11-18 | ||
PCT/US2003/032995 WO2004035583A1 (en) | 2002-10-16 | 2003-10-16 | Method for reducing residual alcohols in crystalline valacyclovir hydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1551838A1 EP1551838A1 (de) | 2005-07-13 |
EP1551838B1 true EP1551838B1 (de) | 2006-08-09 |
Family
ID=32110230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03809127A Expired - Lifetime EP1551838B1 (de) | 2002-10-16 | 2003-10-16 | Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050070711A1 (de) |
EP (1) | EP1551838B1 (de) |
AT (1) | ATE335743T1 (de) |
AU (1) | AU2003277433A1 (de) |
CA (1) | CA2501557A1 (de) |
DE (1) | DE60307494D1 (de) |
ES (1) | ES2270172T3 (de) |
WO (1) | WO2004035583A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2465420A1 (en) * | 2001-11-05 | 2003-05-15 | Glaxo Group Limited | Anhydrous crystal form of valaciclovir hydrochloride |
CA2649826A1 (en) * | 2001-11-14 | 2003-05-22 | Teva Pharmaceutical Industries Ltd. | Synthesis and purification of valacyclovir |
US20050059684A1 (en) * | 2002-10-16 | 2005-03-17 | Ben-Zion Dolitzky | Method for reducing residual alcohols in crystalline valacyclovir hydrochloride |
US7786302B2 (en) * | 2003-05-30 | 2010-08-31 | Eczacibasi-Zentiva Kimyasal Urunler Sanayi Ve Ticaret A.S. | Crystalline forms of valacyclovir hydrochloride |
EP2014660A3 (de) * | 2003-06-02 | 2009-07-15 | Teva Pharmaceutical Industries Ltd | Neuartige kristalline Formen von Valacyclovir-Hydrochlorid |
JP2008504255A (ja) * | 2004-06-30 | 2008-02-14 | テバ ファーマシューティカル インダストリーズ リミティド | 結晶塩酸バラシクロビル中の残留アルコールを低減する方法 |
EP1692134A2 (de) * | 2004-09-04 | 2006-08-23 | Teva Pharmaceutical Industries, Inc. | Valacyclovir-verunreinigung, herstellungsverfahren dafür und verwendung als referenzstandard |
EP1746098A1 (de) * | 2005-07-21 | 2007-01-24 | SOLMAG S.p.A. | Valacyclovir Polymorphe und Verfahren zu deren Herstellung |
AU2020334060A1 (en) * | 2019-08-19 | 2022-03-24 | Ucb Biosciences, Inc. | Polymorphic forms of deoxycytidine, compositions comprising the same and uses |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5161M (de) * | 1965-03-25 | 1967-06-12 | ||
US3989849A (en) * | 1973-03-23 | 1976-11-02 | General Foods Corporation | Improving the flavor of decaffeinated coffee by radio frequency heating to rapidly dry coffee beans |
GB8719367D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
US5270267A (en) * | 1989-05-31 | 1993-12-14 | Mitel Corporation | Curing and passivation of spin on glasses by a plasma process wherein an external polarization field is applied to the substrate |
EP0665229B1 (de) * | 1994-02-01 | 1999-11-17 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von Nukleinsäurebasenderivaten |
JP2723088B2 (ja) * | 1994-09-07 | 1998-03-09 | 藤沢薬品工業株式会社 | セファロスポリン化合物の新規な結晶 |
GB9501178D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Guanine derivative |
GB9501127D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Tablet |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
IL160721A0 (en) * | 2001-09-07 | 2004-08-31 | Teva Pharma | Crystalline forms of valacyclovir hydrochloride |
CA2649826A1 (en) * | 2001-11-14 | 2003-05-22 | Teva Pharmaceutical Industries Ltd. | Synthesis and purification of valacyclovir |
US20050059684A1 (en) * | 2002-10-16 | 2005-03-17 | Ben-Zion Dolitzky | Method for reducing residual alcohols in crystalline valacyclovir hydrochloride |
US7199144B2 (en) * | 2003-04-21 | 2007-04-03 | Teva Pharmaceuticals Industries, Ltd. | Process for the preparation of valsartan and intermediates thereof |
-
2003
- 2003-10-16 AU AU2003277433A patent/AU2003277433A1/en not_active Abandoned
- 2003-10-16 DE DE60307494T patent/DE60307494D1/de not_active Expired - Lifetime
- 2003-10-16 AT AT03809127T patent/ATE335743T1/de not_active IP Right Cessation
- 2003-10-16 WO PCT/US2003/032995 patent/WO2004035583A1/en not_active Application Discontinuation
- 2003-10-16 US US10/688,538 patent/US20050070711A1/en not_active Abandoned
- 2003-10-16 EP EP03809127A patent/EP1551838B1/de not_active Expired - Lifetime
- 2003-10-16 ES ES03809127T patent/ES2270172T3/es not_active Expired - Lifetime
- 2003-10-16 CA CA002501557A patent/CA2501557A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003277433A1 (en) | 2004-05-04 |
CA2501557A1 (en) | 2004-04-29 |
WO2004035583A1 (en) | 2004-04-29 |
EP1551838A1 (de) | 2005-07-13 |
ATE335743T1 (de) | 2006-09-15 |
US20050070711A1 (en) | 2005-03-31 |
DE60307494D1 (de) | 2006-09-21 |
ES2270172T3 (es) | 2007-04-01 |
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