EP1456161A1 - Verfahren zur herstellung von deoxybenzoinen - Google Patents
Verfahren zur herstellung von deoxybenzoinenInfo
- Publication number
- EP1456161A1 EP1456161A1 EP02792928A EP02792928A EP1456161A1 EP 1456161 A1 EP1456161 A1 EP 1456161A1 EP 02792928 A EP02792928 A EP 02792928A EP 02792928 A EP02792928 A EP 02792928A EP 1456161 A1 EP1456161 A1 EP 1456161A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mixture
- residue
- mol
- ether
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
Definitions
- the present invention relates to a process for the preparation of 1,2-diarylethanones, which are also referred to as deoxybenzoins.
- Substituted deoxybenzoins are valuable synthetic intermediates, e.g. B. for the production of isoflavonoids, arylisocoumarins, pyrroles, tolanes, phenylpyranones, arylquinolines, quinazolines and many other compounds.
- the invention therefore relates to a process for the preparation of 1,2-diarylethanones by reacting an arylacetonitrile and an aromatic compound and hydrolysis of the ketimine compound formed, which is characterized in that at least one dialkyl ether of a mono- or polyalkylene glycol or a cyclic ether with at least two oxygen atoms used.
- the aromatic compound has at least one electrophilically substitutable hydrogen atom on an aromatic nucleus.
- the aromatic core is generally benzene, naphthalene or a five- or six-membered aromatic Ring comprising one to three heteroatoms selected from nitrogen, oxygen and sulfur, such as pyrrole, imidazole and the like; preferably around benzene.
- the aryl radical in arylacetonitrile is generally phenyl, naphthyl or a five- or six-membered aromatic radical which comprises one to three heteroatoms selected from nitrogen, oxygen and sulfur.
- the process according to the invention is particularly suitable for the reaction of phenylacetonitriles.
- the arylacetonitrile and the aromatic compound can carry one or more substituents on the aromatic nucleus or on the aryl radical which are inert under the reaction conditions and do not adversely affect the reaction according to the invention, such as in particular hydroxy, C 1 -C 8 alkoxy, C 1 -C 6 alkyl, C 6 -C ⁇ 0 aryl, C ⁇ -C 8 alkylthio, cyano, Ci-C ⁇ alkylamino and / or di (C ⁇ -C 8 alkyl) amino.
- Two substituents on adjacent carbon atoms can be linked together to form a cyclic structure, such as methylenedioxy.
- the process according to the invention is particularly suitable for acylating aromatic compounds which have one to three hydroxy groups on the aromatic nucleus, such as 1,2-dihydroxybenzene (resorcinol) or 1,3,5-trihydroxybenzene (phloroglucinol).
- aromatic compounds which have one to three hydroxy groups on the aromatic nucleus, such as 1,2-dihydroxybenzene (resorcinol) or 1,3,5-trihydroxybenzene (phloroglucinol).
- Phenylacetonitriles which have at least one substituent selected from hydroxy and C 1 -C 6 -alkoxy, such as 4-hydroxyphenylacetonitrile or 4-methoxyphenylacetonitrile, have been used successfully.
- the solvent used according to the invention is generally a di (C 1 -C 6 -alkyl) ether, preferably di (C 1 -C 4 -alkyl) ether, in particular dimethyl ether or diethyl ether of a poly (C 2 -C 8 -alkylene) glycol with up to 10 alkyleneoxy units, preferably 2 to 4 alkyleneoxy units.
- Mono- or polyethylene glycol ethers are preferred.
- diethylene glycol di (C ⁇ -C 4 alkyl) ether, triethylene glycol di (C ⁇ -C 4 -AL- alkyl) ether and / or tetraethylene glycol di (C ⁇ -C 4 alkyl) ethers have proved particularly suitable.
- cyclic ethers with at least two oxygen atoms in the ring such as dioxane or crown ether, for example 18-crown-6, can be used.
- a particular advantage of the process according to the invention is that the solvents used according to the invention do not have to be dried for the reaction.
- a water content of the solvent of up to 5% by weight is possible without any significant loss in yield.
- the reaction according to the invention often proceeds sufficiently quickly even in the absence of a catalyst.
- the reaction according to the invention can be carried out in the presence of an acid catalyst.
- Hydrogen chloride gas is particularly preferred as the acid catalyst.
- the hydrogen chloride gas can suitably be bubbled into a solution of the arylacetonitrile and the aromatic compound.
- Lewis acids are also suitable, such as. B. zinc (II) chloride, ferric chloride and aluminum trichloride.
- the arylacetonitrile and the aromatic compound are generally reacted at a temperature of from -25 to 150 ° C., preferably from 0 to 90 ° C., in particular from 10 to 50 ° C.
- the ketimine compound that forms is in most cases poorly soluble in the reaction solution and can be easily, e.g. B. by filtration, separated from the mother liquor.
- the mother liquor can advantageously be used again as a solvent for the reaction.
- the ketimine compound is then hydrolyzed, generally by treatment with water or a dilute aqueous solution of a base such as sodium hydroxide, sodium carbonate or hydrogen carbonate, or an acid such as hydrochloric acid.
- a base such as sodium hydroxide, sodium carbonate or hydrogen carbonate, or an acid such as hydrochloric acid.
- the 1,2-diarylethanone generally separates out of the aqueous phase as a crystalline precipitate and can optionally be further purified by recrystallization or other cleaning operations known per se.
- you can the ketimine compound can also be hydrolyzed without prior separation by the reaction mixture, for. B. mixed with water or a dilute aqueous solution of an acid.
- the 1,2-diarylethanone is then isolated by conventional methods.
- Example 5 54 g (0.4 mol) of 4-hydroxyphenylacetonitrile and 50.4 g (0.4 mol) of phloroglucinol were added to the mother liquor from Example 5 and the procedure followed as in Example 5. The mother liquor was used further in Example 7. Yield: 86.5 g (83%).
- Example 13 (not according to the invention)
- Example 3 was repeated, but using tetrahydrofuran instead of diethylene glycol diethyl ether. No formation of the ketimine hydrochloride was found.
- Example 3 was repeated, but using tert-butyl methyl ether instead of diethylene glycol diethyl ether. No formation of the ketimine hydrochloride was found.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10160721 | 2001-12-11 | ||
DE10160721A DE10160721A1 (de) | 2001-12-11 | 2001-12-11 | Verfahren zur Herstellung von Deoxybenzoinen |
PCT/EP2002/013883 WO2003053900A1 (de) | 2001-12-11 | 2002-12-06 | Verfahren zur herstellung von deoxybenzoinen |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1456161A1 true EP1456161A1 (de) | 2004-09-15 |
Family
ID=7708745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02792928A Withdrawn EP1456161A1 (de) | 2001-12-11 | 2002-12-06 | Verfahren zur herstellung von deoxybenzoinen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6867331B2 (es) |
EP (1) | EP1456161A1 (es) |
JP (1) | JP3886967B2 (es) |
CN (1) | CN1301951C (es) |
AR (1) | AR037733A1 (es) |
AU (1) | AU2002358637A1 (es) |
DE (1) | DE10160721A1 (es) |
WO (1) | WO2003053900A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005054169A1 (en) * | 2003-12-08 | 2005-06-16 | Hanbul Cosmetic Co., Ltd. | Preparation method of 2-phenylacetophenone derivatives |
US20080113073A1 (en) * | 2005-04-04 | 2008-05-15 | Symrise Gmbh & Co. Kg | Hydroxydeoxybenzoins And The Use Thereof to Mask A Bitter Taste |
EP1871757B1 (en) * | 2005-04-18 | 2009-01-14 | DSMIP Assets B.V. | Process for the manufacture of hydroxylated isoflavones |
US8157837B2 (en) * | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US9388273B2 (en) * | 2013-05-17 | 2016-07-12 | University Of Massachusetts | Multifunctional deoxybenzoin-based monomers and resins having reduced flammability |
CA2964033A1 (en) * | 2014-10-10 | 2016-04-14 | Basf Se | Deoxybenzoin containing flame retardant polymer compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3855301A (en) * | 1971-06-28 | 1974-12-17 | Procter & Gamble | Novel dihydrochalcone and process |
CN1133613C (zh) * | 1999-10-22 | 2004-01-07 | 河南省科学院化学研究所 | 一种合成多羟基去氧安息香及其衍生物的新方法 |
-
2001
- 2001-12-11 DE DE10160721A patent/DE10160721A1/de not_active Withdrawn
-
2002
- 2002-12-06 US US10/498,126 patent/US6867331B2/en not_active Expired - Fee Related
- 2002-12-06 AU AU2002358637A patent/AU2002358637A1/en not_active Abandoned
- 2002-12-06 WO PCT/EP2002/013883 patent/WO2003053900A1/de not_active Application Discontinuation
- 2002-12-06 EP EP02792928A patent/EP1456161A1/de not_active Withdrawn
- 2002-12-06 CN CNB028248449A patent/CN1301951C/zh not_active Expired - Fee Related
- 2002-12-06 JP JP2003554617A patent/JP3886967B2/ja not_active Expired - Fee Related
- 2002-12-06 AR ARP020104742A patent/AR037733A1/es not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO03053900A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003053900A1 (de) | 2003-07-03 |
CN1602289A (zh) | 2005-03-30 |
CN1301951C (zh) | 2007-02-28 |
AU2002358637A1 (en) | 2003-07-09 |
US20050004400A1 (en) | 2005-01-06 |
US6867331B2 (en) | 2005-03-15 |
JP2005513118A (ja) | 2005-05-12 |
DE10160721A1 (de) | 2003-06-18 |
JP3886967B2 (ja) | 2007-02-28 |
AR037733A1 (es) | 2004-12-01 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20040712 |
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AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
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17Q | First examination report despatched |
Effective date: 20060912 |
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Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BASF SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20080116 |