EP1425004A1 - Utilisation de composes en tant qu'antagonistes fonctionnels des recepteurs cannabinoides centraux - Google Patents
Utilisation de composes en tant qu'antagonistes fonctionnels des recepteurs cannabinoides centrauxInfo
- Publication number
- EP1425004A1 EP1425004A1 EP02764671A EP02764671A EP1425004A1 EP 1425004 A1 EP1425004 A1 EP 1425004A1 EP 02764671 A EP02764671 A EP 02764671A EP 02764671 A EP02764671 A EP 02764671A EP 1425004 A1 EP1425004 A1 EP 1425004A1
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- EP
- European Patent Office
- Prior art keywords
- fact
- use according
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- disorders
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Definitions
- the present invention is related to the use of acylamides as functional antagonists to the central cannabinoid receptors. STATE OF THE ART
- Cannabis sativa in addition to being one of the most diffuse recreational drugs in the world, has been used for medical reasons for centuries for its multiple pharmacological effects, the use of which has, however, been limited in the last century mostly for its psychoactive effects on the CNS.
- the principal active component identified is ⁇ 9 -tetrahydrocannabinol ( ⁇ 9 -THC) which, in fact, in addition to possessing psychotropic activity, produces an innumerable series of pharmacological effects both in humans and in animals demonstrating therefore great therapeutic potential, however limited by the central effects mentioned.
- the so-called central receptor because it was initially identified in areas of the CNS and considered the molecular transducer of the central effects of cannabinoids and ii) the so-called peripheral receptor initially identified in peripheral tissues and in turn however considered the molecular transducer of the peripheral effects.
- the central receptors are present in fact in high concentrations in the CNS, and more precisely in the cerebral cortex, hippocampus, caudate-putamen nuclei, substantia nigra, pars reticulata, globus pallidus, endopeduncular nucleus, cerebellum and spinal medulla.
- central receptors are however also present at the peripheral level principally in correspondence with nerve endings as for example in the intestine, as well as on endothelium and on immunocompetent cells.
- peripheral receptors have been principally identified at the peripheral level and above all in immunocompetent cells as for example T- lymphocytes, mastocytes, macrophages, etc.
- the central receptors are considered to mediate not just the "undesired effects” of cannabinoids (such as the psychoactive effects, loss of memory and attention-span, loss of motor co-ordination etc.) but also some of their therapeutically “desired effects” (analgesic effect, anti-hyperalgic, appetite stimulation, ocular hypotension, etc.).
- the peripheral receptors like the central receptors present in the immunocompetent cells, have been associated with the more peripheral effects of cannabinoids as for example the anti-inflammatory effect (Amen A. 1999 ref. cit).
- cannabinomimetic molecules such as the classical cannabinoid agonists (e.g. ⁇ 8 -THC, ⁇ 6 -THC etc.) and non-classical cannabinoid and their derivatives (e.g. CP 55940, HU-210 etc.), derived from the endocannabinoids (e.g. metanandamide, etc.), aminoalkylindoles (e.g. Win 55-212) and molecules capable of interfering with the uptake and the inactivation of the endocannabinoids (e.g.
- AM 404 trifluoromethylketones, etc.
- synthetic derivatives have also been characterised, e.g. pyrrolic derivatives (e.g. SR141716, SR144528), with antagonistic activity towards cannabinoid receptors, believed to be useful in the control of eating disorders, in memory improvement and motor activity and for the weaning from dependency in tobacco as well as cannabis smokers (Ameri A. 1999 ref. cit).
- PEA N- acylethanolamides
- This family comprises derivatives of ethanolamine conjugated with acid radicals, both saturated (PEA) and unsaturated (ANA).
- ANA and PEA can be produced and released by neuronal cells following excitation suggesting that these molecules may act as neurotransmitter belonging to the endocannabinoids system.
- anandamide in vivo provokes cannabinoid-like effects, such as hypothermia, hypomotility, catalepsy, etc.
- these effects have never been reported after administration of PEA in vivo, a result compatible with the absence of affinity of this molecule for the central receptor.
- PEA and ANA are both able to exercise anti-inflammatory effects in vivo, there are disagreements regarding the capacity of PEA, in contrast to that of ANA, to interact with the peripheral cannabinoid receptors (Sugiura T. et al. 2000 J. Biol. Chem.
- PEA is capable of significantly reducing the release of pro- inflammatory mediators from stimulated mastocytes in vitro, through an action on the peripheral receptors expressed on these cells (Facci L et al. 1995 ref. cit), more recent experiments conducted on transfected cell lines overexpressing the peripheral receptor have demonstrated that PEA is not able to displace the binding of cannabinoidmimetic molecules to this receptor (Sugiura T. et al. 2000 ref. cit).
- PEA and analogues have been indicated as possessing neuroprotective activity in vitro and as such useful in pathological conditions associated with neuronal death (WO 9525509 and WO 9618600). This effect has been observed in vitro in newborn mouse cerebellum granule cells which express the peripheral receptor or a CB2-like receptor (Skaper S.D. et al. 1996 ref.cit). Furthermore, a patent application has recently been filed for the use of PEA as a cardio-protective (WO01/28588), an effect mediated also in this case likewise by peripheral receptors, because it is antagonised by SR 144528, antagonist of the peripheral receptor, and not by SR 141716, antagonist of the central receptor.
- Ri — CO — can be an acyl residue of a saturated organic acid, linear or branched comprising from 10 to 20 C atoms — N — R 2 can be:
- an aminohydroxyalkyl residue linear or branched comprising from 2 to 6 C atoms, optionally substituted with one or more aromatic groups on the alkyl chain
- - an aminoacid residue of the series ⁇ , ⁇ or ⁇ R 3 can be H or CH 3 or where -N — R 2 ,R 3 form with the N atom a cyclic aminoether comprising from 5 to 7 C atoms, optionally substituted with linear or branched alkyl groups, behave as functional antagonists of the central cannabinoid receptors. They can therefore be usefully employed as drugs in pathological states or disorders which can be controlled through a reduction of the functionality of these receptors or through a reduction of the effect of the same endocannabinoids caused by a reduced availability or affinity of the receptors.
- the subject of the present invention is the use of said saturated acylamides, or esters or salts of the same, for the preparation of pharmaceutical compositions for the treatment of pathological states or disorders connected with an altered functionality and/or "abusive" activation of the central cannabinoid receptors.
- the aims and advantages of the therapeutic use of the saturated acylamides as functional antagonists of central cannabinoid receptors in pathological states or disorders which can be controlled by reducing the functionality of these receptors or impeding the activity of endocannabinoids, subject of the present invention, will be better understood in the course of the following detailed description.
- the applicant has in fact found surprisingly that after repeated administration of saturated acid acylamides, a marked reduction in the receptor density of the central cannabinoid receptors at the level of the spinal medulla, and a reduction of the affinity constant (Kd), still for these receptors, in different cerebral areas (cerebellum, cortex, hippocampus) have been observed.
- Ri — CO — can be an acyl residue of a saturated organic acid, linear or branched, comprising from 10 to 20 C atoms
- R 2 can be: - an aminohydroxyalkyl residue, linear o branched, comprising from 2 to 6 C atoms, optionally substituted with one or more aromatic groups on the alkyl chain, and the hydroxyl group can be optionally esterified with a pharmaceutically suitable acid group, as for example acetic, tartaric and succinic or equivalent
- R3 can be H or CH 3 or where -N — R 2 .R3 forms with an atom of N a cyclic aminoether comprising from 5 to 7 C atoms optionally substituted with linear or branched alkyl groups,
- R 1 — CO — can be preferentially selected from the group constituted by aliphatic saturated monocarboxylic acids as for example decanoic acid, lauric, myristic, palmitic, stearic or arachidic acids and
- N — R2 when present as an aminohydroxyalkyl residue, can be preferentially chosen, for example, from the group constituted by monoethanolamine, 2- hydroxypropylamine, whilst when it is the residue of an ⁇ , ⁇ o ⁇ aminoacid it can be chosen from the group constituted by serine, glycine, ⁇ -alanine, ⁇ -aminobutyric, phenylalanine and tyrosine instead when -N — R 2 ,R 3 form, with an atom of N, a cyclic aminoether, this is preferentially morpholine.
- the saturated acylamides described in the present invention can be prepared according to various methods and preferably through fusion of the alkylamine salt with a carboxylic acid and formation of the corresponding alkylamide, or through acylation of the alkylamine nitrogen with appropriate activated carboxylic derivatives. Following are reported, for illustration, and not limiting purpose, some examples of saturated monocarboxylic acid amides.
- Example 1 Preparation of N-(2-hydroxyethyl)-palmitoyl amide
- the reaction mixture has then been crystallised from 95% ethanol.
- the crystalline body has been then separated by filtration using a buchner, washed three times with cold 95% ethanol and then taken to dryness under vacuum.
- the yield of the reaction has been approximately 85%.
- Example 5 Preparation of N-palmitoyl-morpholinamide
- morpholine 8.6 mmol
- triethylamine 9 mmol
- dimethylformamide 50 ml
- To the solution have been added, dropwise, 2.35 g of palmitoyl chloride (8.5 mmol) dissolved in dimethylformamide, and made to react for 1 hour at 0°C and for 5 hours at room temperature.
- the suspension obtained has been taken to dryness in a evaporator at reduced pressure.
- the solid residue has then been washed with ethyl ether and crystallised from 70% ethanol.
- the crystalline body was separated by filtration using a buchner, washed three times with cold 70% ethanol and then taken to dryness under vacuum.
- the yield of the reaction has been approximately 85%.
- Example 13 Preparation of N-palmitoyl- ⁇ -alanine 1.5 g of ⁇ -alanine (17 mmol) have been dissolved at 4°C in 1 M potassium hydroxide. To the solution have been added, dropwise and with continuous stirring, 2.75 g of palmitoyl chloride (10 mmol). The reaction mixture has been maintained at 0°C for 16 hours and, following this time, acidified with 6N HCI and extracted with ethyl acetate. The organic phase has been anhydrated with sodium sulphate and evaporated in a evaporator under reduced pressure. The residue was crystallised from (tert-butyl) methylether. The crystalline residue, separated by filtration using a buchner, has been washed three times with cold (tert-butyl) methylether and taken to dryness under vacuum.
- the yield of the reaction has been approximately 80%.
- the saturated fatty acid amide derivatives herein described have surprisingly been demonstrated to act, after repeated administration in normal adult rats, as functional antagonists of the central cannabinoid receptors, in that a reduction of the number of receptors or of their affinity, results in a reduction of their activity, without determining the cannabinomimetic effects known to be modulated by the central receptors (e.g. hypothermia, motor deficiency, etc.).
- the derivatives described in the present invention decrease food intake both after acute or chronic administration.
- the effects on the drastic reduction of the number of the central receptors at the level of the spinal medulla and the significant diminution of the affinity of this receptor in other areas of the CNS are described below in detail. Also described below is the behavioural/pharmacological effect on food intake and body weight after administration of compounds of the present invention.
- the cannabinoid receptors have been characterised using receptor binding techniques. These analyses have been carried out on cells membrane preparations from different areas of the CNS from animals treated repeatedly with the compounds described herein and compared with animals treated with just carrier. a) Treatment of animals
- Rats Male male Sprague Dawley rats have been used, weighing 200-300 g (Harlan- Italy, San Pietro al Natisone, UD, Italia). The animals, maintained on "normal" diets, have received two daily administrations (10mg/Kg peros) of the compounds herein described, for 10 days.
- the nervous tissue membranes have been prepared by the removal and rapid freezing at -80°C of the following cerebral areas: spinal medulla, cortex, hippocampus and cerebellum.
- the tissue have been weighed and suspended in 30 volumes of cold 50 mM Tris-HCI pH 7.4 buffer containing 0.25% of Soybean Type II Trypsin inhibitor, 1 mM EDTA and 4mM MgCb, and has been homogenised with 10 "strokes" in a Potter Teflon/glass homogeniser. After successive centrifugation and washing of the membranes, the pellet has been resuspended in a small volume (approx 1.5ml per g of starting tissue wet weight) of 50 mM Tris-HCI pH 7.4 buffer containing 1 mM EDTA, 4mM MgCI2 and 0.05% Fatty Acid Free BSA. Protein concentration has been determined on these samples by the bicinchinonic acid method.
- the 3 H-WIN55,212-2 possessing a high affinity for the central cannabinoid receptors, has been used at a concentration of around 1-2 nM, whilst the final concentration of cold WIN55.212-2 used to obtain the total displacement of the label from its receptors was from 1 to 10 ⁇ M.
- the final volume was 1ml, constituted by: 870 ⁇ l of binding buffer, 10 ⁇ l of DMSO, 10 ⁇ l of 3 H-WIN55,212-2 100nM, 10 ⁇ l of PMSF 1mM in 1% DMSO and 100 ⁇ l of synaptosomal membrane enriched preparation from nervous tissue (concentration of the homogenate around 1-2 ⁇ g of protein per ⁇ l).
- mice (18-22 g) were housed single per cage under standard conditions. Drugs were dissolved in a vehicle consisting of cremophor/ethanol/saline (1:1 :18 by volume) or suspended in carboxymethylcellulse (CMC) 0.5% in PBS.
- CMC carboxymethylcellulse
- Results are presented as means + SEM and were analysed with an analysis of variance ANOVA followed by Student-Newman-Keuls' test with the level of significance set at P-0.05.
- acylamides obtained following systemic administration in vivo described in the present invention, characterise these compounds as functional antagonists of the central cannabinoid receptors usefully employable therefore for the preparation of pharmaceutical compositions for the therapeutic treatment, alone or in association with other therapeutic agents selected for the specific pathological state or disorders, as for example drugs: anti-epileptics, neuroleptics, atypical neuroleptics, anti-depressives, dopaminergics, dopamine agonists, gaba agonists, weight control drugs, for memory improvement, anti-inflammatory/anti-pain (e.g..
- opiods salicilates, pyrazoles, indoles, arylanthranyles, arylpropionates, arylacetates, oxicam, pyrano carboxylates, glucocorticoids), cathartics (emollients, osmotics, salines, irritants), of pathologic states or disorder connected with altered functionality and/or "abusive" activation of the central cannabinoid receptors and as such in:
- the administration routes that can be used for the preventive or therapeutic treatment of the pathological states or disorders according to the present invention can be oral, parenteral, intramuscularly, subcutaneous or intravenously, and the topical administrations can be transdermical, including rectal, sublingual and intranasal.
- the compounds, according to the therapeutic use as functional antagonists of the central cannabinoid receptors can be administered in pharmaceutical compositions in combination with excipients, dispersants and diluents compatible with the pharmaceutical uses known or new, with the aim of obtaining an improved delivery of the active ingredient to the site of action and to obtain a rapid effect, sustained or delayed in time. For this aim therefore fast, sustained or slow release pharmaceutical compositions can be used.
- the dosages are dependent on the severity of the pathology or disorder and on the chosen route of administration, as well as on the state (age, body weight, general health condition) of the patient.
- the dosage may range between 1 mg/Kg and 50 mg/Kg in daily repeated administrations for a period ranging from 2 to 16 weeks.
- compositions in the form of dispersible granular powders, tablets, pills, hard and soft gelatine capsules, suspensions are suitable; for parenteral administration intramuscularly, subcutaneously, intravenously or peridurally, compositions in the form of buffered aqueous solutions, oil suspensions or lyophilised powders dispersible in appropriate solvents at the time of administration can be suitable; for topical administration transdermally, rectally, intranasally or sublingually, compositions in appropriate excipients or dispersants in the form of patches, suppositories, ovules, aerosols and sprays can be suitable.
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001483A ITMI20011483A1 (it) | 2001-07-11 | 2001-07-11 | Uso di composti come antagonisti funzionali ai recettori centrali deicannabinoidi |
ITMI20011483 | 2001-07-11 | ||
PCT/EP2002/007722 WO2003006007A1 (fr) | 2001-07-11 | 2002-07-11 | Utilisation de composes en tant qu'antagonistes fonctionnels des recepteurs cannabinoides centraux |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1425004A1 true EP1425004A1 (fr) | 2004-06-09 |
Family
ID=11448045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02764671A Withdrawn EP1425004A1 (fr) | 2001-07-11 | 2002-07-11 | Utilisation de composes en tant qu'antagonistes fonctionnels des recepteurs cannabinoides centraux |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1425004A1 (fr) |
IT (1) | ITMI20011483A1 (fr) |
WO (1) | WO2003006007A1 (fr) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9910393D0 (en) | 1999-05-05 | 1999-07-07 | Lucas Ind Plc | Electrical generator,an aero-engine including such a generator and an aircraft including such a generator |
ATE486842T1 (de) | 2002-03-12 | 2010-11-15 | Merck Sharp & Dohme | Substituierte amide |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
EP1546115A4 (fr) | 2002-09-27 | 2010-08-04 | Merck Sharp & Dohme | Pyrimidines substituees |
US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
ITMI20030210A1 (it) * | 2003-02-07 | 2004-08-08 | Res & Innovation Soc Coop A R L | Composti endocannabinoido-simili e loro impiego |
US7176210B2 (en) | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
FR2851460B1 (fr) * | 2003-02-21 | 2007-05-11 | Seppic Sa | Utilisation de n-lauroyl aminoacides comme actif cosmetique et pharmaceutique amincissant |
US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
CN1902177A (zh) | 2003-09-22 | 2007-01-24 | 万有制药株式会社 | 新哌啶衍生物 |
JP2007510647A (ja) | 2003-10-30 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | カンナビノイド受容体調節剤としてのアラルキルアミン類 |
EP1718602A4 (fr) * | 2004-01-30 | 2007-12-12 | Peplin Biolipids Pty Ltd | Molecules porteuses et therapeutiques |
WO2005097127A2 (fr) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques |
BRPI0610580B8 (pt) | 2005-05-30 | 2021-05-25 | Banyu Pharma Co Ltd | composto derivado de piperidina |
AU2006277253A1 (en) | 2005-08-10 | 2007-02-15 | Msd K.K. | Pyridone compound |
AU2006282260A1 (en) | 2005-08-24 | 2007-03-01 | Msd K.K. | Phenylpyridone derivative |
JPWO2007029847A1 (ja) | 2005-09-07 | 2009-03-19 | 萬有製薬株式会社 | 二環性芳香族置換ピリドン誘導体 |
WO2007049798A1 (fr) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de benzoxathiine |
NZ568292A (en) | 2005-11-10 | 2011-08-26 | Msd Kk | Spiro[cyclohexane-1,1'-(3'H)-4'-azaisobenzofuran]-4-carboxamide derivatives |
JPWO2008038692A1 (ja) | 2006-09-28 | 2010-01-28 | 萬有製薬株式会社 | ジアリールケチミン誘導体 |
AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
AU2009220605A1 (en) | 2008-03-06 | 2009-09-11 | Msd K.K. | Alkylaminopyridine derivative |
AU2009229860A1 (en) | 2008-03-28 | 2009-10-01 | Msd K.K. | Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor |
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US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
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WO2010047982A1 (fr) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de benzimidazole cycliques utiles comme agents anti-diabétiques |
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AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
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SI2606070T1 (sl) | 2010-08-20 | 2017-04-26 | Novartis Ag | Protitelesa za receptor 3 epidermalnega rastnega faktorja (HER3) |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
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WO2024130158A1 (fr) | 2022-12-16 | 2024-06-20 | Modernatx, Inc. | Nanoparticules lipidiques et polynucléotides codant l'interleukine-22 à demi-vie sérique étendue pour le traitement d'une maladie métabolique |
Family Cites Families (3)
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IT1271623B (it) * | 1994-03-21 | 1997-06-04 | Lifegroup Spa | N-acilderivati di aminoalcoli con acidi monocarbossilici e bicarbossilici con attivita' neuroprotettiva nelle patologie neurologiche correlate ad eccitotossicita' |
IT1271267B (it) * | 1994-12-14 | 1997-05-27 | Valle Francesco Della | Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi |
IT1271266B (it) * | 1994-12-14 | 1997-05-27 | Valle Francesco Della | Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi |
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2001
- 2001-07-11 IT IT2001MI001483A patent/ITMI20011483A1/it unknown
-
2002
- 2002-07-11 WO PCT/EP2002/007722 patent/WO2003006007A1/fr not_active Application Discontinuation
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Also Published As
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WO2003006007A1 (fr) | 2003-01-23 |
ITMI20011483A0 (it) | 2001-07-11 |
ITMI20011483A1 (it) | 2003-01-11 |
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