Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
  • A61L29/08—Materials for coatings
  • A61L29/085—Macromolecular materials
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T428/00—Stock material or miscellaneous articles
  • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
  • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
  • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article

Definitions

• Tubes for peripheral venous cannulas are used for the administration of infusion and injection solutions as well as for drawing blood in the peripheral vascular system.
• the administration or withdrawal takes place peripherally, i.e. far from the heart, in the vein, using a tube or a plastic cannula.
• FEP or PUR in the form of monotubes with or without X-ray contrast strips are used as the material.
• Table 1 below evaluates some important properties of tubing for venous cannulas made of FEP or PUR.
• Bending stiffness resistance to bending due to radial forces
• Kink resistance resistance to kinking of the tube after its deflection / bending by a narrow radius and prevention of the lumen closure or irreversible damage to the tube.
• Pushability Easy application and positioning of the catheter in vessels due to axial loading without any significant resistance.
• Rolling up behavior The tendency towards contraction / compression of the tubular cannula (accordion effect) resulting from the penetration of the skin, tissue and vein as a result of application and sliding resistance.
• FEP is characterized by a very good ability to be pushed forward.
• PUR has acceptable kink stability and good blood compatibility, and the risk of inflammation or injury to the vessel walls is almost zero. The latter is due to the fact that PUR softens at body temperature within a few minutes and then there is hardly any mechanical irritation of the vessel walls.
• the object of the invention is therefore to provide tubes for peripheral venous cannulas that combine the positive properties of FEP with those of PUR without the negative properties being taken over (see Table 1).
• the task was solved by designing the tubes for peripheral venous cannulas as a layered composite with an inner layer made of polyamide and an outer layer made of polyurethane.
• Homo-polymers are used for the production of tubular extrudates, especially for medicine.
• the standard or self-formulated materials are not sufficient in their range of properties, one is happy to help with layer composites of materials with different properties.
• the inner surface of the hose must have significantly different properties than the outer surface, for example if the outer layer is easy to glue, the inner layer good chemical resistance is important.
• the present invention aims to achieve tubing properties for the area of intravenous cannulas, as described in the task above and which clearly exceed the sum of the individual material properties.
• Such combinations of properties should only be achievable if the systems show a certain synergistic effect and the materials used are precisely coordinated for the respective application.
• a tube is as stiff as possible when it is inserted into the body, but is as flexible as possible when it stays in the body.
• the user therefore has a wide range of options for influencing the properties of the tubes for intravenous cannulas in a simple manner, that is to say tailoring them, so to speak. This is not possible with the currently used mono tubes according to the state of the art.
• the desired properties of the tubes for peripheral venous cannulas in the event of fluctuations in the quality of the raw material can be largely ensured by varying the respective layer thicknesses of the coextruded tube.
• these formulation adjustments are additionally possible and can bring about further property optimization or fine-tuning of the hose properties.
• Table 2 summarizes the properties of the layered composite according to the invention consisting of a PA outer hose and a PUR inner hose compared to hoses made from the starting substances PA and PUR or FEP: Table 2
• This investigated tube for indwelling vein cannulas has an outer diameter of 1.07 mm, an inner diameter of 0.79 mm and has an X-ray contrast strip.
• this hose with the PA inner layer and the PUR outer layer is deflected by a pin with a 4 mm diameter by 180 °, it will not buckle in the temperature range between 23 ° C and 37 ° C.
• An FEP tube inevitably kinks in this temperature range and is damaged in such a way that the flow, for example of the infusion solution, is impaired, even stopped permanently.
• This irreversible damage results in the need to replace the tubing for the indwelling cannula, which leads to an unnecessary burden on the patient, especially if the patient has very difficult to puncture veins.
• a PUR hose does not kink at 37 ° C, but - depending on the wall thickness and outside diameter - the risk of kinking at temperatures below 30 ° C is quite high, so that the pure PUR hose for the
• peripheral cannulas Use of peripheral cannulas is very limited.

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• Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Materials For Medical Uses (AREA)
• Media Introduction/Drainage Providing Device (AREA)
• External Artificial Organs (AREA)

Applications Claiming Priority (3)

Publications (1)

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• 2002
  • 2002-05-08 DE DE10220410A patent/DE10220410B4/de not_active Expired - Fee Related
• 2003
  • 2003-04-30 JP JP2004503068A patent/JP2005530531A/ja active Pending
  • 2003-04-30 US US10/513,662 patent/US20050158498A1/en not_active Abandoned
  • 2003-04-30 AU AU2003227695A patent/AU2003227695A1/en not_active Abandoned
  • 2003-04-30 MX MXPA04010404A patent/MXPA04010404A/es unknown
  • 2003-04-30 CN CNA038083701A patent/CN1646179A/zh active Pending
  • 2003-04-30 WO PCT/EP2003/004515 patent/WO2003094988A1/de not_active Application Discontinuation
  • 2003-04-30 EP EP03725121A patent/EP1501561A1/de not_active Withdrawn

Non-Patent Citations (1)

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