EP1541558A4 - Heterocyclische verbindung mit hiv-integrase-hemmender wirkung - Google Patents
Heterocyclische verbindung mit hiv-integrase-hemmender wirkungInfo
- Publication number
- EP1541558A4 EP1541558A4 EP03795216A EP03795216A EP1541558A4 EP 1541558 A4 EP1541558 A4 EP 1541558A4 EP 03795216 A EP03795216 A EP 03795216A EP 03795216 A EP03795216 A EP 03795216A EP 1541558 A4 EP1541558 A4 EP 1541558A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- optionally substituted
- inhibitory activity
- heterocyclic compound
- hiv integrase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08014371A EP2045242A1 (de) | 2002-08-13 | 2003-08-11 | Heterozyklische Verbindungen mit hemmender HIV-Integrase-Aktivität |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002235582 | 2002-08-13 | ||
JP2002235582 | 2002-08-13 | ||
JP2002245772 | 2002-08-26 | ||
JP2002245772 | 2002-08-26 | ||
JP2003121726 | 2003-04-25 | ||
JP2003121726 | 2003-04-25 | ||
JP2003270863 | 2003-07-04 | ||
JP2003270863 | 2003-07-04 | ||
PCT/JP2003/010212 WO2004024693A1 (ja) | 2002-08-13 | 2003-08-11 | Hivインテグラーゼ阻害活性を有するヘテロ環化合物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08014371A Division EP2045242A1 (de) | 2002-08-13 | 2003-08-11 | Heterozyklische Verbindungen mit hemmender HIV-Integrase-Aktivität |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1541558A1 EP1541558A1 (de) | 2005-06-15 |
EP1541558A4 true EP1541558A4 (de) | 2005-08-17 |
EP1541558B1 EP1541558B1 (de) | 2008-08-13 |
Family
ID=31999406
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08014371A Withdrawn EP2045242A1 (de) | 2002-08-13 | 2003-08-11 | Heterozyklische Verbindungen mit hemmender HIV-Integrase-Aktivität |
EP03795216A Expired - Lifetime EP1541558B1 (de) | 2002-08-13 | 2003-08-11 | Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08014371A Withdrawn EP2045242A1 (de) | 2002-08-13 | 2003-08-11 | Heterozyklische Verbindungen mit hemmender HIV-Integrase-Aktivität |
Country Status (9)
Country | Link |
---|---|
US (3) | US7358249B2 (de) |
EP (2) | EP2045242A1 (de) |
JP (1) | JP3908248B2 (de) |
AR (1) | AR041009A1 (de) |
AT (1) | ATE404537T1 (de) |
AU (1) | AU2003257822A1 (de) |
DE (1) | DE60322920D1 (de) |
TW (1) | TW200407308A (de) |
WO (1) | WO2004024693A1 (de) |
Families Citing this family (79)
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AU2003216049B2 (en) * | 2002-01-17 | 2008-07-17 | Merck Sharp & Dohme Corp. | Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors |
ATE404537T1 (de) * | 2002-08-13 | 2008-08-15 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung |
WO2005075475A1 (ja) * | 2004-02-04 | 2005-08-18 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有するナフチリジン誘導体 |
MXPA06009132A (es) | 2004-02-11 | 2007-03-26 | Smithkline Beecham Corp | Inhibidores de integrasa de vih. |
WO2006030807A1 (ja) * | 2004-09-15 | 2006-03-23 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
NZ562339A (en) | 2005-04-28 | 2011-01-28 | Smithkline Beecham Corp | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
US20080214503A1 (en) * | 2005-08-04 | 2008-09-04 | Smithkline Beecham Corporation | Hiv Integrase Inhibitors |
WO2007019130A2 (en) * | 2005-08-04 | 2007-02-15 | Smithkline Beecham Corporation | Hiv integrase inhibitors |
JP2009503082A (ja) * | 2005-08-04 | 2009-01-29 | スミスクライン ビーチャム コーポレーション | Hivインテグラーゼ阻害薬 |
EP1910363A4 (de) * | 2005-08-04 | 2010-05-26 | Glaxosmithkline Llc | Hiv-integrasehemmer |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
DK1928457T3 (da) * | 2005-09-30 | 2013-02-04 | Pulmagen Therapeutics Asthma Ltd | Quinoliner og deres terapeutiske anvendelse |
TW200800988A (en) | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
DE102005059479A1 (de) * | 2005-12-13 | 2007-06-14 | Merck Patent Gmbh | Hydroxychinolinderivate |
RU2467007C2 (ru) | 2005-12-21 | 2012-11-20 | Эбботт Лэборетриз | Производные [1,8]нафтиридина, полезные в качестве ингибиторов репликации вируса hcv |
KR20080080395A (ko) | 2005-12-21 | 2008-09-03 | 아보트 러보러터리즈 | 항바이러스 화합물 |
WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
ES2487967T3 (es) * | 2006-04-20 | 2014-08-25 | Pfizer Products Inc. | Compuestos amido heterocíclicos condensados con fenilo para la prevención y el tratamiento de enfermedades mediadas por la glucoquinasa |
US20090306054A1 (en) * | 2006-05-16 | 2009-12-10 | Gilead Sciences ,Inc. | Integrase inhibitors |
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ES2442847T3 (es) | 2007-04-18 | 2014-02-13 | Amgen, Inc | Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa |
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EP2155746A2 (de) | 2007-05-04 | 2010-02-24 | Amgen, Inc | Diazachinolone zur hemmung der prolylhydroxylaseaktivität |
EP2150251B9 (de) | 2007-05-04 | 2013-02-27 | Amgen, Inc | Thienopyridin- und thiazolopyridin-derivate zur hemmung der aktivität von prolylhydroxylase |
EP2220095B1 (de) * | 2007-11-15 | 2013-01-02 | Gilead Sciences, Inc. | Inhibitoren der replikation des human immunodeficiency virus |
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EP2345641A1 (de) | 2009-12-29 | 2011-07-20 | Polichem S.A. | Neue sekundäre 8-Hydroxychinolin-7-Carboxamid-Derivate |
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EP2655374B1 (de) | 2010-12-20 | 2019-10-23 | Incyte Holdings Corporation | N-(1-(substituierte phenyl)ethyl)-9h-purin-6-amine als pi3k-hemmer |
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AU2012321762A1 (en) | 2011-10-12 | 2014-04-17 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
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FR2761687B1 (fr) | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
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2003
- 2003-08-11 AT AT03795216T patent/ATE404537T1/de not_active IP Right Cessation
- 2003-08-11 EP EP08014371A patent/EP2045242A1/de not_active Withdrawn
- 2003-08-11 EP EP03795216A patent/EP1541558B1/de not_active Expired - Lifetime
- 2003-08-11 WO PCT/JP2003/010212 patent/WO2004024693A1/ja active IP Right Grant
- 2003-08-11 AU AU2003257822A patent/AU2003257822A1/en not_active Abandoned
- 2003-08-11 JP JP2004571933A patent/JP3908248B2/ja not_active Expired - Fee Related
- 2003-08-11 US US10/524,281 patent/US7358249B2/en not_active Expired - Fee Related
- 2003-08-11 DE DE60322920T patent/DE60322920D1/de not_active Expired - Lifetime
- 2003-08-12 AR ARP030102917A patent/AR041009A1/es unknown
- 2003-08-13 TW TW092122186A patent/TW200407308A/zh unknown
-
2006
- 2006-06-30 US US11/478,218 patent/US20060247212A1/en not_active Abandoned
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2008
- 2008-02-26 US US12/071,807 patent/US20090118233A1/en not_active Abandoned
Non-Patent Citations (1)
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No further relevant documents disclosed * |
Also Published As
Publication number | Publication date |
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US20060247212A1 (en) | 2006-11-02 |
AR041009A1 (es) | 2005-04-27 |
JP3908248B2 (ja) | 2007-04-25 |
US20060128669A1 (en) | 2006-06-15 |
TW200407308A (en) | 2004-05-16 |
US20090118233A1 (en) | 2009-05-07 |
WO2004024693A1 (ja) | 2004-03-25 |
DE60322920D1 (de) | 2008-09-25 |
AU2003257822A1 (en) | 2004-04-30 |
ATE404537T1 (de) | 2008-08-15 |
JPWO2004024693A1 (ja) | 2006-01-26 |
EP1541558A1 (de) | 2005-06-15 |
EP1541558B1 (de) | 2008-08-13 |
US7358249B2 (en) | 2008-04-15 |
EP2045242A1 (de) | 2009-04-08 |
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