EP1453860A2 - Neue glukoseabhängige insuline - Google Patents

Neue glukoseabhängige insuline

Info

Publication number
EP1453860A2
EP1453860A2 EP02781167A EP02781167A EP1453860A2 EP 1453860 A2 EP1453860 A2 EP 1453860A2 EP 02781167 A EP02781167 A EP 02781167A EP 02781167 A EP02781167 A EP 02781167A EP 1453860 A2 EP1453860 A2 EP 1453860A2
Authority
EP
European Patent Office
Prior art keywords
insulin
glucose
residue
derivative according
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02781167A
Other languages
English (en)
French (fr)
Inventor
Thomas Hoeg-Jensen
Svend Havelund
Jan Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of EP1453860A2 publication Critical patent/EP1453860A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP02781167A 2001-12-02 2002-12-02 Neue glukoseabhängige insuline Withdrawn EP1453860A2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200101784 2001-12-02
DK200101784 2001-12-02
US33703301P 2001-12-05 2001-12-05
US337033P 2001-12-05
PCT/DK2002/000804 WO2003048195A2 (en) 2001-12-02 2002-12-02 Glucose dependant release of insulin from glucose sensing insulin derivatives

Publications (1)

Publication Number Publication Date
EP1453860A2 true EP1453860A2 (de) 2004-09-08

Family

ID=26069103

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02781167A Withdrawn EP1453860A2 (de) 2001-12-02 2002-12-02 Neue glukoseabhängige insuline

Country Status (4)

Country Link
EP (1) EP1453860A2 (de)
JP (1) JP2005526009A (de)
AU (1) AU2002349295A1 (de)
WO (1) WO2003048195A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539244A1 (de) * 2002-06-27 2005-06-15 Novo Nordisk A/S Verwendung von dimethylsulfon als isotonizitätsmittel
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
EP2152245B1 (de) 2007-04-30 2015-12-02 Novo Nordisk A/S Verfahren zum Trocknen einer Proteinzusammensetzung, getrocknete Proteinzusammensetzung und pharmazeutische Zusammensetzungen mit dem getrockneten Protein
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
US8691759B2 (en) 2008-03-18 2014-04-08 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
SG2014006597A (en) 2009-01-28 2014-04-28 Smartcells Inc Conjugate based systems for controlled drug delivery
US20120184487A1 (en) 2009-06-30 2012-07-19 Novo Nordisk A/S Insulin derivatives
EP2348360B1 (de) * 2010-01-25 2017-09-27 Rohm and Haas Electronic Materials LLC Photoresist, der eine stickstoffhaltige Verbindung umfasst
SG11201401835VA (en) * 2011-10-27 2014-09-26 Univ Case Western Reserve Ultra-concentrated rapid-acting insulin analogue formulations
BR112014025132A2 (pt) 2012-04-11 2017-07-11 Novo Nordisk As formulações de insulina
WO2014093696A2 (en) * 2012-12-12 2014-06-19 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
US10376644B2 (en) 2013-04-05 2019-08-13 Novo Nordisk A/S Dose logging device for a drug delivery device
BR112016007166A2 (pt) 2013-10-07 2017-09-12 Novo Nordisk As derivado de um análogo de insulina
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2016149222A2 (en) 2015-03-13 2016-09-22 Case Western Reserve University Insulin analogues containing a glucose-regulated conformational switch
JP2019520342A (ja) 2016-06-02 2019-07-18 サノフイＳａｎｏｆｉ グルコース感知タンパク質に結合することができる薬剤および部分のコンジュゲート
CA3044565A1 (en) * 2016-11-21 2018-05-24 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
EP3548135B1 (de) 2016-12-05 2021-10-13 North Carolina State University Kern-schale-mikronadelvorrichtungen und verwendungen davon
JP6690062B2 (ja) 2016-12-16 2020-04-28 ノヴォ ノルディスク アー／エス インスリン含有医薬組成物
JP7254792B2 (ja) 2017-11-09 2023-04-10 ノヴォ ノルディスク アー／エス グルコース感受性アルブミン結合誘導体
KR20200095507A (ko) 2017-12-01 2020-08-10 사노피 글루코오스 감지 단백질에 결합할 수 있는 모이어티 및 약제의 신규 접합체
WO2019204206A1 (en) * 2018-04-16 2019-10-24 Chou Danny Hung Chieh Glucose-responsive insulin
AU2020255195A1 (en) * 2019-03-29 2021-10-14 Novo Nordisk A/S Glucose sensitive insulin derivatives
US20220288213A1 (en) * 2019-07-31 2022-09-15 Thermalin Inc. Insulin analogues with glucose regulated conformational switch
AU2021247169A1 (en) * 2020-03-31 2022-10-20 Protomer Technologies Inc. Conjugates for selective responsiveness to vicinal diols
AU2021382599A1 (en) * 2020-11-19 2023-06-22 Protomer Technologies Inc. Aromatic boron-containing compounds and insulin analogs
WO2022154055A1 (ja) * 2021-01-13 2022-07-21 地方独立行政法人神奈川県立産業技術総合研究所 ポリグリセロール、該ポリグリセロールを含む複合ゲル組成物、該複合ゲル組成物を含む薬剤送達マイクロニードルおよびそれらの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2027930C (en) * 1989-10-19 1998-06-30 Tsuyoshi Miyazaki Polymer complexes of a sugar response type
JP2002543092A (ja) * 1999-04-27 2002-12-17 イーライ・リリー・アンド・カンパニー 肺投与用インスリン結晶
EP1290024A1 (de) * 2000-06-02 2003-03-12 Novo Nordisk A/S Glukose-abhängige freisetzung von insulin aus glukose-erfassenden insulinderivaten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO03048195A2 *

Also Published As

Publication number Publication date
WO2003048195A2 (en) 2003-06-12
AU2002349295A1 (en) 2003-06-17
JP2005526009A (ja) 2005-09-02
AU2002349295A8 (en) 2003-06-17
WO2003048195A3 (en) 2004-03-25

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