DE60307494D1 - Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid - Google Patents

Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid

Info

Publication number
DE60307494D1
DE60307494D1 DE60307494T DE60307494T DE60307494D1 DE 60307494 D1 DE60307494 D1 DE 60307494D1 DE 60307494 T DE60307494 T DE 60307494T DE 60307494 T DE60307494 T DE 60307494T DE 60307494 D1 DE60307494 D1 DE 60307494D1
Authority
DE
Germany
Prior art keywords
reducing
valacyclovir hydrochloride
restalcoolols
crystalline valacyclovir
residual process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60307494T
Other languages
English (en)
Inventor
Ben-Zion Dolitzky
Igor Lifshitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60307494D1 publication Critical patent/DE60307494D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DE60307494T 2002-10-16 2003-10-16 Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid Expired - Lifetime DE60307494D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41927002P 2002-10-16 2002-10-16
US42732002P 2002-11-18 2002-11-18
PCT/US2003/032995 WO2004035583A1 (en) 2002-10-16 2003-10-16 Method for reducing residual alcohols in crystalline valacyclovir hydrochloride

Publications (1)

Publication Number Publication Date
DE60307494D1 true DE60307494D1 (de) 2006-09-21

Family

ID=32110230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307494T Expired - Lifetime DE60307494D1 (de) 2002-10-16 2003-10-16 Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid

Country Status (8)

Country Link
US (1) US20050070711A1 (de)
EP (1) EP1551838B1 (de)
AT (1) ATE335743T1 (de)
AU (1) AU2003277433A1 (de)
CA (1) CA2501557A1 (de)
DE (1) DE60307494D1 (de)
ES (1) ES2270172T3 (de)
WO (1) WO2004035583A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005511612A (ja) * 2001-11-05 2005-04-28 グラクソ　グループ　リミテッド 塩酸バラシクロビルの無水結晶形
CA2465928C (en) * 2001-11-14 2010-01-19 Teva Pharmaceutical Industries Ltd. Synthesis and purification of valacyclovir
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
EP1633753A1 (de) * 2003-05-30 2006-03-15 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Neue kristallmodifikationen von valacyclovir-hydrochlorid
KR100871621B1 (ko) * 2003-06-02 2008-12-02 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로비르 히드로클로라이드의 신규한 결정질 형태
JP2008504255A (ja) * 2004-06-30 2008-02-14 テバ ファーマシューティカル インダストリーズ リミティド 結晶塩酸バラシクロビル中の残留アルコールを低減する方法
CN101068814A (zh) * 2004-09-04 2007-11-07 特瓦制药工业有限公司 分离的伐昔洛韦杂质，制备伐昔洛韦杂质的方法及其作为参比标准物的应用
EP1746098A1 (de) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir Polymorphe und Verfahren zu deren Herstellung
BR112022002513A2 (pt) * 2019-08-19 2022-05-03 Modis Therapeutics Inc Formas polimórficas de deoxicitidina, composições compreendendo as mesmas e usos

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5161M (de) * 1965-03-25 1967-06-12
US3989849A (en) * 1973-03-23 1976-11-02 General Foods Corporation Improving the flavor of decaffeinated coffee by radio frequency heating to rapidly dry coffee beans
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
US5270267A (en) * 1989-05-31 1993-12-14 Mitel Corporation Curing and passivation of spin on glasses by a plasma process wherein an external polarization field is applied to the substrate
EP0665229B1 (de) * 1994-02-01 1999-11-17 Ajinomoto Co., Inc. Verfahren zur Herstellung von Nukleinsäurebasenderivaten
JP2723088B2 (ja) * 1994-09-07 1998-03-09 藤沢薬品工業株式会社 セファロスポリン化合物の新規な結晶
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
EP1436295A4 (de) * 2001-09-07 2007-07-11 Teva Pharma Kristalline formen von valacyclovir-hydrochlorid
CA2465928C (en) * 2001-11-14 2010-01-19 Teva Pharmaceutical Industries Ltd. Synthesis and purification of valacyclovir
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US7199144B2 (en) * 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof

Also Published As

Publication number Publication date
WO2004035583A1 (en) 2004-04-29
CA2501557A1 (en) 2004-04-29
ATE335743T1 (de) 2006-09-15
US20050070711A1 (en) 2005-03-31
EP1551838B1 (de) 2006-08-09
AU2003277433A1 (en) 2004-05-04
ES2270172T3 (es) 2007-04-01
EP1551838A1 (de) 2005-07-13

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DE60307494D1 (de) Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid
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